GREMLIN Database
RSBQ - Sigma factor SigB regulation protein RsbQ
UniProt: O07015 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (247)
Sequences: 64645 (52542)
Seq/√Len: 3343.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_V46_R4.5071.00
91_V115_H4.3551.00
53_V77_D3.5681.00
37_V258_I2.9431.00
79_L105_A2.9041.00
217_A243_E2.7491.00
253_H256_E2.7431.00
240_K260_L2.7081.00
120_G219_D2.6281.00
91_V114_S2.6211.00
212_L264_Y2.5461.00
89_E114_S2.5351.00
242_M260_L2.4281.00
119_V257_T2.3541.00
79_L109_R2.1451.00
79_L83_E2.1211.00
105_A109_R2.1131.00
79_L112_L2.1051.00
92_F102_G2.1031.00
12_K31_Q2.0681.00
231_H237_S2.0631.00
217_A241_Q2.0541.00
8_R59_D2.0531.00
82_C90_T1.9761.00
99_A121_P1.9451.00
83_E112_L1.9201.00
19_A91_V1.8811.00
104_L108_R1.8701.00
40_A258_I1.8701.00
44_D262_G1.8371.00
20_S48_I1.7971.00
224_A241_Q1.7941.00
106_S116_L1.7921.00
11_V81_V1.7881.00
20_S46_R1.7821.00
10_H57_H1.7821.00
91_V265_L1.7611.00
19_A114_S1.7371.00
76_Q108_R1.7331.00
20_S87_L1.7051.00
245_R253_H1.6961.00
13_V48_I1.6701.00
91_V117_V1.6501.00
212_L240_K1.6501.00
14_K49_L1.6361.00
25_P52_Y1.6241.00
260_L263_D1.6231.00
211_S234_L1.6121.00
45_H91_V1.5851.00
25_P55_S1.5651.00
72_D108_R1.5391.00
24_A78_V1.5321.00
229_Y233_H1.5301.00
52_Y101_I1.5171.00
102_G116_L1.5151.00
24_A52_Y1.5121.00
10_H31_Q1.5021.00
75_A104_L1.4941.00
29_C33_V1.4741.00
50_F78_V1.4671.00
109_R112_L1.4621.00
43_E262_G1.4491.00
78_V105_A1.4381.00
70_T73_G1.4161.00
105_A113_F1.4041.00
203_D206_K1.3911.00
259_Q263_D1.3861.00
40_A262_G1.3631.00
256_E260_L1.3471.00
31_Q51_D1.3441.00
83_E109_R1.3271.00
103_M118_M1.3021.00
117_V261_I1.2901.00
40_A43_E1.2811.00
215_Q227_G1.2791.00
105_A112_L1.2691.00
169_R172_I1.2681.00
104_L107_I1.2671.00
118_M121_P1.2541.00
24_A102_G1.2531.00
93_V119_V1.2451.00
48_I81_V1.2431.00
10_H51_D1.2421.00
19_A45_H1.2391.00
95_H250_H1.2111.00
81_V85_L1.2071.00
224_A228_K1.2001.00
38_A49_L1.1941.00
31_Q57_H1.1921.00
23_F47_V1.1921.00
23_F93_V1.1901.00
256_E259_Q1.1851.00
28_G55_S1.1841.00
21_I45_H1.1801.00
96_S247_H1.1701.00
234_L237_S1.1311.00
231_H239_L1.1271.00
117_V212_L1.1251.00
215_Q241_Q1.1221.00
9_N77_D1.1201.00
14_K38_A1.1101.00
107_I203_D1.1011.00
215_Q239_L1.0971.00
242_M245_R1.0941.00
19_A89_E1.0891.00
228_K232_Q1.0871.00
22_M82_C1.0771.00
87_L90_T1.0721.00
26_G96_S1.0631.00
90_T113_F1.0531.00
31_Q49_L1.0531.00
214_L242_M1.0531.00
212_L238_S1.0481.00
15_G46_R1.0451.00
229_Y232_Q1.0351.00
238_S260_L1.0311.00
40_A255_D1.0291.00
205_S233_H1.0271.00
115_H210_P1.0251.00
50_F81_V1.0231.00
24_A92_F1.0141.00
257_T261_I1.0101.00
215_Q224_A1.0001.00
28_G96_S0.9971.00
75_A101_I0.9931.00
