GREMLIN Database
LEVB - Levanbiose-producing levanase
UniProt: O07003 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 516 (442)
Sequences: 3150 (2391)
Seq/√Len: 113.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_N214_D5.4101.00
91_V101_E4.6731.00
308_K359_A4.4691.00
403_G495_Y3.9611.00
94_D97_H3.8301.00
68_K91_V3.8241.00
208_E218_T3.8231.00
337_V462_L3.7571.00
389_Q460_K3.6571.00
235_Y309_R3.4931.00
364_T389_Q3.4181.00
193_K208_E3.3791.00
92_S95_L3.2091.00
388_Y463_V3.0311.00
308_K340_E3.0051.00
68_K93_E2.9871.00
458_H474_D2.9721.00
238_R244_N2.9161.00
299_D306_L2.8431.00
315_M467_T2.8421.00
393_D458_H2.7671.00
233_D296_T2.7601.00
141_Q152_Y2.7511.00
358_E361_E2.6921.00
121_V194_W2.6481.00
49_F90_A2.6271.00
51_T56_K2.5721.00
188_D191_D2.5471.00
70_H89_H2.4611.00
296_T309_R2.3631.00
208_E216_H2.3561.00
45_A50_T2.3281.00
267_T343_L2.3211.00
47_Y462_L2.3211.00
236_M244_N2.3061.00
389_Q462_L2.2861.00
461_I470_V2.2491.00
92_S98_W2.1991.00
184_K233_D2.1831.00
71_Y335_D2.1781.00
419_G428_Y2.1661.00
122_V125_E2.1441.00
310_Y357_I2.1431.00
62_P297_F2.1201.00
73_Y100_D2.0981.00
76_N84_G2.0841.00
337_V360_L2.0371.00
138_I196_M2.0301.00
391_D458_H2.0011.00
236_M246_W1.9991.00
138_I153_L1.9891.00
63_I122_V1.9671.00
310_Y338_I1.9511.00
421_F424_G1.9451.00
250_A266_W1.9241.00
49_F71_Y1.9151.00
342_R355_Q1.8931.00
344_K353_V1.8751.00
123_D194_W1.8701.00
391_D460_K1.8581.00
138_I212_L1.8501.00
91_V99_T1.8491.00
405_R415_H1.8051.00
55_W82_G1.8031.00
415_H433_A1.8001.00
264_A282_A1.7831.00
68_K101_E1.7751.00
473_G476_K1.7741.00
414_R486_K1.7601.00
136_V153_L1.7591.00
367_T507_T1.7521.00
45_A334_T1.7411.00
82_G85_T1.7181.00
44_R50_T1.7151.00
156_S160_G1.7121.00
351_S476_K1.7031.00
294_G311_A1.6901.00
193_K210_D1.6881.00
154_W165_F1.6861.00
315_M480_S1.6861.00
466_T482_E1.6831.00
340_E358_E1.6831.00
315_M336_S1.6731.00
93_E99_T1.6701.00
340_E355_Q1.6381.00
245_K267_T1.6301.00
107_K165_F1.6241.00
306_L358_E1.6171.00
245_K269_S1.6101.00
463_V468_I1.6061.00
166_Y169_N1.5991.00
342_R353_V1.5921.00
142_P149_Q1.5881.00
364_T460_K1.5851.00
407_R483_V1.5831.00
60_Q117_T1.5631.00
356_P471_F1.5621.00
247_V343_L1.5601.00
172_M196_M1.5591.00
427_A472_V1.5281.00
345_E348_G1.5231.00
395_S456_K1.4991.00
203_K220_G1.4911.00
52_P100_D1.4891.00
62_P71_Y1.4771.00
180_F198_M1.4721.00
247_V267_T1.4631.00
233_D309_R1.4571.00
405_R417_D1.4551.00
156_S163_F1.4511.00
185_V196_M1.4291.00
64_Y300_S1.4231.00
355_Q474_D1.4131.00
401_N421_F1.4041.00
300_S306_L1.4011.00
76_N79_Y1.3981.00
190_Q236_M1.3911.00
418_V427_A1.3821.00
416_I434_T1.3781.00
296_T311_A1.3731.00
155_Y166_Y1.3641.00
418_V429_V1.3561.00
68_K161_K1.3511.00
414_R489_D1.3101.00
405_R493_T1.2970.99
101_E161_K1.2960.99
429_V481_N1.2900.99
58_D231_C1.2870.99
204_I229_V1.2790.99
