GREMLIN Database
ASPP - Aspartate-proton symporter
UniProt: O07002 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 520 (423)
Sequences: 24150 (15541)
Seq/√Len: 755.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_F348_F4.3621.00
329_I342_A4.3481.00
52_G244_T3.3591.00
377_A410_F3.2361.00
332_K342_A3.0511.00
230_R234_I3.0071.00
12_S226_Q2.9991.00
334_N337_T2.8551.00
385_A389_N2.8301.00
76_I323_N2.7801.00
225_V231_N2.7091.00
92_S320_W2.6771.00
227_N230_R2.6661.00
177_L253_T2.6181.00
321_A331_S2.5481.00
138_F352_I2.5261.00
334_N341_R2.5141.00
17_I238_I2.4781.00
289_W293_L2.4771.00
329_I332_K2.4491.00
223_G322_R2.4361.00
175_I179_F2.4351.00
13_L238_I2.3921.00
64_E387_R2.3921.00
80_V88_G2.2481.00
345_W349_A2.2111.00
380_P409_S2.1861.00
145_F344_L2.1391.00
318_Y322_R2.1321.00
146_L150_W2.1251.00
16_L225_V2.1221.00
224_E315_R2.1081.00
13_L17_I2.0891.00
142_C352_I2.0851.00
407_P411_I2.0621.00
13_L231_N2.0571.00
153_K157_K2.0491.00
149_Y341_R2.0301.00
53_A57_L2.0141.00
324_G328_G1.9601.00
83_H385_A1.9591.00
138_F355_T1.9561.00
80_V85_H1.9411.00
431_S435_M1.9261.00
96_I347_S1.9211.00
61_V380_P1.9191.00
137_Q355_T1.9081.00
12_S15_D1.9041.00
234_I238_I1.8891.00
330_F346_L1.8781.00
444_K447_P1.8751.00
164_I168_I1.8701.00
437_L441_C1.8561.00
237_I241_I1.8101.00
83_H381_I1.8031.00
7_F333_V1.7991.00
429_L433_L1.7771.00
404_I408_L1.7701.00
280_D283_V1.7591.00
91_I378_I1.7221.00
259_P262_T1.7221.00
79_P91_I1.7111.00
148_N307_N1.7071.00
262_T284_M1.7051.00
227_N231_N1.6831.00
15_D160_F1.6821.00
381_I410_F1.6761.00
440_L444_K1.6741.00
107_V306_G1.6691.00
142_C348_F1.6691.00
20_G239_C1.6421.00
149_Y345_W1.6391.00
168_I172_T1.6361.00
54_I412_F1.6251.00
411_I415_F1.6211.00
17_I242_V1.6131.00
182_Q185_N1.5761.00
84_G87_V1.5621.00
337_T341_R1.5601.00
150_W337_T1.5561.00
114_V136_L1.5521.00
103_I351_S1.5421.00
385_A388_V1.5271.00
11_M15_D1.5271.00
57_L408_L1.5121.00
141_L351_S1.5071.00
441_C445_Y1.5011.00
241_I245_I1.4971.00
93_F435_M1.4911.00
167_Y171_I1.4911.00
47_S202_A1.4831.00
342_A346_L1.4741.00
221_V311_N1.4691.00
334_N339_T1.4691.00
53_A408_L1.4641.00
8_Q338_G1.4631.00
169_V297_D1.4541.00
107_V141_L1.4491.00
328_G332_K1.4461.00
51_G208_V1.4461.00
110_V140_L1.4371.00
178_I253_T1.4341.00
317_V343_S1.4281.00
43_S192_A1.4171.00
313_T347_S1.4121.00
227_N234_I1.4101.00
328_G331_S1.4101.00
138_F142_C1.4051.00
283_V291_A1.4051.00
79_P378_I1.4041.00
72_T223_G1.3991.00
59_G240_I1.3981.00
443_S447_P1.3931.00
15_D156_A1.3901.00
318_Y333_V1.3811.00
141_L348_F1.3781.00
145_F345_W1.3741.00
292_T296_L1.3671.00
36_V44_G1.3651.00
190_G193_P1.3621.00
389_N392_D1.3591.00
381_I385_A1.3581.00
435_M438_I1.3511.00
