GREMLIN Database
PGMB - Beta-phosphoglucomutase
UniProt: O06995 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (195)
Sequences: 27694 (21807)
Seq/√Len: 1561.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_K164_D4.1121.00
124_R129_I3.0711.00
153_T157_M2.9341.00
143_K147_D2.8431.00
178_I185_A2.6681.00
169_E174_G2.5981.00
101_C131_D2.4531.00
3_A160_V2.4161.00
97_G101_C2.3591.00
109_K133_H2.3011.00
153_T156_A2.2631.00
29_Q75_R2.2261.00
111_G134_A2.2211.00
113_A150_I2.1561.00
6_F110_I2.1131.00
155_A165_C2.1061.00
143_K149_D2.0731.00
179_K198_D2.0561.00
202_R206_D2.0491.00
134_A157_M2.0251.00
175_I185_A1.9891.00
25_H79_D1.9811.00
176_S180_S1.9031.00
184_F198_D1.8721.00
161_S164_D1.8591.00
102_Q106_E1.8431.00
114_S119_A1.7971.00
167_A178_I1.7321.00
104_K133_H1.7171.00
155_A183_M1.7161.00
4_V108_I1.7051.00
102_Q208_T1.6861.00
104_K131_D1.6781.00
96_I204_T1.6691.00
166_A186_V1.6551.00
5_I167_A1.6191.00
160_V165_C1.5811.00
120_P129_I1.5771.00
110_I132_F1.5711.00
3_A158_L1.5411.00
5_I154_A1.5381.00
155_A162_P1.5081.00
189_G202_R1.4941.00
29_Q79_D1.4931.00
5_I113_A1.4911.00
30_I75_R1.4651.00
4_V103_L1.4351.00
4_V168_I1.4341.00
49_E52_E1.4291.00
111_G158_L1.4101.00
93_L190_Q1.3861.00
35_D38_M1.3581.00
186_V201_V1.3421.00
79_D82_M1.3221.00
189_G200_V1.3211.00
25_H83_L1.2991.00
11_V168_I1.2901.00
8_L13_T1.2751.00
12_I96_I1.2641.00
68_E71_E1.2591.00
172_E176_S1.2521.00
102_Q105_N1.2501.00
99_L204_T1.2461.00
25_H29_Q1.2411.00
203_Q206_D1.2411.00
75_R78_R1.2371.00
186_V199_L1.2241.00
136_V157_M1.2151.00
83_L86_K1.2031.00
151_F177_A1.1971.00
8_L112_L1.1971.00
120_P124_R1.1941.00
95_G98_R1.1921.00
99_L208_T1.1751.00
92_L128_I1.1611.00
8_L119_A1.1531.00
151_F167_A1.1451.00
5_I165_C1.1441.00
148_P152_L1.1421.00
136_V154_A1.1341.00
98_R205_S1.1281.00
9_D15_T1.1161.00
74_H78_R1.0931.00
75_R79_D1.0931.00
21_L83_L1.0861.00
79_D83_L1.0821.00
119_A137_D1.0741.00
165_C183_M1.0681.00
151_F183_M1.0681.00
26_I30_I1.0611.00
71_E75_R1.0561.00
149_D153_T1.0551.00
28_E33_P1.0461.00
113_A154_A1.0421.00
112_L132_F1.0371.00
8_L116_S1.0361.00
101_C105_N1.0271.00
166_A184_F1.0161.00
78_R82_M1.0101.00
179_K185_A1.0091.00
152_L156_A1.0021.00
24_K28_E1.0001.00
134_A158_L0.9901.00
104_K110_I0.9891.00
21_L25_H0.9811.00
184_F199_L0.9811.00
191_G194_M0.9801.00
127_A130_D0.9751.00
52_E69_K0.9731.00
25_H28_E0.9731.00
97_G131_D0.9711.00
137_D140_T0.9671.00
151_F169_E0.9641.00
152_L181_A0.9601.00
121_K125_R0.9571.00
85_S121_K0.9531.00
100_L132_F0.9491.00
3_A109_K0.9471.00
52_E56_I0.9441.00
121_K124_R0.9421.00
36_R40_E0.9381.00
48_E52_E0.9351.00
167_A183_M0.9311.00
98_R101_C0.9151.00
154_A158_L0.9101.00
9_D116_S0.9091.00
101_C130_D0.9041.00
45_I49_E0.9031.00
95_G203_Q0.8981.00
179_K196_G0.8971.00
173_A176_S0.8851.00
93_L188_V0.8821.00
187_G200_V0.8791.00
142_A149_D0.8711.00
21_L24_K0.8691.00
5_I158_L0.8621.00
136_V153_T0.8431.00
45_I53_S0.8421.00
149_D152_L0.8371.00
119_A122_I0.8351.00
103_L108_I0.8341.00
168_I186_V0.8331.00
92_L97_G0.8311.00
152_L162_P0.8201.00
141_L153_T0.8181.00
53_S56_I0.8151.00
201_V207_L0.8141.00
162_P183_M0.8091.00
48_E70_Q0.8051.00
37_D41_R0.8041.00
9_D170_D0.7991.00
103_L110_I0.7951.00
49_E53_S0.7911.00
