GREMLIN Database
COTR - Putative sporulation hydrolase CotR
UniProt: O06996 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (276)
Sequences: 1929 (1466)
Seq/√Len: 88.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_S154_S6.5411.00
45_I66_F5.6181.00
9_F19_S5.5481.00
51_L151_I4.9231.00
41_S181_S4.5581.00
67_E298_I3.9471.00
178_S198_V3.6221.00
98_R148_S3.6101.00
14_T70_I3.3361.00
94_I152_L3.3091.00
49_T62_T2.8201.00
58_S61_E2.8031.00
44_S157_A2.6881.00
146_K149_D2.6731.00
24_N60_R2.5461.00
52_A62_T2.5121.00
64_Q68_D2.4221.00
19_S201_I2.4021.00
88_L290_D2.2661.00
30_N36_R2.2431.00
39_V185_A2.2351.00
51_L114_I2.1431.00
90_Y162_R2.1091.00
20_L59_P2.0871.00
25_R28_R2.0811.00
41_S115_V2.0671.00
20_L63_L2.0291.00
151_I155_S2.0021.00
157_A160_T1.9751.00
44_S169_D1.8751.00
16_G45_I1.8591.00
27_A59_P1.8451.00
10_D278_R1.8031.00
137_F184_F1.7621.00
288_K291_P1.7581.00
15_L203_T1.7571.00
135_H184_F1.7511.00
51_L116_V1.7371.00
6_I181_S1.7201.00
40_F54_A1.7071.00
148_S152_L1.7051.00
118_S134_F1.6991.00
90_Y152_L1.6941.00
110_L147_V1.6861.00
25_R29_Q1.6781.00
44_S175_T1.6371.00
47_S151_I1.6351.00
94_I98_R1.6201.00
72_P99_N1.6181.00
293_V296_A1.6171.00
6_I41_S1.5961.00
7_M37_T1.5751.00
301_A304_T1.5721.00
200_S278_R1.5441.00
24_N63_L1.4951.00
40_F50_A1.4831.00
287_S291_P1.4560.99
301_A305_N1.4530.99
133_L180_A1.4070.99
90_Y94_I1.4050.99
104_D146_K1.3880.99
10_D176_N1.3770.99
158_P172_V1.3540.99
52_A57_R1.3430.99
157_A171_Y1.3430.99
16_G66_F1.3300.99
50_A54_A1.3270.99
31_P36_R1.3180.99
43_N170_G1.3170.99
17_A63_L1.3030.99
19_S203_T1.3010.99
9_F201_I1.3000.99
151_I154_S1.2820.99
307_Q310_N1.2780.99
21_Q302_N1.2680.98
21_Q63_L1.2660.98
262_Y265_S1.2650.98
30_N33_L1.2610.98
157_A175_T1.2530.98
12_G15_L1.2500.98
53_L59_P1.2480.98
10_D200_S1.2420.98
158_P170_G1.2420.98
6_I185_A1.2390.98
169_D175_T1.2380.98
97_V102_P1.2380.98
171_Y175_T1.2330.98
24_N59_P1.2320.98
113_R136_N1.2250.98
182_I198_V1.2180.98
61_E64_Q1.2170.98
17_A21_Q1.2070.98
108_I144_N1.1980.98
50_A114_I1.1970.98
286_F291_P1.1870.98
264_E267_V1.1700.97
74_F157_A1.1700.97
134_F150_V1.1550.97
94_I149_D1.1450.97
295_P298_I1.1440.97
153_R167_Y1.1370.97
145_E150_V1.1350.97
253_L257_A1.1240.97
218_G222_A1.1140.96
98_R149_D1.0950.96
102_P105_L1.0940.96
51_L154_S1.0940.96
44_S160_T1.0910.96
20_L49_T1.0900.96
44_S171_Y1.0840.96
37_T40_F1.0770.96
286_F290_D1.0740.96
55_S147_V1.0700.96
154_S170_G1.0630.95
199_L279_L1.0580.95
182_I196_I1.0530.95
48_F97_V1.0520.95
11_G175_T1.0490.95
86_Q162_R1.0480.95
18_L301_A1.0330.95
7_M40_F1.0310.95
157_A289_T1.0310.95
119_F172_V1.0270.94
16_G49_T1.0240.94
215_R218_G1.0200.94
171_Y289_T1.0190.94
152_L156_G1.0190.94
40_F53_L1.0170.94
116_V134_F1.0050.94
47_S51_L1.0010.94
152_L155_S0.9870.93
218_G221_S0.9750.93
94_I148_S0.9690.92
54_A114_I0.9590.92
10_D204_G0.9570.92
95_K99_N0.9560.92
34_I59_P0.9540.92
45_I49_T0.9530.92
32_K35_S0.9500.92
