GREMLIN Database
MDXE - Maltodextrin-binding protein MdxE
UniProt: O06989 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (388)
Sequences: 30763 (24681)
Seq/√Len: 1253.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_V66_K3.5791.00
395_S398_T3.4331.00
109_L312_P3.3201.00
150_D279_N3.2581.00
223_V397_Q3.1701.00
230_E234_E3.0401.00
149_K281_G2.9241.00
110_D132_K2.8351.00
39_T66_K2.7851.00
37_V64_T2.6711.00
227_K231_K2.6511.00
163_E231_K2.6101.00
231_K235_T2.5851.00
61_N317_K2.5711.00
167_E235_T2.4911.00
149_K153_K2.4501.00
63_V314_L2.4261.00
147_Y281_G2.4211.00
51_E55_T2.4091.00
158_T161_D2.3821.00
397_Q401_N2.3211.00
74_E77_E2.3211.00
56_K59_K2.3191.00
317_K320_E2.2341.00
58_E64_T2.2251.00
164_K168_D2.2001.00
220_K224_E2.2001.00
401_N405_N2.1781.00
57_F317_K2.1531.00
128_T133_V2.1271.00
152_L262_A2.1201.00
324_N327_N2.1091.00
404_V408_K2.0721.00
112_K132_K2.0591.00
394_K402_D2.0171.00
311_E314_L2.0141.00
218_N401_N2.0071.00
56_K321_Y1.9881.00
309_T312_P1.9781.00
52_S55_T1.9571.00
167_E171_F1.9491.00
161_D164_K1.9131.00
39_T68_V1.9081.00
388_D393_K1.9051.00
227_K396_T1.8961.00
58_E61_N1.8951.00
224_E227_K1.8731.00
150_D154_T1.8561.00
357_S361_K1.8381.00
121_D125_Q1.8381.00
125_Q128_T1.8341.00
55_T59_K1.8301.00
118_S343_A1.8241.00
108_L304_V1.8151.00
114_S316_E1.8061.00
405_N409_E1.7851.00
56_K60_E1.7681.00
164_K167_E1.7561.00
388_D394_K1.7541.00
41_S82_D1.7291.00
156_P161_D1.7151.00
168_D172_A1.7081.00
90_D311_E1.7011.00
56_K330_A1.6741.00
54_K58_E1.6611.00
313_E317_K1.6541.00
398_T402_D1.6421.00
160_K163_E1.6261.00
227_K397_Q1.6231.00
329_Y333_E1.6201.00
92_M306_S1.6151.00
389_A399_S1.6111.00
402_D406_V1.6001.00
135_G302_G1.5731.00
36_K314_L1.5681.00
223_V227_K1.5681.00
55_T58_E1.5611.00
380_T384_S1.5581.00
223_V396_T1.5571.00
145_L283_A1.5531.00
127_V302_G1.5511.00
83_G88_A1.5461.00
149_K279_N1.5381.00
147_Y283_A1.5361.00
163_E167_E1.5301.00
110_D113_P1.5271.00
381_G406_V1.5201.00
151_L261_A1.5131.00
206_G214_D1.5101.00
163_E232_W1.5091.00
54_K318_W1.5081.00
47_K51_E1.5081.00
57_F61_N1.5031.00
325_D329_Y1.5011.00
78_A82_D1.4941.00
157_K161_D1.4911.00
398_T401_N1.4721.00
160_K164_K1.4581.00
401_N404_V1.4521.00
151_L169_P1.4511.00
16_L19_G1.4451.00
230_E389_A1.4451.00
169_P261_A1.4351.00
109_L307_K1.4331.00
402_D405_N1.4171.00
254_M259_K1.4171.00
228_Y231_K1.4141.00
327_N330_A1.4111.00
52_S56_K1.4021.00
361_K364_E1.3811.00
163_E235_T1.3711.00
218_N404_V1.3681.00
