BGAL2 - BACSU - GREMLIN Contacts

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BGAL2 - Beta-galactosidase GanA

UniProt:	O07012	Sequences: MLHGGDYNPDQWLDRPDILADDIKLMKLSHTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTYPEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEYGGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGLHGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFAKHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNVNKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEVAKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTFWEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVNEHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTASVEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVRHGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRIVVNTH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	672 (646)
Sequences:	1725 (1250)
Seq/√Len:	49.2

BACSU - BGAL2 BGAL1
SULSO - Q97UK4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_D	58_D	6.540	1.00
47_E	50_V	6.042	1.00
398_Q	455_K	6.005	1.00
170_L	189_W	5.706	1.00
547_V	552_V	5.326	1.00
124_R	231_E	4.886	1.00
329_L	383_T	4.503	1.00
125_L	128_E	4.404	1.00
35_S	38_I	4.321	1.00
57_D	130_Y	4.135	1.00
89_E	114_V	4.107	1.00
109_C	151_C	4.023	1.00
45_E	49_G	3.809	1.00
60_F	136_L	3.739	1.00
109_C	149_C	3.720	1.00
157_A	213_F	3.615	1.00
645_V	668_V	3.496	1.00
155_Q	194_S	3.400	1.00
151_C	154_C	3.381	1.00
474_K	509_A	3.366	1.00
172_T	176_A	3.365	1.00
549_T	570_H	3.354	1.00
440_I	597_I	3.252	1.00
661_E	664_E	3.234	1.00
48_E	86_T	3.228	1.00
64_H	133_H	3.202	1.00
305_L	342_S	3.173	1.00
476_F	481_G	3.161	1.00
187_N	191_Q	3.160	1.00
149_C	154_C	3.084	1.00
57_D	129_R	3.018	1.00
51_Y	121_H	3.011	1.00
473_L	483_L	2.993	1.00
551_S	569_S	2.944	1.00
94_N	98_V	2.921	1.00
64_H	135_A	2.886	1.00
21_D	24_K	2.819	1.00
647_D	650_T	2.817	1.00
87_Y	118_K	2.794	1.00
13_L	17_D	2.763	1.00
36_V	60_F	2.728	1.00
477_T	483_L	2.713	1.00
333_M	383_T	2.585	1.00
85_Q	191_Q	2.525	1.00
223_E	263_H	2.484	1.00
20_A	62_R	2.475	1.00
511_F	577_A	2.457	1.00
111_T	217_Q	2.418	1.00
124_R	128_E	2.411	1.00
109_C	154_C	2.374	1.00
467_E	499_Y	2.365	1.00
616_V	629_V	2.346	1.00
341_D	392_G	2.306	1.00
569_S	576_K	2.300	1.00
169_S	172_T	2.283	1.00
475_A	478_A	2.266	1.00
556_Y	581_G	2.264	1.00
538_M	582_A	2.252	1.00
229_L	233_T	2.245	1.00
123_N	228_P	2.228	1.00
75_P	122_I	2.194	1.00
120_R	228_P	2.186	1.00
451_F	457_L	2.183	1.00
116_R	220_S	2.177	1.00
60_F	72_L	2.135	1.00
178_W	353_G	2.127	1.00
223_E	227_I	2.119	1.00
30_H	385_E	2.118	1.00
613_G	633_T	2.041	1.00
60_F	70_V	2.037	1.00
124_R	232_L	2.008	1.00
435_F	458_I	1.992	0.99
84_S	102_H	1.988	0.99
397_A	441_P	1.987	0.99
233_T	236_I	1.968	0.99
23_I	66_I	1.968	0.99
19_L	62_R	1.958	0.99
172_T	175_H	1.938	0.99
230_K	238_I	1.938	0.99
401_I	444_V	1.923	0.99
513_V	545_I	1.912	0.99
553_E	578_Y	1.897	0.99
459_V	483_L	1.891	0.99
357_K	496_D	1.880	0.99
216_D	259_K	1.867	0.99
24_K	28_L	1.864	0.99
