GANR - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

GANR - HTH-type transcriptional regulator GanR

UniProt:	O07008	Sequences: MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEKLNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADGIESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKTVNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFSVENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNISFAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (314)
Sequences:	33024 (24512)
Seq/√Len:	1383.3

ECOLI - EBGR GALS GALR PURR RBSR ASCG CYTR IDNR CRA GNTR MALI LACI YCJW TRER TORT ALSB YTFQ RBSB XYLF YPHF ARAF LSRB XYLR DGAL
BACSU - GANR MSMR YVDE KDGR CCPA RBSR NTDR EXUR DEGA YKVZ ARAR CCPB RBSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
154_A	198_S	3.337	1.00
169_H	239_T	3.311	1.00
10_E	44_K	3.138	1.00
262_A	265_N	3.109	1.00
160_T	270_V	2.748	1.00
169_H	268_S	2.609	1.00
274_N	289_H	2.533	1.00
193_E	197_R	2.485	1.00
112_G	303_L	2.476	1.00
147_D	306_Q	2.423	1.00
158_R	202_E	2.342	1.00
32_D	36_E	2.228	1.00
40_E	44_K	2.209	1.00
223_Y	258_E	2.189	1.00
36_E	40_E	2.168	1.00
86_L	301_Q	2.093	1.00
86_L	89_A	2.087	1.00
227_S	259_K	2.062	1.00
165_T	203_K	2.031	1.00
298_N	301_Q	2.023	1.00
158_R	198_S	1.969	1.00
256_L	267_V	1.957	1.00
87_A	300_V	1.953	1.00
21_V	38_I	1.949	1.00
155_Q	159_K	1.946	1.00
82_E	296_C	1.944	1.00
157_T	161_V	1.937	1.00
35_R	39_Y	1.931	1.00
162_N	199_Y	1.930	1.00
162_N	166_E	1.928	1.00
227_S	255_A	1.920	1.00
22_L	42_A	1.907	1.00
158_R	199_Y	1.894	1.00
222_G	251_G	1.890	1.00
231_D	259_K	1.853	1.00
5_K	15_I	1.851	1.00
156_M	272_I	1.851	1.00
157_T	242_M	1.815	1.00
289_H	322_E	1.809	1.00
154_A	194_Q	1.808	1.00
305_E	310_K	1.754	1.00
161_V	196_F	1.753	1.00
162_N	203_K	1.722	1.00
85_K	293_H	1.719	1.00
257_N	282_S	1.709	1.00
164_L	240_A	1.705	1.00
86_L	297_K	1.697	1.00
223_Y	255_A	1.694	1.00
11_A	41_A	1.683	1.00
158_R	162_N	1.670	1.00
10_E	41_A	1.667	1.00
284_P	327_K	1.664	1.00
298_N	317_L	1.659	1.00
261_I	266_R	1.646	1.00
159_K	321_A	1.645	1.00
174_F	244_A	1.640	1.00
291_D	294_E	1.624	1.00
262_A	266_R	1.620	1.00
82_E	293_H	1.615	1.00
226_M	252_C	1.595	1.00
243_I	252_C	1.571	1.00
137_I	299_A	1.560	1.00
64_W	110_T	1.554	1.00
255_A	259_K	1.525	1.00
163_I	167_K	1.523	1.00
21_V	42_A	1.514	1.00
39_Y	43_E	1.513	1.00
274_N	326_R	1.506	1.00
173_G	238_P	1.493	1.00
152_D	155_Q	1.491	1.00