299_E303_K0.9350.91
134_F167_Y0.9270.91
42_G47_S0.9260.91
96_A100_F0.9180.90
11_G169_D0.9170.90
163_A168_V0.9140.90
29_Q32_K0.9110.90
4_Y196_I0.9070.90
54_A57_R0.9060.90
7_M38_H0.9030.90
204_G278_R0.9030.90
59_P63_L0.9030.90
168_V172_V0.8890.89
37_T199_L0.8880.89
305_N310_N0.8860.89
197_A277_F0.8820.88
22_L201_I0.8810.88
106_Q144_N0.8780.88
78_R89_P0.8760.88
201_I261_G0.8750.88
263_Y271_L0.8740.88
117_P150_V0.8740.88
16_G74_F0.8740.88
106_Q109_D0.8700.88
12_G16_G0.8640.87
5_R38_H0.8570.87
18_L281_P0.8530.87
69_E73_A0.8520.87
268_S271_L0.8510.87
48_F74_F0.8490.87
157_A169_D0.8480.86
265_S276_F0.8470.86
39_V188_K0.8450.86
51_L147_V0.8380.86
66_F70_I0.8380.86
93_F152_L0.8360.86
59_P62_T0.8330.85
264_E268_S0.8310.85
26_L33_L0.8310.85
217_W222_A0.8300.85
49_T53_L0.8300.85
107_L134_F0.8290.85
295_P299_E0.8280.85
54_A110_L0.8190.84
92_G96_A0.8190.84
135_H138_P0.8180.84
11_G15_L0.8140.84
251_P255_M0.8090.84
14_T45_I0.8060.84
260_N263_Y0.8010.83
52_A203_T0.7990.83
152_L161_Q0.7970.83
74_F169_D0.7940.83
88_L161_Q0.7920.82
106_Q146_K0.7860.82
155_S175_T0.7850.82
153_R276_F0.7840.82
44_S170_G0.7810.82
48_F155_S0.7810.82
180_A183_A0.7780.81
263_Y266_M0.7740.81
13_G16_G0.7740.81
18_L201_I0.7720.81
214_T221_S0.7670.80
74_F161_Q0.7660.80
68_D99_N0.7610.80
66_F73_A0.7570.80
57_R61_E0.7530.79
44_S155_S0.7530.79
128_R201_I0.7530.79
302_N306_L0.7530.79
52_A102_P0.7510.79
43_N93_F0.7490.79
27_A48_F0.7480.79
18_L27_A0.7460.79
65_Y69_E0.7430.78
66_F74_F0.7430.78
296_A299_E0.7420.78
114_I117_P0.7380.78
25_R302_N0.7370.78
286_F289_T0.7340.77
34_I149_D0.7330.77
261_G264_E0.7320.77
146_K150_V0.7310.77
27_A31_P0.7270.77
174_A180_A0.7250.77
74_F88_L0.7250.77
15_L202_G0.7210.76
157_A161_Q0.7190.76
9_F20_L0.7170.76
92_G95_K0.7080.75
171_Y275_R0.7070.75
13_G169_D0.7060.75
160_T289_T0.7040.74
178_S276_F0.7030.74
42_G46_G0.7010.74
44_S203_T0.7010.74
78_R82_P0.6960.74
9_F117_P0.6960.74
21_Q24_N0.6950.73
72_P95_K0.6930.73
255_M259_G0.6920.73
266_M269_A0.6920.73
260_N280_D0.6920.73
8_T178_S0.6910.73
79_P82_P0.6890.73
287_S290_D0.6860.73
176_N204_G0.6860.73
155_S170_G0.6840.72
155_S158_P0.6740.71
44_S289_T0.6720.71
20_L173_V0.6720.71
153_R156_G0.6720.71
211_R279_L0.6720.71
5_R197_A0.6710.71
155_S162_R0.6710.71
179_T258_G0.6690.71
115_V150_V0.6680.71
193_L253_L0.6660.70
89_P93_F0.6660.70
115_V185_A0.6660.70
182_I193_L0.6650.70
303_K306_L0.6640.70
121_L168_V0.6590.69
132_V142_Y0.6570.69
155_S203_T0.6550.69
69_E99_N0.6530.69
88_L288_K0.6520.69
265_S268_S0.6520.69
39_V115_V0.6520.69
268_S272_L0.6520.69
107_L221_S0.6490.68
264_E272_L0.6480.68
87_Q159_A0.6460.68
11_G16_G0.6450.68
97_V152_L0.6450.68
145_E153_R0.6440.68
110_L114_I0.6440.68
40_F274_D0.6410.67
51_L155_S0.6370.67
67_E70_I0.6340.67
300_I304_T0.6320.66
178_S264_E0.6320.66
18_L22_L0.6300.66
158_P169_D0.6300.66
119_F168_V0.6300.66
19_S66_F0.6280.66
306_L309_A0.6270.66
51_L55_S0.6250.65
73_A90_Y0.6250.65
