GREMLIN Database
YVDE - Uncharacterized HTH-type transcriptional regulator YvdE
UniProt: O06987 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (308)
Sequences: 33556 (24478)
Seq/√Len: 1394.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_E189_R3.2681.00
165_E225_A3.1211.00
10_K42_E3.0801.00
248_R251_E3.0241.00
156_A256_T2.6781.00
165_E254_A2.5821.00
184_E188_I2.5131.00
110_G289_L2.4981.00
260_G275_R2.4341.00
154_F193_K2.2801.00
143_D292_K2.2481.00
30_D34_K2.2331.00
38_S42_E2.2111.00
211_E244_S2.1441.00
34_K38_S2.1201.00
215_R245_L2.0961.00
87_E90_R2.0691.00
161_M194_S2.0661.00
87_E287_K2.0641.00
158_R190_A2.0461.00
151_K155_M2.0231.00
21_V36_V2.0211.00
284_A287_K1.9911.00
154_F189_R1.9711.00
215_R241_A1.9691.00
154_F190_A1.9501.00
88_L286_A1.9301.00
22_I40_M1.9091.00
33_K37_H1.9071.00
153_T157_T1.9001.00
5_S15_K1.8921.00
83_G282_G1.8681.00
210_S237_G1.8571.00
152_G258_N1.8561.00
157_T187_Y1.8521.00
150_E185_Q1.8351.00
158_R162_G1.8061.00
87_E283_E1.7981.00
160_V226_A1.7901.00
153_T228_V1.7791.00
242_A253_V1.7681.00
275_R308_E1.7621.00
10_K39_A1.7621.00
11_A39_A1.7561.00
219_K245_L1.7421.00
158_R194_S1.7341.00
270_R313_E1.7201.00
284_A303_L1.7121.00
86_R279_V1.6841.00
211_E241_A1.6711.00
291_K296_D1.6641.00
170_F230_A1.6591.00
229_C238_V1.6531.00
214_A238_V1.6451.00
154_F158_R1.6291.00
243_Q268_S1.6251.00
83_G279_V1.6221.00
155_M307_P1.6031.00
169_V224_Q1.6001.00
248_R252_D1.5971.00
241_A245_L1.5951.00
63_K108_C1.5921.00
277_P280_E1.5901.00
247_K252_D1.5711.00
135_F285_C1.5621.00
159_H163_L1.5521.00
87_E91_N1.5381.00
37_H41_K1.5131.00
91_N290_L1.4851.00
241_A244_S1.4831.00
167_E223_N1.4671.00
280_E284_A1.4631.00
161_M190_A1.4541.00
21_V40_M1.4451.00
148_N151_K1.4441.00
260_G312_R1.4411.00
151_K154_F1.4401.00
37_H40_M1.4301.00
7_V39_A1.4271.00
185_Q189_R1.4261.00
159_H311_V1.4071.00
159_H162_G1.3831.00
182_A185_Q1.3821.00
60_Q109_D1.3781.00
201_F216_E1.3761.00
280_E283_E1.3701.00
188_I192_N1.3611.00
152_G307_P1.3531.00
10_K43_L1.3351.00
190_A193_K1.3321.00
87_E286_A1.3281.00
242_A247_K1.3101.00
5_S9_K1.2991.00
157_T190_A1.2951.00
169_V217_L1.2881.00
30_D33_K1.2821.00
35_L39_A1.2741.00
153_T186_G1.2701.00
214_A242_A1.2681.00
215_R219_K1.2661.00
20_R25_P1.2641.00
221_M224_Q1.2611.00
167_E225_A1.2541.00
6_D9_K1.2521.00
157_T186_G1.2481.00
204_D209_K1.2481.00
211_E215_R1.2481.00
39_A42_E1.2481.00
60_Q93_Y1.2431.00
165_E226_A1.2421.00
214_A227_F1.2391.00
211_E240_R1.2361.00
