GREMLIN Database
MDXF - Maltodextrin transport system permease protein MdxF
UniProt: O06990 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 435 (380)
Sequences: 1087 (745)
Seq/√Len: 38.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_G178_F4.5791.00
175_F178_F4.5241.00
206_T355_Y4.1061.00
273_P276_E3.4211.00
174_G177_N3.3661.00
121_C125_D3.3581.00
259_G262_N3.3171.00
172_W175_F3.3101.00
172_W178_F3.2821.00
340_F344_L3.2571.00
171_D178_F3.1381.00
181_I185_G3.0671.00
179_L183_F2.9981.00
121_C126_K2.8831.00
210_I351_M2.8571.00
171_D175_F2.7521.00
63_G66_P2.7401.00
173_V177_N2.7271.00
171_D174_G2.6831.00
179_L185_G2.6681.00
120_I125_D2.5911.00
180_N183_F2.5841.00
119_M122_H2.4551.00
182_F185_G2.4551.00
180_N185_G2.4251.00
183_F186_S2.3631.00
122_H126_K2.3531.00
122_H125_D2.3261.00
155_A178_F2.3221.00
121_C124_G2.2691.00
45_A49_C2.2560.99
170_I174_G2.2080.99
180_N186_S2.2040.99
171_D177_N2.1370.99
181_I184_L2.0970.99
181_I186_S2.0920.99
262_N265_V2.0840.99
53_I57_T2.0820.99
179_L182_F2.0680.99
325_K334_R2.0590.99
120_I124_G2.0570.99
371_G383_T2.0370.99
180_N184_L2.0030.99
221_N314_Q1.9900.99
172_W176_K1.9790.99
173_V178_F1.9680.99
55_A58_G1.9630.99
103_A107_A1.9460.98
56_L60_M1.9290.98
170_I177_N1.9160.98
199_V203_I1.8840.98
172_W177_N1.8810.98
179_L186_S1.8690.98
42_G46_F1.8680.98
44_F48_L1.7890.97
120_I126_K1.7860.97
55_A62_L1.7800.97
51_F54_Q1.7590.97
398_S401_Y1.7550.97
62_L66_P1.7530.97
170_I178_F1.7380.97
163_H170_I1.7270.97
170_I175_F1.7260.97
54_Q57_T1.7160.96
58_G61_T1.7120.96
51_F58_G1.6700.96
286_P382_S1.6590.96
191_F195_L1.6490.96
214_I343_I1.6490.96
176_K180_N1.6470.96
119_M125_D1.6290.95
51_F55_A1.5810.94
58_G65_V1.5770.94
52_G56_L1.5710.94
56_L59_L1.5670.94
160_D163_H1.5650.94
118_D122_H1.5400.94
46_F51_F1.5310.93
171_D176_K1.5250.93
57_T64_S1.5230.93
44_F51_F1.5170.93
64_S67_G1.5010.93
179_L184_L1.4900.92
208_L298_T1.4880.92
119_M133_T1.4760.92
118_D123_A1.4630.92
258_I262_N1.4620.92
175_F179_L1.4380.91
287_F290_K1.4310.91
155_A409_L1.4280.91
210_I347_T1.4220.91
125_D136_A1.4220.91
58_G62_L1.4200.90
55_A60_M1.4180.90
118_D121_C1.4160.90
57_T74_M1.4110.90
332_I336_R1.4030.90
251_S288_W1.3980.90
125_D135_P1.3880.89
45_A52_G1.3840.89
182_F393_L1.3820.89
57_T61_T1.3610.88
169_L173_V1.3530.88
288_W291_T1.3410.88
158_N171_D1.3400.88
51_F64_S1.3340.87
48_L51_F1.3330.87
286_P290_K1.3310.87
227_G230_I1.3250.87