23_I	62_R	1.849	0.99
552_V	555_V	1.836	0.99
48_E	87_Y	1.823	0.99
23_I	63_I	1.821	0.99
27_K	66_I	1.813	0.99
485_M	511_F	1.807	0.99
26_M	348_Y	1.794	0.99
516_L	546_D	1.792	0.99
127_A	229_L	1.790	0.99
161_W	209_D	1.779	0.99
34_F	63_I	1.765	0.99
20_A	65_S	1.752	0.99
437_E	590_R	1.745	0.99
330_L	630_M	1.717	0.98
446_T	449_Q	1.708	0.98
294_D	432_Y	1.707	0.98
136_L	236_I	1.693	0.98
253_Q	412_E	1.686	0.98
438_H	594_E	1.676	0.98
471_S	475_A	1.675	0.98
256_D	259_K	1.669	0.98
402_L	469_T	1.654	0.98
298_S	444_V	1.633	0.98
633_T	637_Q	1.621	0.98
457_L	481_G	1.603	0.98
457_L	476_F	1.598	0.98
451_F	469_T	1.593	0.97
660_M	666_R	1.574	0.97
474_K	478_A	1.557	0.97
150_H	194_S	1.553	0.97
456_L	596_L	1.549	0.97
261_A	299_L	1.545	0.97
64_H	70_V	1.538	0.97
551_S	571_E	1.535	0.97
269_W	293_N	1.533	0.97
576_K	599_D	1.531	0.97
170_L	192_I	1.529	0.97
114_V	118_K	1.515	0.97
239_T	268_S	1.513	0.97
399_T	440_I	1.504	0.96
379_K	383_T	1.504	0.96
550_A	570_H	1.500	0.96
51_Y	125_L	1.499	0.96
160_E	163_K	1.488	0.96
43_A	180_P	1.478	0.96
53_F	57_D	1.475	0.96
170_L	187_N	1.474	0.96
592_F	596_L	1.472	0.96
510_I	572_Y	1.469	0.96
621_D	624_N	1.462	0.96
121_H	125_L	1.460	0.96
85_Q	188_D	1.460	0.96
465_I	489_S	1.454	0.96
459_V	462_L	1.452	0.96
620_Q	625_D	1.447	0.96
161_W	216_D	1.445	0.96
336_I	343_V	1.440	0.95
155_Q	159_R	1.432	0.95
167_D	171_K	1.425	0.95
268_S	307_M	1.422	0.95
114_V	117_E	1.413	0.95
162_L	173_L	1.409	0.95
478_A	572_Y	1.401	0.95
443_D	454_Y	1.400	0.95
597_I	602_L	1.399	0.95
596_L	600_L	1.395	0.95
43_A	185_T	1.387	0.94
314_V	320_N	1.387	0.94
291_F	444_V	1.385	0.94
89_E	112_S	1.382	0.94
64_H	134_P	1.379	0.94
226_I	263_H	1.377	0.94
136_L	233_T	1.374	0.94
614_V	660_M	1.373	0.94
205_G	497_L	1.370	0.94
45_E	51_Y	1.369	0.94
93_V	99_K	1.365	0.94
60_F	135_A	1.365	0.94
482_T	578_Y	1.364	0.94
229_L	232_L	1.358	0.94
28_L	369_P	1.347	0.93
61_E	133_H	1.342	0.93
219_I	259_K	1.339	0.93
438_H	590_R	1.338	0.93
63_I	68_G	1.336	0.93
83_L	90_V	1.332	0.93
241_N	270_D	1.328	0.93
636_K	659_T	1.314	0.93
466_S	469_T	1.311	0.93
552_V	565_P	1.310	0.92
20_A	58_D	1.309	0.92
402_L	459_V	1.302	0.92
618_A	625_D	1.301	0.92
243_M	252_Y	1.300	0.92
76_S	119_T	1.289	0.92
61_E	65_S	1.274	0.91
485_M	577_A	1.272	0.91
138_M	237_P	1.270	0.91
123_N	224_N	1.268	0.91
120_R	224_N	1.257	0.91
465_I	507_L	1.255	0.91
37_G	55_W	1.254	0.91
312_S	373_V	1.252	0.91
536_Y	591_D	1.246	0.90
595_G	599_D	1.244	0.90
567_V	580_I	1.242	0.90
85_Q	190_S	1.242	0.90
402_L	445_I	1.237	0.90
467_E	471_S	1.228	0.90
9_P	12_W	1.224	0.90
329_L	333_M	1.222	0.90
372_R	517_E	1.214	0.89
138_M	266_A	1.213	0.89
647_D	651_G	1.212	0.89
116_R	224_N	1.206	0.89
23_I	68_G	1.198	0.89
484_V	580_I	1.192	0.88
28_L	378_A	1.190	0.88
433_R	437_E	1.186	0.88
410_A	463_Y	1.185	0.88
431_H	486_T	1.180	0.88
427_T	583_R	1.169	0.87
243_M	269_W	1.167	0.87
374_F	378_A	1.166	0.87
647_D	666_R	1.165	0.87
94_N	100_Q	1.162	0.87
165_K	209_D	1.160	0.87
69_R	137_L	1.158	0.87
181_F	351_S	1.156	0.87
