GANA - BACSU - GREMLIN Contacts

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GANA - Arabinogalactan endo-beta-1,4-galactanase

UniProt:	O07013	Sequences: MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVKKVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHPYDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLSFEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRAVRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSVLKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVMEAVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKWYGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	429 (345)
Sequences:	378 (278)
Seq/√Len:	15.0

BACSU - GANA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
66_E	126_R	5.025	1.00
196_T	233_T	4.101	1.00
318_Y	331_D	3.971	1.00
65_L	70_V	3.944	1.00
206_T	251_N	3.905	1.00
287_K	342_A	3.762	1.00
93_Y	347_F	3.757	1.00
159_L	167_K	3.755	1.00
173_K	221_E	3.465	0.99
220_R	254_D	3.253	0.99
199_F	208_M	2.830	0.97
98_I	136_A	2.764	0.96
238_A	279_A	2.670	0.96
169_Y	221_E	2.638	0.95
161_F	207_K	2.583	0.95
140_Y	172_T	2.539	0.94
100_N	171_Y	2.524	0.94
93_Y	133_K	2.456	0.93
128_T	186_I	2.439	0.93
217_R	221_E	2.363	0.92
336_V	343_G	2.357	0.91
238_A	276_V	2.320	0.91
81_D	126_R	2.280	0.90
84_T	130_N	2.243	0.89
57_A	91_V	2.237	0.89
223_N	226_I	2.236	0.89
168_L	215_G	2.208	0.88
96_V	136_A	2.178	0.88
71_T	79_R	2.156	0.87
227_L	287_K	2.127	0.86
104_D	108_N	2.120	0.86
237_T	240_R	2.104	0.86
159_L	163_A	2.093	0.86
281_A	339_T	2.031	0.84
302_G	406_F	1.991	0.82
303_D	307_N	1.979	0.82
195_T	212_F	1.970	0.82
74_N	78_K	1.941	0.81
336_V	346_V	1.906	0.80
273_L	290_V	1.893	0.79
80_Q	85_T	1.880	0.79
87_K	132_M	1.874	0.78
74_N	80_Q	1.838	0.77
161_F	165_K	1.832	0.77
246_E	283_T	1.807	0.76
96_V	120_A	1.798	0.75
121_I	182_E	1.789	0.75
161_F	211_L	1.762	0.74
127_A	134_V	1.752	0.73
245_A	258_F	1.737	0.73
83_F	130_N	1.726	0.72
62_V	66_E	1.724	0.72
67_N	119_K	1.719	0.72
246_E	284_Y	1.719	0.72
334_E	338_N	1.716	0.72
165_K	214_E	1.711	0.72
165_K	210_Q	1.701	0.71
117_V	171_Y	1.694	0.71
323_Q	327_T	1.691	0.71
96_V	124_G	1.684	0.70
85_T	410_P	1.673	0.70
89_A	415_Q	1.670	0.70
117_V	178_K	1.664	0.69
73_Y	79_R	1.663	0.69
128_T	187_G	1.656	0.69
160_S	163_A	1.628	0.68
249_S	255_Y	1.625	0.67
169_Y	173_K	1.605	0.66
59_V	83_F	1.594	0.66
65_L	354_I	1.584	0.65
216_S	228_V	1.581	0.65
62_V	83_F	1.566	0.64
189_V	219_V	1.550	0.64
328_A	332_V	1.538	0.63
65_L	72_F	1.527	0.62
62_V	82_I	1.524	0.62
161_F	210_Q	1.502	0.61
242_S	283_T	1.501	0.61
67_N	114_N	1.500	0.61
234_N	241_Y	1.496	0.61
242_S	279_A	1.490	0.60
110_Y	154_K	1.484	0.60
174_Q	178_K	1.475	0.60