305_A319_L1.3671.00
57_F321_Y1.3591.00
221_G224_E1.3451.00
228_Y232_W1.3411.00
167_E236_Y1.3411.00
155_A169_P1.3381.00
57_F63_V1.3311.00
389_A396_T1.3261.00
144_I282_A1.3201.00
385_L394_K1.3201.00
385_L402_D1.3201.00
36_K311_E1.3161.00
255_F280_Y1.3111.00
71_Q74_E1.2931.00
184_L260_A1.2911.00
103_G134_Y1.2851.00
330_A334_D1.2821.00
57_F318_W1.2811.00
166_T262_A1.2761.00
54_K67_I1.2651.00
385_L388_D1.2621.00
358_A361_K1.2601.00
94_A304_V1.2541.00
42_V67_I1.2381.00
405_N408_K1.2261.00
63_V317_K1.2261.00
394_K399_S1.2241.00
163_E228_Y1.2191.00
343_A346_K1.2181.00
145_L262_A1.2181.00
90_D309_T1.2141.00
321_Y327_N1.2091.00
309_T315_A1.2071.00
231_K234_E1.2071.00
314_L317_K1.1991.00
170_R182_G1.1971.00
127_V133_V1.1841.00
48_E51_E1.1811.00
91_V319_L1.1681.00
316_E320_E1.1641.00
165_L168_D1.1601.00
406_V409_E1.1581.00
360_I364_E1.1511.00
253_Q257_E1.1491.00
148_N278_L1.1431.00
148_N151_L1.1411.00
152_L165_L1.1391.00
91_V315_A1.1381.00
385_L403_A1.1371.00
203_Y207_K1.1371.00
150_D278_L1.1281.00
206_G213_G1.1181.00
318_W322_A1.1151.00
23_C26_S1.1081.00
388_D402_D1.1001.00
394_K398_T1.0961.00
312_P316_E1.0951.00
13_A17_A1.0941.00
151_L155_A1.0931.00
384_S406_V1.0931.00
48_E52_S1.0901.00
162_L166_T1.0891.00
166_T236_Y1.0861.00
361_K365_T1.0831.00
124_M128_T1.0831.00
109_L309_T1.0751.00
106_G307_K1.0691.00
305_A316_E1.0601.00
378_V407_I1.0571.00
36_K62_D1.0561.00
60_E324_N1.0501.00
318_W321_Y1.0501.00
168_D171_F1.0461.00
203_Y206_G1.0421.00
227_K230_E1.0401.00
57_F314_L1.0401.00
224_E228_Y1.0381.00
151_L154_T1.0381.00
58_E62_D1.0331.00
223_V400_A1.0301.00
155_A172_A1.0271.00
79_L92_M1.0261.00
381_G384_S1.0241.00
325_D343_A1.0231.00
200_Y224_E1.0211.00
220_K223_V1.0191.00
23_C27_K1.0161.00
197_L202_G1.0161.00
230_E396_T1.0141.00
38_L318_W1.0121.00
151_L180_S1.0081.00
54_K65_V1.0071.00
215_I408_K1.0061.00
254_M260_A1.0021.00
103_G129_V1.0011.00
165_L262_A0.9991.00
92_M304_V0.9991.00
162_L262_A0.9951.00
305_A315_A0.9951.00
35_K64_T0.9951.00
170_R236_Y0.9951.00
91_V318_W0.9871.00
377_E380_T0.9871.00
250_F253_Q0.9851.00
272_N275_E0.9831.00
15_F19_G0.9821.00
53_I56_K0.9791.00
309_T313_E0.9791.00
307_K312_P0.9781.00
86_G308_Y0.9781.00
341_N344_A0.9761.00
347_K350_E0.9681.00
88_A306_S0.9651.00
180_S259_K0.9641.00
83_G107_H0.9571.00
118_S341_N0.9551.00
78_A81_L0.9531.00
65_V318_W0.9481.00
40_V303_W0.9471.00
384_S388_D0.9451.00
330_A333_E0.9441.00
52_S334_D0.9441.00
115_N118_S0.9401.00
