GREMLIN Database
CYCB - Cyclodextrin-binding protein
UniProt: O07009 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (393)
Sequences: 30473 (24309)
Seq/√Len: 1226.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_E68_K3.5851.00
398_D401_Q3.1331.00
111_K315_E3.1091.00
226_V400_K2.9891.00
154_D282_N2.9891.00
153_K284_G2.9461.00
112_E136_K2.9211.00
41_V68_K2.8531.00
169_Y234_K2.7831.00
39_E66_K2.7481.00
233_Q237_K2.6901.00
234_K238_D2.4511.00
173_K238_D2.4301.00
164_T167_E2.3711.00
153_K157_T2.3501.00
230_A234_K2.2991.00
65_V317_L2.2721.00
76_K79_E2.2641.00
63_H320_E2.2621.00
53_K57_A2.2471.00
151_Y284_G2.2171.00
223_E227_K2.1971.00
60_E66_K2.1901.00
404_D408_E2.1511.00
58_A61_K2.1421.00
170_D174_K2.1381.00
114_H136_K2.1331.00
407_A411_K2.1261.00
400_K404_D2.0951.00
132_M137_L2.0781.00
230_A399_P2.0561.00
41_V70_V2.0471.00
327_N330_N2.0331.00
161_L171_Y2.0251.00
397_A405_Q2.0221.00
320_E323_V2.0121.00
58_A324_F2.0011.00
391_T396_K2.0001.00
54_D57_A1.9611.00
314_N317_L1.9251.00
125_D129_Q1.9131.00
156_I265_A1.9041.00
37_G66_K1.8911.00
58_A62_E1.8571.00
250_G253_V1.8561.00
60_E63_H1.8531.00
391_T397_A1.8451.00
227_K230_A1.8411.00
129_Q132_M1.8381.00
154_D158_E1.8351.00
173_K177_D1.8351.00
59_F320_E1.8291.00
167_E170_D1.8201.00
116_K319_Q1.7991.00
57_A61_K1.7861.00
110_L307_N1.7851.00
170_D173_K1.7581.00
58_A333_T1.7541.00
408_E412_G1.7521.00
332_K336_E1.7511.00
221_N404_D1.7211.00
384_P409_T1.7161.00
226_V230_A1.6711.00
360_R364_E1.6611.00
405_Q409_T1.6601.00
383_T387_S1.6521.00
92_D314_N1.6451.00
122_L346_S1.6331.00
56_V60_E1.6301.00
38_S317_L1.6091.00
169_Y173_K1.6091.00
401_Q405_Q1.5971.00
163_K167_E1.5881.00
166_E169_Y1.5871.00
139_G305_S1.5821.00
206_G217_D1.5811.00
184_L263_A1.5801.00
169_Y238_D1.5731.00
316_E320_E1.5721.00
230_A400_K1.5651.00
73_P76_K1.5621.00
131_Q305_S1.5581.00
392_V402_A1.5571.00
155_L264_A1.5521.00
404_D407_A1.5371.00
328_E332_K1.5361.00
43_W84_D1.5311.00
56_V321_L1.5271.00
59_F63_H1.5121.00
94_L309_S1.5101.00
57_A60_E1.5081.00
15_A18_L1.4951.00
80_D84_D1.4871.00
401_Q404_D1.4841.00
257_L262_K1.4681.00
111_K310_A1.4671.00
149_L286_T1.4571.00
175_T264_A1.4551.00
388_A405_Q1.4551.00
169_Y235_F1.4501.00
173_K240_L1.4501.00
330_N333_T1.4491.00
16_V19_S1.4481.00
153_K282_N1.4471.00
233_Q392_V1.4461.00
231_L234_K1.4301.00
405_Q408_E1.4201.00
151_Y286_T1.4171.00
85_G90_G1.4161.00
226_V399_P1.4001.00
388_A397_A1.3951.00
54_D58_A1.3911.00
333_T337_E1.3851.00
308_V322_A1.3841.00
