GREMLIN Database
YVFR - Uncharacterized ABC transporter ATP-binding protein YvfR
UniProt: O07016 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (234)
Sequences: 86453 (51505)
Seq/√Len: 3367.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E199_R3.5751.00
77_K150_E3.0541.00
19_T22_N3.0471.00
7_T27_S3.0211.00
34_A201_L3.0011.00
10_N23_N2.8911.00
9_S61_E2.8191.00
123_D126_T2.7361.00
199_R211_D2.7081.00
35_A197_A2.6991.00
14_H19_T2.6501.00
61_E68_V2.5971.00
29_E32_E2.4961.00
7_T63_K2.4861.00
213_S216_Q2.3641.00
13_K50_M2.3241.00
12_T59_E2.3211.00
212_G216_Q2.3111.00
22_N207_Q2.2311.00
12_T19_T2.2241.00
65_F150_E2.1311.00
201_L208_L2.1171.00
9_S63_K2.1071.00
12_T23_N2.0951.00
201_L211_D2.0361.00
8_V11_V1.9571.00
115_S120_T1.8931.00
30_K150_E1.8561.00
112_E116_L1.8521.00
111_K124_L1.8451.00
175_G179_Q1.7771.00
93_V131_L1.7611.00
94_D124_L1.7601.00
48_V186_S1.7361.00
15_F20_A1.6621.00
148_N181_K1.6621.00
15_F46_T1.6621.00
94_D98_E1.6451.00
126_T130_K1.6431.00
109_S148_N1.6331.00
194_D215_M1.6271.00
174_H195_D1.6241.00
48_V153_I1.6001.00
187_T193_A1.5311.00
116_L175_G1.5171.00
94_D125_K1.5141.00
68_V71_D1.5031.00
13_K55_L1.5001.00
116_L179_Q1.4901.00
212_G217_I1.4751.00
13_K58_S1.4581.00
65_F77_K1.4531.00
26_F201_L1.4481.00
10_N25_S1.4421.00
98_E110_M1.4311.00
8_V26_F1.4281.00
97_L114_V1.4101.00
98_E106_N1.3961.00
12_T22_N1.3861.00
113_L146_A1.3691.00
176_L181_K1.3591.00
32_E198_Q1.3581.00
11_V57_P1.3531.00
34_A211_D1.3451.00
113_L117_T1.3431.00
14_H58_S1.3411.00
114_V124_L1.3361.00
5_A65_F1.3341.00
109_S112_E1.3181.00
28_I34_A1.3021.00
63_K68_V1.2731.00
216_Q220_R1.2701.00
35_A193_A1.2621.00
29_E199_R1.2571.00
92_K95_E1.2391.00
24_I47_V1.2341.00
107_P111_K1.2301.00
26_F47_V1.2251.00
111_K115_S1.2211.00
33_I177_S1.2181.00
94_D110_M1.2131.00
154_L183_I1.2021.00
204_T209_V1.1951.00
91_L95_E1.1771.00
53_G56_K1.1751.00
8_V51_I1.1741.00
34_A199_R1.1711.00
94_D107_P1.1621.00
223_K226_V1.1611.00
5_A27_S1.1521.00
52_L80_V1.1451.00
221_I225_S1.1451.00
94_D111_K1.1301.00
224_Q227_S1.1251.00
9_S27_S1.1221.00
50_M57_P1.1181.00
5_A30_K1.1041.00
113_L142_A1.0991.00
96_I143_L1.0901.00
170_W192_E1.0871.00
118_A168_R1.0791.00
21_V50_M1.0781.00
36_I47_V1.0761.00
30_K65_F1.0761.00
177_S183_I1.0711.00
33_I197_A1.0471.00
210_A220_R1.0461.00
92_K125_K1.0451.00
167_H171_Q1.0351.00
123_D131_L1.0181.00
36_I184_I1.0181.00
49_S55_L1.0161.00
108_L112_E1.0131.00
225_S229_T1.0101.00
9_S25_S1.0091.00
83_Q133_G1.0071.00
215_M219_S1.0001.00
33_I183_I0.9991.00
