MDXG - BACSU - GREMLIN Contacts

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MDXG - Maltodextrin transport system permease protein MdxG

UniProt:	O06991	Sequences: MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAAFQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFAGRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKGYFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLLRSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGTKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	278 (253)
Sequences:	68429 (45146)
Seq/√Len:	2838.3

ECOLI - YCJP MALG UGPE POTH UGPA YCJO POTI YDCV YDCU PSTA PSTC POTC POTB THIP CYST MALF YNJC CYSW MODB PHNE TAUC SSUC YEHY YEHW METI PROW YECS GLNP
BACSU - MDXG GANQ ARAQ AMYC YESQ YURM LPLC YTCP GANP ARAP AMYD MDXF YTEP LPLB YQGI YURN YQGH YESP YVGM YTLD SSUC OPUAB TCYB METP TCYL YXEN OPUCB OPUBB OPUCD OPUBD ARTQ
HALSA - Q9HML6 Q9HHQ6 Q9HMT4 Q9HP02 Q9HP01 Q9HHQ7 Q9HS11 Q9HPK3 Q9HR05 Q9HNI9 Q9HS12
SULSO - Q97UY9 Q97UF3 Q97ZC1 Q97YY3 Q97YY2 Q97VC0 Q97UZ0 Q97ZT7 Q97ZT6 Q97UF4 Q97ZC2 Q97Z98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
182_R	186_S	4.070	1.00
72_S	76_V	3.258	1.00
174_R	183_I	3.144	1.00
159_K	163_D	3.067	1.00
36_A	58_F	2.685	1.00
69_N	72_S	2.676	1.00
80_S	143_T	2.600	1.00
70_W	229_G	2.599	1.00
98_R	170_D	2.587	1.00
179_G	182_R	2.558	1.00
173_A	183_I	2.558	1.00
161_Y	195_M	2.530	1.00
170_D	188_V	2.493	1.00
84_L	147_I	2.489	1.00
224_L	232_S	2.430	1.00
59_K	63_D	2.427	1.00
68_L	72_S	2.415	1.00
56_D	59_K	2.348	1.00
82_M	200_A	2.335	1.00
180_H	183_I	2.314	1.00
158_M	196_L	2.268	1.00
181_L	185_A	2.237	1.00
56_D	60_R	2.195	1.00
241_K	244_L	2.167	1.00
101_F	104_R	2.131	1.00
178_A	182_R	2.063	1.00
182_R	185_A	2.058	1.00
90_T	184_F	2.020	1.00
154_N	199_Q	1.995	1.00
162_F	192_V	1.957	1.00
169_I	191_L	1.956	1.00
76_V	139_Y	1.954	1.00
97_S	163_D	1.951	1.00
30_L	34_S	1.908	1.00
173_A	178_A	1.897	1.00
108_L	159_K	1.852	1.00
34_S	38_R	1.851	1.00
90_T	192_V	1.841	1.00
86_V	200_A	1.826	1.00
69_N	73_N	1.772	1.00
229_G	233_F	1.744	1.00
174_R	180_H	1.731	1.00
170_D	183_I	1.713	1.00
78_A	204_F	1.700	1.00
89_V	154_N	1.692	1.00
76_V	80_S	1.675	1.00
81_V	207_P	1.655	1.00
90_T	158_M	1.644	1.00
92_A	155_T	1.639	1.00
170_D	174_R	1.590	1.00
96_Y	155_T	1.589	1.00
60_R	244_L	1.573	1.00
15_Y	19_T	1.549	1.00
139_Y	223_R	1.544	1.00
167_R	170_D	1.506	1.00
211_Y	215_K	1.502	1.00
103_G	106_K	1.478	1.00
154_N	203_A	1.457	1.00
60_R	63_D	1.436	1.00
100_R	104_R	1.429	1.00
261_F	265_K	1.425	1.00
66_L	69_N	1.416	1.00
55_L	59_K	1.406	1.00