142_S	225_E	1.156	0.87
545_I	581_G	1.151	0.87
493_N	497_L	1.149	0.86
60_F	133_H	1.148	0.86
636_K	661_E	1.145	0.86
456_L	476_F	1.145	0.86
556_Y	566_A	1.144	0.86
473_L	510_I	1.144	0.86
569_S	578_Y	1.144	0.86
382_E	386_R	1.141	0.86
536_Y	588_F	1.132	0.86
138_M	305_L	1.129	0.86
326_G	376_E	1.127	0.85
278_D	522_Y	1.126	0.85
266_A	305_L	1.124	0.85
83_L	118_K	1.121	0.85
33_T	137_L	1.119	0.85
173_L	177_W	1.117	0.85
584_L	588_F	1.110	0.85
118_K	121_H	1.106	0.84
81_A	85_Q	1.106	0.84
208_L	464_L	1.091	0.83
614_V	639_V	1.090	0.83
62_R	66_I	1.087	0.83
24_K	66_I	1.085	0.83
106_H	148_D	1.085	0.83
383_T	649_M	1.081	0.83
423_R	426_Q	1.080	0.83
459_V	485_M	1.078	0.83
163_K	189_W	1.078	0.83
510_I	577_A	1.075	0.83
219_I	263_H	1.075	0.83
157_A	220_S	1.074	0.83
106_H	122_I	1.073	0.82
329_L	379_K	1.073	0.82
400_A	457_L	1.072	0.82
163_K	188_D	1.071	0.82
106_H	147_G	1.067	0.82
585_E	588_F	1.065	0.82
514_E	546_D	1.064	0.82
401_I	435_F	1.062	0.82
53_F	130_Y	1.058	0.82
128_E	131_G	1.057	0.81
242_F	264_V	1.055	0.81
145_Y	222_Y	1.051	0.81
618_A	627_I	1.049	0.81
131_G	233_T	1.049	0.81
113_K	153_L	1.049	0.81
273_P	331_S	1.046	0.81
571_E	576_K	1.044	0.81
479_D	574_Q	1.037	0.80
636_K	662_K	1.034	0.80
38_I	73_A	1.034	0.80
478_A	574_Q	1.033	0.80
508_Q	548_K	1.033	0.80
658_L	668_V	1.029	0.80
37_G	75_P	1.028	0.80
536_Y	585_E	1.027	0.80
100_Q	199_G	1.023	0.79
527_N	531_Y	1.023	0.79
466_S	494_E	1.022	0.79
362_V	377_V	1.022	0.79
452_S	479_D	1.015	0.79
379_K	382_E	1.010	0.78
156_H	190_S	1.006	0.78
456_L	597_I	1.006	0.78
615_S	632_F	1.005	0.78
90_V	114_V	1.004	0.78
61_E	70_V	1.004	0.78
75_P	126_L	1.004	0.78
226_I	230_K	1.004	0.78
462_L	465_I	1.002	0.78
528_A	557_Q	1.002	0.78
210_W	214_V	1.001	0.78
212_R	406_E	1.001	0.78
293_N	335_M	0.998	0.78
457_L	473_L	0.994	0.77
482_T	600_L	0.993	0.77
157_A	217_Q	0.993	0.77
141_I	229_L	0.992	0.77
478_A	571_E	0.989	0.77
437_E	586_D	0.988	0.77
60_F	63_I	0.984	0.77
165_K	495_H	0.983	0.77
58_D	62_R	0.979	0.76
322_A	560_F	0.979	0.76
128_E	232_L	0.974	0.76
40_A	43_A	0.973	0.76
219_I	260_F	0.972	0.76
14_D	19_L	0.970	0.76
469_T	472_R	0.969	0.75
544_V	560_F	0.963	0.75
10_D	37_G	0.960	0.75
638_L	659_T	0.960	0.75
38_I	140_H	0.959	0.75
27_K	379_K	0.958	0.75
365_H	498_T	0.957	0.75
117_E	121_H	0.957	0.75
127_A	232_L	0.951	0.74
216_D	219_I	0.951	0.74
81_A	102_H	0.951	0.74
287_M	432_Y	0.949	0.74
70_V	135_A	0.944	0.74
152_D	193_E	0.941	0.73
513_V	568_T	0.941	0.73
19_L	23_I	0.940	0.73
33_T	344_L	0.940	0.73
3_H	381_G	0.935	0.73
21_D	25_L	0.931	0.73
484_V	593_Y	0.931	0.73
164_S	220_S	0.925	0.72
432_Y	442_V	0.923	0.72
475_A	479_D	0.923	0.72
456_L	600_L	0.920	0.72
60_F	64_H	0.920	0.72
642_D	645_V	0.920	0.72
375_Q	378_A	0.919	0.72
181_F	346_F	0.918	0.71
332_S	380_V	0.915	0.71
79_R	84_S	0.914	0.71
79_R	108_H	0.914	0.71
93_V	152_D	0.909	0.71
13_L	18_I	0.908	0.71
36_V	70_V	0.908	0.71
526_R	537_E	0.906	0.70
259_K	262_K	0.905	0.70
528_A	558_E	0.904	0.70
491_V	518_T	0.903	0.70
348_Y	363_V	0.902	0.70
