GREMLIN Database
GANR - HTH-type transcriptional regulator GanR
UniProt: O07008 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (314)
Sequences: 33024 (24512)
Seq/√Len: 1383.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_A198_S3.3371.00
169_H239_T3.3111.00
10_E44_K3.1381.00
262_A265_N3.1091.00
160_T270_V2.7481.00
169_H268_S2.6091.00
274_N289_H2.5331.00
193_E197_R2.4851.00
112_G303_L2.4761.00
147_D306_Q2.4231.00
158_R202_E2.3421.00
32_D36_E2.2281.00
40_E44_K2.2091.00
223_Y258_E2.1891.00
36_E40_E2.1681.00
86_L301_Q2.0931.00
86_L89_A2.0871.00
227_S259_K2.0621.00
165_T203_K2.0311.00
298_N301_Q2.0231.00
158_R198_S1.9691.00
256_L267_V1.9571.00
87_A300_V1.9531.00
21_V38_I1.9491.00
155_Q159_K1.9461.00
82_E296_C1.9441.00
157_T161_V1.9371.00
35_R39_Y1.9311.00
162_N199_Y1.9301.00
162_N166_E1.9281.00
227_S255_A1.9201.00
22_L42_A1.9071.00
158_R199_Y1.8941.00
222_G251_G1.8901.00
231_D259_K1.8531.00
5_K15_I1.8511.00
156_M272_I1.8511.00
157_T242_M1.8151.00
289_H322_E1.8091.00
154_A194_Q1.8081.00
305_E310_K1.7541.00
161_V196_F1.7531.00
162_N203_K1.7221.00
85_K293_H1.7191.00
257_N282_S1.7091.00
164_L240_A1.7051.00
86_L297_K1.6971.00
223_Y255_A1.6941.00
11_A41_A1.6831.00
158_R162_N1.6701.00
10_E41_A1.6671.00
284_P327_K1.6641.00
298_N317_L1.6591.00
261_I266_R1.6461.00
159_K321_A1.6451.00
174_F244_A1.6401.00
291_D294_E1.6241.00
262_A266_R1.6201.00
82_E293_H1.6151.00
226_M252_C1.5951.00
243_I252_C1.5711.00
137_I299_A1.5601.00
64_W110_T1.5541.00
255_A259_K1.5251.00
163_I167_K1.5231.00
21_V42_A1.5141.00
39_Y43_E1.5131.00
274_N326_R1.5061.00
173_G238_P1.4931.00
152_D155_Q1.4911.00
7_I41_A1.4901.00
171_S208_E1.4641.00
39_Y42_A1.4631.00
213_C228_A1.4621.00
165_T199_Y1.4571.00
194_Q198_S1.4561.00
294_E298_N1.4501.00
86_L90_F1.4371.00
171_S237_L1.4341.00
255_A258_E1.4071.00
163_I325_V1.4061.00
86_L300_V1.3951.00
294_E297_K1.3891.00
226_M241_F1.3891.00
155_Q158_R1.3851.00
156_M321_A1.3821.00
256_L261_I1.3731.00
90_F304_L1.3621.00
191_I194_Q1.3591.00
161_V195_T1.3481.00
63_Y87_A1.3431.00
61_F111_E1.3311.00
208_E211_I1.3311.00
161_V165_T1.3271.00
161_V199_Y1.3191.00
197_R201_R1.3151.00
157_T195_T1.3041.00
162_N202_E1.2841.00
169_H240_A1.2841.00
226_M256_L1.2821.00
5_K9_Q1.2791.00
10_E45_L1.2781.00
6_D9_Q1.2761.00
163_I166_E1.2761.00
195_T199_Y1.2691.00
7_I11_A1.2691.00
173_G229_A1.2651.00
32_D35_R1.2591.00
227_S258_E1.2591.00
61_F92_V1.2531.00
31_P34_T1.2521.00
253_L269_I1.2511.00
199_Y202_E1.2431.00
20_R25_D1.2431.00
227_S231_D1.2341.00
65_L83_V1.2331.00