69_L81_Y1.3351.00
245_I249_V1.3121.00
110_V299_I1.3121.00
430_G434_V1.3071.00
314_S344_L1.2981.00
61_V406_G1.2941.00
280_D284_M1.2881.00
332_K341_R1.2871.00
174_I249_V1.2861.00
83_H87_V1.2831.00
228_P233_P1.2811.00
7_F318_Y1.2811.00
106_E305_N1.2751.00
11_M156_A1.2701.00
401_G405_I1.2671.00
13_L234_I1.2661.00
24_I243_S1.2661.00
60_L237_I1.2631.00
427_W430_G1.2621.00
384_A407_P1.2611.00
181_F185_N1.2521.00
390_A393_L1.2521.00
231_N234_I1.2511.00
59_G236_L1.2471.00
188_V191_F1.2471.00
317_V326_L1.2341.00
184_E187_S1.2331.00
31_F109_A1.2321.00
58_I380_P1.2311.00
144_F306_G1.2281.00
173_I177_L1.2211.00
77_R81_Y1.2201.00
391_K395_R1.2191.00
82_S382_S1.2071.00
426_S429_L1.2061.00
11_M16_L1.2031.00
438_I441_C1.2031.00
391_K394_N1.1971.00
276_L280_D1.1901.00
132_S135_I1.1891.00
421_G425_V1.1881.00
430_G433_L1.1841.00
377_A414_A1.1761.00
147_L158_A1.1731.00
198_G202_A1.1721.00
14_F18_L1.1701.00
181_F256_G1.1661.00
410_F414_A1.1611.00
45_A252_V1.1541.00
438_I442_F1.1491.00
342_A345_W1.1421.00
404_I407_P1.1411.00
441_C444_K1.1391.00
16_L235_A1.1321.00
177_L257_A1.1281.00
198_G201_A1.1271.00
68_A395_R1.1211.00
415_F419_W1.1211.00
172_T176_V1.1161.00
19_I221_V1.1161.00
37_A44_G1.1141.00
96_I317_V1.1111.00
134_W138_F1.1111.00
433_L437_L1.1101.00
402_M406_G1.1071.00
226_Q231_N1.1011.00
76_I319_A1.0991.00
181_F184_E1.0981.00
431_S438_I1.0961.00
392_D395_R1.0911.00
122_T132_S1.0871.00
260_T263_L1.0861.00
436_F440_L1.0841.00
199_I202_A1.0791.00
158_A162_I1.0791.00
71_R77_R1.0781.00
79_P87_V1.0771.00
135_I139_A1.0731.00
421_G424_T1.0731.00
403_S407_P1.0711.00
390_A395_R1.0691.00
21_M243_S1.0671.00
428_L432_Q1.0631.00
21_M242_V1.0611.00
199_I204_S1.0581.00
349_A353_F1.0571.00
20_G218_I1.0561.00
389_N393_L1.0511.00
139_A143_L1.0511.00
322_R331_S1.0471.00
171_I175_I1.0471.00
10_S226_Q1.0441.00
111_R136_L1.0421.00
62_Y75_I1.0411.00
159_N307_N1.0401.00
442_F446_T1.0381.00
188_V192_A1.0301.00
49_I248_T1.0301.00
428_L431_S1.0301.00
383_S406_G1.0291.00
43_S191_F1.0291.00
333_V338_G1.0281.00
195_G198_G1.0251.00
439_Y442_F1.0231.00
66_G78_Y1.0211.00
89_Y93_F1.0191.00
86_L442_F1.0181.00
283_V288_G1.0161.00
43_S199_I1.0141.00
157_K161_I1.0121.00
145_F149_Y1.0091.00
188_V193_P1.0071.00
213_L372_L0.9901.00
426_S430_G0.9891.00
152_V311_N0.9891.00
426_S439_Y0.9881.00
105_I365_V0.9841.00
286_G290_L0.9751.00
173_I282_A0.9701.00
162_I304_G0.9701.00
377_A413_T0.9701.00
388_V403_S0.9701.00
414_A418_Y0.9691.00
52_G212_Y0.9621.00
183_P187_S0.9561.00
142_C146_L0.9541.00
377_A381_I0.9511.00
40_A43_S0.9501.00
114_V299_I0.9491.00
401_G404_I0.9491.00
81_Y390_A0.9451.00
429_L435_M0.9451.00
189_Q192_A0.9451.00
149_Y339_T0.9391.00