55_W85_T1.2780.99
393_D456_K1.2780.99
166_Y170_P1.2710.99
361_E460_K1.2660.99
134_A157_T1.2650.99
292_Y314_W1.2510.99
134_A155_Y1.2490.99
95_L98_W1.2410.99
235_Y296_T1.2390.99
237_M309_R1.2390.99
271_D274_E1.2210.99
122_V135_L1.2160.99
209_S215_W1.2140.99
291_W313_A1.1990.99
299_D308_K1.1980.99
401_N497_D1.1960.99
334_T480_S1.1900.99
63_I135_L1.1900.99
204_I248_L1.1870.99
217_Y220_G1.1860.99
46_A387_T1.1770.99
72_F104_A1.1750.99
158_D162_S1.1750.99
226_A229_V1.1700.99
283_Q351_S1.1700.99
210_D216_H1.1690.99
364_T462_L1.1650.99
408_E493_T1.1640.99
97_H363_L1.1640.99
209_S212_L1.1620.99
503_F506_I1.1440.99
287_Y477_T1.1440.99
123_D136_V1.1300.99
184_K296_T1.1270.99
364_T391_D1.1260.99
245_K278_D1.1230.99
65_F122_V1.0960.98
110_N170_P1.0940.98
55_W75_Y1.0930.98
46_A465_K1.0790.98
190_Q272_G1.0740.98
340_E359_A1.0730.98
291_W311_A1.0700.98
251_S263_Y1.0690.98
496_S501_A1.0560.98
61_K74_L1.0510.98
72_F137_A1.0470.98
123_D212_L1.0460.98
467_T471_F1.0440.98
429_V479_F1.0440.98
287_Y479_F1.0430.98
73_Y88_R1.0360.97
245_K343_L1.0340.97
58_D314_W1.0300.97
386_D465_K1.0200.97
49_F100_D1.0180.97
392_T459_L1.0160.97
205_G217_Y1.0150.97
402_A501_A1.0150.97
360_L462_L1.0140.97
246_W269_S1.0140.97
62_P312_L1.0130.97
198_M207_Y1.0100.97
64_Y69_Y1.0100.97
56_K335_D1.0080.97
138_I185_V1.0050.97
263_Y294_G1.0010.97
416_I468_I0.9980.97
391_D507_T0.9940.97
158_D163_F0.9930.97
315_M334_T0.9920.97
399_L499_G0.9920.97
186_I206_F0.9870.97
139_V165_F0.9830.97
246_W270_F0.9820.97
111_P114_D0.9800.96
387_T465_K0.9790.96
41_P329_N0.9750.96
152_Y169_N0.9740.96
334_T467_T0.9700.96
310_Y359_A0.9680.96
395_S502_S0.9640.96
105_I115_I0.9630.96
160_G163_F0.9600.96
234_L246_W0.9600.96
136_V194_W0.9560.96
187_W192_N0.9550.96
88_R100_D0.9530.96
122_V136_V0.9530.96
468_I481_N0.9530.96
286_D339_R0.9520.96
313_A339_R0.9500.96
85_T116_W0.9450.96
275_F279_Q0.9440.96
43_Y485_P0.9420.96
58_D292_Y0.9370.95
393_D505_N0.9360.95
300_S307_E0.9320.95
181_R230_E0.9310.95
152_Y170_P0.9300.95
426_Y447_K0.9240.95
121_V212_L0.9210.95
298_E309_R0.9200.95
249_G285_L0.9190.95
120_V137_A0.9190.95
407_R463_V0.9140.95
90_A100_D0.9130.95
111_P165_F0.9100.95
188_D195_V0.9090.95
138_I171_V0.9050.95
409_S414_R0.9050.95
344_K476_K0.9040.94
313_A478_V0.9040.94
62_P295_V0.8950.94
317_N320_Y0.8940.94
361_E364_T0.8930.94
339_R354_S0.8920.94
65_F135_L0.8900.94
269_S278_D0.8890.94
392_T404_V0.8860.94
467_T480_S0.8860.94
195_V206_F0.8820.94
290_D318_W0.8810.94
50_T334_T0.8800.94
260_P317_N0.8800.94
403_G419_G0.8770.94
340_E357_I0.8740.93
416_I483_V0.8730.93
184_K295_V0.8720.93
257_W262_T0.8720.93
139_V154_W0.8700.93
57_N74_L0.8690.93
237_M343_L0.8690.93
192_N210_D0.8680.93
76_N86_E0.8650.93
136_V212_L0.8640.93
88_R102_G0.8610.93
390_L461_I0.8600.93
459_L472_V0.8590.93
