GREMLIN Database
PADC - Phenolic acid decarboxylase PadC
UniProt: O07006 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (142)
Sequences: 184 (69)
Seq/√Len: 5.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_I29_I5.1480.99
7_S135_N4.8040.98
14_E129_E4.4670.96
49_N125_P3.2650.83
29_I48_V2.4580.61
94_H97_I2.3930.58
21_I70_V2.0960.48
75_M125_P2.0940.48
12_T15_N2.0230.46
9_M21_I2.0110.45
70_V85_I1.8650.40
122_Y135_N1.8280.39
89_K93_E1.8200.39
44_R101_Y1.7840.37
115_K119_Y1.7780.37
106_I110_K1.7610.37
79_K106_I1.7440.36
33_I99_V1.7050.35
45_D123_V1.6910.34
106_I131_T1.6890.34
81_M128_A1.6250.32
10_I79_K1.6220.32
12_T131_T1.5800.31
26_D107_D1.5770.31
39_A104_D1.5670.31
61_S73_N1.5220.29
10_I14_E1.5090.29
29_I141_E1.5080.29
118_T121_K1.4980.29
23_I60_V1.4850.28
55_E107_D1.4830.28
7_S133_L1.4640.28
48_V140_N1.4420.27
89_K115_K1.4300.27
70_V83_G1.4280.27
26_D77_N1.4200.26
114_E117_E1.4180.26
22_Y113_R1.3820.25
53_L124_V1.3810.25
122_Y125_P1.3810.25
112_S116_Y1.3800.25
47_E96_E1.3740.25
110_K139_D1.3630.25
18_E72_L1.3620.25
57_V123_V1.3290.24
97_I116_Y1.3210.24
83_G127_F1.3070.24
63_T69_D1.3020.23
56_G74_F1.2870.23
100_C105_H1.2560.22
12_T16_G1.2480.22
33_I98_T1.2110.21
53_L72_L1.1880.21
25_N80_R1.1770.20
137_G144_I1.1550.20
10_I133_L1.1540.20
57_V71_S1.1440.20
95_P107_D1.1430.20
6_G32_R1.1260.19
23_I35_S1.1230.19
75_M136_E1.1170.19
44_R141_E1.1060.19
54_T75_M1.0920.19
99_V105_H1.0830.18
21_I72_L1.0750.18
96_E125_P1.0740.18
110_K145_S1.0550.18
65_P109_M1.0440.18
84_I98_T1.0430.18
97_I112_S1.0400.17
33_I72_L1.0240.17
3_N74_F1.0230.17
60_V70_V1.0090.17
118_T124_V0.9910.17
53_L73_N0.9870.16
3_N80_R0.9830.16
7_S25_N0.9820.16
75_M124_V0.9750.16
107_D145_S0.9730.16
71_S100_C0.9690.16
115_K125_P0.9680.16
9_M74_F0.9640.16
9_M79_K0.9490.16
9_M81_M0.9440.16
63_T122_Y0.9300.15
93_E128_A0.9190.15
20_E67_G0.9180.15
48_V121_K0.9050.15
29_I44_R0.9020.15
70_V133_L0.8960.15
15_N126_E0.8950.15
65_P102_Q0.8710.14
35_S100_C0.8540.14
19_Y33_I0.8530.14
54_T91_V0.8450.14
50_I144_I0.8440.14
102_Q109_M0.8410.14
79_K133_L0.8410.14
48_V60_V0.8340.14
8_H136_E0.8320.14
24_K122_Y0.8310.14
4_F9_M0.8290.14
80_R110_K0.8270.14
37_M112_S0.7900.13
140_N143_V0.7820.13
4_F111_E0.7820.13
93_E129_E0.7800.13
91_V98_T0.7790.13
9_M130_I0.7790.13
95_P140_N0.7740.13
27_H129_E0.7720.13
22_Y82_H0.7700.13
132_F140_N0.7680.13
89_K120_P0.7670.13