224_G227_K1.3781.00
388_A391_T1.3781.00
221_N407_A1.3611.00
206_G210_D1.3521.00
166_E170_D1.3461.00
361_A364_E1.3371.00
155_L175_T1.3251.00
169_Y231_L1.3191.00
397_A402_A1.3121.00
392_V399_P1.3081.00
44_E69_V1.3021.00
59_F324_F1.2991.00
364_E367_R1.2911.00
317_L320_E1.2901.00
38_S314_N1.2761.00
312_S315_E1.2711.00
231_L235_F1.2701.00
112_E115_V1.2631.00
207_K210_D1.2631.00
13_C17_S1.2421.00
258_F283_Y1.2401.00
59_F321_L1.2401.00
256_S260_E1.2351.00
408_E411_K1.2271.00
37_G64_D1.2251.00
234_K237_K1.2241.00
105_V138_Y1.2231.00
50_N53_K1.2211.00
161_L174_K1.2171.00
93_V318_A1.2151.00
56_V69_V1.2111.00
319_Q323_V1.1961.00
59_F65_V1.1931.00
397_A401_Q1.1901.00
172_S265_A1.1891.00
312_S318_A1.1871.00
227_K231_L1.1821.00
152_N155_L1.1811.00
96_M307_N1.1791.00
120_Q128_I1.1751.00
409_T412_G1.1641.00
148_V285_I1.1591.00
384_P387_S1.1581.00
149_L265_A1.1571.00
171_Y174_K1.1481.00
351_P355_K1.1371.00
203_Y207_K1.1351.00
131_Q137_L1.1331.00
154_D281_I1.1321.00
166_E292_E1.1291.00
115_V118_D1.1241.00
363_T367_R1.1211.00
80_D83_M1.1211.00
50_N54_D1.1191.00
388_A406_A1.1191.00
324_F330_N1.1161.00
159_K175_T1.1111.00
172_S240_L1.1081.00
156_I171_Y1.1071.00
391_T405_Q1.1061.00
128_I132_M1.1051.00
203_Y206_G1.1021.00
119_V122_L1.1011.00
315_E319_Q1.0951.00
65_V320_E1.0951.00
176_A182_G1.0941.00
346_S349_N1.0901.00
387_S409_T1.0881.00
108_G310_A1.0871.00
62_E327_N1.0871.00
230_A233_Q1.0711.00
275_A278_N1.0701.00
92_D312_S1.0691.00
223_E226_V1.0641.00
88_G311_F1.0601.00
152_N281_I1.0591.00
168_W172_S1.0571.00
42_V306_Y1.0531.00
155_L180_K1.0501.00
176_A240_L1.0501.00
257_L263_A1.0491.00
180_K262_K1.0461.00
321_L325_L1.0441.00
168_W265_A1.0371.00
171_Y265_A1.0241.00
23_C26_K1.0231.00
310_A315_E1.0211.00
333_T336_E1.0191.00
328_E346_S1.0161.00
253_V256_S1.0151.00
226_V403_L1.0131.00
308_V318_A1.0131.00
93_V322_A1.0121.00
51_G54_D1.0101.00
329_K332_K1.0071.00
168_W183_F1.0071.00
309_S312_S1.0001.00
381_I410_A0.9991.00
155_L158_E0.9961.00
233_Q399_P0.9941.00
59_F317_L0.9901.00
356_S360_R0.9901.00
156_I161_L0.9901.00
174_K177_D0.9891.00
105_V133_V0.9841.00
388_A409_T0.9841.00
58_A329_K0.9831.00
387_S391_T0.9811.00
218_I411_K0.9801.00
12_L16_V0.9801.00
344_V347_L0.9791.00
17_S20_L0.9731.00
54_D333_T0.9731.00
94_L307_N0.9721.00
23_C27_E0.9701.00
78_I100_Q0.9651.00
16_V20_L0.9631.00
85_G109_L0.9621.00
155_L159_K0.9611.00
268_S272_N0.9611.00
93_V321_L0.9601.00
81_L94_L0.9581.00
116_K316_E0.9581.00
150_F268_S0.9551.00