150_D153_K0.9341.00
226_V389_A0.9241.00
206_G209_G0.9231.00
385_L406_V0.9201.00
306_S309_T0.9201.00
265_G269_S0.9151.00
152_L169_P0.9061.00
81_L85_A0.9051.00
381_G385_L0.9031.00
157_K287_T0.9001.00
326_A329_Y0.8991.00
121_D342_T0.8981.00
17_A20_L0.8971.00
208_N213_G0.8911.00
146_Y265_G0.8881.00
329_Y347_K0.8871.00
124_M133_V0.8861.00
315_A319_L0.8841.00
198_A367_T0.8781.00
76_L98_R0.8761.00
135_G304_V0.8761.00
400_A404_V0.8761.00
49_Y52_S0.8751.00
56_K326_A0.8681.00
120_G342_T0.8671.00
354_E357_S0.8651.00
326_A330_A0.8631.00
155_A168_D0.8621.00
381_G403_A0.8621.00
121_D124_M0.8621.00
144_I359_V0.8601.00
52_S330_A0.8591.00
162_L183_F0.8581.00
36_K63_V0.8561.00
399_S403_A0.8551.00
138_L303_W0.8541.00
395_S399_S0.8511.00
153_K279_N0.8491.00
114_S313_E0.8481.00
216_G219_N0.8481.00
197_L222_A0.8461.00
14_S18_I0.8461.00
353_N357_S0.8441.00
13_A19_G0.8441.00
313_E316_E0.8411.00
155_A165_L0.8391.00
385_L399_S0.8361.00
60_E326_A0.8341.00
20_L23_C0.8331.00
348_A351_Q0.8301.00
108_L134_Y0.8281.00
92_M108_L0.8231.00
209_G213_G0.8221.00
62_D317_K0.8221.00
110_D134_Y0.8211.00
109_L113_P0.8201.00
56_K327_N0.8181.00
305_A309_T0.8181.00
181_T239_K0.8151.00
119_F323_A0.8131.00
112_K133_V0.8111.00
103_G108_L0.8101.00
154_T180_S0.8101.00
38_L314_L0.8091.00
380_T383_E0.8081.00
41_S70_K0.8081.00
163_E236_Y0.8041.00
329_Y344_A0.8011.00
116_T124_M0.7981.00
40_V91_V0.7981.00
70_K78_A0.7981.00
217_L222_A0.7931.00
249_D252_Q0.7921.00
115_N320_E0.7891.00
215_I404_V0.7881.00
60_E321_Y0.7871.00
226_V400_A0.7861.00
155_A261_A0.7821.00
9_A13_A0.7811.00
112_K128_T0.7751.00
200_Y228_Y0.7741.00
166_T170_R0.7711.00
12_A16_L0.7711.00
128_T131_G0.7681.00
82_D87_N0.7661.00
165_L169_P0.7651.00
253_Q256_L0.7631.00
152_L155_A0.7631.00
109_L306_S0.7621.00
41_S89_P0.7591.00
53_I327_N0.7581.00
226_V399_S0.7581.00
229_A233_F0.7561.00
58_E65_V0.7531.00
384_S387_F0.7511.00
342_T346_K0.7491.00
109_L114_S0.7401.00
23_C28_N0.7401.00
400_A403_A0.7371.00
109_L305_A0.7371.00
38_L311_E0.7361.00
44_E48_E0.7361.00
357_S360_I0.7341.00
382_A403_A0.7321.00
203_Y208_N0.7311.00
13_A16_L0.7281.00
113_P132_K0.7221.00
113_P316_E0.7221.00
122_K125_Q0.7161.00
206_G216_G0.7151.00
202_G222_A0.7151.00
163_E166_T0.7141.00
375_M379_W0.7131.00
379_W383_E0.7121.00
53_I321_Y0.7121.00
148_N279_N0.7101.00
31_S34_G0.7081.00
22_A25_S0.7061.00
156_P165_L0.7041.00
195_G198_A0.7031.00
249_D253_Q0.7031.00
9_A16_L0.7021.00
219_N222_A0.7011.00
