GREMLIN Database
LUTR - HTH-type transcriptional regulator LutR
UniProt: O07007 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (188)
Sequences: 23381 (17099)
Seq/√Len: 1247.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_Q188_A3.8761.00
92_S196_E3.4911.00
191_N194_Q3.0591.00
8_K11_D2.8961.00
114_G181_E2.8141.00
85_L89_G2.5041.00
105_R133_A2.3691.00
16_V27_R2.3161.00
78_Q141_E2.2691.00
84_K204_T2.1741.00
44_E54_K2.1441.00
81_E93_L2.0731.00
96_E192_G2.0621.00
136_D144_K1.9401.00
103_L188_A1.9381.00
186_A194_Q1.8861.00
102_D139_Q1.8861.00
88_I200_L1.8501.00
45_M51_T1.8411.00
133_A136_D1.8251.00
99_T102_D1.7881.00
92_S192_G1.7291.00
110_L184_Y1.7031.00
179_E205_N1.6801.00
82_V146_L1.6791.00
194_Q198_A1.6651.00
89_G92_S1.6521.00
88_I196_E1.6511.00
196_E200_L1.6231.00
182_R198_A1.5781.00
91_A195_A1.5361.00
135_A147_M1.5221.00
112_E126_A1.5141.00
102_D137_A1.5141.00
142_L153_L1.5001.00
131_H180_H1.4851.00
84_K200_L1.4831.00
145_H149_H1.4601.00
107_Q184_Y1.4521.00
185_N189_A1.4361.00
109_A126_A1.4351.00
78_Q142_L1.4351.00
189_A194_Q1.4351.00
114_G177_Y1.4251.00
132_L148_N1.4191.00
46_K49_E1.4111.00
84_K207_E1.4051.00
17_Q21_E1.3871.00
192_G196_E1.3651.00
98_R103_L1.3501.00
181_E185_N1.3191.00
18_A22_S1.2991.00
108_D112_E1.2781.00
107_Q111_K1.2691.00
112_E129_A1.2641.00
110_L181_E1.2501.00
12_K52_Y1.2381.00
19_L30_V1.2341.00
200_L204_T1.2321.00
109_A133_A1.2221.00
84_K88_I1.2141.00
88_I92_S1.2141.00
197_A201_A1.2111.00
132_L136_D1.2101.00
129_A133_A1.2051.00
179_E202_H1.2031.00
7_L53_L1.1951.00
46_K52_Y1.1911.00
38_K45_M1.1781.00
134_L187_V1.1681.00
194_Q197_A1.1631.00
91_A199_M1.1581.00
98_R190_G1.1561.00
98_R137_A1.1531.00
109_A129_A1.1481.00
110_L113_M1.1471.00
92_S193_A1.1391.00
133_A137_A1.1361.00
83_R87_E1.1361.00
126_A129_A1.1331.00
91_A95_A1.1281.00
78_Q140_N1.1261.00
98_R102_D1.1131.00
77_K207_E1.1101.00
185_N188_A1.1091.00
184_Y188_A1.1081.00
90_V135_A1.1051.00
81_E140_N1.0971.00
103_L184_Y1.0911.00
127_D131_H1.0841.00
146_L149_H1.0801.00
107_Q181_E1.0751.00
110_L114_G1.0741.00
44_E52_Y1.0601.00
103_L190_G1.0571.00
105_R136_D1.0451.00
105_R108_D1.0361.00
32_E35_S1.0351.00
95_A192_G1.0241.00
38_K43_V1.0191.00
111_K114_G1.0101.00
34_L51_T1.0061.00
89_G196_E1.0011.00
186_A191_N0.9991.00
122_L125_K0.9991.00
93_L97_K0.9971.00
130_F184_Y0.9951.00
182_R194_Q0.9771.00
131_H202_H0.9771.00
180_H202_H0.9771.00
105_R109_A0.9661.00
125_K129_A0.9571.00
178_E182_R0.9571.00
16_V31_R0.9561.00
46_K50_G0.9541.00
97_K139_Q0.9501.00
182_R201_A0.9491.00
36_A39_A0.9431.00
183_I199_M0.9401.00
144_K148_N0.9381.00
104_E108_D0.9361.00
36_A40_M0.9351.00
182_R185_N0.9311.00
87_E131_H0.9271.00
95_A187_V0.9251.00
109_A112_E0.9171.00
49_E52_Y0.9161.00
26_S29_A0.9131.00
12_K50_G0.9091.00
138_S144_K0.9071.00
89_G93_L0.9051.00
177_Y181_E0.9041.00
82_V142_L0.9041.00
193_A197_A0.9001.00
103_L107_Q0.8961.00
193_A196_E0.8881.00
75_D142_L0.8761.00
14_D18_A0.8701.00
18_A21_E0.8671.00
83_R203_L0.8651.00
74_E139_Q0.8641.00
182_R186_A0.8621.00
112_E115_S0.8611.00
35_S38_K0.8591.00
107_Q185_N0.8551.00
20_A30_V0.8521.00
95_A190_G0.8511.00
100_E104_E0.8471.00