39_A42_G1.3230.87
58_G64_S1.3190.87
53_I56_L1.3130.87
371_G392_K1.3090.86
126_K129_P1.3010.86
106_K109_G1.3000.86
132_F136_A1.2860.85
57_T62_L1.2840.85
116_A125_D1.2810.85
410_L425_K1.2760.85
174_G180_N1.2690.85
330_T333_Q1.2650.85
308_M314_Q1.2610.84
281_A284_T1.2480.84
52_G57_T1.2470.84
344_L347_T1.2430.83
43_L51_F1.2420.83
63_G67_G1.2350.83
182_F186_S1.2220.82
119_M124_G1.1960.81
49_C52_G1.1940.81
48_L53_I1.1880.81
133_T136_A1.1870.80
202_T231_F1.1810.80
175_F180_N1.1810.80
349_P352_I1.1800.80
38_L41_T1.1780.80
174_G181_I1.1760.80
58_G63_G1.1740.80
52_G59_L1.1730.80
117_K121_C1.1710.80
54_Q59_L1.1670.79
265_V276_E1.1620.79
92_Y95_N1.1580.79
123_A126_K1.1500.78
121_C135_P1.1490.78
54_Q58_G1.1410.78
52_G55_A1.1350.77
324_A334_R1.1280.77
353_T356_T1.1240.77
59_L63_G1.1200.76
43_L46_F1.1100.76
313_L318_G1.1000.75
426_S431_N1.0950.75
313_L339_T1.0940.75
119_M126_K1.0910.75
59_L62_L1.0900.74
170_I173_V1.0900.74
227_G231_F1.0890.74
122_H133_T1.0860.74
223_D318_G1.0760.73
83_I149_L1.0750.73
89_L93_I1.0740.73
56_L85_T1.0660.73
204_C208_L1.0630.73
117_K126_K1.0610.72
408_T412_S1.0610.72
43_L114_T1.0560.72
57_T65_V1.0490.72
325_K331_F1.0480.71
324_A329_A1.0390.71
259_G263_A1.0380.71
47_E51_F1.0380.71
241_V327_D1.0350.71
320_L342_M1.0250.70
173_V176_K1.0240.70
51_F63_G1.0180.69
48_L52_G1.0160.69
169_L172_W1.0110.69
149_L153_F1.0100.69
82_L86_M1.0060.68
177_N181_I1.0060.68
79_T93_I1.0050.68
105_M110_L1.0040.68
51_F57_T1.0020.68
88_F92_Y1.0000.68
119_M123_A0.9910.67
389_W393_L0.9900.67
200_I290_K0.9890.67
103_A106_K0.9810.66
233_M396_G0.9760.66
49_C53_I0.9730.66
55_A59_L0.9730.66
363_S367_L0.9670.65
44_F52_G0.9660.65
62_L67_G0.9600.65
59_L66_P0.9590.65
117_K122_H0.9540.64
224_F227_G0.9500.64
46_F50_V0.9490.64
178_F181_I0.9480.64
83_I86_M0.9450.63
169_L175_F0.9430.63
115_T126_K0.9410.63
121_C127_G0.9350.63
57_T63_G0.9340.62
169_L174_G0.9320.62
148_V420_L0.9290.62
118_D125_D0.9230.62
52_G63_G0.9210.61
260_A263_A0.9170.61
249_S419_S0.9160.61
118_D135_P0.9150.61
47_E54_Q0.9150.61
40_I54_Q0.9120.61
202_T210_I0.9100.60
172_W180_N0.9090.60
300_L357_F0.9070.60
314_Q318_G0.8990.59
304_Y357_F0.8850.58
128_F133_T0.8810.58
44_F63_G0.8750.57
383_T393_L0.8680.57
126_K130_Y0.8650.57
64_S68_E0.8610.56
169_L178_F0.8580.56
119_M127_G0.8540.56
316_I338_I0.8530.55
49_C65_V0.8520.55
102_T107_A0.8510.55
297_Q412_S0.8510.55
113_N203_I0.8470.55