121_I	178_K	1.463	0.59
265_F	401_Q	1.439	0.58
152_V	200_A	1.408	0.56
303_D	399_D	1.407	0.56
235_P	276_V	1.400	0.56
133_K	347_F	1.373	0.54
265_F	294_S	1.367	0.54
99_W	146_D	1.350	0.53
121_I	179_M	1.343	0.52
326_A	330_R	1.333	0.52
152_V	203_T	1.308	0.50
172_T	218_A	1.287	0.49
302_G	399_D	1.277	0.49
166_A	170_E	1.277	0.49
307_N	399_D	1.264	0.48
220_R	228_V	1.258	0.48
171_Y	191_V	1.257	0.48
276_V	279_A	1.248	0.47
213_N	230_L	1.243	0.47
317_P	320_I	1.231	0.46
169_Y	217_R	1.229	0.46
241_Y	260_S	1.221	0.46
173_K	177_Q	1.219	0.45
79_R	271_Q	1.216	0.45
277_L	339_T	1.207	0.45
216_S	220_R	1.204	0.45
110_Y	377_A	1.202	0.44
98_I	373_G	1.193	0.44
196_T	399_D	1.192	0.44
99_W	350_E	1.184	0.43
242_S	276_V	1.180	0.43
122_E	179_M	1.178	0.43
235_P	339_T	1.176	0.43
185_D	226_I	1.172	0.43
121_I	184_V	1.169	0.43
135_L	229_A	1.168	0.43
117_V	121_I	1.161	0.42
410_P	414_L	1.149	0.42
401_Q	417_F	1.148	0.41
133_K	187_G	1.141	0.41
169_Y	218_A	1.128	0.40
117_V	179_M	1.125	0.40
107_G	110_Y	1.122	0.40
112_G	397_A	1.119	0.40
99_W	147_P	1.117	0.40
63_I	119_K	1.115	0.40
181_K	221_E	1.097	0.39
146_D	190_Q	1.090	0.38
91_V	414_L	1.090	0.38
259_A	291_A	1.088	0.38
72_F	354_I	1.087	0.38
103_Y	114_N	1.087	0.38
295_Y	307_N	1.077	0.38
281_A	288_V	1.077	0.38
97_R	230_L	1.075	0.38
238_A	242_S	1.072	0.37
253_V	307_N	1.072	0.37
116_D	280_V	1.070	0.37
322_V	413_S	1.067	0.37
217_R	254_D	1.064	0.37
172_T	262_Y	1.064	0.37
125_K	180_I	1.061	0.37
218_A	222_T	1.059	0.37
59_V	347_F	1.054	0.36
232_F	245_A	1.053	0.36
215_G	266_W	1.047	0.36
132_M	187_G	1.047	0.36
213_N	253_V	1.038	0.36
59_V	93_Y	1.035	0.36
62_V	126_R	1.030	0.35
302_G	355_P	1.023	0.35
241_Y	276_V	1.022	0.35
158_N	163_A	1.019	0.35
171_Y	175_S	1.014	0.34
128_T	185_D	1.009	0.34
98_I	117_V	1.009	0.34
115_N	343_G	1.007	0.34
292_E	349_W	1.007	0.34
82_I	130_N	1.006	0.34
294_S	308_T	1.006	0.34
296_T	299_A	1.005	0.34
86_L	284_Y	1.003	0.34
211_L	295_Y	0.994	0.33
229_A	289_M	0.994	0.33
244_I	248_L	0.991	0.33
215_G	228_V	0.989	0.33
57_A	94_V	0.987	0.33
196_T	234_N	0.986	0.33
145_A	332_V	0.983	0.33
134_V	347_F	0.981	0.33
188_M	229_A	0.974	0.32
100_N	167_K	0.970	0.32
319_P	357_G	0.969	0.32
212_F	232_F	0.968	0.32
238_A	283_T	0.967	0.32
163_A	167_K	0.961	0.32
377_A	393_Y	0.960	0.32
247_T	250_K	0.958	0.32
168_L	211_L	0.955	0.32
232_F	241_Y	0.948	0.31
107_G	154_K	0.944	0.31
298_T	353_W	0.941	0.31
234_N	270_L	0.937	0.31
191_V	219_V	0.934	0.30
71_T	334_E	0.934	0.30
53_F	219_V	0.934	0.30
400_N	404_F	0.931	0.30
272_N	276_V	0.929	0.30
288_V	339_T	0.928	0.30
103_Y	154_K	0.926	0.30
274_T	338_N	0.923	0.30
231_H	349_W	0.920	0.30
176_L	218_A	0.920	0.30
138_F	176_L	0.914	0.30
