GREMLIN Database
YVDA - Putative carbonic anhydrase YvdA
UniProt: O06983 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (175)
Sequences: 5126 (3364)
Seq/√Len: 254.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_V171_G4.0411.00
35_K92_E3.9931.00
37_V82_I2.9671.00
154_V171_G2.8991.00
154_V169_V2.6561.00
147_E182_D2.6131.00
8_T12_E2.4051.00
68_G104_M2.3901.00
146_V173_V2.2761.00
67_A81_S2.2311.00
93_E170_H2.2151.00
100_H173_V2.2131.00
122_E125_C2.1421.00
12_E16_R2.1371.00
15_Q19_S1.9941.00
15_Q180_K1.8781.00
106_G142_G1.8161.00
106_G110_S1.8151.00
172_L181_L1.8121.00
83_L87_Y1.7641.00
37_V91_A1.7481.00
13_H17_F1.7241.00
101_E177_E1.7091.00
69_A149_S1.7071.00
175_H182_D1.7001.00
25_P28_T1.6421.00
47_T51_P1.6411.00
11_L183_V1.6411.00
147_E173_V1.6391.00
161_P164_P1.6391.00
93_E168_P1.6301.00
79_M160_H1.5911.00
175_H178_T1.5671.00
96_I157_I1.5621.00
148_E152_H1.5501.00
42_M62_K1.5261.00
54_M61_A1.5261.00
56_L61_A1.5211.00
32_P44_T1.5201.00
148_E151_S1.4641.00
9_S13_H1.4571.00
12_E15_Q1.4461.00
16_R20_E1.4301.00
71_V78_V1.4171.00
16_R55_G1.4041.00
14_N18_V1.3711.00
82_I157_I1.3671.00
64_V81_S1.3381.00
13_H18_V1.2981.00
121_V125_C1.2931.00
38_I97_V1.2861.00
100_H175_H1.2771.00
37_V81_S1.2671.00
72_S77_S1.2631.00
120_G126_L1.2611.00
84_V88_E1.2551.00
127_N130_T1.2261.00
97_V172_L1.2201.00
150_V154_V1.2191.00
79_M157_I1.1931.00
160_H164_P1.1881.00
36_L95_C1.1881.00
40_T46_L1.1851.00
120_G123_D1.1841.00
86_I163_L1.1811.00
13_H55_G1.1741.00
156_M159_N1.1661.00
37_V94_V1.1661.00
32_P103_G1.1441.00
95_C172_L1.1431.00
13_H16_R1.1391.00
158_K169_V1.1301.00
21_K24_E1.1231.00
120_G124_S1.1111.00
69_A98_G1.1091.00
163_L167_V1.0851.00
115_K118_E1.0741.00
114_E117_K1.0721.00
120_G125_C1.0721.00
85_A91_A1.0621.00
101_E106_G1.0591.00
90_Q166_K1.0551.00
10_I54_M1.0541.00
86_I91_A1.0441.00
172_L183_V1.0411.00
18_V180_K1.0381.00
54_M97_V1.0381.00
6_S9_S1.0371.00
109_A145_S1.0221.00
39_V71_V1.0111.00
151_S184_V1.0061.00
86_I167_V1.0021.00
114_E118_E0.9981.00
66_N69_A0.9891.00
14_N17_F0.9891.00
160_H166_K0.9821.00
100_H176_P0.9821.00
129_L133_G0.9741.00
98_G150_V0.9701.00
86_I94_V0.9561.00
38_I54_M0.9551.00
121_V124_S0.9531.00
152_H155_N0.9491.00
157_I169_V0.9481.00
18_V22_K0.9471.00
130_T133_G0.9291.00
161_P166_K0.9211.00
163_L166_K0.9211.00
110_S114_E0.9141.00
48_E51_P0.9121.00
129_L132_A0.8891.00
78_V82_I0.8871.00
162_L165_K0.8831.00
137_K140_L0.8791.00
123_D127_N0.8771.00
155_N158_K0.8761.00
31_F101_E0.8731.00
139_W143_F0.8711.00
135_D138_T0.8590.99
98_G149_S0.8590.99
143_F146_V0.8520.99
150_V173_V0.8490.99
142_G146_V0.8470.99
149_S153_S0.8290.99
84_V103_G0.8210.99
6_S35_K0.8160.99
110_S138_T0.8140.99
42_M89_L0.8100.99
11_L15_Q0.8060.99
13_H22_K0.8030.99
32_P62_K0.8010.99
135_D141_T0.8000.99
170_H183_V0.7970.99
178_T182_D0.7940.99
130_T134_L0.7940.99
86_I166_K0.7910.99
38_I61_A0.7900.99
10_I13_H0.7860.99
