RSBP - BACSU - GREMLIN Contacts

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RSBP - Phosphoserine phosphatase RsbP

UniProt:	O07014	Sequences: MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHMNMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVFDCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQNQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHRYGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEARHYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSSLSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKSDDECFILVDVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	403 (356)
Sequences:	4576 (3460)
Seq/√Len:	183.4

ECOLI - ARCB
BACSU - RSBP RSBU

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
318_T	321_P	3.062	1.00
10_C	107_I	3.058	1.00
130_L	133_K	3.054	1.00
274_E	278_Y	2.882	1.00
130_L	134_Q	2.767	1.00
317_A	321_P	2.644	1.00
232_S	235_L	2.545	1.00
359_L	367_P	2.502	1.00
279_C	286_I	2.459	1.00
307_D	313_H	2.410	1.00
74_Y	113_N	2.403	1.00
231_I	235_L	2.342	1.00
318_T	322_I	2.322	1.00
282_I	286_I	2.265	1.00
67_E	70_I	2.244	1.00
128_E	133_K	2.223	1.00
13_L	104_C	2.215	1.00
279_C	284_L	2.192	1.00
286_I	291_Q	2.180	1.00
96_D	100_S	2.180	1.00
8_A	12_F	2.124	1.00
231_I	239_S	2.078	1.00
281_A	286_I	2.042	1.00
5_L	23_A	1.991	1.00
129_A	133_K	1.984	1.00
283_Y	286_I	1.979	1.00
275_A	278_Y	1.964	1.00
317_A	322_I	1.945	1.00
206_G	210_G	1.875	1.00
13_L	21_I	1.856	1.00
151_Q	168_T	1.836	1.00
11_G	106_L	1.832	1.00
187_I	190_D	1.831	1.00
137_N	140_L	1.830	1.00
298_A	301_P	1.829	1.00
129_A	132_A	1.791	1.00
38_Q	80_R	1.764	1.00
35_E	38_Q	1.759	1.00
112_R	116_E	1.730	1.00
338_T	341_G	1.720	1.00
279_C	287_D	1.695	1.00
139_E	145_E	1.687	1.00
304_L	314_L	1.682	1.00
319_S	322_I	1.681	1.00
143_A	146_T	1.668	1.00
142_I	146_T	1.663	1.00
188_V	191_Q	1.659	1.00
127_Q	130_L	1.634	1.00
34_Y	80_R	1.634	1.00
141_E	144_L	1.629	1.00
127_Q	133_K	1.626	1.00
188_V	193_Q	1.620	1.00
127_Q	131_L	1.614	1.00
207_D	210_G	1.611	1.00
292_R	334_S	1.603	1.00
198_Y	201_S	1.599	1.00
139_E	142_I	1.596	1.00
138_A	142_I	1.583	1.00
129_A	134_Q	1.583	1.00
191_Q	198_Y	1.576	1.00
16_S	20_S	1.567	1.00
26_R	30_K	1.566	1.00
274_E	277_H	1.555	1.00
190_D	198_Y	1.532	1.00
298_A	302_P	1.526	1.00
29_I	36_P	1.524	1.00
195_D	198_Y	1.522	1.00
298_A	303_A	1.521	1.00
139_E	143_A	1.480	1.00
203_E	207_D	1.474	1.00
190_D	201_S	1.473	1.00
131_L	134_Q	1.452	1.00
118_E	121_I	1.450	1.00
141_E	146_T	1.437	1.00
120_L	123_R	1.433	1.00
141_E	145_E	1.432	1.00
252_L	255_V	1.428	1.00
144_L	149_A	1.412	1.00
137_N	141_E	1.400	1.00
147_L	150_K	1.399	1.00
125_E	133_K	1.396	1.00
49_T	52_A	1.389	1.00
187_I	198_Y	1.381	1.00
11_G	28_L	1.378	1.00
205_S	210_G	1.372	1.00