270_D	307_M	0.899	0.70
40_A	55_W	0.896	0.70
8_N	38_I	0.895	0.69
5_G	35_S	0.895	0.69
144_E	308_E	0.895	0.69
396_P	453_P	0.895	0.69
482_T	576_K	0.892	0.69
311_P	359_H	0.892	0.69
294_D	338_H	0.891	0.69
646_K	651_G	0.888	0.69
258_S	444_V	0.886	0.69
401_I	442_V	0.882	0.68
519_D	561_Y	0.878	0.68
476_F	483_L	0.878	0.68
499_Y	506_D	0.877	0.68
258_S	446_T	0.876	0.68
26_M	31_T	0.876	0.68
474_K	572_Y	0.874	0.68
340_S	343_V	0.872	0.67
207_N	413_D	0.871	0.67
463_Y	496_D	0.870	0.67
309_C	331_S	0.870	0.67
33_T	71_I	0.867	0.67
294_D	297_R	0.867	0.67
439_D	610_H	0.866	0.67
109_C	153_L	0.866	0.67
101_L	196_S	0.865	0.67
329_L	649_M	0.865	0.67
647_D	668_V	0.865	0.67
209_D	495_H	0.862	0.67
401_I	458_I	0.861	0.66
43_A	52_Q	0.860	0.66
120_R	124_R	0.859	0.66
71_I	342_S	0.857	0.66
163_K	493_N	0.856	0.66
476_F	482_T	0.854	0.66
179_T	184_H	0.850	0.65
71_I	305_L	0.850	0.65
96_S	197_P	0.849	0.65
44_L	126_L	0.849	0.65
45_E	50_V	0.848	0.65
382_E	385_E	0.846	0.65
658_L	666_R	0.846	0.65
23_I	59_I	0.845	0.65
654_L	658_L	0.845	0.65
47_E	191_Q	0.844	0.65
131_G	232_L	0.843	0.65
156_H	159_R	0.842	0.65
641_F	645_V	0.841	0.65
44_L	53_F	0.840	0.65
13_L	19_L	0.840	0.65
437_E	612_K	0.838	0.64
353_G	497_L	0.838	0.64
37_G	40_A	0.837	0.64
403_Y	408_H	0.832	0.64
274_V	317_H	0.831	0.64
480_G	575_G	0.829	0.64
179_T	186_F	0.828	0.63
327_M	330_L	0.827	0.63
530_S	555_V	0.826	0.63
204_H	354_S	0.823	0.63
180_P	353_G	0.823	0.63
446_T	472_R	0.821	0.63
73_A	140_H	0.821	0.63
593_Y	596_L	0.820	0.63
378_A	382_E	0.819	0.63
176_A	495_H	0.818	0.62
35_S	140_H	0.816	0.62
164_S	167_D	0.816	0.62
291_F	428_L	0.816	0.62
297_R	443_D	0.815	0.62
470_V	510_I	0.812	0.62
161_W	166_Y	0.811	0.62
331_S	632_F	0.810	0.62
8_N	140_H	0.810	0.62
424_Y	428_L	0.808	0.62
35_S	73_A	0.807	0.61
352_R	500_T	0.807	0.61
222_Y	226_I	0.806	0.61
140_H	225_E	0.806	0.61
448_E	472_R	0.806	0.61
314_V	359_H	0.805	0.61
372_R	376_E	0.804	0.61
400_A	454_Y	0.804	0.61
39_F	77_G	0.803	0.61
309_C	346_F	0.802	0.61
477_T	510_I	0.802	0.61
10_D	180_P	0.801	0.61
544_V	564_T	0.800	0.61
36_V	73_A	0.799	0.61
605_V	616_V	0.799	0.61
436_W	441_P	0.798	0.61
215_T	219_I	0.797	0.60
393_T	621_D	0.795	0.60
156_H	160_E	0.794	0.60
266_A	342_S	0.791	0.60
90_V	112_S	0.790	0.60
455_K	476_F	0.790	0.60
514_E	548_K	0.790	0.60
358_L	491_V	0.789	0.60
629_V	658_L	0.788	0.60
29_S	374_F	0.788	0.60
588_F	592_F	0.787	0.59
273_P	309_C	0.786	0.59
652_D	666_R	0.784	0.59
641_F	654_L	0.784	0.59
253_Q	408_H	0.782	0.59
233_T	237_P	0.780	0.59
520_T	541_Y	0.776	0.58
48_E	118_K	0.775	0.58
166_Y	209_D	0.774	0.58
184_H	203_L	0.773	0.58
148_D	214_V	0.771	0.58
484_V	596_L	0.770	0.58
258_S	449_Q	0.768	0.58
515_P	543_T	0.767	0.58
87_Y	114_V	0.766	0.57
64_H	67_G	0.765	0.57
584_L	592_F	0.763	0.57
17_D	602_L	0.762	0.57
186_F	206_L	0.761	0.57
301_Q	449_Q	0.761	0.57
389_E	626_Y	0.757	0.57
176_A	493_N	0.756	0.56
18_I	367_N	0.754	0.56
43_A	55_W	0.754	0.56
456_L	602_L	0.754	0.56
111_T	154_C	0.751	0.56
173_L	192_I	0.750	0.56
368_S	374_F	0.750	0.56