308_V319_Q0.9541.00
364_E368_F0.9501.00
154_D157_T0.9471.00
384_P388_A0.9451.00
175_T178_G0.9421.00
54_D337_E0.9391.00
40_L321_L0.9341.00
380_E383_T0.9331.00
55_A58_A0.9311.00
12_L18_L0.9261.00
12_L15_A0.9261.00
321_L324_F0.9251.00
229_A392_V0.9231.00
200_Y227_K0.9191.00
318_A322_A0.9141.00
357_E360_R0.9131.00
124_T345_K0.9131.00
67_V321_L0.9081.00
125_D128_I0.9061.00
64_D320_E0.9051.00
142_K306_Y0.9031.00
90_G309_S0.9021.00
351_P354_M0.9011.00
38_S64_D0.8961.00
383_T386_D0.8951.00
111_K312_S0.8861.00
163_K290_K0.8851.00
157_T282_N0.8841.00
8_S19_S0.8811.00
316_E319_Q0.8781.00
122_L344_V0.8781.00
15_A19_S0.8751.00
256_S259_T0.8741.00
126_A129_Q0.8701.00
403_L407_A0.8701.00
329_K333_T0.8681.00
161_L175_T0.8651.00
19_S22_A0.8641.00
11_M15_A0.8611.00
56_V67_V0.8601.00
388_A402_A0.8561.00
162_P167_E0.8461.00
83_M87_A0.8441.00
8_S15_A0.8421.00
84_D89_T0.8401.00
332_K350_D0.8391.00
398_D402_A0.8351.00
128_I137_L0.8341.00
55_A330_N0.8311.00
158_E180_K0.8301.00
40_L317_L0.8281.00
308_V312_S0.8201.00
152_N282_N0.8191.00
229_A403_L0.8181.00
139_G307_N0.8181.00
13_C19_S0.8151.00
218_I407_A0.8151.00
235_F240_L0.8151.00
20_L23_C0.8151.00
169_Y240_L0.8131.00
58_A330_N0.8131.00
43_W72_K0.8121.00
197_M225_A0.8111.00
402_A406_A0.8091.00
114_H118_D0.8091.00
210_D217_D0.8091.00
72_K80_D0.8051.00
62_E324_F0.8041.00
181_F243_A0.8041.00
11_M17_S0.8011.00
239_G243_A0.7981.00
384_P406_A0.7981.00
103_T107_E0.7971.00
132_M135_Q0.7951.00
159_K174_K0.7931.00
233_Q236_Y0.7931.00
377_E380_E0.7921.00
114_H137_L0.7921.00
94_L110_L0.7901.00
206_G211_G0.7811.00
38_S65_V0.7771.00
197_M202_G0.7771.00
148_V362_V0.7751.00
79_E83_M0.7731.00
8_S11_M0.7701.00
366_S369_S0.7691.00
402_A405_Q0.7681.00
123_Y326_A0.7681.00
165_L169_Y0.7671.00
193_A197_M0.7671.00
14_A18_L0.7661.00
169_Y172_S0.7641.00
114_H132_M0.7631.00
40_L314_N0.7571.00
14_A17_S0.7571.00
105_V110_L0.7561.00
60_E67_V0.7561.00
382_W386_D0.7551.00
62_E329_K0.7541.00
173_K176_A0.7541.00
332_K347_L0.7531.00
219_G222_N0.7531.00
220_I225_A0.7531.00
23_C28_S0.7501.00
229_A402_A0.7471.00
361_A365_Q0.7461.00
172_S182_G0.7431.00
111_K308_V0.7421.00
110_L138_Y0.7411.00
387_S390_Q0.7411.00
252_N255_E0.7401.00
385_A406_A0.7371.00
156_I175_T0.7361.00
60_E64_D0.7361.00
159_K178_G0.7351.00
13_C16_V0.7341.00
11_M18_L0.7321.00
171_Y175_T0.7321.00
111_K309_S0.7321.00
102_G106_T0.7291.00
111_K319_Q0.7291.00
8_S18_L0.7261.00
274_E278_N0.7251.00
360_R363_T0.7241.00
8_S12_L0.7241.00
111_K115_V0.7211.00