286_I	290_R	1.372	1.00
96_D	99_A	1.371	1.00
190_D	193_Q	1.371	1.00
205_S	208_L	1.356	1.00
72_E	88_L	1.348	1.00
136_A	140_L	1.345	1.00
136_A	141_E	1.338	1.00
282_I	285_E	1.335	1.00
284_L	287_D	1.328	1.00
356_S	362_L	1.323	1.00
146_T	149_A	1.322	1.00
88_L	112_R	1.320	1.00
141_E	149_A	1.315	1.00
199_N	202_S	1.305	1.00
191_Q	201_S	1.297	1.00
79_A	83_E	1.295	1.00
191_Q	200_A	1.290	1.00
140_L	147_L	1.289	1.00
27_T	30_K	1.287	1.00
304_L	307_D	1.286	1.00
117_N	120_L	1.285	1.00
360_F	367_P	1.284	1.00
193_Q	199_N	1.281	1.00
204_L	207_D	1.280	1.00
279_C	282_I	1.271	1.00
128_E	132_A	1.270	1.00
279_C	285_E	1.270	1.00
142_I	147_L	1.267	1.00
231_I	237_T	1.265	1.00
146_T	150_K	1.264	1.00
308_D	341_G	1.263	1.00
358_Y	367_P	1.259	1.00
349_G	352_D	1.259	1.00
138_A	141_E	1.255	1.00
135_K	138_A	1.254	1.00
359_L	363_L	1.253	1.00
358_Y	362_L	1.252	1.00
208_L	211_Y	1.248	1.00
147_L	151_Q	1.244	1.00
140_L	144_L	1.240	1.00
235_L	239_S	1.240	1.00
142_I	145_E	1.238	1.00
6_N	26_R	1.230	1.00
115_Y	118_E	1.221	1.00
135_K	139_E	1.221	1.00
140_L	145_E	1.214	1.00
233_S	236_I	1.213	1.00
145_E	153_E	1.210	1.00
128_E	131_L	1.208	1.00
292_R	336_S	1.208	1.00
137_N	142_I	1.206	1.00
125_E	128_E	1.205	1.00
359_L	362_L	1.203	1.00
52_A	76_S	1.197	1.00
240_L	268_L	1.197	1.00
196_S	201_S	1.190	1.00
143_A	149_A	1.180	1.00
187_I	191_Q	1.178	1.00
203_E	210_G	1.177	1.00
15_L	21_I	1.170	1.00
195_D	201_S	1.166	1.00
28_L	32_L	1.157	1.00
34_Y	38_Q	1.155	1.00
141_E	147_L	1.155	1.00
13_L	28_L	1.150	1.00
149_A	153_E	1.147	1.00
361_D	365_D	1.145	1.00
274_E	279_C	1.143	1.00
287_D	290_R	1.134	1.00
195_D	199_N	1.132	1.00
138_A	143_A	1.132	1.00
362_L	366_H	1.131	1.00
122_A	125_E	1.130	1.00
207_D	212_Y	1.128	1.00
187_I	193_Q	1.125	1.00
333_S	336_S	1.125	1.00
197_Y	200_A	1.120	1.00
125_E	129_A	1.115	1.00
193_Q	198_Y	1.112	1.00
119_L	123_R	1.105	1.00
303_A	307_D	1.099	1.00
144_L	147_L	1.095	1.00
128_E	134_Q	1.095	1.00
258_M	296_V	1.095	1.00
279_C	283_Y	1.093	1.00
61_F	65_K	1.092	1.00
317_A	320_P	1.089	1.00
206_G	209_Y	1.087	1.00
150_K	153_E	1.083	1.00
42_Q	46_M	1.082	1.00
164_F	168_T	1.079	1.00
139_E	144_L	1.073	1.00
159_K	162_Q	1.073	1.00
144_L	148_K	1.072	1.00
148_K	153_E	1.071	1.00
136_A	139_E	1.071	1.00
145_E	149_A	1.065	1.00
193_Q	202_S	1.057	1.00
138_A	144_L	1.054	1.00
351_M	354_T	1.053	1.00
258_M	262_D	1.053	1.00
78_K	84_E	1.052	1.00
139_E	149_A	1.051	1.00
197_Y	202_S	1.046	1.00
119_L	122_A	1.044	1.00
113_N	116_E	1.044	1.00
140_L	149_A	1.041	1.00
203_E	206_G	1.036	1.00
204_L	210_G	1.032	1.00
191_Q	197_Y	1.031	1.00
138_A	147_L	1.030	1.00
49_T	84_E	1.027	1.00
121_I	125_E	1.021	1.00
11_G	31_I	1.020	1.00
193_Q	197_Y	1.020	1.00
142_I	151_Q	1.015	0.99
193_Q	201_S	1.013	0.99
145_E	150_K	1.010	0.99