174_I178_I0.9371.00
332_K335_K0.9351.00
180_H183_P0.9351.00
68_A393_L0.9341.00
196_F199_I0.9321.00
238_I242_V0.9291.00
143_L303_G0.9281.00
71_R81_Y0.9261.00
111_R137_Q0.9251.00
259_P284_M0.9241.00
244_T248_T0.9171.00
287_L290_L0.9161.00
435_M439_Y0.9161.00
201_A204_S0.9161.00
434_V438_I0.9111.00
73_G77_R0.9101.00
200_Q204_S0.9081.00
18_L160_F0.9031.00
174_I253_T0.9021.00
418_Y422_W0.9021.00
288_G292_T0.9021.00
67_A396_P0.9011.00
200_Q415_F0.9011.00
64_E67_A0.9001.00
393_L396_P0.8961.00
216_H220_S0.8951.00
196_F200_Q0.8941.00
167_Y246_I0.8851.00
222_A232_I0.8851.00
25_F28_A0.8811.00
428_L433_L0.8811.00
439_Y443_S0.8681.00
428_L435_M0.8661.00
15_D157_K0.8661.00
131_I135_I0.8571.00
57_L405_I0.8571.00
10_S153_K0.8551.00
13_L235_A0.8521.00
310_M348_F0.8501.00
182_Q186_L0.8491.00
149_Y334_N0.8471.00
367_V371_A0.8421.00
440_L443_S0.8421.00
341_R345_W0.8401.00
144_F307_N0.8351.00
93_F326_L0.8341.00
330_F342_A0.8331.00
380_P410_F0.8331.00
146_L149_Y0.8301.00
257_A281_I0.8291.00
348_F352_I0.8291.00
80_V323_N0.8291.00
14_F160_F0.8281.00
428_L442_F0.8271.00
413_T416_I0.8261.00
114_V118_F0.8261.00
79_P382_S0.8251.00
384_A406_G0.8231.00
178_I249_V0.8221.00
58_I413_T0.8211.00
105_I210_F0.8201.00
86_L90_L0.8161.00
110_V302_P0.8131.00
118_F121_L0.8131.00
56_L60_L0.8111.00
180_H184_E0.8071.00
49_I53_A0.8041.00
141_L355_T0.8041.00
233_P236_L0.8031.00
68_A396_P0.8021.00
402_M405_I0.8021.00
192_A196_F0.7971.00
409_S413_T0.7971.00
252_V256_G0.7961.00
217_P312_T0.7951.00
426_S435_M0.7921.00
7_F315_R0.7911.00
442_F445_Y0.7891.00
213_L376_Y0.7861.00
157_K160_F0.7831.00
25_F166_K0.7811.00
110_V303_G0.7811.00
199_I203_I0.7801.00
326_L330_F0.7791.00
136_L139_A0.7781.00
131_I134_W0.7751.00
144_F310_M0.7721.00
87_V378_I0.7701.00
440_L447_P0.7691.00
434_V437_L0.7681.00
166_K301_S0.7671.00
263_L266_G0.7621.00
73_G76_I0.7611.00
7_F224_E0.7611.00
370_V428_L0.7551.00
415_F418_Y0.7541.00
262_T265_H0.7511.00
56_L237_I0.7451.00
389_N394_N0.7431.00
17_I235_A0.7421.00
108_T364_L0.7401.00
390_A394_N0.7381.00
266_G280_D0.7381.00
429_L432_Q0.7371.00
384_A388_V0.7361.00
29_W250_L0.7341.00
46_F50_L0.7341.00
192_A199_I0.7331.00
384_A403_S0.7331.00
442_F447_P0.7321.00
349_A352_I0.7321.00
57_L61_V0.7321.00
111_R133_G0.7301.00
439_Y444_K0.7301.00
65_L383_S0.7291.00
68_A391_K0.7261.00
335_K341_R0.7231.00
436_F444_K0.7221.00
427_W431_S0.7191.00
432_Q436_F0.7171.00
39_K42_P0.7171.00
227_N233_P0.7161.00
317_V346_L0.7161.00
55_I215_L0.7151.00
98_A372_L0.7151.00
10_S152_V0.7131.00
65_L78_Y0.7111.00
389_N395_R0.7101.00
310_M314_S0.7091.00
426_S433_L0.7081.00
420_S424_T0.7051.00
14_F157_K0.7041.00
84_G443_S0.7011.00
134_W355_T0.7001.00