7_I	41_A	1.490	1.00
171_S	208_E	1.464	1.00
39_Y	42_A	1.463	1.00
213_C	228_A	1.462	1.00
165_T	199_Y	1.457	1.00
194_Q	198_S	1.456	1.00
294_E	298_N	1.450	1.00
86_L	90_F	1.437	1.00
171_S	237_L	1.434	1.00
255_A	258_E	1.407	1.00
163_I	325_V	1.406	1.00
86_L	300_V	1.395	1.00
294_E	297_K	1.389	1.00
226_M	241_F	1.389	1.00
155_Q	158_R	1.385	1.00
156_M	321_A	1.382	1.00
256_L	261_I	1.373	1.00
90_F	304_L	1.362	1.00
191_I	194_Q	1.359	1.00
161_V	195_T	1.348	1.00
63_Y	87_A	1.343	1.00
61_F	111_E	1.331	1.00
208_E	211_I	1.331	1.00
161_V	165_T	1.327	1.00
161_V	199_Y	1.319	1.00
197_R	201_R	1.315	1.00
157_T	195_T	1.304	1.00
162_N	202_E	1.284	1.00
169_H	240_A	1.284	1.00
226_M	256_L	1.282	1.00
5_K	9_Q	1.279	1.00
10_E	45_L	1.278	1.00
6_D	9_Q	1.276	1.00
163_I	166_E	1.276	1.00
195_T	199_Y	1.269	1.00
7_I	11_A	1.269	1.00
173_G	229_A	1.265	1.00
32_D	35_R	1.259	1.00
227_S	258_E	1.259	1.00
61_F	92_V	1.253	1.00
31_P	34_T	1.252	1.00
253_L	269_I	1.251	1.00
199_Y	202_E	1.243	1.00
20_R	25_D	1.243	1.00
227_S	231_D	1.234	1.00
65_L	83_V	1.233	1.00
216_G	221_N	1.230	1.00
41_A	45_L	1.230	1.00
83_V	114_I	1.225	1.00
301_Q	305_E	1.218	1.00
270_V	286_T	1.214	1.00
223_Y	227_S	1.213	1.00
37_K	41_A	1.212	1.00
171_S	239_T	1.196	1.00
41_A	44_K	1.196	1.00
7_I	45_L	1.180	1.00
154_A	191_I	1.175	1.00
235_D	238_P	1.174	1.00
223_Y	254_Q	1.171	1.00
175_I	252_C	1.167	1.00
83_V	300_V	1.166	1.00
4_I	15_I	1.163	1.00
87_A	94_M	1.153	1.00
65_L	94_M	1.146	1.00
34_T	37_K	1.144	1.00
114_I	299_A	1.144	1.00
228_A	232_T	1.138	1.00
246_D	287_T	1.137	1.00
172_I	200_M	1.135	1.00
50_K	55_L	1.131	1.00
159_K	162_N	1.129	1.00
304_L	308_Q	1.123	1.00
251_G	255_A	1.113	1.00
241_F	252_C	1.108	1.00
167_K	325_V	1.108	1.00
170_K	239_T	1.106	1.00
220_E	224_R	1.105	1.00
125_A	129_N	1.103	1.00
97_Y	106_I	1.100	1.00
200_M	205_M	1.098	1.00
21_V	30_V	1.095	1.00
246_D	271_S	1.091	1.00
154_A	158_R	1.090	1.00
4_I	18_V	1.082	1.00
196_F	200_M	1.075	1.00
198_S	202_E	1.072	1.00
40_E	43_E	1.069	1.00
298_N	302_L	1.069	1.00
36_E	39_Y	1.068	1.00
166_E	203_K	1.065	1.00
296_C	300_V	1.065	1.00
293_H	297_K	1.059	1.00
174_F	193_E	1.055	1.00
160_T	242_M	1.051	1.00
171_S	236_Q	1.051	1.00
165_T	205_M	1.048	1.00
253_L	263_I	1.044	1.00
51_T	54_P	1.042	1.00
90_F	301_Q	1.039	1.00
154_A	195_T	1.035	1.00
199_Y	203_K	1.026	1.00
302_L	317_L	1.024	1.00
24_N	35_R	1.019	1.00
222_G	226_M	1.004	1.00
42_A	45_L	1.003	1.00
90_F	308_Q	0.999	1.00
