GREMLIN Database
MDXG - Maltodextrin transport system permease protein MdxG
UniProt: O06991 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (253)
Sequences: 68429 (45146)
Seq/√Len: 2838.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_R186_S4.0701.00
72_S76_V3.2581.00
174_R183_I3.1441.00
159_K163_D3.0671.00
36_A58_F2.6851.00
69_N72_S2.6761.00
80_S143_T2.6001.00
70_W229_G2.5991.00
98_R170_D2.5871.00
179_G182_R2.5581.00
173_A183_I2.5581.00
161_Y195_M2.5301.00
170_D188_V2.4931.00
84_L147_I2.4891.00
224_L232_S2.4301.00
59_K63_D2.4271.00
68_L72_S2.4151.00
56_D59_K2.3481.00
82_M200_A2.3351.00
180_H183_I2.3141.00
158_M196_L2.2681.00
181_L185_A2.2371.00
56_D60_R2.1951.00
241_K244_L2.1671.00
101_F104_R2.1311.00
178_A182_R2.0631.00
182_R185_A2.0581.00
90_T184_F2.0201.00
154_N199_Q1.9951.00
162_F192_V1.9571.00
169_I191_L1.9561.00
76_V139_Y1.9541.00
97_S163_D1.9511.00
30_L34_S1.9081.00
173_A178_A1.8971.00
108_L159_K1.8521.00
34_S38_R1.8511.00
90_T192_V1.8411.00
86_V200_A1.8261.00
69_N73_N1.7721.00
229_G233_F1.7441.00
174_R180_H1.7311.00
170_D183_I1.7131.00
78_A204_F1.7001.00
89_V154_N1.6921.00
76_V80_S1.6751.00
81_V207_P1.6551.00
90_T158_M1.6441.00
92_A155_T1.6391.00
170_D174_R1.5901.00
96_Y155_T1.5891.00
60_R244_L1.5731.00
15_Y19_T1.5491.00
139_Y223_R1.5441.00
167_R170_D1.5061.00
211_Y215_K1.5021.00
103_G106_K1.4781.00
154_N203_A1.4571.00
60_R63_D1.4361.00
100_R104_R1.4291.00
261_F265_K1.4251.00
66_L69_N1.4161.00
55_L59_K1.4061.00
97_S159_K1.3991.00
27_Y31_I1.3931.00
33_A250_I1.3911.00
77_I225_T1.3841.00
31_I35_S1.3811.00
162_F188_V1.3671.00
87_T91_L1.3621.00
189_L196_L1.3591.00
198_V202_W1.3581.00
224_L229_G1.3481.00
93_G158_M1.3391.00
85_Q203_A1.3241.00
158_M199_Q1.3011.00
167_R171_E1.2921.00
98_R167_R1.2791.00
54_T57_H1.2781.00
94_Y162_F1.2571.00
210_D213_L1.2491.00
90_T196_L1.2361.00
168_E171_E1.2361.00
173_A187_I1.2271.00
130_A141_F1.2181.00
106_K109_I1.2141.00
165_V191_L1.2051.00
211_Y231_Q1.1951.00
83_V87_T1.1901.00
80_S83_V1.1771.00
42_S52_S1.1731.00
86_V196_L1.1681.00
220_S223_R1.1641.00
193_K197_A1.1591.00
19_T23_I1.1521.00
32_T250_I1.1511.00
73_N76_V1.1461.00
9_L13_C1.1421.00
12_I16_L1.1331.00
179_G183_I1.1291.00
10_N14_T1.1261.00
229_G232_S1.0971.00
151_I155_T1.0931.00
106_K110_F1.0861.00
60_R64_E1.0861.00
12_I15_Y1.0731.00
142_L214_T1.0701.00
158_M195_M1.0671.00
232_S236_N1.0671.00
233_F241_K1.0631.00
224_L228_V1.0601.00
225_T228_V1.0591.00
39_V42_S1.0551.00
128_V132_L1.0531.00
170_D180_H1.0491.00
80_S84_L1.0391.00
143_T147_I1.0361.00
84_L143_T1.0311.00
210_D214_T1.0311.00
9_L12_I1.0311.00
256_I260_F1.0281.00
157_L199_Q1.0281.00
81_V85_Q1.0241.00
94_Y180_H1.0221.00
81_V146_Y1.0201.00
191_L194_P1.0151.00
139_Y143_T1.0141.00