403_L406_A0.7191.00
222_N225_A0.7181.00
292_E295_K0.7181.00
362_V366_S0.7171.00
125_D345_K0.7151.00
176_A239_G0.7141.00
206_G219_G0.7141.00
120_Q132_M0.7131.00
119_V323_V0.7111.00
104_A110_L0.7071.00
200_Y231_L0.7051.00
123_Y128_I0.7051.00
345_K349_N0.7041.00
11_M14_A0.6991.00
172_S176_A0.6991.00
275_A279_A0.6981.00
111_K116_K0.6981.00
112_E138_Y0.6961.00
117_K137_L0.6961.00
42_V93_V0.6961.00
45_D48_K0.6961.00
82_R103_T0.6931.00
150_F285_I0.6931.00
100_Q103_T0.6901.00
222_N226_V0.6861.00
151_Y156_I0.6851.00
9_V13_C0.6831.00
9_V16_V0.6821.00
347_L350_D0.6821.00
43_W91_P0.6811.00
165_L231_L0.6781.00
7_C18_L0.6781.00
227_K291_L0.6781.00
217_D411_K0.6771.00
12_L19_S0.6771.00
242_P245_I0.6761.00
202_G225_A0.6751.00
111_K311_F0.6681.00
252_N256_S0.6651.00
77_Q81_L0.6641.00
70_V84_D0.6631.00
390_Q394_T0.6611.00
66_K69_V0.6601.00
242_P257_L0.6571.00
358_A362_V0.6561.00
198_S370_E0.6541.00
159_K180_K0.6531.00
122_L328_E0.6501.00
359_A363_T0.6491.00
352_A355_K0.6471.00
369_S372_T0.6461.00
40_L318_A0.6451.00
357_E361_A0.6451.00
124_T127_S0.6451.00
55_A324_F0.6451.00
63_H317_L0.6441.00
10_F14_A0.6421.00
159_K171_Y0.6411.00
378_M382_W0.6401.00
349_N354_M0.6371.00
41_V92_D0.6371.00
154_D261_G0.6361.00
237_K395_G0.6331.00
195_S198_S0.6311.00
181_F242_P0.6301.00
399_P403_L0.6281.00
60_E65_V0.6271.00
18_L21_A0.6251.00
9_V12_L0.6251.00
232_I236_Y0.6231.00
152_N261_G0.6231.00
124_T348_A0.6211.00
115_V136_K0.6151.00
79_E82_R0.6151.00
306_Y322_A0.6151.00
17_S21_A0.6141.00
14_A19_S0.6131.00
274_E277_S0.6131.00
198_S203_Y0.6121.00
35_S64_D0.6111.00
392_V397_A0.6091.00
254_L266_I0.6091.00
156_I159_K0.6081.00
55_A333_T0.6081.00
249_Q257_L0.6071.00
173_K234_K0.6061.00
42_V69_V0.6061.00
85_G309_S0.6061.00
228_G232_I0.6041.00
76_K80_D0.6031.00
131_Q139_G0.6021.00
163_K168_W0.6011.00
224_G228_G0.6001.00
176_A181_F0.6001.00
70_V80_D0.5991.00
38_S42_V0.5981.00
113_L322_A0.5981.00
52_I55_A0.5971.00
320_E324_F0.5971.00
78_I103_T0.5971.00
149_L267_I0.5961.00
22_A25_P0.5951.00
101_I139_G0.5941.00
220_I410_A0.5931.00
323_V327_N0.5931.00
222_N407_A0.5931.00
112_E137_L0.5921.00
184_L254_L0.5921.00
46_K49_S0.5911.00
194_E198_S0.5911.00
257_L260_E0.5901.00
377_E381_I0.5881.00
93_V306_Y0.5871.00
26_K29_S0.5861.00
150_F273_V0.5851.00
350_D353_I0.5821.00
255_E259_T0.5821.00
188_D250_G0.5821.00
358_A361_A0.5791.00
273_V277_S0.5791.00
43_W70_V0.5791.00
117_K319_Q0.5791.00
319_Q322_A0.5781.00
7_C10_F0.5781.00
328_E344_V0.5781.00