255_D259_Q0.9891.00
82_C105_A0.9871.00
144_L148_M0.9791.00
72_D104_L0.9741.00
33_V250_H0.9721.00
93_V261_I0.9711.00
191_F194_A0.9711.00
45_H265_L0.9681.00
246_G252_S0.9651.00
79_L108_R0.9631.00
142_L146_E0.9591.00
228_K239_L0.9571.00
174_E178_S0.9551.00
17_G46_R0.9541.00
240_K263_D0.9521.00
94_G102_G0.9481.00
51_D56_G0.9481.00
186_V190_Q0.9471.00
11_V85_L0.9441.00
228_K241_Q0.9341.00
175_E179_R0.9321.00
242_M256_E0.9281.00
119_V250_H0.9241.00
193_K196_F0.9191.00
16_S46_R0.9141.00
214_L260_L0.9081.00
79_L82_C0.9011.00
228_K231_H0.8961.00
95_H248_C0.8961.00
48_I85_L0.8951.00
245_R252_S0.8941.00
179_R182_S0.8901.00
80_D84_A0.8861.00
188_A191_F0.8841.00
119_V249_P0.8841.00
170_P174_E0.8831.00
36_A39_P0.8781.00
177_E181_C0.8741.00
22_M90_T0.8731.00
174_E177_E0.8681.00
90_T112_L0.8631.00
178_S181_C0.8621.00
68_Y73_G0.8591.00
52_Y97_V0.8581.00
35_N49_L0.8551.00
184_D187_I0.8541.00
240_K256_E0.8541.00
217_A244_A0.8531.00
189_R193_K0.8501.00
80_D83_E0.8471.00
21_I47_V0.8441.00
21_I93_V0.8431.00
104_L203_D0.8371.00
245_R249_P0.8311.00
13_V16_S0.8301.00
73_G76_Q0.8261.00
75_A108_R0.8251.00
213_I237_S0.8241.00
9_N58_S0.8211.00
116_L211_S0.8181.00
106_S113_F0.8101.00
38_A47_V0.8061.00
82_C87_L0.8051.00
173_K177_E0.8031.00
138_E142_L0.7991.00
20_S90_T0.7951.00
190_Q193_K0.7931.00
76_Q79_L0.7911.00
208_T235_P0.7891.00
19_A115_H0.7831.00
186_V189_R0.7781.00
39_P42_E0.7751.00
24_A50_F0.7751.00
142_L145_L0.7691.00
20_S45_H0.7631.00
227_G239_L0.7621.00
226_V229_Y0.7621.00
175_E178_S0.7571.00
187_I190_Q0.7561.00
190_Q194_A0.7551.00
188_A192_A0.7541.00
35_N39_P0.7521.00
141_L144_L0.7521.00
22_M78_V0.7491.00
74_Y97_V0.7481.00
23_F34_W0.7461.00
94_G99_A0.7461.00
75_A105_A0.7351.00
92_F113_F0.7311.00
86_D89_E0.7311.00
216_C249_P0.7251.00
76_Q80_D0.7221.00
115_H264_Y0.7211.00
51_D57_H0.7201.00
95_H120_G0.7181.00
225_T228_K0.7141.00
258_I262_G0.7131.00
143_G147_M0.7041.00
217_A224_A0.7031.00
192_A195_A0.6991.00
37_V40_A0.6971.00
259_Q262_G0.6961.00
45_H262_G0.6951.00
120_G249_P0.6941.00
32_S35_N0.6921.00
178_S182_S0.6921.00
27_F97_V0.6901.00
154_G158_V0.6901.00
162_T165_N0.6871.00
176_L180_F0.6861.00
52_Y74_Y0.6811.00
28_G97_V0.6801.00
25_P50_F0.6791.00
117_V265_L0.6771.00
155_W159_F0.6761.00
145_L148_M0.6751.00
244_A253_H0.6741.00
170_P173_K0.6731.00
72_D76_Q0.6731.00
106_S209_V0.6731.00
139_E143_G0.6701.00
242_M253_H0.6701.00
92_F105_A0.6661.00
191_F195_A0.6651.00
48_I87_L0.6651.00
172_I175_E0.6631.00
141_L145_L0.6621.00
31_Q50_F0.6601.00
21_I91_V0.6571.00
154_G157_T0.6561.00
120_G216_C0.6521.00
160_A164_L0.6511.00
173_K176_L0.6501.00
100_L122_S0.6501.00
93_V117_V0.6451.00
120_G215_Q0.6421.00