97_S	159_K	1.399	1.00
27_Y	31_I	1.393	1.00
33_A	250_I	1.391	1.00
77_I	225_T	1.384	1.00
31_I	35_S	1.381	1.00
162_F	188_V	1.367	1.00
87_T	91_L	1.362	1.00
189_L	196_L	1.359	1.00
198_V	202_W	1.358	1.00
224_L	229_G	1.348	1.00
93_G	158_M	1.339	1.00
85_Q	203_A	1.324	1.00
158_M	199_Q	1.301	1.00
167_R	171_E	1.292	1.00
98_R	167_R	1.279	1.00
54_T	57_H	1.278	1.00
94_Y	162_F	1.257	1.00
210_D	213_L	1.249	1.00
90_T	196_L	1.236	1.00
168_E	171_E	1.236	1.00
173_A	187_I	1.227	1.00
130_A	141_F	1.218	1.00
106_K	109_I	1.214	1.00
165_V	191_L	1.205	1.00
211_Y	231_Q	1.195	1.00
83_V	87_T	1.190	1.00
80_S	83_V	1.177	1.00
42_S	52_S	1.173	1.00
86_V	196_L	1.168	1.00
220_S	223_R	1.164	1.00
193_K	197_A	1.159	1.00
19_T	23_I	1.152	1.00
32_T	250_I	1.151	1.00
73_N	76_V	1.146	1.00
9_L	13_C	1.142	1.00
12_I	16_L	1.133	1.00
179_G	183_I	1.129	1.00
10_N	14_T	1.126	1.00
229_G	232_S	1.097	1.00
151_I	155_T	1.093	1.00
106_K	110_F	1.086	1.00
60_R	64_E	1.086	1.00
12_I	15_Y	1.073	1.00
142_L	214_T	1.070	1.00
158_M	195_M	1.067	1.00
232_S	236_N	1.067	1.00
233_F	241_K	1.063	1.00
224_L	228_V	1.060	1.00
225_T	228_V	1.059	1.00
39_V	42_S	1.055	1.00
128_V	132_L	1.053	1.00
170_D	180_H	1.049	1.00
80_S	84_L	1.039	1.00
143_T	147_I	1.036	1.00
84_L	143_T	1.031	1.00
210_D	214_T	1.031	1.00
9_L	12_I	1.031	1.00
256_I	260_F	1.028	1.00
157_L	199_Q	1.028	1.00
81_V	85_Q	1.024	1.00
94_Y	180_H	1.022	1.00
81_V	146_Y	1.020	1.00
191_L	194_P	1.015	1.00
139_Y	143_T	1.014	1.00
94_Y	184_F	1.005	1.00
97_S	162_F	1.004	1.00
140_W	144_A	1.002	1.00
91_L	95_S	1.001	1.00
62_F	68_L	0.996	1.00
31_I	34_S	0.995	1.00
58_F	250_I	0.986	1.00
138_Q	223_R	0.979	1.00
178_A	183_I	0.979	1.00
75_L	79_L	0.974	1.00
262_F	266_N	0.969	1.00
183_I	186_S	0.966	1.00
104_R	163_D	0.955	1.00
74_T	226_I	0.941	1.00
14_T	18_L	0.938	1.00
11_K	15_Y	0.936	1.00
233_F	239_Q	0.933	1.00
83_V	200_A	0.928	1.00
81_V	143_T	0.926	1.00
76_V	79_L	0.923	1.00
135_A	140_W	0.913	1.00
105_K	108_L	0.909	1.00
93_G	97_S	0.907	1.00
79_L	83_V	0.902	1.00
146_Y	207_P	0.902	1.00
76_V	140_W	0.899	1.00
161_Y	192_V	0.898	1.00
40_G	44_A	0.892	1.00
73_N	139_Y	0.888	1.00
214_T	225_T	0.887	1.00
41_N	44_A	0.884	1.00
22_S	26_I	0.876	1.00
192_V	195_M	0.871	1.00
77_I	139_Y	0.870	1.00
85_Q	89_V	0.862	1.00
102_A	105_K	0.861	1.00
184_F	189_L	0.856	1.00
38_R	42_S	0.855	1.00
126_F	145_I	0.854	1.00
89_V	155_T	0.849	1.00
67_Y	248_G	0.848	1.00
95_S	101_F	0.848	1.00
84_L	87_T	0.846	1.00
71_Y	75_L	0.846	1.00
193_K	196_L	0.843	1.00
145_I	213_L	0.842	1.00
185_A	189_L	0.842	1.00
112_L	156_W	0.841	1.00
158_M	192_V	0.841	1.00
96_Y	108_L	0.839	1.00