338_H	615_S	0.749	0.56
580_I	584_L	0.749	0.56
484_V	614_V	0.749	0.56
11_Q	347_Q	0.749	0.56
477_T	573_Q	0.748	0.56
267_I	299_L	0.745	0.55
578_Y	596_L	0.745	0.55
180_P	185_T	0.742	0.55
455_K	479_D	0.741	0.55
47_E	187_N	0.741	0.55
110_L	218_T	0.740	0.55
227_I	231_E	0.737	0.54
312_S	331_S	0.734	0.54
75_P	142_S	0.730	0.54
568_T	577_A	0.730	0.54
450_D	453_P	0.729	0.54
61_E	135_A	0.728	0.54
6_D	11_Q	0.728	0.54
140_H	323_K	0.727	0.53
490_G	505_P	0.726	0.53
431_H	580_I	0.724	0.53
48_E	51_Y	0.723	0.53
328_N	345_Y	0.723	0.53
223_E	262_K	0.722	0.53
485_M	489_S	0.721	0.53
115_Y	142_S	0.721	0.53
463_Y	492_V	0.719	0.53
567_V	581_G	0.718	0.53
534_Q	591_D	0.718	0.53
108_H	147_G	0.717	0.52
390_V	628_F	0.715	0.52
124_R	228_P	0.712	0.52
81_A	187_N	0.712	0.52
211_R	412_E	0.712	0.52
456_L	484_V	0.712	0.52
531_Y	534_Q	0.712	0.52
619_R	628_F	0.711	0.52
6_D	346_F	0.710	0.52
154_C	217_Q	0.709	0.52
406_E	616_V	0.706	0.51
473_L	515_P	0.703	0.51
4_G	7_Y	0.703	0.51
140_H	347_Q	0.702	0.51
471_S	474_K	0.702	0.51
142_S	221_F	0.702	0.51
34_F	68_G	0.700	0.51
154_C	210_W	0.699	0.51
545_I	556_Y	0.698	0.51
8_N	73_A	0.698	0.51
27_K	67_G	0.698	0.51
630_M	665_V	0.698	0.51
310_T	331_S	0.697	0.50
646_K	650_T	0.697	0.50
47_E	188_D	0.697	0.50
468_D	471_S	0.696	0.50
480_G	573_Q	0.696	0.50
4_G	10_D	0.696	0.50
107_N	147_G	0.695	0.50
20_A	66_I	0.694	0.50
57_D	61_E	0.693	0.50
662_K	667_I	0.693	0.50
37_G	126_L	0.691	0.50
310_T	317_H	0.690	0.50
120_R	227_I	0.689	0.50
92_R	108_H	0.689	0.50
36_V	59_I	0.689	0.50
77_G	108_H	0.687	0.49
290_G	294_D	0.685	0.49
7_Y	22_D	0.685	0.49
504_H	508_Q	0.684	0.49
188_D	453_P	0.684	0.49
527_N	538_M	0.683	0.49
387_L	390_V	0.683	0.49
29_S	381_G	0.682	0.49
120_R	123_N	0.682	0.49
153_L	156_H	0.682	0.49
369_P	374_F	0.682	0.49
89_E	153_L	0.681	0.49
327_M	331_S	0.680	0.49
477_T	577_A	0.680	0.49
48_E	121_H	0.680	0.49
311_P	360_G	0.679	0.49
654_L	668_V	0.679	0.49
587_Q	652_D	0.677	0.48
547_V	550_A	0.677	0.48
558_E	562_A	0.677	0.48
545_I	579_F	0.676	0.48
528_A	535_I	0.674	0.48
157_A	160_E	0.674	0.48
141_I	222_Y	0.673	0.48
138_M	236_I	0.673	0.48
222_Y	264_V	0.673	0.48
324_R	559_D	0.672	0.48
350_K	364_D	0.672	0.48
101_L	194_S	0.671	0.48
429_Q	432_Y	0.671	0.48
108_H	331_S	0.671	0.48
505_P	508_Q	0.670	0.48
323_K	347_Q	0.669	0.48
54_E	129_R	0.669	0.48
242_F	261_A	0.668	0.47
167_D	172_T	0.665	0.47
92_R	99_K	0.664	0.47
23_I	34_F	0.664	0.47
438_H	597_I	0.662	0.47
549_T	552_V	0.662	0.47
86_T	191_Q	0.662	0.47
467_E	506_D	0.662	0.47
313_A	401_I	0.660	0.47
209_D	212_R	0.659	0.47
544_V	561_Y	0.659	0.47
366_D	371_N	0.659	0.47
128_E	132_H	0.657	0.46
627_I	645_V	0.656	0.46
92_R	147_G	0.656	0.46
315_N	359_H	0.655	0.46
597_I	601_S	0.654	0.46
159_R	190_S	0.652	0.46
243_M	257_Y	0.652	0.46
163_K	170_L	0.652	0.46
227_I	238_I	0.652	0.46
646_K	655_S	0.651	0.46
90_V	290_G	0.651	0.46
188_D	192_I	0.649	0.46
217_Q	220_S	0.649	0.46
288_K	429_Q	0.647	0.45
484_V	592_F	0.646	0.45
473_L	624_N	0.645	0.45
223_E	226_I	0.645	0.45