243_I	249_A	0.998	1.00
64_W	106_I	0.996	1.00
225_L	228_A	0.991	1.00
298_N	319_V	0.988	1.00
62_L	95_T	0.983	1.00
197_R	207_D	0.976	1.00
167_K	268_S	0.972	1.00
291_D	319_V	0.970	1.00
303_L	307_V	0.969	1.00
194_Q	197_R	0.968	1.00
224_R	228_A	0.966	1.00
160_T	288_F	0.962	1.00
11_A	18_V	0.962	1.00
84_E	88_K	0.962	1.00
172_I	240_A	0.961	1.00
155_Q	320_G	0.961	1.00
253_L	281_V	0.959	1.00
297_K	301_Q	0.952	1.00
92_V	304_L	0.948	1.00
218_S	221_N	0.928	1.00
65_L	80_R	0.926	1.00
232_T	235_D	0.923	1.00
104_E	126_F	0.921	1.00
177_G	217_F	0.921	1.00
85_K	297_K	0.917	1.00
161_V	200_M	0.914	1.00
170_K	205_M	0.913	1.00
60_A	111_E	0.908	1.00
243_I	248_I	0.908	1.00
151_P	291_D	0.899	1.00
322_E	325_V	0.899	1.00
219_V	254_Q	0.897	1.00
221_N	224_R	0.894	1.00
149_V	302_L	0.892	1.00
148_S	316_T	0.890	1.00
226_M	230_I	0.889	1.00
190_D	194_Q	0.888	1.00
213_C	225_L	0.888	1.00
289_H	324_I	0.887	1.00
165_T	170_K	0.886	1.00
152_D	318_Y	0.883	1.00
205_M	209_R	0.880	1.00
24_N	39_Y	0.879	1.00
114_I	303_L	0.878	1.00
83_V	296_C	0.872	1.00
151_P	321_A	0.871	1.00
89_A	297_K	0.870	1.00
241_F	267_V	0.863	1.00
196_F	242_M	0.862	1.00
63_Y	114_I	0.856	1.00
155_Q	321_A	0.854	1.00
147_D	302_L	0.852	1.00
274_N	324_I	0.852	1.00
230_I	255_A	0.851	1.00
150_R	318_Y	0.851	1.00
21_V	39_Y	0.851	1.00
179_Y	214_H	0.850	1.00
152_D	320_G	0.847	1.00
49_K	53_R	0.847	1.00
246_D	249_A	0.846	1.00
246_D	274_N	0.846	1.00
261_I	267_V	0.846	1.00
62_L	93_D	0.844	1.00
200_M	207_D	0.837	1.00
147_D	315_K	0.837	1.00
239_T	268_S	0.832	1.00
271_S	287_T	0.831	1.00
256_L	269_I	0.829	1.00
302_L	305_E	0.823	1.00
171_S	211_I	0.820	1.00
237_L	261_I	0.819	1.00
173_G	241_F	0.818	1.00
224_R	227_S	0.814	1.00
215_R	248_I	0.814	1.00
64_W	113_F	0.809	1.00
291_D	322_E	0.804	1.00
81_L	85_K	0.801	1.00
78_T	293_H	0.801	1.00
274_N	278_A	0.798	1.00
112_G	307_V	0.798	1.00
75_Y	292_I	0.795	1.00
150_R	316_T	0.794	1.00
164_L	270_V	0.789	1.00
175_I	243_I	0.788	1.00
33_E	36_E	0.788	1.00
300_V	304_L	0.786	1.00
151_P	290_I	0.782	1.00
121_D	125_A	0.781	1.00
79_M	137_I	0.781	1.00
250_V	281_V	0.780	1.00
242_M	270_V	0.779	1.00
33_E	37_K	0.779	1.00
163_I	286_T	0.778	1.00
13_F	38_I	0.775	1.00
59_I	111_E	0.773	1.00
174_F	242_M	0.772	1.00
82_E	297_K	0.772	1.00
176_G	193_E	0.772	1.00
52_V	55_L	0.767	1.00
191_I	195_T	0.766	1.00
17_T	20_R	0.764	1.00
163_I	323_L	0.762	1.00
193_E	212_F	0.757	1.00
198_S	201_R	0.756	1.00
153_L	192_R	0.754	1.00
