GREMLIN Database
RSBP - Phosphoserine phosphatase RsbP
UniProt: O07014 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 403 (356)
Sequences: 4576 (3460)
Seq/√Len: 183.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
318_T321_P3.0621.00
10_C107_I3.0581.00
130_L133_K3.0541.00
274_E278_Y2.8821.00
130_L134_Q2.7671.00
317_A321_P2.6441.00
232_S235_L2.5451.00
359_L367_P2.5021.00
279_C286_I2.4591.00
307_D313_H2.4101.00
74_Y113_N2.4031.00
231_I235_L2.3421.00
318_T322_I2.3221.00
282_I286_I2.2651.00
67_E70_I2.2441.00
128_E133_K2.2231.00
13_L104_C2.2151.00
279_C284_L2.1921.00
286_I291_Q2.1801.00
96_D100_S2.1801.00
8_A12_F2.1241.00
231_I239_S2.0781.00
281_A286_I2.0421.00
5_L23_A1.9911.00
129_A133_K1.9841.00
283_Y286_I1.9791.00
275_A278_Y1.9641.00
317_A322_I1.9451.00
206_G210_G1.8751.00
13_L21_I1.8561.00
151_Q168_T1.8361.00
11_G106_L1.8321.00
187_I190_D1.8311.00
137_N140_L1.8301.00
298_A301_P1.8291.00
129_A132_A1.7911.00
38_Q80_R1.7641.00
35_E38_Q1.7591.00
112_R116_E1.7301.00
338_T341_G1.7201.00
279_C287_D1.6951.00
139_E145_E1.6871.00
304_L314_L1.6821.00
319_S322_I1.6811.00
143_A146_T1.6681.00
142_I146_T1.6631.00
188_V191_Q1.6591.00
127_Q130_L1.6341.00
34_Y80_R1.6341.00
141_E144_L1.6291.00
127_Q133_K1.6261.00
188_V193_Q1.6201.00
127_Q131_L1.6141.00
207_D210_G1.6111.00
292_R334_S1.6031.00
198_Y201_S1.5991.00
139_E142_I1.5961.00
138_A142_I1.5831.00
129_A134_Q1.5831.00
191_Q198_Y1.5761.00
16_S20_S1.5671.00
26_R30_K1.5661.00
274_E277_H1.5551.00
190_D198_Y1.5321.00
298_A302_P1.5261.00
29_I36_P1.5241.00
195_D198_Y1.5221.00
298_A303_A1.5211.00
139_E143_A1.4801.00
203_E207_D1.4741.00
190_D201_S1.4731.00
131_L134_Q1.4521.00
118_E121_I1.4501.00
141_E146_T1.4371.00
120_L123_R1.4331.00
141_E145_E1.4321.00
252_L255_V1.4281.00
144_L149_A1.4121.00
137_N141_E1.4001.00
147_L150_K1.3991.00
125_E133_K1.3961.00
49_T52_A1.3891.00
187_I198_Y1.3811.00
11_G28_L1.3781.00
205_S210_G1.3721.00
286_I290_R1.3721.00
96_D99_A1.3711.00
190_D193_Q1.3711.00
205_S208_L1.3561.00
72_E88_L1.3481.00
136_A140_L1.3451.00
136_A141_E1.3381.00
282_I285_E1.3351.00
284_L287_D1.3281.00
356_S362_L1.3231.00
146_T149_A1.3221.00
88_L112_R1.3201.00
141_E149_A1.3151.00
199_N202_S1.3051.00
191_Q201_S1.2971.00
79_A83_E1.2951.00
191_Q200_A1.2901.00
140_L147_L1.2891.00
27_T30_K1.2871.00
304_L307_D1.2861.00
117_N120_L1.2851.00
360_F367_P1.2841.00
193_Q199_N1.2811.00
204_L207_D1.2801.00
279_C282_I1.2711.00
128_E132_A1.2701.00
279_C285_E1.2701.00
142_I147_L1.2671.00
231_I237_T1.2651.00
146_T150_K1.2641.00
308_D341_G1.2631.00
358_Y367_P1.2591.00
349_G352_D1.2591.00
138_A141_E1.2551.00
135_K138_A1.2541.00
359_L363_L1.2531.00
358_Y362_L1.2521.00
208_L211_Y1.2481.00
147_L151_Q1.2441.00
140_L144_L1.2401.00
235_L239_S1.2401.00
142_I145_E1.2381.00
6_N26_R1.2301.00
115_Y118_E1.2211.00
135_K139_E1.2211.00
140_L145_E1.2141.00
