COTR - BACSU - GREMLIN Contacts

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COTR - Putative sporulation hydrolase CotR

UniProt:	O06996	Sequences: MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNSIGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFPADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPATQRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWGMVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRFFRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	320 (276)
Sequences:	1929 (1466)
Seq/√Len:	88.3

BACSU - COTR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_S	154_S	6.541	1.00
45_I	66_F	5.618	1.00
9_F	19_S	5.548	1.00
51_L	151_I	4.923	1.00
41_S	181_S	4.558	1.00
67_E	298_I	3.947	1.00
178_S	198_V	3.622	1.00
98_R	148_S	3.610	1.00
14_T	70_I	3.336	1.00
94_I	152_L	3.309	1.00
49_T	62_T	2.820	1.00
58_S	61_E	2.803	1.00
44_S	157_A	2.688	1.00
146_K	149_D	2.673	1.00
24_N	60_R	2.546	1.00
52_A	62_T	2.512	1.00
64_Q	68_D	2.422	1.00
19_S	201_I	2.402	1.00
88_L	290_D	2.266	1.00
30_N	36_R	2.243	1.00
39_V	185_A	2.235	1.00
51_L	114_I	2.143	1.00
90_Y	162_R	2.109	1.00
20_L	59_P	2.087	1.00
25_R	28_R	2.081	1.00
41_S	115_V	2.067	1.00
20_L	63_L	2.029	1.00
151_I	155_S	2.002	1.00
157_A	160_T	1.975	1.00
44_S	169_D	1.875	1.00
16_G	45_I	1.859	1.00
27_A	59_P	1.845	1.00
10_D	278_R	1.803	1.00
137_F	184_F	1.762	1.00
288_K	291_P	1.758	1.00
15_L	203_T	1.757	1.00
135_H	184_F	1.751	1.00
51_L	116_V	1.737	1.00
6_I	181_S	1.720	1.00
40_F	54_A	1.707	1.00
148_S	152_L	1.705	1.00
118_S	134_F	1.699	1.00
90_Y	152_L	1.694	1.00
110_L	147_V	1.686	1.00
25_R	29_Q	1.678	1.00
44_S	175_T	1.637	1.00
47_S	151_I	1.635	1.00
94_I	98_R	1.620	1.00
72_P	99_N	1.618	1.00
293_V	296_A	1.617	1.00
6_I	41_S	1.596	1.00
7_M	37_T	1.575	1.00
301_A	304_T	1.572	1.00
200_S	278_R	1.544	1.00
24_N	63_L	1.495	1.00
40_F	50_A	1.483	1.00
287_S	291_P	1.456	0.99
301_A	305_N	1.453	0.99
133_L	180_A	1.407	0.99
90_Y	94_I	1.405	0.99
104_D	146_K	1.388	0.99
10_D	176_N	1.377	0.99
158_P	172_V	1.354	0.99
52_A	57_R	1.343	0.99
157_A	171_Y	1.343	0.99
16_G	66_F	1.330	0.99
50_A	54_A	1.327	0.99
31_P	36_R	1.318	0.99
43_N	170_G	1.317	0.99
17_A	63_L	1.303	0.99
19_S	203_T	1.301	0.99
9_F	201_I	1.300	0.99
151_I	154_S	1.282	0.99
307_Q	310_N	1.278	0.99
21_Q	302_N	1.268	0.98
21_Q	63_L	1.266	0.98
262_Y	265_S	1.265	0.98
30_N	33_L	1.261	0.98
157_A	175_T	1.253	0.98
12_G	15_L	1.250	0.98
53_L	59_P	1.248	0.98
10_D	200_S	1.242	0.98
158_P	170_G	1.242	0.98
6_I	185_A	1.239	0.98
169_D	175_T	1.238	0.98
97_V	102_P	1.238	0.98
171_Y	175_T	1.233	0.98
24_N	59_P	1.232	0.98
113_R	136_N	1.225	0.98
182_I	198_V	1.218	0.98