98_R187_V0.8461.00
94_A137_A0.8271.00
116_I122_L0.8261.00
43_V51_T0.8231.00
111_K115_S0.8221.00
94_A98_R0.8091.00
142_L146_L0.8091.00
93_L96_E0.8081.00
113_M123_G0.8081.00
186_A198_A0.8071.00
132_L151_S0.8021.00
102_D105_R0.8011.00
183_I198_A0.7981.00
95_A195_A0.7971.00
93_L140_N0.7971.00
92_S96_E0.7971.00
25_V30_V0.7891.00
74_E78_Q0.7891.00
19_L34_L0.7871.00
127_D180_H0.7861.00
34_L43_V0.7831.00
106_I184_Y0.7821.00
198_A201_A0.7781.00
111_K181_E0.7761.00
14_D17_Q0.7751.00
128_F155_L0.7751.00
115_S119_D0.7741.00
81_E207_E0.7731.00
106_I133_A0.7701.00
100_E190_G0.7681.00
174_Q178_E0.7681.00
142_L145_H0.7671.00
104_E188_A0.7571.00
35_S45_M0.7561.00
82_V143_L0.7531.00
122_L126_A0.7361.00
114_G118_A0.7321.00
183_I195_A0.7311.00
104_E107_Q0.7311.00
201_A205_N0.7311.00
81_E97_K0.7291.00
197_A200_L0.7281.00
204_T208_D0.7251.00
112_E122_L0.7221.00
116_I126_A0.7171.00
80_L206_V0.7131.00
132_L144_K0.7011.00
179_E182_R0.6971.00
7_L11_D0.6931.00
204_T207_E0.6881.00
105_R129_A0.6851.00
128_F151_S0.6831.00
102_D133_A0.6741.00
81_E89_G0.6731.00
108_D111_K0.6721.00
48_G51_T0.6641.00
112_E116_I0.6621.00
29_A33_A0.6621.00
110_L177_Y0.6601.00
85_L143_L0.6591.00
82_V90_V0.6551.00
129_A132_L0.6541.00
102_D136_D0.6501.00
183_I202_H0.6501.00
145_H153_L0.6421.00
23_F30_V0.6381.00
94_A138_S0.6371.00
82_V86_L0.6341.00
205_N209_V0.6331.00
75_D141_E0.6331.00
119_D122_L0.6271.00
90_V138_S0.6271.00
117_E120_G0.6191.00
9_P55_E0.6191.00
103_L187_V0.6181.00
91_A192_G0.6101.00
84_K203_L0.6081.00
57_E75_D0.6051.00
90_V143_L0.5921.00
3_K42_L0.5901.00
123_G176_L0.5851.00
106_I137_A0.5841.00
17_Q20_A0.5791.00
74_E141_E0.5761.00
81_E84_K0.5741.00
101_A105_R0.5741.00
88_I199_M0.5731.00
13_L43_V0.5721.00
92_S200_L0.5711.00
113_M177_Y0.5701.00
52_Y55_E0.5691.00
87_E180_H0.5691.00
7_L22_S0.5691.00
10_G55_E0.5681.00
94_A134_L0.5651.00
128_F132_L0.5651.00
20_A23_F0.5641.00
183_I186_A0.5621.00
88_I192_G0.5591.00
47_Q50_G0.5581.00
172_S175_R0.5561.00
7_L13_L0.5561.00
35_S39_A0.5551.00
86_L147_M0.5521.00
54_K156_E0.5511.00
85_L88_I0.5501.00
199_M203_L0.5471.00
2_I53_L0.5471.00
116_I120_G0.5431.00
135_A151_S0.5431.00
100_E188_A0.5411.00
115_S118_A0.5411.00
82_V85_L0.5361.00
156_E160_E0.5341.00
145_H148_N0.5331.00
141_E144_K0.5301.00
87_E203_L0.5301.00
106_I110_L0.5291.00
77_K81_E0.5261.00
91_A134_L0.5231.00
171_T174_Q0.5211.00
21_E24_Q0.5191.00
123_G173_V0.5161.00
17_Q27_R0.5151.00
178_E181_E0.5131.00
89_G143_L0.5081.00
75_D78_Q0.5081.00
121_E159_R0.5071.00
179_E201_A0.5071.00
93_L138_S0.5041.00
75_D153_L0.5031.00
201_A204_T0.5021.00
81_E85_L0.5021.00
175_R178_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p96A 2 0.9772 100 0.146 Contact Map
3c7jA 4 0.8995 100 0.148 Contact Map
2di3A 2 0.9726 100 0.149 Contact Map
3sxyA 2 0.8676 100 0.164 Contact Map
3ihuA 1 0.8676 100 0.167 Contact Map
4p9fA 1 0.895 100 0.171 Contact Map
2hs5A 1 0.8767 100 0.172 Contact Map
1hw1A 2 0.9498 100 0.192 Contact Map
3ic7A 2 0.4521 99.8 0.544 Contact Map
3by6A 2 0.4658 99.8 0.547 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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