233_S236_I1.2131.00
145_E153_E1.2101.00
128_E131_L1.2081.00
292_R336_S1.2081.00
137_N142_I1.2061.00
125_E128_E1.2051.00
359_L362_L1.2031.00
52_A76_S1.1971.00
240_L268_L1.1971.00
196_S201_S1.1901.00
143_A149_A1.1801.00
187_I191_Q1.1781.00
203_E210_G1.1771.00
15_L21_I1.1701.00
195_D201_S1.1661.00
28_L32_L1.1571.00
34_Y38_Q1.1551.00
141_E147_L1.1551.00
13_L28_L1.1501.00
149_A153_E1.1471.00
361_D365_D1.1451.00
274_E279_C1.1431.00
287_D290_R1.1341.00
195_D199_N1.1321.00
138_A143_A1.1321.00
362_L366_H1.1311.00
122_A125_E1.1301.00
207_D212_Y1.1281.00
187_I193_Q1.1251.00
333_S336_S1.1251.00
197_Y200_A1.1201.00
125_E129_A1.1151.00
193_Q198_Y1.1121.00
119_L123_R1.1051.00
303_A307_D1.0991.00
144_L147_L1.0951.00
128_E134_Q1.0951.00
258_M296_V1.0951.00
279_C283_Y1.0931.00
61_F65_K1.0921.00
317_A320_P1.0891.00
206_G209_Y1.0871.00
150_K153_E1.0831.00
42_Q46_M1.0821.00
164_F168_T1.0791.00
139_E144_L1.0731.00
159_K162_Q1.0731.00
144_L148_K1.0721.00
148_K153_E1.0711.00
136_A139_E1.0711.00
145_E149_A1.0651.00
193_Q202_S1.0571.00
138_A144_L1.0541.00
351_M354_T1.0531.00
258_M262_D1.0531.00
78_K84_E1.0521.00
139_E149_A1.0511.00
197_Y202_S1.0461.00
119_L122_A1.0441.00
113_N116_E1.0441.00
140_L149_A1.0411.00
203_E206_G1.0361.00
204_L210_G1.0321.00
191_Q197_Y1.0311.00
138_A147_L1.0301.00
49_T84_E1.0271.00
121_I125_E1.0211.00
11_G31_I1.0201.00
193_Q197_Y1.0201.00
142_I151_Q1.0150.99
193_Q201_S1.0130.99
145_E150_K1.0100.99
137_N143_A1.0030.99
190_D199_N1.0000.99
361_D364_K0.9970.99
146_T151_Q0.9940.99
127_Q132_A0.9890.99
193_Q200_A0.9890.99
293_I298_A0.9870.99
298_A304_L0.9860.99
88_L107_I0.9850.99
303_A306_Q0.9850.99
343_L348_D0.9830.99
140_L152_E0.9820.99
198_Y202_S0.9790.99
187_I196_S0.9750.99
315_L335_L0.9700.99
344_L348_D0.9700.99
136_A142_I0.9660.99
123_R127_Q0.9650.99
256_K260_E0.9630.99
76_S84_E0.9580.99
76_S86_P0.9570.99
148_K172_L0.9540.99
138_A145_E0.9540.99
15_L19_G0.9530.99
79_A85_I0.9500.99
191_Q199_N0.9490.99
207_D211_Y0.9480.99
190_D195_D0.9430.99
205_S212_Y0.9420.99
139_E147_L0.9380.99
141_E151_Q0.9380.99
125_E130_L0.9300.99
190_D197_Y0.9250.99
142_I152_E0.9250.99
328_L332_S0.9250.99
5_L14_A0.9240.99
285_E288_I0.9210.99
201_S205_S0.9180.99
118_E123_R0.9140.99
162_Q166_L0.9130.99
353_P356_S0.9130.99
137_N149_A0.9100.99
138_A146_T0.9080.99
136_A149_A0.9050.99
140_L146_T0.9020.99
26_R29_I0.8990.99
190_D200_A0.8970.99
91_A104_C0.8970.99
135_K142_I0.8940.99
187_I192_V0.8920.99
43_H46_M0.8900.99
148_K152_E0.8870.99
137_N144_L0.8870.99
313_H316_H0.8870.99
243_L246_R0.8860.99
274_E284_L0.8840.99
203_E208_L0.8830.99
287_D291_Q0.8810.99
208_L212_Y0.8810.99
187_I201_S0.8780.99
136_A143_A0.8760.98
135_K141_E0.8750.98
75_I89_I0.8690.98
195_D200_A0.8680.98
135_K143_A0.8680.98
91_A102_F0.8670.98
302_P307_D0.8660.98
208_L213_Q0.8620.98
147_L153_E0.8600.98
362_L365_D0.8590.98
204_L208_L0.8580.98