137_N	143_A	1.003	0.99
190_D	199_N	1.000	0.99
361_D	364_K	0.997	0.99
146_T	151_Q	0.994	0.99
127_Q	132_A	0.989	0.99
193_Q	200_A	0.989	0.99
293_I	298_A	0.987	0.99
298_A	304_L	0.986	0.99
88_L	107_I	0.985	0.99
303_A	306_Q	0.985	0.99
343_L	348_D	0.983	0.99
140_L	152_E	0.982	0.99
198_Y	202_S	0.979	0.99
187_I	196_S	0.975	0.99
315_L	335_L	0.970	0.99
344_L	348_D	0.970	0.99
136_A	142_I	0.966	0.99
123_R	127_Q	0.965	0.99
256_K	260_E	0.963	0.99
76_S	84_E	0.958	0.99
76_S	86_P	0.957	0.99
148_K	172_L	0.954	0.99
138_A	145_E	0.954	0.99
15_L	19_G	0.953	0.99
79_A	85_I	0.950	0.99
191_Q	199_N	0.949	0.99
207_D	211_Y	0.948	0.99
190_D	195_D	0.943	0.99
205_S	212_Y	0.942	0.99
139_E	147_L	0.938	0.99
141_E	151_Q	0.938	0.99
125_E	130_L	0.930	0.99
190_D	197_Y	0.925	0.99
142_I	152_E	0.925	0.99
328_L	332_S	0.925	0.99
5_L	14_A	0.924	0.99
285_E	288_I	0.921	0.99
201_S	205_S	0.918	0.99
118_E	123_R	0.914	0.99
162_Q	166_L	0.913	0.99
353_P	356_S	0.913	0.99
137_N	149_A	0.910	0.99
138_A	146_T	0.908	0.99
136_A	149_A	0.905	0.99
140_L	146_T	0.902	0.99
26_R	29_I	0.899	0.99
190_D	200_A	0.897	0.99
91_A	104_C	0.897	0.99
135_K	142_I	0.894	0.99
187_I	192_V	0.892	0.99
43_H	46_M	0.890	0.99
148_K	152_E	0.887	0.99
137_N	144_L	0.887	0.99
313_H	316_H	0.887	0.99
243_L	246_R	0.886	0.99
274_E	284_L	0.884	0.99
203_E	208_L	0.883	0.99
287_D	291_Q	0.881	0.99
208_L	212_Y	0.881	0.99
187_I	201_S	0.878	0.99
136_A	143_A	0.876	0.98
135_K	141_E	0.875	0.98
75_I	89_I	0.869	0.98
195_D	200_A	0.868	0.98
135_K	143_A	0.868	0.98
91_A	102_F	0.867	0.98
302_P	307_D	0.866	0.98
208_L	213_Q	0.862	0.98
147_L	153_E	0.860	0.98
362_L	365_D	0.859	0.98
204_L	208_L	0.858	0.98
187_I	195_D	0.855	0.98
22_I	101_V	0.852	0.98
304_L	312_Q	0.848	0.98
136_A	147_L	0.848	0.98
326_E	329_E	0.846	0.98
215_D	218_R	0.846	0.98
125_E	134_Q	0.845	0.98
125_E	132_A	0.845	0.98
285_E	290_R	0.844	0.98
299_G	302_P	0.843	0.98
12_F	25_N	0.842	0.98
295_Y	298_A	0.838	0.98
142_I	149_A	0.838	0.98
11_G	27_T	0.836	0.98
191_Q	195_D	0.832	0.98
187_I	200_A	0.829	0.98
142_I	153_E	0.827	0.98
327_D	334_S	0.825	0.98
122_A	126_A	0.824	0.98
144_L	152_E	0.822	0.98
206_G	213_Q	0.821	0.98
319_S	324_M	0.819	0.98
29_I	35_E	0.815	0.98
281_A	284_L	0.814	0.98
205_S	213_Q	0.814	0.98
58_L	62_P	0.813	0.98
358_Y	366_H	0.810	0.97
307_D	341_G	0.810	0.97
48_L	52_A	0.808	0.97
141_E	152_E	0.808	0.97
123_R	126_A	0.807	0.97
254_P	258_M	0.804	0.97
314_L	360_F	0.804	0.97
304_L	308_D	0.803	0.97
21_I	77_L	0.803	0.97
298_A	306_Q	0.798	0.97
206_G	212_Y	0.798	0.97
32_L	39_V	0.793	0.97
329_E	332_S	0.792	0.97
16_S	22_I	0.789	0.97
196_S	200_A	0.789	0.97
124_N	130_L	0.787	0.97
187_I	202_S	0.785	0.97
136_A	145_E	0.785	0.97
260_E	264_H	0.783	0.97
144_L	153_E	0.781	0.97
255_V	332_S	0.779	0.97