159_F228_Y0.6981.00
14_S17_A0.6981.00
359_V363_Y0.6971.00
77_E81_L0.6941.00
58_E63_V0.6931.00
100_G104_Q0.6931.00
109_L316_E0.6921.00
169_P262_A0.6891.00
11_L14_S0.6891.00
101_G105_Q0.6881.00
119_F124_M0.6871.00
232_W236_Y0.6861.00
193_S197_L0.6831.00
22_A26_S0.6801.00
325_D341_N0.6801.00
396_T400_A0.6781.00
102_L108_L0.6771.00
12_A15_F0.6771.00
109_L308_Y0.6751.00
38_L315_A0.6731.00
159_F163_E0.6721.00
91_V303_W0.6711.00
344_A347_K0.6691.00
230_E233_F0.6631.00
15_F18_I0.6621.00
358_A362_Q0.6601.00
12_A19_G0.6601.00
61_N314_L0.6591.00
75_Q79_L0.6591.00
147_Y152_L0.6581.00
399_S402_D0.6581.00
36_K61_N0.6571.00
172_A178_G0.6551.00
44_E47_K0.6551.00
83_G306_S0.6521.00
354_E358_A0.6501.00
8_F11_L0.6501.00
254_M257_E0.6501.00
256_L276_A0.6491.00
167_E170_R0.6481.00
271_A275_E0.6461.00
146_Y282_A0.6461.00
272_N276_A0.6451.00
214_D408_K0.6451.00
154_T172_A0.6441.00
120_G345_R0.6431.00
11_L17_A0.6411.00
11_L15_F0.6371.00
114_S312_P0.6351.00
12_A18_I0.6351.00
77_E80_P0.6311.00
287_T291_G0.6301.00
99_I135_G0.6301.00
14_S19_G0.6261.00
182_G186_K0.6251.00
389_A394_K0.6241.00
251_I263_I0.6241.00
312_P315_A0.6231.00
118_S325_D0.6201.00
61_N318_W0.6191.00
111_I319_L0.6181.00
53_I330_A0.6171.00
181_T185_A0.6151.00
234_E392_G0.6151.00
40_V67_I0.6131.00
99_I103_G0.6131.00
374_E377_E0.6131.00
9_A12_A0.6121.00
146_Y270_A0.6121.00
10_I14_S0.6121.00
238_P254_M0.6111.00
270_A274_K0.6101.00
148_N258_G0.6091.00
74_E78_A0.6091.00
387_F391_S0.6081.00
40_V93_L0.6071.00
224_E288_L0.6061.00
197_L225_A0.6061.00
320_E324_N0.6041.00
94_A102_L0.6041.00
99_I108_L0.6031.00
396_T399_S0.6031.00
98_R101_G0.6011.00
219_N223_V0.6011.00
225_A229_A0.6001.00
127_V135_G0.6001.00
217_L407_I0.6001.00
76_L101_G0.6001.00
166_T182_G0.5991.00
155_A180_S0.5991.00
157_K165_L0.5981.00
13_A18_I0.5971.00
61_N321_Y0.5971.00
181_T238_P0.5941.00
303_W322_A0.5931.00
157_K162_L0.5921.00
21_A24_S0.5871.00
348_A352_K0.5871.00
145_L264_I0.5871.00
7_G10_I0.5861.00
180_S184_L0.5851.00
309_T314_L0.5841.00
167_E231_K0.5841.00
21_A25_S0.5821.00
397_Q400_A0.5811.00
355_L358_A0.5811.00
316_E319_L0.5811.00
355_L359_V0.5801.00
112_K316_E0.5791.00
68_V82_D0.5791.00
7_G11_L0.5791.00
170_R181_T0.5781.00
150_D258_G0.5781.00
353_N356_T0.5781.00
196_L225_A0.5771.00
41_S68_V0.5761.00
255_F278_L0.5751.00
250_F254_M0.5751.00
64_T67_I0.5731.00
80_P101_G0.5731.00
356_T360_I0.5721.00
287_T292_E0.5721.00
117_K120_G0.5721.00
187_W191_Y0.5711.00
72_M75_Q0.5701.00