227_G254_G0.8570.93
116_W142_P0.8570.93
76_N83_N0.8570.93
86_E106_P0.8560.93
299_D310_Y0.8550.93
166_Y213_K0.8520.93
64_Y68_K0.8480.92
104_A163_F0.8470.92
58_D293_G0.8460.92
265_Y343_L0.8440.92
86_E103_V0.8370.92
299_D358_E0.8360.92
406_L418_V0.8350.92
156_S162_S0.8350.92
76_N82_G0.8330.92
188_D236_M0.8330.92
291_W336_S0.8310.92
231_C314_W0.8300.92
416_I489_D0.8300.92
402_A420_I0.8250.91
427_A459_L0.8250.91
361_E389_Q0.8250.91
235_Y249_G0.8240.91
60_Q231_C0.8230.91
76_N85_T0.8230.91
42_D329_N0.8230.91
386_D407_R0.8220.91
89_H98_W0.8210.91
102_G161_K0.8200.91
115_I165_F0.8190.91
255_K259_K0.8190.91
377_G381_L0.8180.91
298_E307_E0.8170.91
106_P114_D0.8140.91
111_P141_Q0.8120.91
60_Q295_V0.8100.91
77_R86_E0.8090.91
354_S478_V0.8080.90
188_D192_N0.8080.90
179_D228_M0.8070.90
117_T231_C0.8060.90
418_V470_V0.8050.90
43_Y466_T0.8020.90
249_G263_Y0.8020.90
313_A336_S0.8000.90
468_I483_V0.7990.90
443_Y446_S0.7970.90
287_Y449_P0.7940.90
58_D182_D0.7920.90
153_L171_V0.7880.89
293_G314_W0.7880.89
71_Y98_W0.7870.89
125_E134_A0.7870.89
420_I459_L0.7870.89
155_Y213_K0.7840.89
179_D253_N0.7830.89
430_N434_T0.7790.89
194_W209_S0.7750.89
361_E462_L0.7730.88
233_D295_V0.7720.88
39_Q46_A0.7700.88
356_P360_L0.7700.88
82_G116_W0.7670.88
186_I192_N0.7670.88
230_E314_W0.7630.88
199_A204_I0.7620.88
261_N316_N0.7600.88
209_S213_K0.7600.88
97_H362_Q0.7600.88
266_W277_A0.7570.87
79_Y82_G0.7550.87
376_N500_T0.7550.87
108_Y111_P0.7540.87
107_K111_P0.7530.87
448_A477_T0.7500.87
151_Q154_W0.7500.87
72_F89_H0.7500.87
326_T484_F0.7490.87
401_N419_G0.7480.87
369_E507_T0.7450.87
262_T284_W0.7450.87
110_N152_Y0.7450.87
314_W333_G0.7410.86
256_P262_T0.7390.86
341_L354_S0.7380.86
291_W294_G0.7310.85
472_V479_F0.7300.85
427_A470_V0.7290.85
374_D500_T0.7280.85
234_L270_F0.7280.85
289_F481_N0.7270.85
277_A280_T0.7260.85
72_F163_F0.7250.85
45_A467_T0.7230.85
360_L460_K0.7230.85
259_K262_T0.7220.85
253_N319_D0.7200.85
72_F135_L0.7200.85
144_A147_K0.7190.85
235_Y247_V0.7180.84
255_K258_G0.7160.84
74_L117_T0.7150.84
344_K351_S0.7140.84
220_G223_P0.7140.84
72_F161_K0.7130.84
74_L88_R0.7100.84
308_K357_I0.7080.84
187_W209_S0.7080.84
231_C292_Y0.7080.84
231_C293_G0.7070.84
71_Y312_L0.7050.83
219_S275_F0.7050.83
105_I137_A0.7050.83
74_L87_W0.7040.83
56_K333_G0.7020.83
96_V363_L0.7000.83
70_H98_W0.6980.83
230_E292_Y0.6970.83
136_V155_Y0.6960.83
135_L160_G0.6960.83
65_F68_K0.6950.83
445_E448_A0.6930.82
344_K355_Q0.6930.82
464_D469_E0.6870.82
209_S265_Y0.6870.82
151_Q172_M0.6860.82
158_D161_K0.6850.82
141_Q150_E0.6810.81
374_D502_S0.6800.81
409_S413_K0.6800.81
57_N314_W0.6800.81
262_T282_A0.6800.81
156_S161_K0.6780.81
270_F275_F0.6770.81
137_A163_F0.6770.81
228_M253_N0.6760.81
297_F312_L0.6750.81
78_D86_E0.6730.80
68_K99_T0.6710.80
439_K443_Y0.6700.80