438_I444_K0.6981.00
100_T350_L0.6981.00
156_A160_F0.6951.00
181_F186_L0.6951.00
111_R114_V0.6901.00
409_S412_F0.6881.00
383_S387_R0.6851.00
102_L368_C0.6851.00
46_F49_I0.6841.00
400_K404_I0.6841.00
314_S343_S0.6821.00
104_S354_W0.6821.00
138_F356_L0.6811.00
429_L444_K0.6801.00
95_T99_Y0.6791.00
59_G215_L0.6791.00
431_S434_V0.6781.00
417_V420_S0.6761.00
45_A248_T0.6761.00
289_W292_T0.6751.00
219_V236_L0.6741.00
148_N344_L0.6731.00
186_L255_I0.6731.00
23_A308_I0.6721.00
149_Y337_T0.6701.00
140_L306_G0.6681.00
116_Y295_I0.6671.00
72_T318_Y0.6671.00
54_I57_L0.6671.00
104_S364_L0.6641.00
21_M163_S0.6631.00
86_L436_F0.6631.00
48_W211_A0.6631.00
82_S385_A0.6621.00
382_S386_L0.6621.00
60_L405_I0.6581.00
115_A119_P0.6581.00
371_A375_S0.6571.00
45_A255_I0.6541.00
433_L436_F0.6531.00
242_V246_I0.6531.00
150_W154_T0.6521.00
435_M443_S0.6511.00
102_L105_I0.6511.00
435_M442_F0.6481.00
335_K338_G0.6481.00
25_F246_I0.6451.00
156_A307_N0.6451.00
388_V391_K0.6441.00
419_W423_K0.6431.00
329_I346_L0.6431.00
438_I443_S0.6421.00
174_I250_L0.6421.00
238_I241_I0.6391.00
76_I80_V0.6381.00
20_G24_I0.6381.00
148_N311_N0.6331.00
426_S431_S0.6321.00
82_S386_L0.6321.00
242_V245_I0.6311.00
334_N338_G0.6301.00
21_M24_I0.6291.00
182_Q187_S0.6291.00
401_G406_G0.6271.00
17_I20_G0.6271.00
57_L409_S0.6271.00
46_F199_I0.6251.00
194_F197_T0.6231.00
321_A330_F0.6231.00
35_N362_N0.6221.00
24_I239_C0.6211.00
121_L132_S0.6211.00
223_G318_Y0.6211.00
33_V251_Q0.6201.00
430_G437_L0.6191.00
395_R398_Y0.6191.00
189_Q193_P0.6191.00
397_F400_K0.6181.00
117_W296_L0.6171.00
370_V417_V0.6171.00
330_F343_S0.6161.00
436_F439_Y0.6141.00
101_S367_V0.6111.00
22_G163_S0.6101.00
114_V140_L0.6101.00
76_I92_S0.6091.00
441_C446_T0.6081.00
277_P281_I0.6061.00
99_Y309_F0.6061.00
249_V253_T0.6061.00
154_T157_K0.6051.00
403_S406_G0.6041.00
426_S440_L0.6031.00
434_V442_F0.6031.00
62_Y379_A0.6011.00
315_R318_Y0.6001.00
232_I236_L0.6001.00
44_G251_Q0.6001.00
42_P255_I0.5981.00
32_A365_V0.5971.00
422_W425_V0.5961.00
154_T158_A0.5961.00
25_F30_L0.5961.00
429_L438_I0.5961.00
427_W444_K0.5961.00
61_V399_L0.5951.00
113_Y298_A0.5931.00
426_S438_I0.5911.00
142_C145_F0.5911.00
66_G219_V0.5901.00
253_T256_G0.5891.00
373_I413_T0.5891.00
51_G209_M0.5881.00
386_L390_A0.5881.00
439_Y445_Y0.5871.00
35_N38_S0.5871.00
10_S14_F0.5851.00
94_V375_S0.5841.00
427_W439_Y0.5831.00
26_G30_L0.5821.00
152_V221_V0.5811.00
220_S312_T0.5811.00
399_L405_I0.5801.00
417_V425_V0.5791.00
61_V409_S0.5791.00
149_Y344_L0.5781.00
399_L402_M0.5771.00
151_S154_T0.5761.00
435_M444_K0.5761.00
276_L279_K0.5751.00
144_F303_G0.5731.00
277_P282_A0.5731.00
165_F297_D0.5731.00
313_T317_V0.5731.00