61_E	64_Q	1.217	0.98
17_A	21_Q	1.207	0.98
108_I	144_N	1.198	0.98
50_A	114_I	1.197	0.98
286_F	291_P	1.187	0.98
264_E	267_V	1.170	0.97
74_F	157_A	1.170	0.97
134_F	150_V	1.155	0.97
94_I	149_D	1.145	0.97
295_P	298_I	1.144	0.97
153_R	167_Y	1.137	0.97
145_E	150_V	1.135	0.97
253_L	257_A	1.124	0.97
218_G	222_A	1.114	0.96
98_R	149_D	1.095	0.96
102_P	105_L	1.094	0.96
51_L	154_S	1.094	0.96
44_S	160_T	1.091	0.96
20_L	49_T	1.090	0.96
44_S	171_Y	1.084	0.96
37_T	40_F	1.077	0.96
286_F	290_D	1.074	0.96
55_S	147_V	1.070	0.96
154_S	170_G	1.063	0.95
199_L	279_L	1.058	0.95
182_I	196_I	1.053	0.95
48_F	97_V	1.052	0.95
11_G	175_T	1.049	0.95
86_Q	162_R	1.048	0.95
18_L	301_A	1.033	0.95
7_M	40_F	1.031	0.95
157_A	289_T	1.031	0.95
119_F	172_V	1.027	0.94
16_G	49_T	1.024	0.94
215_R	218_G	1.020	0.94
171_Y	289_T	1.019	0.94
152_L	156_G	1.019	0.94
40_F	53_L	1.017	0.94
116_V	134_F	1.005	0.94
47_S	51_L	1.001	0.94
152_L	155_S	0.987	0.93
218_G	221_S	0.975	0.93
94_I	148_S	0.969	0.92
54_A	114_I	0.959	0.92
10_D	204_G	0.957	0.92
95_K	99_N	0.956	0.92
34_I	59_P	0.954	0.92
45_I	49_T	0.953	0.92
32_K	35_S	0.950	0.92
299_E	303_K	0.935	0.91
134_F	167_Y	0.927	0.91
42_G	47_S	0.926	0.91
96_A	100_F	0.918	0.90
11_G	169_D	0.917	0.90
163_A	168_V	0.914	0.90
29_Q	32_K	0.911	0.90
4_Y	196_I	0.907	0.90
54_A	57_R	0.906	0.90
7_M	38_H	0.903	0.90
204_G	278_R	0.903	0.90
59_P	63_L	0.903	0.90
168_V	172_V	0.889	0.89
37_T	199_L	0.888	0.89
305_N	310_N	0.886	0.89
197_A	277_F	0.882	0.88
22_L	201_I	0.881	0.88
106_Q	144_N	0.878	0.88
78_R	89_P	0.876	0.88
201_I	261_G	0.875	0.88
263_Y	271_L	0.874	0.88
117_P	150_V	0.874	0.88
16_G	74_F	0.874	0.88
106_Q	109_D	0.870	0.88
12_G	16_G	0.864	0.87
5_R	38_H	0.857	0.87
18_L	281_P	0.853	0.87
69_E	73_A	0.852	0.87
268_S	271_L	0.851	0.87
48_F	74_F	0.849	0.87
157_A	169_D	0.848	0.86
265_S	276_F	0.847	0.86
39_V	188_K	0.845	0.86
51_L	147_V	0.838	0.86
66_F	70_I	0.838	0.86
93_F	152_L	0.836	0.86
59_P	62_T	0.833	0.85
264_E	268_S	0.831	0.85
26_L	33_L	0.831	0.85
217_W	222_A	0.830	0.85
49_T	53_L	0.830	0.85
107_L	134_F	0.829	0.85
295_P	299_E	0.828	0.85
54_A	110_L	0.819	0.84
92_G	96_A	0.819	0.84
135_H	138_P	0.818	0.84
11_G	15_L	0.814	0.84
251_P	255_M	0.809	0.84
14_T	45_I	0.806	0.84
260_N	263_Y	0.801	0.83
52_A	203_T	0.799	0.83
152_L	161_Q	0.797	0.83
74_F	169_D	0.794	0.83
88_L	161_Q	0.792	0.82
106_Q	146_K	0.786	0.82
155_S	175_T	0.785	0.82
153_R	276_F	0.784	0.82
44_S	170_G	0.781	0.82
48_F	155_S	0.781	0.82
180_A	183_A	0.778	0.81
263_Y	266_M	0.774	0.81
13_G	16_G	0.774	0.81
18_L	201_I	0.772	0.81
214_T	221_S	0.767	0.80
74_F	161_Q	0.766	0.80
68_D	99_N	0.761	0.80
66_F	73_A	0.757	0.80