187_I195_D0.8550.98
22_I101_V0.8520.98
304_L312_Q0.8480.98
136_A147_L0.8480.98
326_E329_E0.8460.98
215_D218_R0.8460.98
125_E134_Q0.8450.98
125_E132_A0.8450.98
285_E290_R0.8440.98
299_G302_P0.8430.98
12_F25_N0.8420.98
295_Y298_A0.8380.98
142_I149_A0.8380.98
11_G27_T0.8360.98
191_Q195_D0.8320.98
187_I200_A0.8290.98
142_I153_E0.8270.98
327_D334_S0.8250.98
122_A126_A0.8240.98
144_L152_E0.8220.98
206_G213_Q0.8210.98
319_S324_M0.8190.98
29_I35_E0.8150.98
281_A284_L0.8140.98
205_S213_Q0.8140.98
58_L62_P0.8130.98
358_Y366_H0.8100.97
307_D341_G0.8100.97
48_L52_A0.8080.97
141_E152_E0.8080.97
123_R126_A0.8070.97
254_P258_M0.8040.97
314_L360_F0.8040.97
304_L308_D0.8030.97
21_I77_L0.8030.97
298_A306_Q0.7980.97
206_G212_Y0.7980.97
32_L39_V0.7930.97
329_E332_S0.7920.97
16_S22_I0.7890.97
196_S200_A0.7890.97
124_N130_L0.7870.97
187_I202_S0.7850.97
136_A145_E0.7850.97
260_E264_H0.7830.97
144_L153_E0.7810.97
255_V332_S0.7790.97
21_I43_H0.7790.97
129_A141_E0.7780.97
67_E72_E0.7780.97
116_E120_L0.7740.97
50_I53_Q0.7730.97
160_Q164_F0.7700.97
189_N200_A0.7700.97
343_L346_Y0.7680.97
299_G303_A0.7670.96
14_A103_D0.7650.96
127_Q134_Q0.7640.96
49_T76_S0.7640.96
327_D330_F0.7610.96
282_I288_I0.7610.96
140_L143_A0.7600.96
187_I197_Y0.7590.96
282_I291_Q0.7570.96
149_A154_L0.7550.96
15_L91_A0.7450.96
128_E139_E0.7440.96
139_E146_T0.7410.96
188_V198_Y0.7390.96
163_Q167_N0.7380.96
196_S209_Y0.7360.96
192_V196_S0.7340.96
149_A152_E0.7330.95
11_G25_N0.7320.95
32_L77_L0.7300.95
341_G344_L0.7300.95
196_S199_N0.7240.95
137_N147_L0.7240.95
188_V197_Y0.7210.95
147_L152_E0.7210.95
189_N192_V0.7160.95
114_E117_N0.7160.95
210_G213_Q0.7140.95
21_I28_L0.7140.95
139_E151_Q0.7130.95
89_I106_L0.7130.95
188_V200_A0.7100.95
195_D206_G0.7070.95
307_D337_Y0.7070.95
282_I287_D0.7060.94
145_E154_L0.7060.94
279_C290_R0.7060.94
205_S211_Y0.7050.94
143_A153_E0.7050.94
359_L366_H0.7040.94
144_L154_L0.7040.94
302_P306_Q0.7020.94
61_F64_L0.7020.94
192_V198_Y0.7010.94
193_Q196_S0.7000.94
284_L293_I0.6950.94
280_T286_I0.6930.94
143_A152_E0.6910.94
24_A29_I0.6890.94
24_A28_L0.6890.94
132_A137_N0.6890.94
14_A101_V0.6890.94
362_L367_P0.6890.94
145_E151_Q0.6870.94
280_T287_D0.6860.94
143_A175_A0.6860.94
280_T285_E0.6820.93
167_N171_E0.6820.93
277_H284_L0.6800.93
279_C291_Q0.6790.93
141_E154_L0.6770.93
121_I126_A0.6770.93
137_N145_E0.6730.93
257_V268_L0.6720.93
190_D202_S0.6720.93
161_N164_F0.6700.93
197_Y201_S0.6690.93
157_I164_F0.6680.93
348_D351_M0.6670.93
302_P308_D0.6670.93
205_S209_Y0.6670.93
253_S332_S0.6670.93
262_D267_S0.6660.93
92_I103_D0.6660.93
135_K146_T0.6660.93
281_A285_E0.6590.92
203_E209_Y0.6570.92
198_Y205_S0.6550.92
348_D352_D0.6520.92
328_L331_Q0.6510.92
155_L166_L0.6490.92
198_Y209_Y0.6490.92
45_N57_Q0.6480.92
201_S208_L0.6430.91
278_Y286_I0.6420.91
113_N117_N0.6400.91
131_L135_K0.6400.91
276_R279_C0.6390.91