353_F356_L0.5721.00
418_Y421_G0.5721.00
140_L303_G0.5711.00
438_I447_P0.5711.00
14_F17_I0.5701.00
104_S351_S0.5691.00
75_I216_H0.5681.00
213_L368_C0.5671.00
250_L254_F0.5671.00
75_I220_S0.5641.00
141_L352_I0.5631.00
66_G232_I0.5631.00
340_P343_S0.5631.00
437_L440_L0.5621.00
428_L438_I0.5621.00
140_L144_F0.5621.00
84_G88_G0.5601.00
406_G410_F0.5601.00
145_F310_M0.5581.00
76_I88_G0.5571.00
160_F164_I0.5561.00
213_L216_H0.5561.00
435_M440_L0.5551.00
155_F311_N0.5551.00
433_L442_F0.5541.00
51_G54_I0.5541.00
293_L297_D0.5521.00
362_N365_V0.5521.00
411_I414_A0.5511.00
420_S425_V0.5501.00
29_W32_A0.5491.00
176_V287_L0.5471.00
201_A207_G0.5471.00
387_R402_M0.5471.00
198_G204_S0.5461.00
116_Y119_P0.5451.00
427_W435_M0.5441.00
216_H376_Y0.5441.00
426_S446_T0.5431.00
430_G435_M0.5431.00
52_G57_L0.5421.00
115_A133_G0.5411.00
416_I420_S0.5411.00
142_C345_W0.5401.00
296_L300_L0.5401.00
360_S363_A0.5401.00
187_S190_G0.5391.00
36_V40_A0.5371.00
106_E302_P0.5361.00
183_P188_V0.5361.00
23_A309_F0.5351.00
387_R391_K0.5341.00
182_Q188_V0.5331.00
100_T347_S0.5321.00
16_L221_V0.5311.00
301_S304_G0.5311.00
65_L82_S0.5311.00
310_M344_L0.5301.00
83_H382_S0.5301.00
361_W365_V0.5301.00
412_F416_I0.5301.00
429_L439_Y0.5301.00
35_N39_K0.5291.00
165_F169_V0.5281.00
315_R340_P0.5271.00
282_A286_G0.5271.00
250_L278_F0.5271.00
39_K201_A0.5261.00
101_S368_C0.5261.00
63_A236_L0.5251.00
139_A142_C0.5251.00
258_I281_I0.5241.00
433_L446_T0.5241.00
439_Y447_P0.5231.00
98_A371_A0.5221.00
102_L106_E0.5201.00
91_I375_S0.5191.00
346_L350_L0.5171.00
143_L147_L0.5171.00
427_W433_L0.5171.00
229_K394_N0.5151.00
431_S444_K0.5151.00
117_W295_I0.5151.00
12_S153_K0.5141.00
107_V111_R0.5141.00
384_A410_F0.5131.00
333_V337_T0.5131.00
443_S446_T0.5121.00
255_I259_P0.5111.00
200_Q419_W0.5111.00
426_S447_P0.5101.00
30_L170_P0.5101.00
431_S439_Y0.5101.00
74_G219_V0.5101.00
86_L439_Y0.5101.00
48_W251_Q0.5091.00
58_I216_H0.5091.00
228_P231_N0.5081.00
224_E333_V0.5081.00
278_F282_A0.5071.00
429_L436_F0.5071.00
79_P88_G0.5071.00
25_F32_A0.5051.00
426_S442_F0.5041.00
159_N304_G0.5031.00
261_E265_H0.5021.00
225_V232_I0.5011.00
63_A67_A0.5001.00
435_M447_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8019 100 0.342 Contact Map
3giaA 1 0.8231 100 0.391 Contact Map
4djkA 2 0.8096 100 0.4 Contact Map
2jlnA 1 0.7962 99.2 0.86 Contact Map
3dh4A 3 0.8731 98.7 0.881 Contact Map
2xq2A 2 0.8885 98.5 0.889 Contact Map
4wgvA 2 0.7038 97.6 0.912 Contact Map
4xp4A 1 0.8404 97.1 0.919 Contact Map
2a65A 2 0.8173 96.4 0.926 Contact Map
4us3A 1 0.7481 96.4 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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