50_V58_G0.8470.55
200_I383_T0.8450.55
417_G421_I0.8440.55
129_P135_P0.8430.55
61_T64_S0.8430.55
141_V322_E0.8400.54
109_G112_V0.8400.54
230_I234_I0.8380.54
206_T326_I0.8370.54
70_H202_T0.8360.54
157_T386_L0.8360.54
55_A63_G0.8340.54
50_V54_Q0.8310.54
243_A359_F0.8310.54
118_D126_K0.8290.53
297_Q368_F0.8280.53
51_F62_L0.8270.53
44_F49_C0.8270.53
287_F291_T0.8250.53
102_T112_V0.8250.53
214_I350_V0.8250.53
75_L79_T0.8240.53
50_V340_F0.8220.53
89_L94_F0.8220.53
349_P403_V0.8190.52
226_K229_R0.8180.52
344_L422_A0.8180.52
45_A413_F0.8160.52
48_L63_G0.8150.52
239_W304_Y0.8150.52
44_F88_F0.8130.52
91_F112_V0.8050.51
45_A97_H0.8010.51
71_S81_Q0.8010.51
130_Y135_P0.8000.51
410_L414_I0.7990.51
63_G68_E0.7990.51
44_F85_T0.7980.51
389_W392_K0.7980.51
373_P381_G0.7950.50
65_V68_E0.7940.50
242_P303_P0.7930.50
122_H127_G0.7920.50
255_N292_A0.7880.50
156_L160_D0.7850.49
292_A368_F0.7840.49
146_F406_A0.7840.49
177_N191_F0.7820.49
114_T226_K0.7800.49
359_F418_I0.7780.49
414_I421_I0.7770.49
214_I309_V0.7760.49
57_T60_M0.7720.48
51_F59_L0.7710.48
318_G325_K0.7700.48
45_A48_L0.7700.48
132_F135_P0.7680.48
176_K179_L0.7680.48
56_L63_G0.7670.48
116_A119_M0.7670.48
127_G130_Y0.7660.48
154_V418_I0.7630.47
204_C291_T0.7630.47
116_A121_C0.7580.47
305_I354_Q0.7570.47
50_V64_S0.7570.47
153_F374_G0.7560.47
221_N318_G0.7540.47
205_A242_P0.7530.47
200_I371_G0.7480.46
72_L386_L0.7480.46
81_Q89_L0.7480.46
43_L54_Q0.7480.46
48_L54_Q0.7470.46
111_E114_T0.7440.46
214_I340_F0.7430.46
373_P384_D0.7420.46
107_A110_L0.7410.45
202_T355_Y0.7370.45
255_N258_I0.7360.45
285_D290_K0.7330.45
292_A393_L0.7320.45
116_A122_H0.7320.45
169_L177_N0.7320.45
51_F56_L0.7310.45
194_V234_I0.7310.45
115_T121_C0.7210.44
76_I127_G0.7210.44
125_D133_T0.7180.43
214_I330_T0.7180.43
105_M108_A0.7170.43
302_F408_T0.7160.43
375_S382_S0.7120.43
359_F387_I0.7100.43
121_C129_P0.7090.43
304_Y307_V0.7090.43
95_N226_K0.7090.43
49_C58_G0.7080.43
293_L364_I0.7070.42
47_E58_G0.7070.42
39_A58_G0.7050.42
149_L224_F0.7000.42
62_L65_V0.7000.42
52_G58_G0.7000.42
333_Q407_V0.6970.42
204_C294_I0.6960.41
115_T125_D0.6960.41
49_C56_L0.6950.41
210_I343_I0.6940.41
48_L56_L0.6930.41
412_S416_I0.6930.41
80_L98_D0.6920.41
220_V409_L0.6910.41
46_F49_C0.6910.41
172_W181_I0.6890.41
272_L276_E0.6890.41
254_F265_V0.6860.41
41_T45_A0.6850.41
203_I207_T0.6850.41
414_I417_G0.6850.41
50_V53_I0.6840.40
359_F408_T0.6840.40