126_A130_L0.6380.91
133_K141_E0.6370.91
160_Q163_Q0.6370.91
21_I39_V0.6360.91
143_A148_K0.6350.91
192_V195_D0.6350.91
133_K137_N0.6340.91
360_F365_D0.6340.91
321_P324_M0.6290.90
275_A279_C0.6280.90
309_S312_Q0.6280.90
261_L265_L0.6270.90
320_P324_M0.6250.90
168_T172_L0.6240.90
220_G283_Y0.6230.90
163_Q166_L0.6220.90
148_K151_Q0.6210.90
139_E150_K0.6190.90
188_V201_S0.6160.89
9_P12_F0.6160.89
247_Q250_Q0.6150.89
143_A151_Q0.6150.89
164_F167_N0.6140.89
220_G282_I0.6130.89
331_Q339_E0.6130.89
86_P113_N0.6110.89
48_L76_S0.6090.89
126_A134_Q0.6080.89
136_A144_L0.6060.89
137_N146_T0.6050.89
187_I205_S0.6050.89
146_T153_E0.6030.88
26_R36_P0.6030.88
144_L151_Q0.6030.88
297_N318_T0.6010.88
165_K168_T0.6010.88
195_D205_S0.5980.88
342_R348_D0.5970.88
191_Q194_I0.5950.88
346_Y351_M0.5950.88
196_S202_S0.5940.88
194_I202_S0.5940.88
63_L102_F0.5930.88
293_I302_P0.5930.88
54_L58_L0.5890.87
227_M278_Y0.5880.87
138_A149_A0.5870.87
142_I148_K0.5840.87
135_K140_L0.5830.87
281_A287_D0.5820.87
262_D265_L0.5820.87
118_E122_A0.5810.86
57_Q61_F0.5810.86
200_A207_D0.5790.86
201_S206_G0.5780.86
261_L268_L0.5770.86
195_D202_S0.5760.86
117_N121_I0.5760.86
296_V302_P0.5740.86
198_Y210_G0.5720.86
137_N151_Q0.5710.86
141_E148_K0.5710.86
21_I25_N0.5690.85
243_L264_H0.5650.85
187_I199_N0.5620.85
206_G211_Y0.5590.84
176_R180_K0.5570.84
294_D334_S0.5560.84
327_D331_Q0.5560.84
145_E148_K0.5540.84
154_L165_K0.5540.84
279_C288_I0.5480.83
293_I303_A0.5470.83
282_I290_R0.5470.83
195_D208_L0.5460.83
56_C59_Y0.5450.83
300_H304_L0.5440.83
140_L153_E0.5430.83
138_A151_Q0.5390.82
55_F58_L0.5370.82
359_L364_K0.5350.82
93_A102_F0.5350.82
141_E153_E0.5340.82
143_A154_L0.5340.82
190_D194_I0.5330.81
256_K259_K0.5320.81
191_Q202_S0.5310.81
203_E213_Q0.5310.81
111_K114_E0.5300.81
19_G60_F0.5280.81
148_K169_K0.5280.81
218_R287_D0.5270.81
259_K263_R0.5270.81
136_A146_T0.5250.80
19_G28_L0.5230.80
151_Q154_L0.5190.80
138_A153_E0.5180.80
126_A129_A0.5160.79
12_F103_D0.5160.79
204_L209_Y0.5150.79
239_S268_L0.5150.79
280_T291_Q0.5140.79
14_A23_A0.5130.79
199_N210_G0.5120.79
214_I218_R0.5100.79
94_R103_D0.5080.78
77_L85_I0.5070.78
126_A133_K0.5070.78
295_Y315_L0.5070.78
121_I124_N0.5060.78
93_A101_V0.5050.78
204_L211_Y0.5050.78
135_K144_L0.5040.78
142_I154_L0.5040.78
145_E152_E0.5030.78
189_N193_Q0.5010.77
89_I104_C0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ke6A 2 0.5385 100 0.574 Contact Map
3eq2A 2 0.9032 100 0.579 Contact Map
3f79A 2 0.5658 100 0.587 Contact Map
4gczA 2 0.727 100 0.598 Contact Map
3pu9A 2 0.5236 100 0.644 Contact Map
3a0rA 2 0.6725 100 0.654 Contact Map
3t91A 3 0.5161 100 0.659 Contact Map
4i5sA 2 0.6501 100 0.664 Contact Map
4r3aA 1 0.6526 99.9 0.69 Contact Map
3zt9A 1 0.4715 99.9 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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