8_H121_K0.7570.12
3_N56_G0.7540.12
137_G140_N0.7530.12
40_G81_M0.7500.12
42_W70_V0.7460.12
26_D80_R0.7420.12
69_D121_K0.7400.12
91_V97_I0.7380.12
73_N124_V0.7340.12
63_T114_E0.7340.12
56_G93_E0.7300.12
35_S105_H0.7140.12
97_I117_E0.7100.12
75_M97_I0.7070.12
11_Y40_G0.7070.12
63_T121_K0.7070.12
20_E34_H0.7030.12
93_E107_D0.7020.12
89_K114_E0.6980.12
38_V65_P0.6970.12
53_L78_E0.6960.12
40_G92_H0.6930.12
9_M56_G0.6920.12
38_V109_M0.6690.11
46_Q66_T0.6610.11
49_N70_V0.6580.11
44_R133_L0.6560.11
15_N104_D0.6560.11
20_E116_Y0.6510.11
7_S77_N0.6470.11
72_L81_M0.6460.11
70_V119_Y0.6390.11
92_H110_K0.6310.11
31_Y36_G0.6250.11
107_D111_E0.6240.11
56_G108_L0.6210.11
49_N56_G0.6190.11
92_H100_C0.6180.11
44_R58_Y0.6180.11
114_E119_Y0.6180.11
54_T145_S0.6140.10
101_Y108_L0.6130.10
8_H11_Y0.6100.10
18_E118_T0.6080.10
8_H132_F0.6070.10
96_E129_E0.6060.10
7_S61_S0.6020.10
33_I74_F0.5990.10
132_F136_E0.5950.10
94_H115_K0.5910.10
15_N101_Y0.5860.10
52_K142_E0.5840.10
60_V93_E0.5830.10
49_N55_E0.5820.10
7_S106_I0.5820.10
30_D42_W0.5790.10
76_P130_I0.5770.10
28_T72_L0.5770.10
6_G117_E0.5760.10
38_V99_V0.5760.10
105_H108_L0.5750.10
4_F108_L0.5740.10
50_I63_T0.5730.10
104_D144_I0.5690.10
60_V142_E0.5680.10
4_F49_N0.5640.10
32_R103_N0.5620.10
4_F106_I0.5590.10
95_P117_E0.5580.10
42_W83_G0.5580.10
47_E136_E0.5570.10
3_N53_L0.5570.10
94_H137_G0.5560.10
7_S52_K0.5560.10
45_D135_N0.5550.10
29_I142_E0.5510.10
116_Y125_P0.5510.10
78_E110_K0.5510.10
66_T87_F0.5470.10
24_K42_W0.5400.10
5_I97_I0.5390.10
6_G22_Y0.5380.10
6_G126_E0.5370.09
26_D120_P0.5340.09
86_F126_E0.5320.09
120_P131_T0.5310.09
8_H33_I0.5280.09
19_Y34_H0.5250.09
59_K127_F0.5250.09
25_N122_Y0.5250.09
60_V140_N0.5230.09
53_L118_T0.5200.09
9_M125_P0.5160.09
10_I57_V0.5150.09
56_G77_N0.5140.09
29_I68_T0.5140.09
39_A84_I0.5100.09
102_Q143_V0.5080.09
84_I123_V0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uu3A 2 0.9938 100 0.146 Contact Map
2w2aA 2 1 100 0.192 Contact Map
2p8gA 2 1 100 0.198 Contact Map
4q51A 2 0.8137 97.4 0.906 Contact Map
1ckmA 3 0.6708 33.6 0.96 Contact Map
3rtxA 2 0.3478 23.1 0.963 Contact Map
4k0mC 1 0.5155 6.4 0.971 Contact Map
3q12A 2 0.4969 5.8 0.972 Contact Map
1vw4P 1 0.0497 5.2 0.972 Contact Map
2kxtA 1 0.5963 5.2 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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