530_S	557_Q	0.644	0.45
402_L	442_V	0.644	0.45
38_I	225_E	0.644	0.45
476_F	479_D	0.643	0.45
110_L	217_Q	0.643	0.45
123_N	221_F	0.643	0.45
319_V	421_T	0.642	0.45
644_S	653_I	0.642	0.45
329_L	665_V	0.641	0.45
241_N	307_M	0.641	0.45
333_M	387_L	0.641	0.45
590_R	593_Y	0.640	0.45
160_E	164_S	0.640	0.45
290_G	617_Q	0.639	0.45
160_E	190_S	0.639	0.45
435_F	593_Y	0.638	0.44
31_T	34_F	0.638	0.44
14_D	175_H	0.638	0.44
330_L	632_F	0.637	0.44
271_A	330_L	0.637	0.44
438_H	593_Y	0.637	0.44
155_Q	193_E	0.636	0.44
229_L	238_I	0.635	0.44
591_D	594_E	0.634	0.44
664_E	668_V	0.634	0.44
610_H	616_V	0.633	0.44
110_L	260_F	0.632	0.44
105_R	182_W	0.632	0.44
133_H	136_L	0.631	0.44
65_S	636_K	0.629	0.44
453_P	478_A	0.629	0.44
147_G	200_E	0.629	0.44
462_L	469_T	0.628	0.43
8_N	11_Q	0.628	0.43
289_V	292_I	0.628	0.43
5_G	38_I	0.628	0.43
273_P	335_M	0.628	0.43
597_I	600_L	0.628	0.43
512_G	568_T	0.628	0.43
230_K	234_P	0.627	0.43
637_Q	640_T	0.626	0.43
262_K	448_E	0.625	0.43
377_V	381_G	0.625	0.43
77_G	106_H	0.625	0.43
311_P	350_K	0.624	0.43
345_Y	380_V	0.623	0.43
567_V	592_F	0.623	0.43
408_H	412_E	0.622	0.43
79_R	107_N	0.622	0.43
83_L	142_S	0.622	0.43
60_F	236_I	0.621	0.43
322_A	544_V	0.621	0.43
644_S	655_S	0.621	0.43
287_M	429_Q	0.620	0.43
587_Q	636_K	0.620	0.43
152_D	155_Q	0.619	0.43
578_Y	592_F	0.618	0.42
301_Q	453_P	0.618	0.42
65_S	160_E	0.618	0.42
19_L	59_I	0.616	0.42
420_A	660_M	0.616	0.42
184_H	198_I	0.615	0.42
71_I	138_M	0.615	0.42
167_D	571_E	0.614	0.42
509_A	548_K	0.614	0.42
375_Q	516_L	0.614	0.42
40_A	44_L	0.613	0.42
500_T	503_W	0.613	0.42
491_V	503_W	0.613	0.42
445_I	457_L	0.613	0.42
3_H	345_Y	0.612	0.42
32_N	545_I	0.612	0.42
538_M	584_L	0.611	0.42
115_Y	221_F	0.611	0.42
349_R	367_N	0.611	0.42
7_Y	12_W	0.610	0.42
55_W	208_L	0.610	0.42
474_K	510_I	0.610	0.42
193_E	206_L	0.609	0.42
75_P	225_E	0.608	0.41
430_Q	586_D	0.608	0.41
8_N	35_S	0.607	0.41
106_H	115_Y	0.606	0.41
64_H	69_R	0.606	0.41
5_G	138_M	0.605	0.41
469_T	473_L	0.605	0.41
21_D	367_N	0.603	0.41
112_S	153_L	0.603	0.41
45_E	75_P	0.602	0.41
106_H	142_S	0.602	0.41
357_K	463_Y	0.602	0.41
393_T	620_Q	0.600	0.41
178_W	363_V	0.600	0.41
336_I	384_L	0.599	0.41
181_F	315_N	0.599	0.41
565_P	568_T	0.599	0.41
218_T	255_L	0.598	0.40
228_P	232_L	0.597	0.40
119_T	224_N	0.597	0.40
309_C	335_M	0.596	0.40
33_T	138_M	0.595	0.40
214_V	254_G	0.594	0.40
379_K	649_M	0.593	0.40
510_I	570_H	0.593	0.40
399_T	597_I	0.593	0.40
396_P	620_Q	0.593	0.40
122_I	225_E	0.592	0.40
136_L	234_P	0.592	0.40
399_T	458_I	0.591	0.40
17_D	635_E	0.590	0.40
5_G	8_N	0.590	0.40
227_I	263_H	0.590	0.40
33_T	69_R	0.589	0.40
430_Q	583_R	0.589	0.40
515_P	545_I	0.589	0.40
32_N	381_G	0.589	0.40
478_A	570_H	0.588	0.40
257_Y	269_W	0.587	0.39
453_P	655_S	0.587	0.39
252_Y	269_W	0.586	0.39
477_T	480_G	0.586	0.39
48_E	126_L	0.585	0.39
230_K	235_D	0.584	0.39
203_L	355_S	0.584	0.39
329_L	664_E	0.584	0.39
408_H	424_Y	0.584	0.39
38_I	142_S	0.583	0.39
115_Y	126_L	0.583	0.39
350_K	359_H	0.582	0.39