95_H119_V0.6421.00
21_I265_L0.6411.00
107_I206_K0.6411.00
117_V264_Y0.6401.00
161_A165_N0.6401.00
153_I156_A0.6381.00
12_K35_N0.6351.00
103_M123_P0.6351.00
156_A159_F0.6321.00
169_R173_K0.6311.00
9_N53_V0.6311.00
218_D244_A0.6301.00
156_A160_A0.6301.00
187_I191_F0.6301.00
156_A163_V0.6301.00
141_L148_M0.6291.00
14_K39_P0.6281.00
214_L257_T0.6271.00
115_H265_L0.6261.00
176_L179_R0.6261.00
53_V74_Y0.6241.00
146_E150_K0.6241.00
168_D172_I0.6221.00
200_H203_D0.6211.00
94_G98_G0.6191.00
185_P188_A0.6161.00
157_T160_A0.6151.00
163_V166_Q0.6121.00
15_G18_K0.6121.00
90_T114_S0.6101.00
34_W37_V0.6101.00
254_P258_I0.6071.00
34_W38_A0.6051.00
143_G146_E0.5981.00
117_V214_L0.5961.00
145_L149_E0.5951.00
158_V162_T0.5931.00
46_R87_L0.5911.00
13_V17_G0.5901.00
52_Y55_S0.5871.00
113_F209_V0.5871.00
183_T188_A0.5851.00
171_E175_E0.5841.00
22_M92_F0.5831.00
147_M150_K0.5781.00
219_D247_H0.5771.00
23_F49_L0.5771.00
14_K42_E0.5741.00
115_H212_L0.5731.00
202_E205_S0.5721.00
159_F164_L0.5711.00
118_M213_I0.5701.00
37_V257_T0.5641.00
99_A118_M0.5621.00
250_H257_T0.5621.00
22_M50_F0.5611.00
103_M121_P0.5601.00
74_Y101_I0.5591.00
88_K112_L0.5571.00
214_L240_K0.5571.00
10_H58_S0.5571.00
71_L104_L0.5561.00
155_W158_V0.5561.00
227_G231_H0.5551.00
158_V161_A0.5541.00
159_F163_V0.5521.00
213_I227_G0.5521.00
238_S263_D0.5511.00
18_K46_R0.5491.00
140_Q143_G0.5451.00
183_T187_I0.5441.00
157_T161_A0.5441.00
21_I41_F0.5401.00
207_V211_S0.5381.00
189_R192_A0.5371.00
75_A79_L0.5351.00
142_L149_E0.5321.00
164_L167_P0.5321.00
199_D203_D0.5321.00
201_R233_H0.5301.00
81_V84_A0.5301.00
82_C112_L0.5281.00
13_V85_L0.5271.00
52_Y78_V0.5261.00
12_K49_L0.5251.00
143_G148_M0.5231.00
90_T105_A0.5221.00
41_F261_I0.5221.00
100_L103_M0.5221.00
185_P189_R0.5221.00
230_M234_L0.5201.00
44_D47_V0.5201.00
213_I239_L0.5191.00
171_E174_E0.5191.00
106_S207_V0.5191.00
76_Q109_R0.5181.00
152_Y155_W0.5161.00
160_A163_V0.5161.00
183_T186_V0.5161.00
153_I157_T0.5121.00
96_S248_C0.5121.00
146_E149_E0.5091.00
218_D243_E0.5091.00
201_R229_Y0.5081.00
26_G95_H0.5051.00
172_I176_L0.5041.00
138_E141_L0.5041.00
207_V234_L0.5011.00
89_E112_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1womA 1 0.9963 100 0.147 Contact Map
4inzA 1 0.9814 100 0.15 Contact Map
3om8A 4 0.9442 100 0.156 Contact Map
1ehyA 1 0.9591 100 0.158 Contact Map
3oosA 1 0.974 100 0.166 Contact Map
2xuaA 2 0.9405 100 0.166 Contact Map
1iupA 2 0.9591 100 0.178 Contact Map
4psuA 1 0.9665 100 0.179 Contact Map
1zoiA 3 0.9777 100 0.18 Contact Map
3fobA 3 0.974 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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