110_D133_V0.5681.00
39_T42_V0.5681.00
36_K42_V0.5671.00
347_K351_Q0.5671.00
136_M319_L0.5671.00
149_K278_L0.5661.00
76_L80_P0.5661.00
68_V78_A0.5661.00
303_W319_L0.5651.00
169_P172_A0.5641.00
221_G225_A0.5641.00
36_K39_T0.5641.00
39_T90_D0.5631.00
146_Y280_Y0.5621.00
244_N254_M0.5621.00
141_E301_K0.5611.00
345_R348_A0.5611.00
36_K40_V0.5601.00
166_T232_W0.5591.00
107_H110_D0.5581.00
82_D89_P0.5571.00
219_N404_V0.5571.00
19_G23_C0.5561.00
80_P84_P0.5551.00
346_K351_Q0.5551.00
10_I13_A0.5541.00
156_P283_A0.5541.00
230_E395_S0.5541.00
68_V89_P0.5531.00
120_G123_E0.5521.00
252_Q256_L0.5521.00
152_L261_A0.5511.00
106_G109_L0.5511.00
388_D399_S0.5491.00
95_A369_T0.5491.00
53_I322_A0.5481.00
198_A203_Y0.5471.00
103_G106_G0.5461.00
274_K280_Y0.5461.00
24_S27_K0.5451.00
76_L102_L0.5441.00
72_M76_L0.5441.00
19_G22_A0.5431.00
171_F178_G0.5431.00
238_P241_M0.5431.00
50_I53_I0.5421.00
376_A380_T0.5411.00
40_V54_K0.5401.00
377_E381_G0.5391.00
169_P180_S0.5381.00
194_Y198_A0.5361.00
252_Q265_G0.5351.00
111_I316_E0.5341.00
386_I390_A0.5341.00
45_T48_E0.5331.00
11_L16_L0.5321.00
35_K62_D0.5321.00
57_F65_V0.5311.00
360_I363_Y0.5291.00
328_A340_A0.5281.00
223_V401_N0.5251.00
37_V41_S0.5201.00
172_A180_S0.5201.00
110_D114_S0.5201.00
118_S342_T0.5201.00
385_L389_A0.5191.00
49_Y53_I0.5191.00
251_I260_A0.5191.00
184_L251_I0.5181.00
153_K281_G0.5181.00
104_Q130_D0.5171.00
363_Y366_A0.5171.00
100_G129_V0.5161.00
222_A226_V0.5151.00
161_D165_L0.5141.00
70_K75_Q0.5141.00
32_S35_K0.5141.00
238_P244_N0.5131.00
43_E46_Y0.5131.00
38_L41_S0.5131.00
281_G358_A0.5131.00
38_L42_V0.5121.00
208_N214_D0.5121.00
216_G404_V0.5101.00
202_G221_G0.5091.00
340_A345_R0.5081.00
36_K41_S0.5071.00
362_Q365_T0.5071.00
205_F209_G0.5061.00
160_K288_L0.5051.00
82_D85_A0.5051.00
95_A98_R0.5041.00
88_A308_Y0.5021.00
218_N400_A0.5021.00
25_S28_N0.5021.00
10_I15_F0.5021.00
222_A404_V0.5011.00
90_D315_A0.5001.00
403_A407_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xd3A 1 0.8969 100 0.153 Contact Map
3uorA 1 0.8921 100 0.18 Contact Map
4r2fA 1 0.8681 100 0.182 Contact Map
4r9fA 1 0.8849 100 0.192 Contact Map
4mfiA 1 0.8897 100 0.201 Contact Map
2zyoA 1 0.8993 100 0.205 Contact Map
4r6kA 1 0.8897 100 0.218 Contact Map
4r6hA 1 0.8921 100 0.244 Contact Map
1ursA 1 0.8513 100 0.245 Contact Map
4ovjA 1 0.8801 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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