57_R	61_E	0.753	0.79
44_S	155_S	0.753	0.79
128_R	201_I	0.753	0.79
302_N	306_L	0.753	0.79
52_A	102_P	0.751	0.79
43_N	93_F	0.749	0.79
27_A	48_F	0.748	0.79
18_L	27_A	0.746	0.79
65_Y	69_E	0.743	0.78
66_F	74_F	0.743	0.78
296_A	299_E	0.742	0.78
114_I	117_P	0.738	0.78
25_R	302_N	0.737	0.78
286_F	289_T	0.734	0.77
34_I	149_D	0.733	0.77
261_G	264_E	0.732	0.77
146_K	150_V	0.731	0.77
27_A	31_P	0.727	0.77
174_A	180_A	0.725	0.77
74_F	88_L	0.725	0.77
15_L	202_G	0.721	0.76
157_A	161_Q	0.719	0.76
9_F	20_L	0.717	0.76
92_G	95_K	0.708	0.75
171_Y	275_R	0.707	0.75
13_G	169_D	0.706	0.75
160_T	289_T	0.704	0.74
178_S	276_F	0.703	0.74
42_G	46_G	0.701	0.74
44_S	203_T	0.701	0.74
78_R	82_P	0.696	0.74
9_F	117_P	0.696	0.74
21_Q	24_N	0.695	0.73
72_P	95_K	0.693	0.73
255_M	259_G	0.692	0.73
266_M	269_A	0.692	0.73
260_N	280_D	0.692	0.73
8_T	178_S	0.691	0.73
79_P	82_P	0.689	0.73
287_S	290_D	0.686	0.73
176_N	204_G	0.686	0.73
155_S	170_G	0.684	0.72
155_S	158_P	0.674	0.71
44_S	289_T	0.672	0.71
20_L	173_V	0.672	0.71
153_R	156_G	0.672	0.71
211_R	279_L	0.672	0.71
5_R	197_A	0.671	0.71
155_S	162_R	0.671	0.71
179_T	258_G	0.669	0.71
115_V	150_V	0.668	0.71
193_L	253_L	0.666	0.70
89_P	93_F	0.666	0.70
115_V	185_A	0.666	0.70
182_I	193_L	0.665	0.70
303_K	306_L	0.664	0.70
121_L	168_V	0.659	0.69
132_V	142_Y	0.657	0.69
155_S	203_T	0.655	0.69
69_E	99_N	0.653	0.69
88_L	288_K	0.652	0.69
265_S	268_S	0.652	0.69
39_V	115_V	0.652	0.69
268_S	272_L	0.652	0.69
107_L	221_S	0.649	0.68
264_E	272_L	0.648	0.68
87_Q	159_A	0.646	0.68
11_G	16_G	0.645	0.68
97_V	152_L	0.645	0.68
145_E	153_R	0.644	0.68
110_L	114_I	0.644	0.68
40_F	274_D	0.641	0.67
51_L	155_S	0.637	0.67
67_E	70_I	0.634	0.67
300_I	304_T	0.632	0.66
178_S	264_E	0.632	0.66
18_L	22_L	0.630	0.66
158_P	169_D	0.630	0.66
119_F	168_V	0.630	0.66
19_S	66_F	0.628	0.66
306_L	309_A	0.627	0.66
51_L	55_S	0.625	0.65
73_A	90_Y	0.625	0.65
23_L	61_E	0.624	0.65
106_Q	147_V	0.623	0.65
18_L	283_I	0.619	0.65
221_S	224_N	0.617	0.64
86_Q	92_G	0.617	0.64
20_L	24_N	0.617	0.64
305_N	309_A	0.616	0.64
257_A	263_Y	0.615	0.64
26_L	174_A	0.614	0.64
43_N	169_D	0.611	0.64
156_G	160_T	0.607	0.63
199_L	277_F	0.607	0.63
186_V	196_I	0.606	0.63
150_V	154_S	0.606	0.63
28_R	31_P	0.604	0.63
218_G	267_V	0.604	0.63
19_S	49_T	0.603	0.63
205_E	280_D	0.603	0.63
15_L	204_G	0.602	0.63
161_Q	256_I	0.600	0.62
88_L	157_A	0.599	0.62
32_K	36_R	0.596	0.62
152_L	162_R	0.596	0.62
208_T	254_Q	0.596	0.62
39_V	181_S	0.594	0.61
18_L	297_V	0.594	0.61
193_L	196_I	0.594	0.61
72_P	75_S	0.592	0.61
20_L	69_E	0.589	0.61
150_V	163_A	0.588	0.61
139_G	270_N	0.587	0.61
294_V	298_I	0.586	0.60