55_A64_S0.6830.40
97_H231_F0.6820.40
261_V388_S0.6820.40
118_D131_L0.6770.40
60_M64_S0.6770.40
155_A340_F0.6770.40
265_V275_V0.6770.40
297_Q306_Y0.6750.40
87_I142_F0.6750.40
85_T93_I0.6740.40
84_V88_F0.6720.39
272_L275_V0.6720.39
222_Q331_F0.6710.39
206_T382_S0.6700.39
302_F385_I0.6690.39
339_T420_L0.6690.39
171_D182_F0.6680.39
355_Y382_S0.6670.39
276_E282_W0.6660.39
225_I295_M0.6660.39
225_I229_R0.6660.39
55_A74_M0.6650.39
320_L350_V0.6640.39
120_I123_A0.6600.38
56_L340_F0.6600.38
250_F359_F0.6590.38
120_I135_P0.6580.38
236_L307_V0.6560.38
48_L57_T0.6560.38
202_T412_S0.6550.38
45_A51_F0.6520.38
197_W240_A0.6520.38
38_L145_I0.6500.38
281_A418_I0.6490.37
74_M78_G0.6490.37
399_P402_S0.6490.37
356_T415_V0.6480.37
273_P281_A0.6480.37
349_P355_Y0.6480.37
296_I369_N0.6460.37
60_M65_V0.6450.37
115_T119_M0.6410.37
156_L414_I0.6400.37
320_L351_M0.6350.36
45_A58_G0.6340.36
44_F47_E0.6340.36
149_L414_I0.6340.36
93_I138_I0.6330.36
226_K331_F0.6330.36
283_K369_N0.6320.36
213_G412_S0.6320.36
90_M176_K0.6290.36
247_I300_L0.6290.36
357_F364_I0.6260.36
127_G135_P0.6260.36
184_L187_Y0.6250.35
177_N351_M0.6240.35
157_T388_S0.6230.35
367_L389_W0.6220.35
124_G127_G0.6210.35
47_E52_G0.6210.35
138_I285_D0.6210.35
95_N149_L0.6210.35
395_T398_S0.6200.35
98_D130_Y0.6190.35
314_Q350_V0.6180.35
178_F366_Y0.6180.35
66_P264_Q0.6180.35
116_A120_I0.6160.35
71_S82_L0.6140.35
90_M332_I0.6140.35
121_C131_L0.6130.34
259_G265_V0.6130.34
45_A50_V0.6130.34
76_I207_T0.6100.34
290_K389_W0.6090.34
174_G179_L0.6070.34
198_T365_I0.6070.34
57_T66_P0.6050.34
80_L264_Q0.6040.34
41_T48_L0.6020.34
124_G136_A0.6010.34
74_M337_H0.5980.33
304_Y316_I0.5970.33
122_H136_A0.5930.33
273_P279_A0.5920.33
47_E50_V0.5920.33
289_T369_N0.5900.33
141_V344_L0.5860.32
265_V285_D0.5860.32
38_L42_G0.5850.32
400_Q403_V0.5840.32
305_I390_I0.5830.32
222_Q308_M0.5820.32
52_G65_V0.5820.32
323_A343_I0.5810.32
210_I355_Y0.5810.32
69_D99_S0.5800.32
385_I390_I0.5760.32
261_V265_V0.5750.31
49_C54_Q0.5740.31
244_F367_L0.5720.31
120_I132_F0.5720.31
115_T122_H0.5710.31
248_M368_F0.5700.31
76_I149_L0.5680.31
243_A300_L0.5670.31
265_V273_P0.5670.31
79_T100_R0.5650.31
275_V280_I0.5650.31
62_L71_S0.5650.31
352_I427_N0.5650.31
188_R383_T0.5650.31
393_L402_S0.5640.31
202_T428_A0.5640.31
122_H130_Y0.5630.31
61_T226_K0.5630.31
119_M135_P0.5630.31
371_G389_W0.5630.31
393_L403_V0.5630.31
122_H129_P0.5620.30