194_S	210_W	0.582	0.39
617_Q	632_F	0.581	0.39
347_Q	359_H	0.581	0.39
270_D	346_F	0.581	0.39
427_T	431_H	0.580	0.39
8_N	40_A	0.580	0.39
14_D	20_A	0.579	0.39
143_N	241_N	0.579	0.39
414_A	488_I	0.578	0.39
529_V	538_M	0.577	0.38
227_I	466_S	0.577	0.38
478_A	599_D	0.577	0.38
586_D	590_R	0.577	0.38
239_T	266_A	0.577	0.38
587_Q	598_T	0.576	0.38
23_I	70_V	0.576	0.38
78_A	147_G	0.576	0.38
525_D	529_V	0.575	0.38
305_L	344_L	0.574	0.38
59_I	62_R	0.572	0.38
431_H	458_I	0.571	0.38
629_V	668_V	0.570	0.38
262_K	636_K	0.570	0.38
271_A	335_M	0.569	0.38
84_S	91_L	0.569	0.38
242_F	258_S	0.569	0.38
122_I	126_L	0.569	0.38
579_F	631_N	0.569	0.38
42_S	543_T	0.569	0.38
222_Y	263_H	0.568	0.38
31_T	348_Y	0.568	0.38
386_R	603_S	0.567	0.37
12_W	349_R	0.567	0.37
100_Q	104_G	0.566	0.37
84_S	106_H	0.565	0.37
191_Q	211_R	0.565	0.37
186_F	191_Q	0.564	0.37
24_K	136_L	0.564	0.37
83_L	89_E	0.564	0.37
538_M	566_A	0.563	0.37
177_W	206_L	0.563	0.37
149_C	255_L	0.563	0.37
5_G	33_T	0.562	0.37
485_M	507_L	0.562	0.37
315_N	320_N	0.562	0.37
398_Q	603_S	0.562	0.37
428_L	444_V	0.561	0.37
527_N	530_S	0.561	0.37
36_V	61_E	0.561	0.37
550_A	568_T	0.561	0.37
123_N	145_Y	0.560	0.37
3_H	328_N	0.560	0.37
435_F	597_I	0.560	0.37
198_I	202_G	0.560	0.37
175_H	537_E	0.560	0.37
554_A	567_V	0.560	0.37
127_A	139_W	0.559	0.37
27_K	169_S	0.559	0.37
404_D	407_N	0.558	0.37
37_G	44_L	0.558	0.37
110_L	299_L	0.558	0.37
67_G	571_E	0.558	0.37
13_L	58_D	0.558	0.37
262_K	574_Q	0.557	0.37
21_D	390_V	0.557	0.37
309_C	332_S	0.557	0.37
537_E	585_E	0.557	0.37
329_L	380_V	0.556	0.36
104_G	198_I	0.556	0.36
169_S	445_I	0.555	0.36
229_L	234_P	0.555	0.36
243_M	293_N	0.555	0.36
375_Q	379_K	0.554	0.36
485_M	545_I	0.554	0.36
403_Y	428_L	0.554	0.36
178_W	203_L	0.554	0.36
551_S	555_V	0.554	0.36
465_I	469_T	0.554	0.36
427_T	430_Q	0.553	0.36
593_Y	597_I	0.553	0.36
390_V	393_T	0.553	0.36
273_P	338_H	0.553	0.36
8_N	225_E	0.553	0.36
269_W	335_M	0.552	0.36
38_I	147_G	0.552	0.36
386_R	647_D	0.551	0.36
35_S	71_I	0.551	0.36
96_S	567_V	0.551	0.36
38_I	323_K	0.551	0.36
63_I	70_V	0.551	0.36
89_E	117_E	0.550	0.36
244_A	292_I	0.550	0.36
84_S	90_V	0.550	0.36
128_E	586_D	0.550	0.36
261_A	493_N	0.550	0.36
478_A	551_S	0.549	0.36
312_S	357_K	0.549	0.36
4_G	22_D	0.548	0.36
421_T	523_P	0.548	0.36
459_V	477_T	0.547	0.36
271_A	334_Q	0.547	0.36
484_V	567_V	0.547	0.36
35_S	347_Q	0.546	0.36
38_I	488_I	0.546	0.36
147_G	199_G	0.545	0.35
120_R	231_E	0.545	0.35
42_S	185_T	0.544	0.35
187_N	190_S	0.544	0.35
11_Q	351_S	0.543	0.35
152_D	196_S	0.543	0.35
167_D	591_D	0.543	0.35
271_A	293_N	0.542	0.35
51_Y	667_I	0.542	0.35
255_L	260_F	0.542	0.35
319_V	523_P	0.542	0.35
23_I	27_K	0.541	0.35
311_P	315_N	0.541	0.35
386_R	648_I	0.540	0.35
427_T	487_Y	0.540	0.35
40_A	180_P	0.538	0.35
5_G	73_A	0.536	0.35
641_F	644_S	0.536	0.35
428_L	435_F	0.536	0.35
341_D	619_R	0.536	0.35
559_D	562_A	0.536	0.35
143_N	308_E	0.535	0.34
644_S	658_L	0.535	0.34
603_S	612_K	0.535	0.34
320_N	359_H	0.535	0.34
6_D	12_W	0.535	0.34