264_E	271_L	0.584	0.60
43_N	74_F	0.583	0.60
97_V	203_T	0.582	0.60
258_G	263_Y	0.582	0.60
25_R	305_N	0.581	0.60
192_P	270_N	0.581	0.60
43_N	154_S	0.579	0.60
136_N	283_I	0.578	0.59
269_A	272_L	0.577	0.59
16_G	169_D	0.576	0.59
26_L	301_A	0.576	0.59
115_V	137_F	0.575	0.59
169_D	290_D	0.574	0.59
102_P	147_V	0.571	0.58
10_D	14_T	0.570	0.58
10_D	66_F	0.568	0.58
95_K	100_F	0.568	0.58
15_L	254_Q	0.566	0.58
141_P	213_D	0.564	0.58
18_L	50_A	0.563	0.57
281_P	304_T	0.563	0.57
282_R	307_Q	0.563	0.57
45_I	203_T	0.562	0.57
174_A	179_T	0.561	0.57
108_I	138_P	0.560	0.57
172_V	175_T	0.560	0.57
146_K	172_V	0.560	0.57
47_S	156_G	0.560	0.57
49_T	93_F	0.559	0.57
36_R	41_S	0.559	0.57
23_L	59_P	0.558	0.57
88_L	160_T	0.557	0.57
167_Y	287_S	0.557	0.57
10_D	45_I	0.557	0.57
133_L	137_F	0.555	0.56
27_A	30_N	0.554	0.56
59_P	280_D	0.551	0.56
160_T	175_T	0.550	0.56
152_L	163_A	0.550	0.56
16_G	171_Y	0.549	0.56
160_T	171_Y	0.548	0.55
220_V	224_N	0.547	0.55
263_Y	267_V	0.547	0.55
12_G	74_F	0.547	0.55
138_P	280_D	0.547	0.55
201_I	279_L	0.538	0.54
300_I	303_K	0.537	0.54
29_Q	309_A	0.537	0.54
173_V	259_G	0.535	0.54
60_R	64_Q	0.535	0.54
70_I	294_V	0.535	0.54
60_R	149_D	0.533	0.53
157_A	290_D	0.532	0.53
60_R	63_L	0.532	0.53
66_F	172_V	0.532	0.53
201_I	222_A	0.531	0.53
76_I	150_V	0.531	0.53
16_G	19_S	0.531	0.53
181_S	197_A	0.531	0.53
161_Q	169_D	0.530	0.53
41_S	202_G	0.530	0.53
74_F	160_T	0.528	0.53
187_G	205_E	0.528	0.53
146_K	182_I	0.527	0.53
29_Q	296_A	0.527	0.53
169_D	203_T	0.524	0.52
16_G	157_A	0.524	0.52
200_S	204_G	0.521	0.52
223_D	252_F	0.521	0.52
303_K	309_A	0.521	0.52
149_D	152_L	0.518	0.51
189_A	192_P	0.518	0.51
53_L	63_L	0.517	0.51
121_L	163_A	0.515	0.51
51_L	54_A	0.515	0.51
120_K	172_V	0.513	0.51
160_T	170_G	0.513	0.51
137_F	199_L	0.510	0.50
180_A	267_V	0.509	0.50
36_R	56_G	0.509	0.50
91_S	95_K	0.509	0.50
204_G	261_G	0.508	0.50
45_I	161_Q	0.507	0.50
154_S	162_R	0.505	0.50
16_G	46_G	0.505	0.50
21_Q	301_A	0.504	0.49
48_F	151_I	0.504	0.49
293_V	301_A	0.504	0.49
33_L	36_R	0.502	0.49
26_L	117_P	0.502	0.49
86_Q	90_Y	0.502	0.49
187_G	268_S	0.501	0.49
300_I	307_Q	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pk9A	2	0.8906	100	0.356	Contact Map
4qmkA	2	0.6656	100	0.62	Contact Map
3tu3B	1	0.7063	100	0.638	Contact Map
4akfA	2	0.8781	100	0.657	Contact Map
1cjyA	1	0.7063	95.7	0.922	Contact Map
1gklA	1	0.5031	82.1	0.943	Contact Map
3fnbA	2	0.5156	77.3	0.946	Contact Map
3d7rA	1	0.5594	76.9	0.946	Contact Map
3c8dA	2	0.5	76.3	0.946	Contact Map
2qmqA	1	0.6438	70.1	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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