157_T161_M1.2361.00
215_R244_S1.2341.00
29_T32_L1.2311.00
62_V88_L1.2281.00
186_G190_A1.2171.00
167_E199_N1.2151.00
7_V11_A1.2131.00
239_I255_V1.2051.00
39_A43_L1.2051.00
287_K291_K1.2041.00
290_L294_N1.2041.00
84_I286_A1.1971.00
158_R193_K1.1921.00
155_M158_R1.1821.00
7_V43_L1.1811.00
4_L15_K1.1791.00
32_L35_L1.1781.00
256_T272_T1.1761.00
150_E154_F1.1691.00
112_I285_C1.1651.00
21_V28_V1.1631.00
84_I112_I1.1561.00
150_E182_A1.1301.00
123_G127_A1.1281.00
64_L84_I1.1281.00
190_A194_S1.1241.00
187_Y191_M1.1231.00
216_E220_S1.1191.00
88_L95_L1.1151.00
34_K37_H1.1141.00
168_V191_M1.1131.00
98_V103_L1.1091.00
279_V283_E1.1061.00
232_D273_T1.0881.00
161_M196_K1.0831.00
38_S41_K1.0801.00
284_A288_M1.0791.00
171_F238_V1.0791.00
282_G286_A1.0781.00
91_N287_K1.0741.00
227_F238_V1.0711.00
150_E186_G1.0701.00
232_D257_G1.0581.00
170_F184_E1.0581.00
24_H33_K1.0571.00
163_L311_V1.0561.00
208_K212_C1.0561.00
237_G241_A1.0481.00
189_R193_K1.0481.00
156_A228_V1.0471.00
213_L216_E1.0471.00
4_L18_V1.0471.00
167_E222_D1.0461.00
166_R225_A1.0421.00
64_L95_L1.0351.00
288_M303_L1.0341.00
61_V96_Q1.0321.00
185_Q188_I1.0251.00
229_C235_A1.0201.00
91_N294_N1.0101.00
40_M43_L1.0061.00
50_A53_A1.0041.00
63_K103_L1.0021.00
284_A305_F1.0021.00
151_K306_E1.0011.00
162_G194_S0.9991.00
48_N54_L0.9941.00
93_Y290_L0.9891.00
191_M196_K0.9681.00
11_A18_V0.9681.00
283_E287_K0.9631.00
161_M166_R0.9611.00
210_S214_A0.9611.00
206_S209_K0.9551.00
168_V226_A0.9491.00
289_L293_M0.9481.00
85_S89_D0.9471.00
163_L254_A0.9451.00
48_N51_A0.9401.00
156_A274_V0.9331.00
229_C234_I0.9321.00
209_K212_C0.9291.00
239_I249_I0.9281.00
181_R185_Q0.9271.00
144_F302_S0.9261.00
51_A54_L0.9221.00
239_I267_S0.9221.00
212_C216_E0.9201.00
214_A218_L0.9171.00
308_E311_V0.9161.00
61_V94_A0.9151.00
24_H37_H0.9131.00
178_P182_A0.9071.00
47_P52_R0.9001.00
188_I198_S0.8961.00
275_R310_I0.8961.00
227_F253_V0.8941.00
143_D288_M0.8921.00
187_Y228_V0.8901.00
166_R196_K0.8881.00
147_V277_P0.8821.00
207_S240_R0.8801.00
288_M291_K0.8791.00
151_K307_P0.8771.00
112_I289_L0.8761.00
157_T191_M0.8761.00
90_R283_E0.8721.00
86_R283_E0.8691.00
62_V112_I0.8691.00
21_V37_H0.8681.00
175_L202_R0.8641.00
201_F213_L0.8631.00
277_P308_E0.8601.00
277_P305_F0.8541.00
147_V307_P0.8501.00
146_D304_F0.8411.00
148_N306_E0.8371.00
172_G184_E0.8361.00
148_N304_F0.8351.00
260_G310_I0.8331.00
145_I288_M0.8331.00
84_I282_G0.8321.00
212_C215_R0.8311.00
146_D302_S0.8291.00