174_H177_S0.9951.00
104_Y147_G0.9821.00
102_S106_N0.9741.00
79_G149_P0.9711.00
98_E107_P0.9681.00
5_A29_E0.9681.00
172_T175_G0.9591.00
90_G95_E0.9591.00
209_V223_K0.9531.00
161_M169_F0.9451.00
216_Q219_S0.9441.00
101_R146_A0.9431.00
114_V119_L0.9421.00
152_L181_K0.9401.00
8_V47_V0.9391.00
166_R192_E0.9361.00
81_M154_L0.9301.00
97_L146_A0.9291.00
224_Q228_F0.9261.00
131_L139_L0.9231.00
200_I214_P0.9201.00
47_V203_F0.9161.00
128_A139_L0.9161.00
98_E102_S0.9111.00
166_R189_Y0.9101.00
10_N59_E0.9031.00
92_K127_R0.9011.00
73_Q76_E0.8961.00
39_P204_T0.8851.00
8_V62_I0.8831.00
95_E98_E0.8811.00
112_E115_S0.8801.00
117_T142_A0.8751.00
36_I201_L0.8731.00
67_R77_K0.8661.00
173_I183_I0.8651.00
52_L153_I0.8611.00
81_M141_F0.8581.00
152_L183_I0.8551.00
154_L173_I0.8541.00
33_I185_F0.8511.00
177_S198_Q0.8501.00
79_G144_A0.8451.00
93_V139_L0.8441.00
51_I184_I0.8391.00
101_R105_P0.8371.00
111_K120_T0.8371.00
119_L122_E0.8291.00
55_L58_S0.8281.00
156_E188_H0.8271.00
127_R130_K0.8261.00
110_M113_L0.8211.00
30_K180_G0.8201.00
118_A175_G0.8191.00
87_V136_K0.8171.00
6_V51_I0.8151.00
14_H22_N0.8151.00
171_Q174_H0.8071.00
227_S231_H0.8071.00
123_D135_Q0.8041.00
97_L110_M0.8031.00
113_L116_L0.8011.00
91_L96_I0.7981.00
13_K46_T0.7971.00
174_H178_D0.7911.00
33_I174_H0.7891.00
57_P70_D0.7871.00
11_V50_M0.7861.00
214_P224_Q0.7851.00
56_K70_D0.7831.00
50_M62_I0.7811.00
49_S54_L0.7801.00
170_W195_D0.7781.00
90_G129_E0.7771.00
101_R106_N0.7741.00
185_F197_A0.7711.00
204_T228_F0.7711.00
50_M55_L0.7691.00
42_A203_F0.7651.00
100_F143_L0.7631.00
23_N207_Q0.7631.00
14_H20_A0.7631.00
120_T123_D0.7621.00
81_M144_A0.7611.00
96_I128_A0.7581.00
37_L193_A0.7531.00
214_P218_R0.7521.00
74_V78_I0.7521.00
131_L135_Q0.7411.00
106_N110_M0.7391.00
114_V120_T0.7381.00
120_T124_L0.7371.00
150_E181_K0.7371.00
34_A184_I0.7351.00
210_A221_I0.7351.00
153_I184_I0.7351.00
210_A217_I0.7321.00
28_I182_T0.7321.00
194_D214_P0.7311.00
24_I208_L0.7301.00
21_V24_I0.7291.00
29_E182_T0.7281.00
67_R73_Q0.7221.00
14_H18_K0.7221.00
171_Q175_G0.7151.00
21_V47_V0.7131.00
92_K96_I0.7131.00
174_H196_A0.7091.00
61_E70_D0.7081.00
101_R109_S0.7061.00
158_T169_F0.7061.00
6_V151_L0.7021.00
194_D218_R0.7001.00
226_V230_L0.6991.00
107_P124_L0.6951.00
33_I196_A0.6951.00
109_S113_L0.6921.00
226_V229_T0.6911.00
23_N59_E0.6901.00
91_L99_L0.6881.00
168_R171_Q0.6851.00
73_Q77_K0.6831.00
125_K128_A0.6831.00
101_R104_Y0.6781.00
151_L182_T0.6771.00
111_K114_V0.6761.00
208_L211_D0.6761.00
113_L145_L0.6711.00
133_G138_R0.6681.00