21_I	43_H	0.779	0.97
129_A	141_E	0.778	0.97
67_E	72_E	0.778	0.97
116_E	120_L	0.774	0.97
50_I	53_Q	0.773	0.97
160_Q	164_F	0.770	0.97
189_N	200_A	0.770	0.97
343_L	346_Y	0.768	0.97
299_G	303_A	0.767	0.96
14_A	103_D	0.765	0.96
127_Q	134_Q	0.764	0.96
49_T	76_S	0.764	0.96
327_D	330_F	0.761	0.96
282_I	288_I	0.761	0.96
140_L	143_A	0.760	0.96
187_I	197_Y	0.759	0.96
282_I	291_Q	0.757	0.96
149_A	154_L	0.755	0.96
15_L	91_A	0.745	0.96
128_E	139_E	0.744	0.96
139_E	146_T	0.741	0.96
188_V	198_Y	0.739	0.96
163_Q	167_N	0.738	0.96
196_S	209_Y	0.736	0.96
192_V	196_S	0.734	0.96
149_A	152_E	0.733	0.95
11_G	25_N	0.732	0.95
32_L	77_L	0.730	0.95
341_G	344_L	0.730	0.95
196_S	199_N	0.724	0.95
137_N	147_L	0.724	0.95
188_V	197_Y	0.721	0.95
147_L	152_E	0.721	0.95
189_N	192_V	0.716	0.95
114_E	117_N	0.716	0.95
210_G	213_Q	0.714	0.95
21_I	28_L	0.714	0.95
139_E	151_Q	0.713	0.95
89_I	106_L	0.713	0.95
188_V	200_A	0.710	0.95
195_D	206_G	0.707	0.95
307_D	337_Y	0.707	0.95
282_I	287_D	0.706	0.94
145_E	154_L	0.706	0.94
279_C	290_R	0.706	0.94
205_S	211_Y	0.705	0.94
143_A	153_E	0.705	0.94
359_L	366_H	0.704	0.94
144_L	154_L	0.704	0.94
302_P	306_Q	0.702	0.94
61_F	64_L	0.702	0.94
192_V	198_Y	0.701	0.94
193_Q	196_S	0.700	0.94
284_L	293_I	0.695	0.94
280_T	286_I	0.693	0.94
143_A	152_E	0.691	0.94
24_A	29_I	0.689	0.94
24_A	28_L	0.689	0.94
132_A	137_N	0.689	0.94
14_A	101_V	0.689	0.94
362_L	367_P	0.689	0.94
145_E	151_Q	0.687	0.94
280_T	287_D	0.686	0.94
143_A	175_A	0.686	0.94
280_T	285_E	0.682	0.93
167_N	171_E	0.682	0.93
277_H	284_L	0.680	0.93
279_C	291_Q	0.679	0.93
141_E	154_L	0.677	0.93
121_I	126_A	0.677	0.93
137_N	145_E	0.673	0.93
257_V	268_L	0.672	0.93
190_D	202_S	0.672	0.93
161_N	164_F	0.670	0.93
197_Y	201_S	0.669	0.93
157_I	164_F	0.668	0.93
348_D	351_M	0.667	0.93
302_P	308_D	0.667	0.93
205_S	209_Y	0.667	0.93
253_S	332_S	0.667	0.93
262_D	267_S	0.666	0.93
92_I	103_D	0.666	0.93
135_K	146_T	0.666	0.93
281_A	285_E	0.659	0.92
203_E	209_Y	0.657	0.92
198_Y	205_S	0.655	0.92
348_D	352_D	0.652	0.92
328_L	331_Q	0.651	0.92
155_L	166_L	0.649	0.92
198_Y	209_Y	0.649	0.92
45_N	57_Q	0.648	0.92
201_S	208_L	0.643	0.91
278_Y	286_I	0.642	0.91
113_N	117_N	0.640	0.91
131_L	135_K	0.640	0.91
276_R	279_C	0.639	0.91
126_A	130_L	0.638	0.91
133_K	141_E	0.637	0.91
160_Q	163_Q	0.637	0.91
21_I	39_V	0.636	0.91
143_A	148_K	0.635	0.91
192_V	195_D	0.635	0.91
133_K	137_N	0.634	0.91
360_F	365_D	0.634	0.91
321_P	324_M	0.629	0.90
275_A	279_C	0.628	0.90
309_S	312_Q	0.628	0.90
261_L	265_L	0.627	0.90
320_P	324_M	0.625	0.90
168_T	172_L	0.624	0.90
220_G	283_Y	0.623	0.90
163_Q	166_L	0.622	0.90
148_K	151_Q	0.621	0.90
139_E	150_K	0.619	0.90
188_V	201_S	0.616	0.89
9_P	12_F	0.616	0.89
247_Q	250_Q	0.615	0.89