119_V124_T0.5771.00
63_H321_L0.5761.00
115_V319_Q0.5761.00
163_K171_Y0.5751.00
10_F17_S0.5751.00
236_Y241_F0.5741.00
106_T134_D0.5741.00
13_C18_L0.5731.00
350_D354_M0.5731.00
174_K178_G0.5721.00
21_A24_G0.5721.00
315_E318_A0.5711.00
151_Y265_A0.5701.00
306_Y325_L0.5691.00
391_T402_A0.5681.00
399_P402_A0.5671.00
172_S235_F0.5671.00
391_T395_G0.5661.00
277_S283_Y0.5661.00
51_G55_A0.5641.00
41_V44_E0.5621.00
184_L257_L0.5621.00
37_G63_H0.5601.00
150_F283_Y0.5601.00
167_E171_Y0.5601.00
140_L322_A0.5591.00
105_V108_G0.5581.00
92_D318_A0.5581.00
175_T265_A0.5561.00
365_Q368_F0.5561.00
379_N383_T0.5561.00
345_K348_A0.5561.00
78_I82_R0.5541.00
203_Y219_G0.5541.00
101_I105_V0.5531.00
259_T279_A0.5531.00
37_G65_V0.5521.00
109_L112_E0.5501.00
120_Q123_Y0.5501.00
38_S41_V0.5491.00
121_S124_T0.5481.00
116_K315_E0.5481.00
356_S359_A0.5471.00
70_V91_P0.5471.00
175_T180_K0.5471.00
55_A325_L0.5461.00
45_D49_S0.5461.00
363_T366_S0.5441.00
36_K64_D0.5431.00
127_S144_V0.5421.00
9_V15_A0.5421.00
348_A351_P0.5411.00
181_F185_A0.5401.00
249_Q253_V0.5401.00
19_S23_C0.5401.00
25_P28_S0.5381.00
114_H319_Q0.5371.00
157_T160_E0.5341.00
96_M104_A0.5321.00
10_F16_V0.5321.00
180_K184_L0.5311.00
10_F13_C0.5301.00
253_V257_L0.5301.00
41_V91_P0.5301.00
63_H324_F0.5301.00
197_M228_G0.5291.00
21_A25_P0.5291.00
272_N276_F0.5281.00
207_K211_G0.5261.00
233_Q398_D0.5251.00
235_F241_F0.5241.00
263_A267_I0.5241.00
38_S63_H0.5231.00
23_C29_S0.5231.00
380_E384_P0.5211.00
180_K264_A0.5211.00
237_K240_L0.5211.00
35_S38_S0.5201.00
290_K295_K0.5201.00
159_K264_A0.5201.00
102_G133_V0.5201.00
82_R86_P0.5191.00
42_V52_I0.5191.00
24_G27_E0.5181.00
305_S309_S0.5151.00
7_C14_A0.5151.00
9_V19_S0.5141.00
22_A26_K0.5131.00
140_L326_A0.5111.00
108_G111_K0.5101.00
258_F281_I0.5101.00
284_G287_K0.5101.00
225_A229_A0.5071.00
166_E291_L0.5071.00
287_K364_E0.5051.00
301_I305_S0.5041.00
53_K69_V0.5041.00
192_Y200_Y0.5021.00
78_I97_P0.5011.00
20_L24_G0.5011.00
153_K281_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uorA 1 0.8907 100 0.147 Contact Map
4r2fA 1 0.8717 100 0.148 Contact Map
4r9fA 1 0.8717 100 0.185 Contact Map
4r6kA 1 0.8884 100 0.191 Contact Map
2zyoA 1 0.9002 100 0.193 Contact Map
4mfiA 1 0.8884 100 0.195 Contact Map
2xd3A 1 0.8694 100 0.203 Contact Map
1ursA 1 0.8575 100 0.222 Contact Map
4r6hA 1 0.8884 100 0.222 Contact Map
3vxbA 1 0.8717 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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