291_A	294_S	0.914	0.30
127_A	130_N	0.913	0.30
310_P	314_Q	0.911	0.29
403_L	414_L	0.910	0.29
135_L	190_Q	0.910	0.29
205_W	248_L	0.909	0.29
57_A	397_A	0.908	0.29
221_E	254_D	0.907	0.29
127_A	329_V	0.895	0.29
140_Y	218_A	0.894	0.29
111_G	154_K	0.894	0.29
301_D	304_G	0.890	0.28
281_A	343_G	0.889	0.28
76_N	158_N	0.889	0.28
290_V	336_V	0.884	0.28
66_E	81_D	0.882	0.28
239_G	260_S	0.877	0.28
277_L	281_A	0.871	0.28
115_N	119_K	0.871	0.28
229_A	344_L	0.870	0.28
205_W	247_T	0.868	0.27
199_F	253_V	0.868	0.27
230_L	248_L	0.867	0.27
127_A	187_G	0.861	0.27
94_V	127_A	0.860	0.27
136_A	185_D	0.859	0.27
253_V	295_Y	0.857	0.27
97_R	136_A	0.857	0.27
109_G	114_N	0.856	0.27
403_L	413_S	0.855	0.27
229_A	291_A	0.854	0.27
322_V	411_L	0.854	0.27
95_R	292_E	0.844	0.26
93_Y	187_G	0.844	0.26
350_E	353_W	0.841	0.26
336_V	339_T	0.837	0.26
399_D	406_F	0.835	0.26
218_A	329_V	0.833	0.26
74_N	89_A	0.832	0.26
398_V	404_F	0.828	0.26
93_Y	188_M	0.827	0.26
133_K	217_R	0.825	0.26
97_R	115_N	0.824	0.26
125_K	182_E	0.823	0.25
57_A	351_P	0.823	0.25
144_W	292_E	0.821	0.25
67_N	78_K	0.819	0.25
113_G	353_W	0.818	0.25
117_V	136_A	0.815	0.25
247_T	251_N	0.813	0.25
235_P	350_E	0.813	0.25
261_S	292_E	0.813	0.25
173_K	217_R	0.812	0.25
138_F	175_S	0.808	0.25
179_M	205_W	0.808	0.25
115_N	319_P	0.806	0.25
135_L	188_M	0.803	0.25
66_E	417_F	0.802	0.25
60_S	146_D	0.801	0.25
143_F	297_Y	0.800	0.25
182_E	321_S	0.799	0.24
374_S	377_A	0.798	0.24
172_T	258_F	0.796	0.24
170_E	173_K	0.792	0.24
82_I	91_V	0.790	0.24
191_V	299_A	0.788	0.24
139_H	147_P	0.786	0.24
144_W	231_H	0.784	0.24
233_T	402_A	0.782	0.24
144_W	261_S	0.779	0.24
183_G	338_N	0.778	0.24
231_H	292_E	0.777	0.24
76_N	160_S	0.777	0.24
326_A	416_V	0.772	0.23
171_Y	178_K	0.768	0.23
173_K	218_A	0.767	0.23
377_A	394_G	0.766	0.23
71_T	130_N	0.764	0.23
112_G	154_K	0.764	0.23
331_D	334_E	0.762	0.23
176_L	222_T	0.761	0.23
113_G	376_W	0.761	0.23
217_R	243_F	0.760	0.23
414_L	418_Q	0.759	0.23
261_S	349_W	0.759	0.23
171_Y	230_L	0.758	0.23
95_R	349_W	0.758	0.23
137_D	146_D	0.758	0.23
413_S	417_F	0.757	0.23
329_V	403_L	0.756	0.23
99_W	139_H	0.756	0.23
233_T	307_N	0.746	0.22
274_T	335_A	0.746	0.22
132_M	300_E	0.744	0.22
135_L	351_P	0.744	0.22
273_L	351_P	0.742	0.22
99_W	190_Q	0.742	0.22
137_D	147_P	0.739	0.22
281_A	342_A	0.736	0.22
119_K	132_M	0.733	0.22
111_G	114_N	0.731	0.22
281_A	336_V	0.730	0.22
412_P	415_Q	0.727	0.22
308_T	398_V	0.722	0.21
181_K	214_E	0.720	0.21
152_V	211_L	0.720	0.21
144_W	349_W	0.720	0.21
197_G	243_F	0.719	0.21
69_G	266_W	0.718	0.21
99_W	353_W	0.714	0.21
99_W	115_N	0.714	0.21
123_I	126_R	0.713	0.21
52_D	72_F	0.712	0.21
213_N	254_D	0.708	0.21