143_A	151_Q	0.615	0.89
164_F	167_N	0.614	0.89
220_G	282_I	0.613	0.89
331_Q	339_E	0.613	0.89
86_P	113_N	0.611	0.89
48_L	76_S	0.609	0.89
126_A	134_Q	0.608	0.89
136_A	144_L	0.606	0.89
137_N	146_T	0.605	0.89
187_I	205_S	0.605	0.89
146_T	153_E	0.603	0.88
26_R	36_P	0.603	0.88
144_L	151_Q	0.603	0.88
297_N	318_T	0.601	0.88
165_K	168_T	0.601	0.88
195_D	205_S	0.598	0.88
342_R	348_D	0.597	0.88
191_Q	194_I	0.595	0.88
346_Y	351_M	0.595	0.88
196_S	202_S	0.594	0.88
194_I	202_S	0.594	0.88
63_L	102_F	0.593	0.88
293_I	302_P	0.593	0.88
54_L	58_L	0.589	0.87
227_M	278_Y	0.588	0.87
138_A	149_A	0.587	0.87
142_I	148_K	0.584	0.87
135_K	140_L	0.583	0.87
281_A	287_D	0.582	0.87
262_D	265_L	0.582	0.87
118_E	122_A	0.581	0.86
57_Q	61_F	0.581	0.86
200_A	207_D	0.579	0.86
201_S	206_G	0.578	0.86
261_L	268_L	0.577	0.86
195_D	202_S	0.576	0.86
117_N	121_I	0.576	0.86
296_V	302_P	0.574	0.86
198_Y	210_G	0.572	0.86
137_N	151_Q	0.571	0.86
141_E	148_K	0.571	0.86
21_I	25_N	0.569	0.85
243_L	264_H	0.565	0.85
187_I	199_N	0.562	0.85
206_G	211_Y	0.559	0.84
176_R	180_K	0.557	0.84
294_D	334_S	0.556	0.84
327_D	331_Q	0.556	0.84
145_E	148_K	0.554	0.84
154_L	165_K	0.554	0.84
279_C	288_I	0.548	0.83
293_I	303_A	0.547	0.83
282_I	290_R	0.547	0.83
195_D	208_L	0.546	0.83
56_C	59_Y	0.545	0.83
300_H	304_L	0.544	0.83
140_L	153_E	0.543	0.83
138_A	151_Q	0.539	0.82
55_F	58_L	0.537	0.82
359_L	364_K	0.535	0.82
93_A	102_F	0.535	0.82
141_E	153_E	0.534	0.82
143_A	154_L	0.534	0.82
190_D	194_I	0.533	0.81
256_K	259_K	0.532	0.81
191_Q	202_S	0.531	0.81
203_E	213_Q	0.531	0.81
111_K	114_E	0.530	0.81
19_G	60_F	0.528	0.81
148_K	169_K	0.528	0.81
218_R	287_D	0.527	0.81
259_K	263_R	0.527	0.81
136_A	146_T	0.525	0.80
19_G	28_L	0.523	0.80
151_Q	154_L	0.519	0.80
138_A	153_E	0.518	0.80
126_A	129_A	0.516	0.79
12_F	103_D	0.516	0.79
204_L	209_Y	0.515	0.79
239_S	268_L	0.515	0.79
280_T	291_Q	0.514	0.79
14_A	23_A	0.513	0.79
199_N	210_G	0.512	0.79
214_I	218_R	0.510	0.79
94_R	103_D	0.508	0.78
77_L	85_I	0.507	0.78
126_A	133_K	0.507	0.78
295_Y	315_L	0.507	0.78
121_I	124_N	0.506	0.78
93_A	101_V	0.505	0.78
204_L	211_Y	0.505	0.78
135_K	144_L	0.504	0.78
142_I	154_L	0.504	0.78
145_E	152_E	0.503	0.78
189_N	193_Q	0.501	0.77
89_I	104_C	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ke6A	2	0.5385	100	0.574	Contact Map
3eq2A	2	0.9032	100	0.579	Contact Map
3f79A	2	0.5658	100	0.587	Contact Map
4gczA	2	0.727	100	0.598	Contact Map
3pu9A	2	0.5236	100	0.644	Contact Map
3a0rA	2	0.6725	100	0.654	Contact Map
3t91A	3	0.5161	100	0.659	Contact Map
4i5sA	2	0.6501	100	0.664	Contact Map
4r3aA	1	0.6526	99.9	0.69	Contact Map
3zt9A	1	0.4715	99.9	0.692	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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