216_G221_N1.2301.00
41_A45_L1.2301.00
83_V114_I1.2251.00
301_Q305_E1.2181.00
270_V286_T1.2141.00
223_Y227_S1.2131.00
37_K41_A1.2121.00
171_S239_T1.1961.00
41_A44_K1.1961.00
7_I45_L1.1801.00
154_A191_I1.1751.00
235_D238_P1.1741.00
223_Y254_Q1.1711.00
175_I252_C1.1671.00
83_V300_V1.1661.00
4_I15_I1.1631.00
87_A94_M1.1531.00
65_L94_M1.1461.00
34_T37_K1.1441.00
114_I299_A1.1441.00
228_A232_T1.1381.00
246_D287_T1.1371.00
172_I200_M1.1351.00
50_K55_L1.1311.00
159_K162_N1.1291.00
304_L308_Q1.1231.00
251_G255_A1.1131.00
241_F252_C1.1081.00
167_K325_V1.1081.00
170_K239_T1.1061.00
220_E224_R1.1051.00
125_A129_N1.1031.00
97_Y106_I1.1001.00
200_M205_M1.0981.00
21_V30_V1.0951.00
246_D271_S1.0911.00
154_A158_R1.0901.00
4_I18_V1.0821.00
196_F200_M1.0751.00
198_S202_E1.0721.00
40_E43_E1.0691.00
298_N302_L1.0691.00
36_E39_Y1.0681.00
166_E203_K1.0651.00
296_C300_V1.0651.00
293_H297_K1.0591.00
174_F193_E1.0551.00
160_T242_M1.0511.00
171_S236_Q1.0511.00
165_T205_M1.0481.00
253_L263_I1.0441.00
51_T54_P1.0421.00
90_F301_Q1.0391.00
154_A195_T1.0351.00
199_Y203_K1.0261.00
302_L317_L1.0241.00
24_N35_R1.0191.00
222_G226_M1.0041.00
42_A45_L1.0031.00
90_F308_Q0.9991.00
243_I249_A0.9981.00
64_W106_I0.9961.00
225_L228_A0.9911.00
298_N319_V0.9881.00
62_L95_T0.9831.00
197_R207_D0.9761.00
167_K268_S0.9721.00
291_D319_V0.9701.00
303_L307_V0.9691.00
194_Q197_R0.9681.00
224_R228_A0.9661.00
160_T288_F0.9621.00
11_A18_V0.9621.00
84_E88_K0.9621.00
172_I240_A0.9611.00
155_Q320_G0.9611.00
253_L281_V0.9591.00
297_K301_Q0.9521.00
92_V304_L0.9481.00
218_S221_N0.9281.00
65_L80_R0.9261.00
232_T235_D0.9231.00
104_E126_F0.9211.00
177_G217_F0.9211.00
85_K297_K0.9171.00
161_V200_M0.9141.00
170_K205_M0.9131.00
60_A111_E0.9081.00
243_I248_I0.9081.00
151_P291_D0.8991.00
322_E325_V0.8991.00
219_V254_Q0.8971.00
221_N224_R0.8941.00
149_V302_L0.8921.00
148_S316_T0.8901.00
226_M230_I0.8891.00
190_D194_Q0.8881.00
213_C225_L0.8881.00
289_H324_I0.8871.00
165_T170_K0.8861.00
152_D318_Y0.8831.00
205_M209_R0.8801.00
24_N39_Y0.8791.00
114_I303_L0.8781.00
83_V296_C0.8721.00
151_P321_A0.8711.00
89_A297_K0.8701.00
241_F267_V0.8631.00
196_F242_M0.8621.00
63_Y114_I0.8561.00
155_Q321_A0.8541.00
147_D302_L0.8521.00
274_N324_I0.8521.00
230_I255_A0.8511.00
150_R318_Y0.8511.00
21_V39_Y0.8511.00
179_Y214_H0.8501.00
152_D320_G0.8471.00
49_K53_R0.8471.00
246_D249_A0.8461.00
246_D274_N0.8461.00
261_I267_V0.8461.00
62_L93_D0.8441.00
200_M207_D0.8371.00
147_D315_K0.8371.00
239_T268_S0.8321.00