72_F	342_A	0.707	0.21
103_Y	110_Y	0.705	0.21
305_H	392_W	0.704	0.21
93_Y	295_Y	0.704	0.21
62_V	148_A	0.704	0.21
121_I	208_M	0.704	0.21
310_P	315_T	0.702	0.21
74_N	171_Y	0.699	0.21
99_W	343_G	0.698	0.21
205_W	243_F	0.696	0.20
394_G	399_D	0.695	0.20
115_N	412_P	0.694	0.20
72_F	116_D	0.694	0.20
214_E	217_R	0.693	0.20
255_Y	286_K	0.690	0.20
59_V	91_V	0.690	0.20
299_A	310_P	0.689	0.20
235_P	245_A	0.688	0.20
99_W	395_G	0.686	0.20
235_P	290_V	0.684	0.20
82_I	352_A	0.682	0.20
125_K	282_N	0.681	0.20
300_E	316_L	0.680	0.20
278_K	282_N	0.680	0.20
294_S	298_T	0.680	0.20
276_V	283_T	0.680	0.20
136_A	259_A	0.677	0.20
164_K	168_L	0.676	0.20
95_R	146_D	0.675	0.20
62_V	81_D	0.675	0.20
246_E	279_A	0.674	0.20
124_G	164_K	0.674	0.20
118_Q	129_A	0.672	0.20
83_F	195_T	0.672	0.20
135_L	171_Y	0.670	0.20
376_W	404_F	0.669	0.19
99_W	137_D	0.662	0.19
162_E	213_N	0.660	0.19
274_T	321_S	0.657	0.19
122_E	203_T	0.657	0.19
139_H	231_H	0.656	0.19
278_K	340_G	0.653	0.19
213_N	216_S	0.653	0.19
76_N	334_E	0.651	0.19
146_D	149_K	0.649	0.19
291_A	332_V	0.648	0.19
76_N	227_L	0.648	0.19
96_V	189_V	0.647	0.19
232_F	396_S	0.646	0.19
405_D	409_H	0.644	0.19
152_V	164_K	0.644	0.19
279_A	283_T	0.641	0.19
46_V	323_Q	0.641	0.19
199_F	215_G	0.640	0.18
121_I	191_V	0.639	0.18
234_N	332_V	0.638	0.18
160_S	225_N	0.638	0.18
185_D	227_L	0.637	0.18
87_K	180_I	0.636	0.18
167_K	171_Y	0.634	0.18
134_V	184_V	0.633	0.18
230_L	253_V	0.628	0.18
170_E	221_E	0.626	0.18
84_T	160_S	0.625	0.18
59_V	75_T	0.623	0.18
80_Q	84_T	0.623	0.18
260_S	280_V	0.619	0.18
86_L	290_V	0.618	0.18
144_W	147_P	0.617	0.18
95_R	231_H	0.616	0.18
113_G	124_G	0.616	0.18
69_G	356_V	0.615	0.18
175_S	226_I	0.615	0.18
179_M	186_I	0.612	0.18
190_Q	294_S	0.611	0.18
94_V	227_L	0.609	0.17
95_R	147_P	0.608	0.17
164_K	211_L	0.608	0.17
166_A	169_Y	0.607	0.17
98_I	265_F	0.605	0.17
259_A	328_A	0.603	0.17
195_T	277_L	0.603	0.17
97_R	292_E	0.603	0.17
198_G	201_G	0.600	0.17
196_T	307_N	0.599	0.17
87_K	277_L	0.599	0.17
76_N	177_Q	0.598	0.17
143_F	377_A	0.596	0.17
409_H	412_P	0.596	0.17
138_F	167_K	0.596	0.17
283_T	396_S	0.596	0.17
206_T	247_T	0.595	0.17
405_D	411_L	0.594	0.17
291_A	406_F	0.592	0.17
175_S	236_E	0.592	0.17
99_W	145_A	0.592	0.17
138_F	189_V	0.591	0.17
267_H	273_L	0.591	0.17
95_R	261_S	0.591	0.17
295_Y	320_I	0.591	0.17
311_K	407_N	0.590	0.17
165_K	321_S	0.590	0.17
306_G	310_P	0.588	0.17
128_T	184_V	0.587	0.17
164_K	284_Y	0.587	0.17
100_N	200_A	0.586	0.17
139_H	144_W	0.586	0.17
147_P	268_G	0.584	0.17
145_A	375_G	0.583	0.17
114_N	138_F	0.582	0.17
99_W	144_W	0.582	0.17
139_H	190_Q	0.580	0.17
92_N	187_G	0.580	0.17
199_F	209_C	0.580	0.17
136_A	216_S	0.580	0.17