3_T	6_D	0.751	1.00
82_E	86_L	0.748	1.00
16_S	20_R	0.748	1.00
159_K	288_F	0.745	1.00
226_M	255_A	0.744	1.00
273_N	290_I	0.743	1.00
230_I	259_K	0.742	1.00
83_V	94_M	0.741	1.00
20_R	26_E	0.741	1.00
62_L	108_E	0.738	1.00
126_F	129_N	0.736	1.00
211_I	232_T	0.733	1.00
48_R	107_P	0.732	1.00
59_I	308_Q	0.732	1.00
221_N	225_L	0.727	1.00
226_M	229_A	0.725	1.00
284_P	326_R	0.723	1.00
63_Y	300_V	0.721	1.00
215_R	221_N	0.721	1.00
84_E	94_M	0.716	1.00
254_Q	257_N	0.714	1.00
256_L	263_I	0.713	1.00
140_T	316_T	0.711	1.00
213_C	229_A	0.709	1.00
232_T	237_L	0.709	1.00
232_T	236_Q	0.707	1.00
120_S	123_E	0.699	1.00
165_T	200_M	0.698	1.00
69_E	76_F	0.697	1.00
226_M	251_G	0.697	1.00
80_R	96_T	0.695	1.00
232_T	238_P	0.695	1.00
136_F	146_F	0.693	1.00
257_N	284_P	0.693	1.00
112_G	135_V	0.689	1.00
180_K	190_D	0.688	1.00
127_L	134_G	0.686	1.00
286_T	323_L	0.685	1.00
136_F	141_P	0.682	1.00
36_E	43_E	0.681	1.00
222_G	225_L	0.679	1.00
305_E	309_D	0.679	1.00
196_F	207_D	0.673	1.00
254_Q	284_P	0.671	1.00
305_E	315_K	0.670	1.00
172_I	239_T	0.669	1.00
254_Q	282_S	0.667	1.00
172_I	196_F	0.667	1.00
128_R	145_H	0.665	1.00
189_M	217_F	0.664	1.00
213_C	232_T	0.663	1.00
158_R	195_T	0.661	1.00
85_K	89_A	0.659	1.00
128_R	134_G	0.659	1.00
81_L	84_E	0.657	1.00
79_M	292_I	0.655	1.00
134_G	146_F	0.655	1.00
21_V	35_R	0.650	1.00
125_A	128_R	0.649	1.00
254_Q	258_E	0.647	1.00
159_K	163_I	0.646	1.00
18_V	42_A	0.645	1.00
293_H	296_C	0.645	1.00
92_V	307_V	0.641	1.00
256_L	259_K	0.639	1.00
282_S	327_K	0.638	1.00
73_D	247_P	0.638	1.00
128_R	146_F	0.637	1.00
18_V	21_V	0.636	1.00
114_I	137_I	0.635	1.00
37_K	40_E	0.634	1.00
20_R	30_V	0.634	1.00
228_A	231_D	0.632	1.00
5_K	56_V	0.629	1.00
43_E	46_N	0.626	1.00
7_I	18_V	0.625	1.00
95_T	110_T	0.621	1.00
153_L	191_I	0.620	1.00
250_V	275_I	0.620	1.00
278_A	281_V	0.619	1.00
13_F	34_T	0.619	1.00
135_V	149_V	0.618	1.00
207_D	212_F	0.617	1.00
81_L	293_H	0.613	1.00
272_I	290_I	0.612	1.00
27_S	31_P	0.611	1.00
197_R	209_R	0.611	1.00
147_D	314_V	0.610	1.00
78_T	292_I	0.609	1.00
80_R	84_E	0.609	1.00
245_A	273_N	0.608	1.00
174_F	196_F	0.607	1.00
158_R	161_V	0.607	1.00
135_V	303_L	0.605	1.00
75_Y	79_M	0.603	1.00
217_F	244_A	0.601	1.00
177_G	189_M	0.601	1.00
81_L	100_A	0.599	1.00
164_L	242_M	0.598	1.00
258_E	282_S	0.597	1.00
306_Q	309_D	0.595	1.00
278_A	285_L	0.595	1.00
205_M	208_E	0.594	1.00
92_V	111_E	0.589	1.00
182_P	191_I	0.587	1.00