23_L61_E0.6240.65
106_Q147_V0.6230.65
18_L283_I0.6190.65
221_S224_N0.6170.64
86_Q92_G0.6170.64
20_L24_N0.6170.64
305_N309_A0.6160.64
257_A263_Y0.6150.64
26_L174_A0.6140.64
43_N169_D0.6110.64
156_G160_T0.6070.63
199_L277_F0.6070.63
186_V196_I0.6060.63
150_V154_S0.6060.63
28_R31_P0.6040.63
218_G267_V0.6040.63
19_S49_T0.6030.63
205_E280_D0.6030.63
15_L204_G0.6020.63
161_Q256_I0.6000.62
88_L157_A0.5990.62
32_K36_R0.5960.62
152_L162_R0.5960.62
208_T254_Q0.5960.62
39_V181_S0.5940.61
18_L297_V0.5940.61
193_L196_I0.5940.61
72_P75_S0.5920.61
20_L69_E0.5890.61
150_V163_A0.5880.61
139_G270_N0.5870.61
294_V298_I0.5860.60
264_E271_L0.5840.60
43_N74_F0.5830.60
97_V203_T0.5820.60
258_G263_Y0.5820.60
25_R305_N0.5810.60
192_P270_N0.5810.60
43_N154_S0.5790.60
136_N283_I0.5780.59
269_A272_L0.5770.59
16_G169_D0.5760.59
26_L301_A0.5760.59
115_V137_F0.5750.59
169_D290_D0.5740.59
102_P147_V0.5710.58
10_D14_T0.5700.58
10_D66_F0.5680.58
95_K100_F0.5680.58
15_L254_Q0.5660.58
141_P213_D0.5640.58
18_L50_A0.5630.57
281_P304_T0.5630.57
282_R307_Q0.5630.57
45_I203_T0.5620.57
174_A179_T0.5610.57
108_I138_P0.5600.57
172_V175_T0.5600.57
146_K172_V0.5600.57
47_S156_G0.5600.57
49_T93_F0.5590.57
36_R41_S0.5590.57
23_L59_P0.5580.57
88_L160_T0.5570.57
167_Y287_S0.5570.57
10_D45_I0.5570.57
133_L137_F0.5550.56
27_A30_N0.5540.56
59_P280_D0.5510.56
160_T175_T0.5500.56
152_L163_A0.5500.56
16_G171_Y0.5490.56
160_T171_Y0.5480.55
220_V224_N0.5470.55
263_Y267_V0.5470.55
12_G74_F0.5470.55
138_P280_D0.5470.55
201_I279_L0.5380.54
300_I303_K0.5370.54
29_Q309_A0.5370.54
173_V259_G0.5350.54
60_R64_Q0.5350.54
70_I294_V0.5350.54
60_R149_D0.5330.53
157_A290_D0.5320.53
60_R63_L0.5320.53
66_F172_V0.5320.53
201_I222_A0.5310.53
76_I150_V0.5310.53
16_G19_S0.5310.53
181_S197_A0.5310.53
161_Q169_D0.5300.53
41_S202_G0.5300.53
74_F160_T0.5280.53
187_G205_E0.5280.53
146_K182_I0.5270.53
29_Q296_A0.5270.53
169_D203_T0.5240.52
16_G157_A0.5240.52
200_S204_G0.5210.52
223_D252_F0.5210.52
303_K309_A0.5210.52
149_D152_L0.5180.51
189_A192_P0.5180.51
53_L63_L0.5170.51
121_L163_A0.5150.51
51_L54_A0.5150.51
120_K172_V0.5130.51
160_T170_G0.5130.51
137_F199_L0.5100.50
180_A267_V0.5090.50
36_R56_G0.5090.50
91_S95_K0.5090.50
204_G261_G0.5080.50
45_I161_Q0.5070.50
154_S162_R0.5050.50
16_G46_G0.5050.50
21_Q301_A0.5040.49
48_F151_I0.5040.49
293_V301_A0.5040.49
33_L36_R0.5020.49
26_L117_P0.5020.49
86_Q90_Y0.5020.49
187_G268_S0.5010.49
300_I307_Q0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pk9A 2 0.8906 100 0.356 Contact Map
4qmkA 2 0.6656 100 0.62 Contact Map
3tu3B 1 0.7063 100 0.638 Contact Map
4akfA 2 0.8781 100 0.657 Contact Map
1cjyA 1 0.7063 95.7 0.922 Contact Map
1gklA 1 0.5031 82.1 0.943 Contact Map
3fnbA 2 0.5156 77.3 0.946 Contact Map
3d7rA 1 0.5594 76.9 0.946 Contact Map
3c8dA 2 0.5 76.3 0.946 Contact Map
2qmqA 1 0.6438 70.1 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.