82_T86_R0.8291.00
191_M198_S0.8241.00
232_D260_G0.8241.00
160_V256_T0.8241.00
13_V36_V0.8221.00
176_D181_R0.8211.00
169_V227_F0.8181.00
247_K253_V0.8181.00
76_Y278_V0.8141.00
286_A290_L0.8141.00
243_Q270_R0.8111.00
173_I205_N0.8101.00
64_L81_L0.8071.00
218_L241_A0.8041.00
80_L135_F0.8031.00
17_T20_R0.8001.00
171_F229_C0.8001.00
49_Y52_R0.7961.00
3_T6_D0.7931.00
59_T109_D0.7921.00
16_M20_R0.7901.00
167_E197_K0.7851.00
104_N128_F0.7831.00
214_A241_A0.7831.00
147_V276_Q0.7831.00
31_E34_K0.7781.00
149_N183_R0.7781.00
83_G87_E0.7751.00
189_R192_N0.7741.00
223_N247_K0.7741.00
143_D301_G0.7721.00
209_K213_L0.7671.00
228_V256_T0.7651.00
79_N279_V0.7581.00
184_E200_M0.7501.00
31_E35_L0.7491.00
218_L245_L0.7471.00
242_A255_V0.7471.00
155_M274_V0.7461.00
20_R27_T0.7451.00
263_L267_S0.7451.00
110_G293_M0.7431.00
260_G264_D0.7431.00
182_A186_G0.7421.00
85_S99_T0.7411.00
20_R26_E0.7391.00
83_G283_E0.7381.00
81_L85_S0.7351.00
257_G273_T0.7351.00
58_R109_D0.7341.00
242_A249_I0.7341.00
225_A254_A0.7291.00
84_I95_L0.7281.00
61_V106_G0.7261.00
62_V286_A0.7201.00
67_L77_Y0.7191.00
236_L267_S0.7181.00
214_A217_L0.7181.00
138_N302_S0.7151.00
132_L142_Y0.7131.00
170_F228_V0.7121.00
201_F220_S0.7101.00
240_R243_Q0.7091.00
161_M191_M0.7061.00
124_V127_A0.7041.00
21_V33_K0.7021.00
240_R270_R0.7011.00
168_V225_A0.7011.00
85_S95_L0.7011.00
126_K141_G0.6991.00
63_K111_I0.6951.00
126_K132_L0.6931.00
232_D235_A0.6921.00
81_L97_L0.6921.00
86_R90_R0.6861.00
264_D267_S0.6851.00
125_I132_L0.6851.00
159_H272_T0.6841.00
263_L266_I0.6831.00
240_R244_S0.6811.00
159_H309_L0.6811.00
291_K295_E0.6801.00
184_E202_R0.6791.00
34_K41_K0.6781.00
58_R294_N0.6761.00
216_E219_K0.6751.00
259_D276_Q0.6751.00
203_I234_I0.6731.00
270_R312_R0.6731.00
210_S213_L0.6681.00
13_V32_L0.6671.00
112_I135_F0.6661.00
155_M159_H0.6611.00
295_E298_A0.6601.00
240_R268_S0.6521.00
82_T85_S0.6511.00
220_S224_Q0.6511.00
235_A257_G0.6481.00
154_F186_G0.6441.00
110_G133_V0.6431.00
220_S223_N0.6401.00
134_V142_Y0.6391.00
170_F187_Y0.6391.00
35_L38_S0.6371.00
5_S55_V0.6361.00
214_A237_G0.6361.00
27_T32_L0.6351.00
180_E205_N0.6351.00
96_Q108_C0.6341.00
133_V289_L0.6321.00
269_P272_T0.6291.00
18_V40_M0.6251.00
82_T279_V0.6241.00
79_N278_V0.6241.00
187_Y198_S0.6241.00
272_T309_L0.6231.00
168_V187_Y0.6231.00
201_F217_L0.6221.00
7_V18_V0.6191.00
267_S270_R0.6181.00
123_G126_K0.6161.00
291_K301_G0.6151.00
46_I105_I0.6141.00
172_G202_R0.6131.00
93_Y293_M0.6121.00