114_N	215_G	0.578	0.16
170_E	311_K	0.577	0.16
49_M	52_D	0.577	0.16
257_V	287_K	0.576	0.16
242_S	246_E	0.575	0.16
91_V	206_T	0.575	0.16
399_D	402_A	0.573	0.16
356_V	375_G	0.572	0.16
95_R	144_W	0.572	0.16
218_A	226_I	0.572	0.16
157_A	166_A	0.570	0.16
140_Y	215_G	0.570	0.16
191_V	262_Y	0.570	0.16
72_F	351_P	0.569	0.16
165_K	314_Q	0.568	0.16
321_S	416_V	0.566	0.16
137_D	149_K	0.565	0.16
257_V	260_S	0.565	0.16
169_Y	214_E	0.565	0.16
191_V	228_V	0.562	0.16
64_A	154_K	0.562	0.16
100_N	340_G	0.561	0.16
145_A	291_A	0.560	0.16
61_S	352_A	0.560	0.16
111_G	378_S	0.558	0.16
126_R	284_Y	0.556	0.16
68_S	374_S	0.553	0.16
273_L	336_V	0.550	0.16
131_G	176_L	0.546	0.16
139_H	292_E	0.546	0.16
108_N	409_H	0.545	0.15
158_N	285_G	0.545	0.15
93_Y	132_M	0.543	0.15
319_P	328_A	0.543	0.15
161_F	203_T	0.542	0.15
227_L	257_V	0.541	0.15
160_S	179_M	0.541	0.15
343_G	353_W	0.538	0.15
92_N	119_K	0.538	0.15
177_Q	181_K	0.537	0.15
305_H	397_A	0.536	0.15
86_L	198_G	0.536	0.15
322_V	416_V	0.535	0.15
294_S	374_S	0.535	0.15
101_H	415_Q	0.533	0.15
198_G	292_E	0.533	0.15
176_L	248_L	0.531	0.15
63_I	122_E	0.531	0.15
61_S	65_L	0.530	0.15
91_V	94_V	0.530	0.15
118_Q	180_I	0.529	0.15
93_Y	121_I	0.529	0.15
71_T	378_S	0.527	0.15
147_P	190_Q	0.527	0.15
301_D	307_N	0.526	0.15
196_T	402_A	0.526	0.15
233_T	303_D	0.523	0.15
171_Y	215_G	0.523	0.15
148_A	397_A	0.520	0.15
180_I	226_I	0.520	0.15
96_V	123_I	0.519	0.15
97_R	349_W	0.519	0.15
296_T	309_A	0.519	0.15
196_T	240_R	0.518	0.15
129_A	403_L	0.517	0.15
137_D	268_G	0.516	0.15
350_E	356_V	0.516	0.15
64_A	258_F	0.516	0.15
59_V	159_L	0.513	0.15
217_R	252_K	0.513	0.15
190_Q	347_F	0.513	0.15
98_I	229_A	0.512	0.15
61_S	374_S	0.511	0.15
214_E	322_V	0.511	0.15
60_S	99_W	0.510	0.14
121_I	175_S	0.509	0.14
162_E	210_Q	0.509	0.14
120_A	179_M	0.509	0.14
231_H	261_S	0.508	0.14
166_A	228_V	0.507	0.14
236_E	267_H	0.507	0.14
88_Q	174_Q	0.506	0.14
95_R	139_H	0.505	0.14
257_V	281_A	0.505	0.14
176_L	224_S	0.505	0.14
216_S	299_A	0.503	0.14
81_D	357_G	0.502	0.14
207_K	237_T	0.501	0.14
97_R	408_G	0.500	0.14
145_A	190_Q	0.500	0.14
87_K	166_A	0.500	0.14
213_N	407_N	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ur4A	1	0.9021	100	0.544	Contact Map
1fobA	1	0.7483	100	0.653	Contact Map
1hjsA	1	0.7459	100	0.657	Contact Map
4cd8A	1	0.697	100	0.812	Contact Map
4k68A	1	0.7413	100	0.819	Contact Map
4v2xA	2	0.7925	100	0.82	Contact Map
3ndzA	3	0.7296	100	0.828	Contact Map
1ur1A	1	0.7319	100	0.83	Contact Map
4pmuA	2	0.7529	100	0.831	Contact Map
4w8bA	1	0.7506	100	0.832	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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