94_Y184_F1.0051.00
97_S162_F1.0041.00
140_W144_A1.0021.00
91_L95_S1.0011.00
62_F68_L0.9961.00
31_I34_S0.9951.00
58_F250_I0.9861.00
138_Q223_R0.9791.00
178_A183_I0.9791.00
75_L79_L0.9741.00
262_F266_N0.9691.00
183_I186_S0.9661.00
104_R163_D0.9551.00
74_T226_I0.9411.00
14_T18_L0.9381.00
11_K15_Y0.9361.00
233_F239_Q0.9331.00
83_V200_A0.9281.00
81_V143_T0.9261.00
76_V79_L0.9231.00
135_A140_W0.9131.00
105_K108_L0.9091.00
93_G97_S0.9071.00
79_L83_V0.9021.00
146_Y207_P0.9021.00
76_V140_W0.8991.00
161_Y192_V0.8981.00
40_G44_A0.8921.00
73_N139_Y0.8881.00
214_T225_T0.8871.00
41_N44_A0.8841.00
22_S26_I0.8761.00
192_V195_M0.8711.00
77_I139_Y0.8701.00
85_Q89_V0.8621.00
102_A105_K0.8611.00
184_F189_L0.8561.00
38_R42_S0.8551.00
126_F145_I0.8541.00
89_V155_T0.8491.00
67_Y248_G0.8481.00
95_S101_F0.8481.00
84_L87_T0.8461.00
71_Y75_L0.8461.00
193_K196_L0.8431.00
145_I213_L0.8421.00
185_A189_L0.8421.00
112_L156_W0.8411.00
158_M192_V0.8411.00
96_Y108_L0.8391.00
119_T149_G0.8391.00
35_S38_R0.8371.00
71_Y226_I0.8371.00
183_I188_V0.8361.00
154_N158_M0.8351.00
231_Q235_S0.8331.00
127_Y131_M0.8291.00
215_K228_V0.8251.00
35_S246_A0.8241.00
232_S235_S0.8231.00
229_G248_G0.8221.00
57_H243_A0.8201.00
258_V262_F0.8111.00
72_S75_L0.8091.00
93_G155_T0.8081.00
234_I245_F0.8071.00
203_A207_P0.8011.00
61_L251_L0.7941.00
252_A256_I0.7861.00
85_Q154_N0.7821.00
93_G162_F0.7801.00
77_I146_Y0.7791.00
180_H184_F0.7791.00
37_F53_W0.7751.00
193_K266_N0.7721.00
49_F52_S0.7701.00
169_I187_I0.7631.00
178_A186_S0.7621.00
140_W143_T0.7591.00
138_Q141_F0.7581.00
70_W73_N0.7561.00
80_S147_I0.7531.00
137_D220_S0.7481.00
85_Q150_G0.7481.00
62_F65_T0.7471.00
233_F248_G0.7421.00
27_Y30_L0.7371.00
123_L216_F0.7371.00
228_V232_S0.7361.00
82_M204_F0.7351.00
36_A40_G0.7331.00
39_V52_S0.7311.00
32_T246_A0.7251.00
244_L248_G0.7241.00
131_M136_L0.7221.00
263_L266_N0.7211.00
141_F145_I0.7181.00
112_L115_Q0.7171.00
196_L199_Q0.7161.00
37_F54_T0.7131.00
85_Q207_P0.7121.00
165_V192_V0.7111.00
184_F188_V0.7071.00
78_A82_M0.7041.00
158_M162_F0.7031.00
86_V158_M0.7011.00
96_Y159_K0.7011.00
96_Y107_S0.6991.00
123_L212_L0.6981.00
119_T212_L0.6951.00
133_I136_L0.6951.00
60_R241_K0.6941.00
221_P224_L0.6941.00
246_A250_I0.6921.00
59_K62_F0.6921.00
172_A176_D0.6901.00
167_R174_R0.6891.00
218_L223_R0.6871.00
16_L19_T0.6861.00
188_V191_L0.6861.00
150_G203_A0.6791.00
89_V158_M0.6791.00
57_H60_R0.6791.00
150_G206_A0.6781.00
21_L25_I0.6751.00
13_C16_L0.6751.00
38_R50_S0.6731.00
13_C17_F0.6711.00
122_A148_G0.6651.00
32_T249_A0.6651.00
77_I143_T0.6651.00
262_F265_K0.6631.00
260_F264_Q0.6601.00
74_T227_A0.6591.00
77_I142_L0.6581.00
172_A175_I0.6571.00
68_L71_Y0.6551.00
242_V245_F0.6551.00
233_F244_L0.6541.00