353_V476_K0.6700.80
155_Y164_K0.6690.80
206_F248_L0.6680.80
197_V204_I0.6680.80
151_Q165_F0.6660.80
75_Y103_V0.6650.80
36_K39_Q0.6630.79
253_N261_N0.6630.79
420_I457_V0.6610.79
135_L156_S0.6610.79
409_S489_D0.6590.79
147_K151_Q0.6570.79
187_W272_G0.6560.79
401_N495_Y0.6560.79
123_D134_A0.6550.79
221_F234_L0.6550.79
255_K426_Y0.6530.78
272_G275_F0.6530.78
91_V161_K0.6500.78
214_D217_Y0.6490.78
448_A451_D0.6480.78
271_D276_K0.6470.78
315_M471_F0.6450.78
98_W104_A0.6450.78
356_P462_L0.6440.77
62_P73_Y0.6430.77
72_F101_E0.6430.77
47_Y387_T0.6430.77
69_Y95_L0.6420.77
186_I234_L0.6400.77
147_K150_E0.6380.77
261_N317_N0.6370.77
461_I468_I0.6360.77
157_T162_S0.6360.77
191_D195_V0.6360.77
231_C251_S0.6360.77
294_G313_A0.6360.77
47_Y356_P0.6350.76
229_V331_F0.6350.76
57_N60_Q0.6340.76
235_Y341_L0.6340.76
57_N85_T0.6340.76
377_G380_T0.6330.76
470_V479_F0.6330.76
312_L335_D0.6320.76
57_N116_W0.6320.76
446_S450_Y0.6300.76
154_W170_P0.6290.76
420_I427_A0.6290.76
285_L311_A0.6290.76
207_Y217_Y0.6290.76
407_R416_I0.6280.76
311_A341_L0.6280.76
147_K152_Y0.6280.76
320_Y332_N0.6270.76
268_G277_A0.6270.76
123_D155_Y0.6270.76
394_L402_A0.6260.75
47_Y471_F0.6240.75
311_A336_S0.6240.75
291_W296_T0.6230.75
418_V472_V0.6210.75
149_Q318_W0.6210.75
421_F425_G0.6200.75
48_H469_E0.6200.75
50_T331_F0.6190.75
38_K50_T0.6180.75
182_D231_C0.6160.74
310_Y340_E0.6150.74
385_G490_K0.6120.74
85_T333_G0.6110.74
78_D84_G0.6100.74
456_K502_S0.6100.74
141_Q165_F0.6090.73
290_D431_R0.6070.73
60_Q314_W0.6070.73
119_S185_V0.6060.73
149_Q156_S0.6060.73
251_S262_T0.6060.73
231_C295_V0.6060.73
406_L463_V0.6060.73
157_T164_K0.6040.73
143_S150_E0.6040.73
202_S228_M0.6030.73
473_G477_T0.6030.73
72_F91_V0.6030.73
400_K423_E0.5990.72
388_Y406_L0.5990.72
463_V483_V0.5980.72
75_Y85_T0.5980.72
150_E173_P0.5980.72
100_D103_V0.5980.72
334_T482_E0.5970.72
195_V218_T0.5960.72
58_D181_R0.5960.72
101_E104_A0.5950.72
332_N482_E0.5940.72
95_L297_F0.5940.72
124_K134_A0.5940.72
60_Q74_L0.5930.72
121_V136_V0.5920.71
452_V457_V0.5920.71
140_T181_R0.5910.71
134_A213_K0.5880.71
385_G388_Y0.5870.71
483_V489_D0.5870.71
137_A156_S0.5860.71
153_L166_Y0.5860.71
432_A438_D0.5860.71
405_R408_E0.5820.70
70_H91_V0.5800.70
114_D142_P0.5790.70
46_A50_T0.5790.70
356_P460_K0.5790.70
185_V209_S0.5780.70
116_W261_N0.5780.70
185_V194_W0.5770.69
289_F319_D0.5770.69
140_T232_P0.5770.69
176_G220_G0.5770.69
199_A227_G0.5760.69
200_E205_G0.5760.69
185_V215_W0.5740.69
257_W260_P0.5740.69
188_D193_K0.5740.69
380_T383_I0.5730.69
142_P147_K0.5720.69
148_K178_D0.5710.69
448_A452_V0.5710.69
260_P266_W0.5700.69
63_I120_V0.5680.68
493_T496_S0.5680.68
142_P316_N0.5670.68
430_N433_A0.5670.68
89_H104_A0.5670.68
414_R435_N0.5670.68
119_S197_V0.5650.68
234_L248_L0.5650.68
402_A495_Y0.5650.68
69_Y299_D0.5650.68