426_S430_G0.5610.30
43_L55_A0.5600.30
299_W327_D0.5590.30
92_Y226_K0.5580.30
310_T314_Q0.5580.30
138_I224_F0.5580.30
112_V229_R0.5570.30
43_L64_S0.5570.30
287_F312_V0.5570.30
367_L380_A0.5560.30
416_I419_S0.5550.30
47_E65_V0.5550.30
138_I142_F0.5530.30
200_I389_W0.5530.30
143_V239_W0.5520.30
54_Q62_L0.5520.30
177_N227_G0.5520.30
383_T392_K0.5510.30
43_L47_E0.5510.30
210_I424_K0.5500.30
255_N393_L0.5500.30
110_L113_N0.5470.29
43_L53_I0.5460.29
288_W292_A0.5460.29
99_S103_A0.5450.29
327_D339_T0.5450.29
293_L304_Y0.5450.29
383_T389_W0.5440.29
42_G45_A0.5430.29
43_L48_L0.5430.29
59_L65_V0.5430.29
91_F424_K0.5420.29
215_V319_E0.5410.29
328_G341_P0.5400.29
152_L156_L0.5400.29
320_L339_T0.5400.29
47_E55_A0.5400.29
260_A264_Q0.5390.29
371_G384_D0.5390.29
48_L88_F0.5390.29
142_F155_A0.5380.29
234_I324_A0.5380.29
60_M66_P0.5380.29
52_G61_T0.5370.29
388_S408_T0.5360.29
117_K124_G0.5360.29
58_G76_I0.5350.28
53_I203_I0.5350.28
74_M99_S0.5350.28
197_W242_P0.5340.28
316_I321_Y0.5320.28
148_V264_Q0.5320.28
321_Y339_T0.5320.28
182_F187_Y0.5320.28
117_K120_I0.5320.28
414_I418_I0.5310.28
298_T367_L0.5300.28
40_I87_I0.5290.28
296_I412_S0.5290.28
89_L101_K0.5280.28
288_W395_T0.5280.28
427_N431_N0.5270.28
193_N378_A0.5270.28
116_A126_K0.5260.28
41_T46_F0.5250.28
399_P403_V0.5240.28
53_I60_M0.5230.28
198_T317_P0.5230.28
236_L239_W0.5220.28
124_G135_P0.5210.27
51_F68_E0.5210.27
101_K104_A0.5200.27
248_M392_K0.5200.27
109_G230_I0.5190.27
107_A230_I0.5190.27
41_T52_G0.5180.27
112_V237_F0.5160.27
281_A287_F0.5160.27
309_V313_L0.5150.27
195_L244_F0.5140.27
248_M371_G0.5140.27
384_D389_W0.5120.27
91_F226_K0.5110.27
131_L413_F0.5110.27
421_I425_K0.5100.27
387_I408_T0.5100.27
85_T114_T0.5080.27
83_I424_K0.5070.26
276_E283_K0.5070.26
104_A107_A0.5050.26
326_I355_Y0.5050.26
175_F181_I0.5040.26
49_C60_M0.5010.26
91_F127_G0.5000.26
76_I245_I0.5000.26
53_I66_P0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.6483 100 0.608 Contact Map
3rlfF 1 0.8253 100 0.633 Contact Map
2onkC 2 0.5793 100 0.634 Contact Map
3d31C 2 0.5701 100 0.654 Contact Map
3rlfG 1 0.6322 100 0.658 Contact Map
4tquN 1 0.6161 100 0.668 Contact Map
4ymuD 2 0.4943 100 0.742 Contact Map
3tuiA 2 0.4805 100 0.746 Contact Map
3tx3A 2 0.469 7 0.977 Contact Map
2m20A 2 0.0874 6.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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