271_S287_T0.8311.00
256_L269_I0.8291.00
302_L305_E0.8231.00
171_S211_I0.8201.00
237_L261_I0.8191.00
173_G241_F0.8181.00
224_R227_S0.8141.00
215_R248_I0.8141.00
64_W113_F0.8091.00
291_D322_E0.8041.00
81_L85_K0.8011.00
78_T293_H0.8011.00
274_N278_A0.7981.00
112_G307_V0.7981.00
75_Y292_I0.7951.00
150_R316_T0.7941.00
164_L270_V0.7891.00
175_I243_I0.7881.00
33_E36_E0.7881.00
300_V304_L0.7861.00
151_P290_I0.7821.00
121_D125_A0.7811.00
79_M137_I0.7811.00
250_V281_V0.7801.00
242_M270_V0.7791.00
33_E37_K0.7791.00
163_I286_T0.7781.00
13_F38_I0.7751.00
59_I111_E0.7731.00
174_F242_M0.7721.00
82_E297_K0.7721.00
176_G193_E0.7721.00
52_V55_L0.7671.00
191_I195_T0.7661.00
17_T20_R0.7641.00
163_I323_L0.7621.00
193_E212_F0.7571.00
198_S201_R0.7561.00
153_L192_R0.7541.00
3_T6_D0.7511.00
82_E86_L0.7481.00
16_S20_R0.7481.00
159_K288_F0.7451.00
226_M255_A0.7441.00
273_N290_I0.7431.00
230_I259_K0.7421.00
83_V94_M0.7411.00
20_R26_E0.7411.00
62_L108_E0.7381.00
126_F129_N0.7361.00
211_I232_T0.7331.00
48_R107_P0.7321.00
59_I308_Q0.7321.00
221_N225_L0.7271.00
226_M229_A0.7251.00
284_P326_R0.7231.00
63_Y300_V0.7211.00
215_R221_N0.7211.00
84_E94_M0.7161.00
254_Q257_N0.7141.00
256_L263_I0.7131.00
140_T316_T0.7111.00
213_C229_A0.7091.00
232_T237_L0.7091.00
232_T236_Q0.7071.00
120_S123_E0.6991.00
165_T200_M0.6981.00
69_E76_F0.6971.00
226_M251_G0.6971.00
80_R96_T0.6951.00
232_T238_P0.6951.00
136_F146_F0.6931.00
257_N284_P0.6931.00
112_G135_V0.6891.00
180_K190_D0.6881.00
127_L134_G0.6861.00
286_T323_L0.6851.00
136_F141_P0.6821.00
36_E43_E0.6811.00
222_G225_L0.6791.00
305_E309_D0.6791.00
196_F207_D0.6731.00
254_Q284_P0.6711.00
305_E315_K0.6701.00
172_I239_T0.6691.00
254_Q282_S0.6671.00
172_I196_F0.6671.00
128_R145_H0.6651.00
189_M217_F0.6641.00
213_C232_T0.6631.00
158_R195_T0.6611.00
85_K89_A0.6591.00
128_R134_G0.6591.00
81_L84_E0.6571.00
79_M292_I0.6551.00
134_G146_F0.6551.00
21_V35_R0.6501.00
125_A128_R0.6491.00
254_Q258_E0.6471.00
159_K163_I0.6461.00
18_V42_A0.6451.00
293_H296_C0.6451.00
92_V307_V0.6411.00
256_L259_K0.6391.00
282_S327_K0.6381.00
73_D247_P0.6381.00
128_R146_F0.6371.00
18_V21_V0.6361.00
114_I137_I0.6351.00
37_K40_E0.6341.00
20_R30_V0.6341.00
228_A231_D0.6321.00
5_K56_V0.6291.00
43_E46_N0.6261.00
7_I18_V0.6251.00
95_T110_T0.6211.00
153_L191_I0.6201.00
250_V275_I0.6201.00
278_A281_V0.6191.00
13_F34_T0.6191.00
135_V149_V0.6181.00
207_D212_F0.6171.00
81_L293_H0.6131.00
272_I290_I0.6121.00
27_S31_P0.6111.00
197_R209_R0.6111.00
147_D314_V0.6101.00
78_T292_I0.6091.00