196_L200_A0.6521.00
18_L22_S0.6511.00
64_E68_L0.6481.00
53_W56_D0.6471.00
92_A151_I0.6451.00
22_S25_I0.6431.00
61_L244_L0.6401.00
82_M86_V0.6401.00
101_F107_S0.6371.00
95_S99_Y0.6371.00
195_M199_Q0.6361.00
39_V51_G0.6361.00
50_S53_W0.6341.00
128_V131_M0.6341.00
88_I147_I0.6321.00
92_A111_F0.6291.00
102_A106_K0.6261.00
126_F129_L0.6251.00
246_A249_A0.6231.00
17_F21_L0.6231.00
142_L146_Y0.6221.00
257_C261_F0.6201.00
228_V231_Q0.6201.00
233_F236_N0.6161.00
61_L248_G0.6141.00
243_A246_A0.6121.00
157_L195_M0.6111.00
42_S51_G0.6091.00
111_F152_P0.6061.00
212_L215_K0.6051.00
218_L221_P0.6041.00
108_L156_W0.6021.00
229_G234_I0.6001.00
85_Q147_I0.6001.00
35_S39_V0.6001.00
226_I252_A0.5981.00
103_G107_S0.5951.00
74_T208_F0.5941.00
206_A209_G0.5941.00
185_A188_V0.5911.00
100_R105_K0.5881.00
65_T69_N0.5871.00
55_L58_F0.5801.00
78_A207_P0.5791.00
58_F247_A0.5771.00
244_L247_A0.5771.00
23_I27_Y0.5741.00
119_T123_L0.5731.00
86_V90_T0.5711.00
109_I113_I0.5701.00
210_D225_T0.5691.00
52_S56_D0.5691.00
93_G159_K0.5671.00
26_I30_L0.5641.00
230_L248_G0.5621.00
183_I187_I0.5611.00
38_R52_S0.5611.00
15_Y18_L0.5601.00
73_N223_R0.5601.00
236_N239_Q0.5581.00
36_A247_A0.5571.00
94_Y188_V0.5561.00
65_T68_L0.5561.00
66_L229_G0.5541.00
77_I81_V0.5541.00
120_M216_F0.5511.00
115_Q152_P0.5511.00
105_K109_I0.5511.00
88_I151_I0.5511.00
200_A203_A0.5501.00
11_K14_T0.5471.00
81_V147_I0.5471.00
114_I152_P0.5461.00
197_A200_A0.5441.00
258_V261_F0.5431.00
115_Q153_M0.5421.00
100_R167_R0.5411.00
240_Q244_L0.5401.00
52_S55_L0.5391.00
99_Y180_H0.5371.00
39_V43_A0.5351.00
207_P210_D0.5351.00
78_A208_F0.5351.00
205_M209_G0.5341.00
42_S45_F0.5341.00
179_G185_A0.5331.00
54_T58_F0.5321.00
227_A230_L0.5301.00
92_A95_S0.5291.00
211_Y214_T0.5271.00
110_F114_I0.5251.00
123_L127_Y0.5251.00
129_L136_L0.5231.00
146_Y214_T0.5221.00
130_A136_L0.5221.00
72_S139_Y0.5151.00
249_A252_A0.5131.00
212_L216_F0.5131.00
49_F53_W0.5111.00
36_A250_I0.5111.00
165_V170_D0.5101.00
89_V151_I0.5101.00
107_S111_F0.5081.00
108_L163_D0.5081.00
69_N76_V0.5081.00
90_T189_L0.5071.00
82_M87_T0.5071.00
40_G50_S0.5071.00
242_V246_A0.5071.00
146_Y210_D0.5071.00
82_M207_P0.5051.00
45_F49_F0.5041.00
38_R51_G0.5011.00
171_E174_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfG 1 0.9604 100 0.233 Contact Map
4tquN 1 0.9532 100 0.245 Contact Map
2onkC 2 0.8705 100 0.297 Contact Map
4tquM 1 0.9173 100 0.313 Contact Map
3d31C 2 0.8525 100 0.318 Contact Map
3rlfF 1 0.9245 100 0.37 Contact Map
4ymuD 2 0.7662 99.9 0.476 Contact Map
3tuiA 2 0.7482 99.9 0.518 Contact Map
3hd7A 1 0.1259 10.2 0.947 Contact Map
3mktA 1 0.554 8.9 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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