447_K	472_R	0.534	0.34
412_E	423_R	0.534	0.34
416_G	492_V	0.534	0.34
52_Q	524_K	0.534	0.34
488_I	492_V	0.534	0.34
533_S	562_A	0.533	0.34
327_M	663_Y	0.533	0.34
613_G	616_V	0.533	0.34
291_F	363_V	0.532	0.34
316_W	320_N	0.532	0.34
289_V	334_Q	0.531	0.34
646_K	653_I	0.531	0.34
538_M	543_T	0.530	0.34
4_G	9_P	0.529	0.34
458_I	667_I	0.529	0.34
650_T	668_V	0.529	0.34
38_I	347_Q	0.529	0.34
178_W	497_L	0.529	0.34
9_P	39_F	0.529	0.34
451_F	472_R	0.528	0.34
34_F	38_I	0.528	0.34
405_W	408_H	0.528	0.34
294_D	442_V	0.528	0.34
383_T	386_R	0.528	0.34
317_H	320_N	0.527	0.34
70_V	584_L	0.527	0.34
82_W	356_E	0.527	0.34
289_V	335_M	0.526	0.34
653_I	668_V	0.526	0.34
399_T	602_L	0.525	0.34
104_G	200_E	0.524	0.33
8_N	142_S	0.523	0.33
210_W	345_Y	0.523	0.33
328_N	332_S	0.523	0.33
453_P	539_K	0.522	0.33
401_I	622_Q	0.522	0.33
527_N	559_D	0.522	0.33
478_A	602_L	0.521	0.33
215_T	409_W	0.521	0.33
434_T	589_Q	0.521	0.33
395_R	439_D	0.521	0.33
92_R	148_D	0.521	0.33
170_L	190_S	0.519	0.33
399_T	456_L	0.519	0.33
290_G	334_Q	0.518	0.33
63_I	66_I	0.518	0.33
14_D	17_D	0.518	0.33
142_S	357_K	0.517	0.33
190_S	594_E	0.517	0.33
603_S	607_P	0.516	0.33
478_A	528_A	0.516	0.33
233_T	320_N	0.516	0.33
107_N	184_H	0.516	0.33
28_L	87_Y	0.515	0.33
90_V	142_S	0.515	0.33
294_D	550_A	0.515	0.33
114_V	153_L	0.515	0.33
90_V	221_F	0.515	0.33
590_R	594_E	0.515	0.33
56_L	243_M	0.515	0.33
108_H	142_S	0.515	0.33
219_I	222_Y	0.515	0.33
214_V	217_Q	0.514	0.33
436_W	439_D	0.514	0.33
304_F	360_G	0.514	0.33
228_P	234_P	0.513	0.33
72_L	126_L	0.512	0.32
461_M	487_Y	0.511	0.32
47_E	160_E	0.511	0.32
255_L	405_W	0.511	0.32
580_I	589_Q	0.511	0.32
650_T	659_T	0.510	0.32
145_Y	221_F	0.510	0.32
182_W	356_E	0.509	0.32
229_L	236_I	0.509	0.32
499_Y	507_L	0.509	0.32
397_A	443_D	0.508	0.32
566_A	582_A	0.508	0.32
41_W	45_E	0.508	0.32
489_S	507_L	0.508	0.32
335_M	340_S	0.507	0.32
79_R	106_H	0.507	0.32
120_R	402_L	0.507	0.32
577_A	596_L	0.507	0.32
595_G	653_I	0.507	0.32
170_L	188_D	0.506	0.32
159_R	193_E	0.506	0.32
259_K	448_E	0.506	0.32
659_T	666_R	0.506	0.32
226_I	238_I	0.506	0.32
152_D	398_Q	0.505	0.32
296_Y	299_L	0.505	0.32
35_S	305_L	0.505	0.32
54_E	652_D	0.505	0.32
396_P	399_T	0.505	0.32
75_P	106_H	0.503	0.32
567_V	578_Y	0.502	0.32
229_L	594_E	0.502	0.32
89_E	127_A	0.502	0.32
85_Q	102_H	0.501	0.31
260_F	498_T	0.501	0.31
244_A	269_W	0.501	0.31
271_A	309_C	0.500	0.31
39_F	349_R	0.500	0.31
440_I	604_P	0.500	0.31
83_L	114_V	0.500	0.31
581_G	584_L	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4oifA	3	0.997	100	0.252	Contact Map
3ttyA	4	0.9702	100	0.256	Contact Map
4uozA	3	0.9658	100	0.265	Contact Map
1kwgA	3	0.9375	100	0.275	Contact Map
4d1iA	4	0.6949	100	0.668	Contact Map
3u7vA	3	0.6443	100	0.685	Contact Map
2zuvA	2	0.8393	100	0.699	Contact Map
1wdpA	1	0.5863	100	0.71	Contact Map
1fa2A	3	0.5908	100	0.743	Contact Map
3og2A	1	0.6295	100	0.75	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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