235_S238_R0.6631.00
19_T23_N0.6611.00
28_I184_I0.6601.00
28_I151_L0.6581.00
14_H17_R0.6581.00
20_A46_T0.6491.00
202_F217_I0.6481.00
37_L202_F0.6461.00
228_F231_H0.6441.00
171_Q195_D0.6441.00
204_T207_Q0.6431.00
15_F55_L0.6411.00
78_I151_L0.6401.00
217_I226_V0.6401.00
190_L218_R0.6351.00
79_G147_G0.6341.00
108_L111_K0.6341.00
210_A222_Q0.6321.00
63_K66_N0.6271.00
10_N13_K0.6261.00
65_F151_L0.6261.00
6_V64_L0.6251.00
197_A200_I0.6241.00
100_F147_G0.6161.00
85_V140_S0.6151.00
65_F69_P0.6141.00
13_K21_V0.6101.00
228_F232_S0.6101.00
192_E196_A0.6051.00
50_M58_S0.6031.00
223_K227_S0.6021.00
187_T192_E0.6011.00
27_S211_D0.6001.00
66_N69_P0.5981.00
107_P110_M0.5961.00
51_I62_I0.5951.00
88_M91_L0.5951.00
37_L190_L0.5941.00
204_T223_K0.5931.00
112_E148_N0.5921.00
151_L184_I0.5881.00
14_H59_E0.5871.00
148_N179_Q0.5861.00
99_L103_Y0.5851.00
53_G70_D0.5841.00
232_S235_S0.5831.00
45_T49_S0.5791.00
221_I224_Q0.5771.00
52_L78_I0.5771.00
64_L74_V0.5721.00
185_F196_A0.5701.00
118_A122_E0.5661.00
5_A64_L0.5571.00
64_L77_K0.5561.00
61_E71_D0.5541.00
100_F103_Y0.5541.00
32_E211_D0.5541.00
105_P109_S0.5541.00
88_M96_I0.5541.00
81_M140_S0.5541.00
158_T192_E0.5531.00
199_R213_S0.5491.00
132_S135_Q0.5491.00
13_K16_Q0.5481.00
89_P129_E0.5461.00
218_R221_I0.5461.00
175_G178_D0.5451.00
202_F221_I0.5451.00
84_E136_K0.5411.00
64_L151_L0.5401.00
51_I153_I0.5381.00
191_Q195_D0.5361.00
197_A214_P0.5351.00
113_L119_L0.5351.00
31_G182_T0.5351.00
106_N109_S0.5341.00
165_S168_R0.5331.00
40_N156_E0.5331.00
205_E228_F0.5331.00
193_A197_A0.5321.00
33_I198_Q0.5321.00
82_L85_V0.5281.00
216_Q222_Q0.5271.00
193_A200_I0.5271.00
85_V136_K0.5241.00
67_R71_D0.5221.00
54_L82_L0.5201.00
30_K182_T0.5201.00
141_F169_F0.5201.00
128_A136_K0.5181.00
40_N165_S0.5171.00
11_V62_I0.5171.00
67_R74_V0.5151.00
209_V224_Q0.5151.00
5_A151_L0.5141.00
5_A182_T0.5141.00
100_F104_Y0.5131.00
225_S228_F0.5131.00
222_Q227_S0.5111.00
19_T59_E0.5111.00
49_S80_V0.5061.00
7_T66_N0.5041.00
89_P136_K0.5011.00
221_I229_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9037 100 0.14 Contact Map
3tuiC 2 0.9867 100 0.182 Contact Map
1b0uA 2 0.7807 100 0.198 Contact Map
4u00A 1 0.7674 100 0.201 Contact Map
2oljA 2 0.7674 100 0.201 Contact Map
4ymuJ 2 0.7608 100 0.203 Contact Map
4mkiB 2 0.887 100 0.205 Contact Map
4rvcA 4 0.7741 100 0.207 Contact Map
4huqB 1 0.8738 100 0.209 Contact Map
3fvqA 2 0.9834 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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