80_R84_E0.6091.00
245_A273_N0.6081.00
174_F196_F0.6071.00
158_R161_V0.6071.00
135_V303_L0.6051.00
75_Y79_M0.6031.00
217_F244_A0.6011.00
177_G189_M0.6011.00
81_L100_A0.5991.00
164_L242_M0.5981.00
258_E282_S0.5971.00
306_Q309_D0.5951.00
278_A285_L0.5951.00
205_M208_E0.5941.00
92_V111_E0.5891.00
182_P191_I0.5871.00
167_K239_T0.5851.00
27_S34_T0.5841.00
171_S206_L0.5831.00
253_L257_N0.5811.00
278_A287_T0.5811.00
112_G299_A0.5811.00
82_E292_I0.5791.00
219_V251_G0.5761.00
257_N262_A0.5761.00
135_V299_A0.5731.00
221_N248_I0.5731.00
279_K284_P0.5711.00
160_T240_A0.5711.00
295_L319_V0.5711.00
163_I270_V0.5691.00
243_I271_S0.5691.00
25_D30_V0.5671.00
87_A304_L0.5661.00
73_D76_F0.5641.00
288_F321_A0.5641.00
18_V38_I0.5631.00
138_D153_L0.5631.00
53_R57_K0.5631.00
249_A271_S0.5621.00
277_F281_V0.5601.00
151_P272_I0.5591.00
63_Y307_V0.5561.00
302_L306_Q0.5541.00
230_I256_L0.5521.00
11_A21_V0.5521.00
135_V306_Q0.5521.00
70_E81_L0.5521.00
113_F132_E0.5511.00
252_C269_I0.5511.00
122_E125_A0.5511.00
223_Y251_G0.5501.00
54_P57_K0.5491.00
238_P261_I0.5481.00
74_V247_P0.5471.00
48_R51_T0.5471.00
135_V302_L0.5461.00
242_M272_I0.5451.00
151_P156_M0.5451.00
252_C256_L0.5441.00
63_Y92_V0.5431.00
220_E223_Y0.5431.00
209_R212_F0.5431.00
13_F18_V0.5421.00
245_A248_I0.5421.00
149_V298_N0.5411.00
254_Q279_K0.5401.00
62_L111_E0.5381.00
286_T325_V0.5381.00
298_N305_E0.5371.00
189_M244_A0.5361.00
110_T113_F0.5341.00
171_S238_P0.5341.00
16_S25_D0.5311.00
173_G211_I0.5301.00
78_T276_S0.5301.00
274_N279_K0.5281.00
76_F116_V0.5281.00
261_I264_P0.5271.00
193_E207_D0.5271.00
30_V35_R0.5251.00
263_I266_R0.5241.00
246_D275_I0.5241.00
237_L266_R0.5231.00
275_I287_T0.5191.00
86_L304_L0.5191.00
104_E107_P0.5161.00
6_D10_E0.5141.00
123_E126_F0.5141.00
154_A157_T0.5121.00
63_Y112_G0.5111.00
318_Y321_A0.5101.00
217_F248_I0.5091.00
306_Q310_K0.5081.00
277_F280_Y0.5071.00
83_V87_A0.5071.00
26_E30_V0.5041.00
161_V203_K0.5041.00
115_A136_F0.5021.00
238_P241_F0.5011.00
223_Y226_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8 100 0.091 Contact Map
2hsgA 1 0.9606 100 0.093 Contact Map
2o20A 2 0.8061 100 0.096 Contact Map
1qpzA 2 0.9667 100 0.099 Contact Map
3bilA 2 0.7424 100 0.109 Contact Map
4o5aA 2 0.7788 100 0.109 Contact Map
3ctpA 2 0.7758 100 0.11 Contact Map
3kjxA 2 0.9697 100 0.113 Contact Map
3jvdA 2 0.7667 100 0.115 Contact Map
3e3mA 2 0.7818 100 0.117 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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