123_D187_W0.5640.68
237_M244_N0.5630.68
179_D227_G0.5630.68
116_W227_G0.5620.67
446_S452_V0.5620.67
117_T251_S0.5620.67
180_F333_G0.5610.67
184_K235_Y0.5610.67
148_K173_P0.5610.67
69_Y310_Y0.5590.67
74_L85_T0.5580.67
181_R292_Y0.5570.67
80_P84_G0.5560.67
74_L77_R0.5540.66
143_S148_K0.5530.66
286_D313_A0.5530.66
394_L495_Y0.5520.66
406_L416_I0.5520.66
187_W190_Q0.5490.66
49_F88_R0.5490.66
496_S499_G0.5480.66
69_Y297_F0.5480.66
58_D230_E0.5460.65
438_D441_N0.5460.65
135_L163_F0.5460.65
60_Q293_G0.5440.65
199_A482_E0.5440.65
466_T484_F0.5430.65
227_G253_N0.5420.65
417_D433_A0.5420.65
60_Q116_W0.5420.65
356_P389_Q0.5410.65
57_N76_N0.5410.65
234_L320_Y0.5400.64
210_D400_K0.5400.64
254_G261_N0.5400.64
122_V134_A0.5390.64
193_K218_T0.5390.64
115_I139_V0.5380.64
273_K277_A0.5370.64
45_A465_K0.5360.64
237_M342_R0.5360.64
71_Y297_F0.5340.64
267_T278_D0.5340.64
116_W151_Q0.5330.63
41_P45_A0.5330.63
78_D85_T0.5310.63
193_K216_H0.5300.63
286_D291_W0.5300.63
440_S443_Y0.5290.63
403_G409_S0.5290.63
259_K264_A0.5290.63
252_A261_N0.5280.63
79_Y84_G0.5270.63
142_P227_G0.5270.63
294_G333_G0.5260.62
373_Q503_F0.5260.62
55_W149_Q0.5260.62
57_N231_C0.5250.62
401_N499_G0.5250.62
419_G430_N0.5240.62
453_N456_K0.5240.62
374_D377_G0.5240.62
389_Q392_T0.5230.62
375_V378_S0.5230.62
226_A254_G0.5220.62
285_L352_L0.5220.62
83_N86_E0.5210.62
261_N284_W0.5210.62
420_I425_G0.5210.62
259_K284_W0.5210.62
57_N77_R0.5200.62
257_W284_W0.5200.62
237_M341_L0.5200.62
375_V381_L0.5200.62
79_Y86_E0.5200.62
63_I68_K0.5180.61
289_F440_S0.5160.61
149_Q180_F0.5150.61
387_T396_W0.5150.61
77_R82_G0.5140.61
306_L359_A0.5130.60
124_K299_D0.5130.60
397_S500_T0.5130.60
45_A331_F0.5130.60
41_P330_G0.5120.60
378_S404_V0.5120.60
187_W194_W0.5110.60
55_W88_R0.5110.60
498_G501_A0.5100.60
74_L82_G0.5090.60
75_Y82_G0.5080.60
195_V208_E0.5060.59
434_T489_D0.5060.59
324_T327_M0.5060.59
95_L312_L0.5050.59
466_T485_P0.5050.59
444_V448_A0.5050.59
466_T483_V0.5040.59
77_R106_P0.5040.59
115_I141_Q0.5030.59
403_G408_E0.5030.59
405_R495_Y0.5030.59
197_V482_E0.5020.59
56_K73_Y0.5020.59
449_P452_V0.5020.59
408_E489_D0.5020.59
116_W147_K0.5020.59
247_V265_Y0.5020.59
73_Y90_A0.5010.59
42_D487_P0.5010.59
380_T405_R0.5010.59
143_S313_A0.5010.59
57_N87_W0.5000.59
55_W332_N0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y4wA 1 0.9167 100 0.198 Contact Map
3sc7X 1 0.9031 100 0.225 Contact Map
4ffhA 1 0.8876 100 0.227 Contact Map
3kf3A 2 0.905 100 0.232 Contact Map
3pijA 2 0.9438 100 0.234 Contact Map
4eqvA 3 0.9012 100 0.238 Contact Map
2ac1A 1 0.8798 100 0.254 Contact Map
1st8A 1 0.8818 100 0.257 Contact Map
3ligA 2 0.9264 100 0.264 Contact Map
3ugfA 2 0.8992 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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