167_K	239_T	0.585	1.00
27_S	34_T	0.584	1.00
171_S	206_L	0.583	1.00
253_L	257_N	0.581	1.00
278_A	287_T	0.581	1.00
112_G	299_A	0.581	1.00
82_E	292_I	0.579	1.00
219_V	251_G	0.576	1.00
257_N	262_A	0.576	1.00
135_V	299_A	0.573	1.00
221_N	248_I	0.573	1.00
279_K	284_P	0.571	1.00
160_T	240_A	0.571	1.00
295_L	319_V	0.571	1.00
163_I	270_V	0.569	1.00
243_I	271_S	0.569	1.00
25_D	30_V	0.567	1.00
87_A	304_L	0.566	1.00
73_D	76_F	0.564	1.00
288_F	321_A	0.564	1.00
18_V	38_I	0.563	1.00
138_D	153_L	0.563	1.00
53_R	57_K	0.563	1.00
249_A	271_S	0.562	1.00
277_F	281_V	0.560	1.00
151_P	272_I	0.559	1.00
63_Y	307_V	0.556	1.00
302_L	306_Q	0.554	1.00
230_I	256_L	0.552	1.00
11_A	21_V	0.552	1.00
135_V	306_Q	0.552	1.00
70_E	81_L	0.552	1.00
113_F	132_E	0.551	1.00
252_C	269_I	0.551	1.00
122_E	125_A	0.551	1.00
223_Y	251_G	0.550	1.00
54_P	57_K	0.549	1.00
238_P	261_I	0.548	1.00
74_V	247_P	0.547	1.00
48_R	51_T	0.547	1.00
135_V	302_L	0.546	1.00
242_M	272_I	0.545	1.00
151_P	156_M	0.545	1.00
252_C	256_L	0.544	1.00
63_Y	92_V	0.543	1.00
220_E	223_Y	0.543	1.00
209_R	212_F	0.543	1.00
13_F	18_V	0.542	1.00
245_A	248_I	0.542	1.00
149_V	298_N	0.541	1.00
254_Q	279_K	0.540	1.00
62_L	111_E	0.538	1.00
286_T	325_V	0.538	1.00
298_N	305_E	0.537	1.00
189_M	244_A	0.536	1.00
110_T	113_F	0.534	1.00
171_S	238_P	0.534	1.00
16_S	25_D	0.531	1.00
173_G	211_I	0.530	1.00
78_T	276_S	0.530	1.00
274_N	279_K	0.528	1.00
76_F	116_V	0.528	1.00
261_I	264_P	0.527	1.00
193_E	207_D	0.527	1.00
30_V	35_R	0.525	1.00
263_I	266_R	0.524	1.00
246_D	275_I	0.524	1.00
237_L	266_R	0.523	1.00
275_I	287_T	0.519	1.00
86_L	304_L	0.519	1.00
104_E	107_P	0.516	1.00
6_D	10_E	0.514	1.00
123_E	126_F	0.514	1.00
154_A	157_T	0.512	1.00
63_Y	112_G	0.511	1.00
318_Y	321_A	0.510	1.00
217_F	248_I	0.509	1.00
306_Q	310_K	0.508	1.00
277_F	280_Y	0.507	1.00
83_V	87_A	0.507	1.00
26_E	30_V	0.504	1.00
161_V	203_K	0.504	1.00
115_A	136_F	0.502	1.00
238_P	241_F	0.501	1.00
223_Y	226_M	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dbiA	2	0.8	100	0.091	Contact Map
2hsgA	1	0.9606	100	0.093	Contact Map
2o20A	2	0.8061	100	0.096	Contact Map
1qpzA	2	0.9667	100	0.099	Contact Map
3bilA	2	0.7424	100	0.109	Contact Map
4o5aA	2	0.7788	100	0.109	Contact Map
3ctpA	2	0.7758	100	0.11	Contact Map
3kjxA	2	0.9697	100	0.113	Contact Map
3jvdA	2	0.7667	100	0.115	Contact Map
3e3mA	2	0.7818	100	0.117	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.