36_L61_A0.7850.99
121_V126_L0.7830.99
105_S146_V0.7830.99
67_A104_M0.7830.99
128_L133_G0.7810.99
39_V82_I0.7800.99
123_D126_L0.7800.99
70_I153_S0.7790.99
113_L117_K0.7710.99
26_Y30_K0.7700.99
62_K85_A0.7700.99
128_L132_A0.7690.99
155_N159_N0.7690.99
7_L183_V0.7690.99
44_T62_K0.7620.99
147_E151_S0.7590.99
48_E52_Q0.7580.99
152_H156_M0.7560.99
56_L60_D0.7550.99
109_A142_G0.7520.99
117_K123_D0.7510.99
138_T141_T0.7500.99
28_T58_N0.7490.99
113_L165_K0.7490.99
143_F147_E0.7400.98
25_P29_T0.7370.98
105_S108_N0.7370.98
143_F175_H0.7360.98
129_L134_L0.7360.98
11_L181_L0.7340.98
64_V78_V0.7320.98
42_M64_V0.7300.98
40_T97_V0.7290.98
95_C170_H0.7260.98
72_S78_V0.7220.98
131_S134_L0.7200.98
151_S171_G0.7100.98
37_V85_A0.7050.98
20_E24_E0.7030.98
112_I115_K0.7020.98
18_V23_Y0.7000.98
133_G136_L0.6920.98
132_A135_D0.6880.98
29_T33_S0.6830.97
71_V153_S0.6750.97
47_T63_I0.6740.97
122_E126_L0.6730.97
54_M172_L0.6730.97
62_K84_V0.6730.97
87_Y166_K0.6710.97
47_T53_A0.6630.97
143_F173_V0.6630.97
77_S80_R0.6560.97
66_N77_S0.6550.97
115_K119_R0.6540.97
105_S145_S0.6530.97
14_N22_K0.6530.97
39_V66_N0.6400.96
125_C129_L0.6380.96
9_S12_E0.6360.96
36_L92_E0.6350.96
154_V158_K0.6340.96
26_Y29_T0.6290.96
36_L93_E0.6290.96
7_L93_E0.6260.96
40_T47_T0.6210.96
10_I14_N0.6190.95
113_L116_A0.6180.95
38_I48_E0.6160.95
31_F44_T0.6130.95
57_K60_D0.6100.95
99_H102_C0.6100.95
40_T48_E0.6060.95
9_S14_N0.6000.95
144_H148_E0.5990.95
77_S91_A0.5990.95
48_E58_N0.5990.95
54_M181_L0.5960.94
51_P56_L0.5940.94
127_N131_S0.5940.94
10_I17_F0.5940.94
140_L143_F0.5910.94
100_H177_E0.5900.94
111_S114_E0.5850.94
133_G137_K0.5850.94
161_P165_K0.5850.94
48_E63_I0.5830.94
33_S90_Q0.5830.94
46_L53_A0.5810.94
6_S13_H0.5790.94
69_A153_S0.5770.93
51_P61_A0.5740.93
141_T145_S0.5720.93
67_A103_G0.5710.93
139_W144_H0.5690.93
116_A119_R0.5640.93
138_T142_G0.5630.93
37_V64_V0.5600.92
53_A181_L0.5510.92
70_I149_S0.5510.92
106_G109_A0.5480.92
121_V129_L0.5470.92
42_M67_A0.5460.91
16_R19_S0.5460.91
67_A80_R0.5370.91
122_E127_N0.5360.91
10_I181_L0.5290.90
64_V67_A0.5280.90
173_V182_D0.5270.90
66_N78_V0.5270.90
18_V178_T0.5210.89
36_L83_L0.5200.89
87_Y165_K0.5170.89
140_L144_H0.5170.89
10_I36_L0.5120.89
9_S35_K0.5080.88
132_A148_E0.5050.88
87_Y162_L0.5040.88
21_K52_Q0.5040.88
137_K141_T0.5040.88
62_K91_A0.5030.88
21_K57_K0.5030.88
42_M84_V0.5010.88
13_H24_E0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w3qA 2 0.9492 100 0.133 Contact Map
1ddzA 2 0.9645 100 0.15 Contact Map
3e3iA 6 0.9289 100 0.153 Contact Map
4rxyA 4 0.9391 100 0.154 Contact Map
3qy1A 4 0.9442 100 0.157 Contact Map
1ekjA 5 0.9848 100 0.159 Contact Map
4o1jA 4 0.9137 100 0.161 Contact Map
1ym3A 2 0.9086 100 0.164 Contact Map
3ucjA 4 0.9391 100 0.167 Contact Map
4o1kA 4 0.9543 100 0.168 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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