119_T	149_G	0.839	1.00
35_S	38_R	0.837	1.00
71_Y	226_I	0.837	1.00
183_I	188_V	0.836	1.00
154_N	158_M	0.835	1.00
231_Q	235_S	0.833	1.00
127_Y	131_M	0.829	1.00
215_K	228_V	0.825	1.00
35_S	246_A	0.824	1.00
232_S	235_S	0.823	1.00
229_G	248_G	0.822	1.00
57_H	243_A	0.820	1.00
258_V	262_F	0.811	1.00
72_S	75_L	0.809	1.00
93_G	155_T	0.808	1.00
234_I	245_F	0.807	1.00
203_A	207_P	0.801	1.00
61_L	251_L	0.794	1.00
252_A	256_I	0.786	1.00
85_Q	154_N	0.782	1.00
93_G	162_F	0.780	1.00
77_I	146_Y	0.779	1.00
180_H	184_F	0.779	1.00
37_F	53_W	0.775	1.00
193_K	266_N	0.772	1.00
49_F	52_S	0.770	1.00
169_I	187_I	0.763	1.00
178_A	186_S	0.762	1.00
140_W	143_T	0.759	1.00
138_Q	141_F	0.758	1.00
70_W	73_N	0.756	1.00
80_S	147_I	0.753	1.00
137_D	220_S	0.748	1.00
85_Q	150_G	0.748	1.00
62_F	65_T	0.747	1.00
233_F	248_G	0.742	1.00
27_Y	30_L	0.737	1.00
123_L	216_F	0.737	1.00
228_V	232_S	0.736	1.00
82_M	204_F	0.735	1.00
36_A	40_G	0.733	1.00
39_V	52_S	0.731	1.00
32_T	246_A	0.725	1.00
244_L	248_G	0.724	1.00
131_M	136_L	0.722	1.00
263_L	266_N	0.721	1.00
141_F	145_I	0.718	1.00
112_L	115_Q	0.717	1.00
196_L	199_Q	0.716	1.00
37_F	54_T	0.713	1.00
85_Q	207_P	0.712	1.00
165_V	192_V	0.711	1.00
184_F	188_V	0.707	1.00
78_A	82_M	0.704	1.00
158_M	162_F	0.703	1.00
86_V	158_M	0.701	1.00
96_Y	159_K	0.701	1.00
96_Y	107_S	0.699	1.00
123_L	212_L	0.698	1.00
119_T	212_L	0.695	1.00
133_I	136_L	0.695	1.00
60_R	241_K	0.694	1.00
221_P	224_L	0.694	1.00
246_A	250_I	0.692	1.00
59_K	62_F	0.692	1.00
172_A	176_D	0.690	1.00
167_R	174_R	0.689	1.00
218_L	223_R	0.687	1.00
16_L	19_T	0.686	1.00
188_V	191_L	0.686	1.00
150_G	203_A	0.679	1.00
89_V	158_M	0.679	1.00
57_H	60_R	0.679	1.00
150_G	206_A	0.678	1.00
21_L	25_I	0.675	1.00
13_C	16_L	0.675	1.00
38_R	50_S	0.673	1.00
13_C	17_F	0.671	1.00
122_A	148_G	0.665	1.00
32_T	249_A	0.665	1.00
77_I	143_T	0.665	1.00
262_F	265_K	0.663	1.00
260_F	264_Q	0.660	1.00
74_T	227_A	0.659	1.00
77_I	142_L	0.658	1.00
172_A	175_I	0.657	1.00
68_L	71_Y	0.655	1.00
242_V	245_F	0.655	1.00
233_F	244_L	0.654	1.00
196_L	200_A	0.652	1.00
18_L	22_S	0.651	1.00
64_E	68_L	0.648	1.00
53_W	56_D	0.647	1.00
92_A	151_I	0.645	1.00
22_S	25_I	0.643	1.00
61_L	244_L	0.640	1.00
82_M	86_V	0.640	1.00
101_F	107_S	0.637	1.00
95_S	99_Y	0.637	1.00
195_M	199_Q	0.636	1.00
39_V	51_G	0.636	1.00
50_S	53_W	0.634	1.00
128_V	131_M	0.634	1.00
88_I	147_I	0.632	1.00
92_A	111_F	0.629	1.00
102_A	106_K	0.626	1.00
126_F	129_L	0.625	1.00
246_A	249_A	0.623	1.00
17_F	21_L	0.623	1.00
142_L	146_Y	0.622	1.00
257_C	261_F	0.620	1.00
228_V	231_Q	0.620	1.00