177_A181_A0.7891.00
51_L55_L0.7881.00
3_A165_C0.7861.00
4_V166_A0.7851.00
114_S137_D0.7831.00
27_A32_I0.7831.00
5_I183_M0.7771.00
3_A111_G0.7711.00
20_F24_K0.7681.00
38_M41_R0.7671.00
93_L96_I0.7631.00
9_D114_S0.7601.00
111_G154_A0.7591.00
24_K36_R0.7491.00
95_G205_S0.7461.00
70_Q74_H0.7451.00
117_R121_K0.7371.00
100_L131_D0.7371.00
8_L122_I0.7331.00
175_I197_A0.7321.00
19_H76_K0.7321.00
185_A198_D0.7271.00
46_S49_E0.7271.00
97_G130_D0.7241.00
56_I59_G0.7221.00
175_I187_G0.7211.00
168_I207_L0.7211.00
13_T122_I0.7161.00
188_V204_T0.7161.00
110_I131_D0.7141.00
120_P135_I0.7131.00
47_R50_S0.7061.00
134_A154_A0.7061.00
160_V164_D0.6991.00
5_I111_G0.6951.00
150_I154_A0.6941.00
20_F39_N0.6931.00
151_F174_G0.6901.00
22_A26_I0.6871.00
176_S179_K0.6861.00
10_G16_A0.6841.00
190_Q204_T0.6781.00
73_M77_N0.6771.00
18_Y90_E0.6741.00
11_V188_V0.6661.00
115_S144_G0.6631.00
14_D91_D0.6631.00
13_T126_L0.6611.00
150_I177_A0.6601.00
17_E91_D0.6591.00
119_A135_I0.6581.00
141_L150_I0.6571.00
47_R51_L0.6551.00
97_G127_A0.6501.00
92_L126_L0.6491.00
13_T90_E0.6461.00
113_A167_A0.6451.00
74_H77_N0.6371.00
39_N43_K0.6361.00
201_V204_T0.6361.00
72_L75_R0.6351.00
76_K80_Y0.6291.00
98_R102_Q0.6261.00
123_L129_I0.6261.00
167_A174_G0.6201.00
136_V150_I0.6191.00
148_P180_S0.6181.00
22_A79_D0.6181.00
80_Y84_I0.6181.00
110_I133_H0.6171.00
30_I72_L0.6161.00
99_L168_I0.6151.00
9_D122_I0.6151.00
46_S50_S0.6151.00
2_K160_V0.6141.00
109_K160_V0.6141.00
116_S119_A0.6131.00
187_G197_A0.6111.00
95_G99_L0.6111.00
40_E43_K0.6091.00
19_H23_W0.6071.00
53_S57_F0.6071.00
55_L58_G0.6011.00
85_S125_R0.6011.00
167_A177_A0.5971.00
186_V207_L0.5941.00
82_M85_S0.5931.00
205_S208_T0.5911.00
204_T208_T0.5871.00
11_V174_G0.5851.00
48_E69_K0.5831.00
113_A136_V0.5801.00
162_P165_C0.5781.00
14_D17_E0.5781.00
45_I50_S0.5771.00
81_Q117_R0.5761.00
116_S169_E0.5751.00
19_H116_S0.5751.00
30_I71_E0.5751.00
82_M86_K0.5731.00
81_Q121_K0.5681.00
151_F178_I0.5671.00
132_F135_I0.5661.00
101_C104_K0.5641.00
2_K108_I0.5631.00
6_F99_L0.5591.00
140_T157_M0.5591.00
48_E73_M0.5581.00
37_D40_E0.5561.00
94_P205_S0.5521.00
36_R39_N0.5521.00
155_A160_V0.5521.00
134_A137_D0.5481.00
118_N122_I0.5481.00
19_H80_Y0.5471.00
41_R53_S0.5471.00
96_I99_L0.5461.00
138_P150_I0.5401.00
95_G190_Q0.5391.00
38_M43_K0.5351.00
124_R130_D0.5301.00
96_I100_L0.5291.00
155_A181_A0.5271.00
152_L155_A0.5261.00
41_R57_F0.5261.00
173_A177_A0.5261.00
39_N42_L0.5251.00
71_E74_H0.5241.00
17_E21_L0.5241.00
104_K130_D0.5211.00
20_F36_R0.5191.00
38_M42_L0.5191.00
115_S173_A0.5171.00
26_I75_R0.5091.00
50_S55_L0.5071.00
15_T116_S0.5071.00
99_L103_L0.5051.00
115_S146_P0.5041.00
14_D93_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uw9A 1 0.9292 100 0.26 Contact Map
3nasA 2 0.9513 100 0.27 Contact Map
2wf7A 1 0.9558 100 0.296 Contact Map
1swvA 2 0.9381 100 0.313 Contact Map
4g9bA 2 0.9646 100 0.317 Contact Map
3iruA 4 0.9735 100 0.318 Contact Map
3s6jA 2 0.9336 100 0.321 Contact Map
4gibA 1 0.9779 100 0.324 Contact Map
3l5kA 1 0.9292 100 0.327 Contact Map
1te2A 2 0.9159 100 0.329 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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