41_K44_N0.6111.00
239_I243_Q0.6101.00
93_Y109_D0.6091.00
160_V228_V0.6061.00
74_E233_R0.6051.00
18_V21_V0.6051.00
149_N182_A0.6041.00
231_S259_D0.6021.00
154_F157_T0.6001.00
110_G285_C0.6001.00
205_N230_A0.6001.00
20_R28_V0.5981.00
207_S237_G0.5961.00
274_V307_P0.5951.00
258_N276_Q0.5941.00
242_A245_L0.5941.00
173_I180_E0.5931.00
76_Y80_L0.5891.00
268_S313_E0.5881.00
136_G179_F0.5871.00
288_M292_K0.5851.00
111_I130_K0.5851.00
80_L278_V0.5831.00
46_I50_A0.5821.00
279_V282_G0.5821.00
83_G278_V0.5811.00
104_N130_K0.5811.00
203_I209_K0.5811.00
236_L261_V0.5781.00
133_V292_K0.5781.00
62_V110_G0.5771.00
156_A226_A0.5751.00
133_V145_I0.5741.00
62_V293_M0.5731.00
82_T101_N0.5711.00
143_D300_Q0.5701.00
284_A291_K0.5661.00
240_R265_R0.5651.00
136_G149_N0.5651.00
265_R270_R0.5651.00
159_H256_T0.5651.00
88_L290_L0.5651.00
243_Q248_R0.5621.00
104_N107_Q0.5601.00
180_E230_A0.5601.00
228_V258_N0.5581.00
247_K250_P0.5561.00
25_P28_V0.5561.00
238_V242_A0.5551.00
103_L108_C0.5551.00
211_E237_G0.5531.00
133_V288_M0.5531.00
292_K295_E0.5521.00
281_M305_F0.5511.00
13_V18_V0.5501.00
126_K142_Y0.5501.00
18_V36_V0.5491.00
231_S234_I0.5481.00
121_F124_V0.5471.00
62_V93_Y0.5471.00
218_L242_A0.5461.00
229_C257_G0.5421.00
96_Q106_G0.5411.00
145_I284_A0.5411.00
208_K211_E0.5411.00
79_N262_F0.5361.00
146_D149_N0.5331.00
11_A21_V0.5311.00
264_D271_L0.5311.00
217_L221_M0.5301.00
133_V285_C0.5291.00
167_E224_Q0.5281.00
304_F307_P0.5281.00
77_Y114_T0.5241.00
53_A56_Q0.5231.00
75_P233_R0.5221.00
163_L225_A0.5211.00
167_E221_M0.5201.00
244_S268_S0.5191.00
16_M25_P0.5181.00
157_T228_V0.5171.00
224_Q227_F0.5161.00
232_D261_V0.5161.00
84_I88_L0.5151.00
172_G200_M0.5131.00
213_L217_L0.5111.00
6_D10_K0.5091.00
147_V258_N0.5091.00
24_H27_T0.5081.00
211_E214_A0.5071.00
61_V109_D0.5071.00
188_I200_M0.5061.00
28_V33_K0.5061.00
149_N179_F0.5061.00
73_T79_N0.5051.00
52_R56_Q0.5041.00
209_K234_I0.5031.00
230_A234_I0.5021.00
71_D82_T0.5011.00
87_E290_L0.5011.00
196_K199_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8101 100 0.102 Contact Map
2hsgA 1 0.981 100 0.104 Contact Map
4o5aA 2 0.7975 100 0.106 Contact Map
1qpzA 2 0.9873 100 0.109 Contact Map
3jvdA 2 0.7848 100 0.111 Contact Map
2o20A 2 0.8165 100 0.111 Contact Map
3ctpA 2 0.7911 100 0.112 Contact Map
3bilA 2 0.7563 100 0.113 Contact Map
1jyeA 2 0.8006 100 0.119 Contact Map
3e3mA 2 0.788 100 0.121 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.