233_F	236_N	0.616	1.00
61_L	248_G	0.614	1.00
243_A	246_A	0.612	1.00
157_L	195_M	0.611	1.00
42_S	51_G	0.609	1.00
111_F	152_P	0.606	1.00
212_L	215_K	0.605	1.00
218_L	221_P	0.604	1.00
108_L	156_W	0.602	1.00
229_G	234_I	0.600	1.00
85_Q	147_I	0.600	1.00
35_S	39_V	0.600	1.00
226_I	252_A	0.598	1.00
103_G	107_S	0.595	1.00
74_T	208_F	0.594	1.00
206_A	209_G	0.594	1.00
185_A	188_V	0.591	1.00
100_R	105_K	0.588	1.00
65_T	69_N	0.587	1.00
55_L	58_F	0.580	1.00
78_A	207_P	0.579	1.00
58_F	247_A	0.577	1.00
244_L	247_A	0.577	1.00
23_I	27_Y	0.574	1.00
119_T	123_L	0.573	1.00
86_V	90_T	0.571	1.00
109_I	113_I	0.570	1.00
210_D	225_T	0.569	1.00
52_S	56_D	0.569	1.00
93_G	159_K	0.567	1.00
26_I	30_L	0.564	1.00
230_L	248_G	0.562	1.00
183_I	187_I	0.561	1.00
38_R	52_S	0.561	1.00
15_Y	18_L	0.560	1.00
73_N	223_R	0.560	1.00
236_N	239_Q	0.558	1.00
36_A	247_A	0.557	1.00
94_Y	188_V	0.556	1.00
65_T	68_L	0.556	1.00
66_L	229_G	0.554	1.00
77_I	81_V	0.554	1.00
120_M	216_F	0.551	1.00
115_Q	152_P	0.551	1.00
105_K	109_I	0.551	1.00
88_I	151_I	0.551	1.00
200_A	203_A	0.550	1.00
11_K	14_T	0.547	1.00
81_V	147_I	0.547	1.00
114_I	152_P	0.546	1.00
197_A	200_A	0.544	1.00
258_V	261_F	0.543	1.00
115_Q	153_M	0.542	1.00
100_R	167_R	0.541	1.00
240_Q	244_L	0.540	1.00
52_S	55_L	0.539	1.00
99_Y	180_H	0.537	1.00
39_V	43_A	0.535	1.00
207_P	210_D	0.535	1.00
78_A	208_F	0.535	1.00
205_M	209_G	0.534	1.00
42_S	45_F	0.534	1.00
179_G	185_A	0.533	1.00
54_T	58_F	0.532	1.00
227_A	230_L	0.530	1.00
92_A	95_S	0.529	1.00
211_Y	214_T	0.527	1.00
110_F	114_I	0.525	1.00
123_L	127_Y	0.525	1.00
129_L	136_L	0.523	1.00
146_Y	214_T	0.522	1.00
130_A	136_L	0.522	1.00
72_S	139_Y	0.515	1.00
249_A	252_A	0.513	1.00
212_L	216_F	0.513	1.00
49_F	53_W	0.511	1.00
36_A	250_I	0.511	1.00
165_V	170_D	0.510	1.00
89_V	151_I	0.510	1.00
107_S	111_F	0.508	1.00
108_L	163_D	0.508	1.00
69_N	76_V	0.508	1.00
90_T	189_L	0.507	1.00
82_M	87_T	0.507	1.00
40_G	50_S	0.507	1.00
242_V	246_A	0.507	1.00
146_Y	210_D	0.507	1.00
82_M	207_P	0.505	1.00
45_F	49_F	0.504	1.00
38_R	51_G	0.501	1.00
171_E	174_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rlfG	1	0.9604	100	0.233	Contact Map
4tquN	1	0.9532	100	0.245	Contact Map
2onkC	2	0.8705	100	0.297	Contact Map
4tquM	1	0.9173	100	0.313	Contact Map
3d31C	2	0.8525	100	0.318	Contact Map
3rlfF	1	0.9245	100	0.37	Contact Map
4ymuD	2	0.7662	99.9	0.476	Contact Map
3tuiA	2	0.7482	99.9	0.518	Contact Map
3hd7A	1	0.1259	10.2	0.947	Contact Map
3mktA	1	0.554	8.9	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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