GREMLIN Database
YVCQ - Sensor histidine kinase YvcQ
UniProt: O06979 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (300)
Sequences: 71379 (57116)
Seq/√Len: 3297.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_D285_G3.4331.00
280_A340_V3.3761.00
199_F236_S3.1451.00
274_E344_V3.0591.00
319_K323_S2.9911.00
330_Y342_T2.9871.00
278_S340_V2.7661.00
149_I167_L2.6881.00
278_S342_T2.5061.00
291_L333_S2.5041.00
267_R278_S2.4851.00
256_S282_E2.4791.00
236_S325_L2.4531.00
224_T265_T2.3861.00
276_R342_T2.3681.00
269_E276_R2.3491.00
153_K168_E2.3461.00
276_R344_V2.3131.00
198_T235_S2.3091.00
287_P290_D2.2641.00
331_A341_M2.2421.00
224_T263_P2.2121.00
226_H267_R2.1991.00
146_S172_E2.1821.00
265_T280_A2.1681.00
269_E278_S2.1211.00
263_P282_E2.1041.00
334_K337_A2.0911.00
318_A329_L2.0881.00
153_K165_E2.0711.00
244_V322_C2.0651.00
332_E342_T2.0531.00
198_T233_Q2.0391.00
295_F329_L2.0201.00
267_R280_A2.0191.00
291_L331_A1.9881.00
332_E340_V1.9711.00
146_S171_N1.9601.00
200_D203_E1.8901.00
286_I294_I1.8801.00
207_S242_S1.8781.00
290_D293_R1.8711.00
322_C327_H1.8691.00
270_T347_S1.8581.00
226_H265_T1.8421.00
157_S160_F1.8321.00
328_K344_V1.8141.00
333_S339_T1.7841.00
197_Q238_Q1.7741.00
222_F263_P1.7671.00
212_E246_E1.7541.00
262_D282_E1.7281.00
293_R296_D1.7241.00
293_R299_F1.7171.00
322_C343_I1.6951.00
146_S175_R1.6891.00
288_P291_L1.6861.00
196_P235_S1.6711.00
156_T160_F1.6701.00
250_F254_K1.6511.00
175_R179_D1.6381.00
256_S262_D1.5981.00
236_S241_L1.5711.00
145_I171_N1.5711.00
330_Y344_V1.5661.00
244_V318_A1.5601.00
150_Q168_E1.5581.00
271_Q276_R1.5541.00
106_I110_G1.5481.00
286_I339_T1.5391.00
290_D299_F1.5261.00
286_I290_D1.5171.00
244_V321_V1.5061.00
216_F253_L1.4721.00
323_S328_K1.4631.00
321_V325_L1.4621.00
124_Q127_H1.4401.00
117_L120_Y1.4121.00
290_D301_G1.4021.00
137_H243_F1.3991.00
125_K129_T1.3951.00
97_G100_A1.3791.00
295_F331_A1.3681.00
245_V277_L1.3611.00
168_E172_E1.3561.00
149_I168_E1.3531.00
256_S264_I1.3451.00
86_G89_L1.3411.00
202_A206_R1.3401.00
129_T133_Q1.3371.00
153_K161_P1.3351.00
148_M163_F1.3281.00
265_T282_E1.2881.00
95_R100_A1.2671.00
155_G160_F1.2661.00
247_Q318_A1.2651.00
237_D240_W1.2601.00
156_T159_S1.2591.00
333_S337_A1.2581.00
287_P335_E1.2501.00
240_W243_F1.2401.00
81_S86_G1.2301.00
61_D65_Q1.2251.00
107_N110_G1.2211.00
211_Q242_S1.2181.00
200_D233_Q1.2131.00
296_D299_F1.2111.00
213_K217_I1.1981.00
277_L343_I1.1921.00
96_T100_A1.1921.00
106_I109_L1.1831.00
333_S336_G1.1811.00
146_S168_E1.1781.00
200_D231_A1.1601.00
207_S238_Q1.1601.00
145_I167_L1.1601.00
274_E328_K1.1421.00
117_L121_I1.1421.00
322_C329_L1.1361.00
152_G164_L1.1301.00
238_Q242_S1.1301.00
291_L295_F1.1231.00
202_A268_I1.1221.00
275_T347_S1.1181.00
127_H131_T1.1001.00
114_E118_S1.0961.00
149_I171_N1.0951.00
320_Q323_S1.0891.00
227_V268_I1.0841.00
240_W324_R1.0741.00
281_D338_G1.0741.00
209_I225_L1.0731.00
133_Q297_A1.0681.00
215_Q218_K1.0631.00
206_R225_L1.0581.00
148_M166_E1.0531.00
144_V170_E1.0531.00
124_Q128_Y1.0531.00
165_E169_D1.0481.00
240_W321_V1.0401.00
129_T297_A1.0341.00
176_H239_K1.0331.00
241_L325_L1.0321.00
204_M208_L1.0291.00
79_A83_N1.0241.00
202_A231_A1.0201.00
196_P325_L1.0171.00
294_I331_A1.0151.00
116_R119_Q1.0131.00
244_V343_I1.0101.00
123_Q127_H1.0091.00
202_A227_V1.0041.00
302_E307_M1.0031.00
76_A80_S1.0021.00
115_S119_Q0.9981.00
79_A82_S0.9891.00
194_V237_D0.9871.00
99_Q102_W0.9791.00
99_Q103_T0.9771.00
280_A334_K0.9691.00
122_N126_Q0.9661.00
327_H345_F0.9601.00
149_I153_K0.9571.00
208_L212_E0.9521.00
157_S161_P0.9501.00
152_G160_F0.9491.00
147_L151_E0.9471.00
331_A339_T0.9471.00
179_D183_Q0.9451.00
110_G114_E0.9421.00
44_M48_I0.9351.00
109_L113_Y0.9341.00
199_F204_M0.9301.00
144_V148_M0.9291.00
208_L246_E0.9261.00
58_F62_Y0.9201.00
255_Y300_T0.9201.00
208_L242_S0.9121.00
204_M236_S0.9111.00
215_Q250_F0.9071.00
68_F71_Y0.9061.00
116_R120_Y0.9031.00
295_F319_K0.9031.00
281_D339_T0.9001.00
205_V268_I0.9001.00
139_K179_D0.8971.00
211_Q246_E0.8961.00
170_E173_R0.8941.00
114_E117_L0.8911.00
295_F341_M0.8901.00
212_E249_L0.8861.00
228_P269_E0.8841.00
166_E170_E0.8831.00
327_H343_I0.8821.00
257_K262_D0.8811.00
232_V275_T0.8801.00
65_Q69_L0.8761.00
149_I164_L0.8701.00
86_G90_K0.8681.00
59_A63_V0.8631.00
119_Q122_N0.8541.00
285_G339_T0.8441.00
320_Q324_R0.8421.00
286_I292_P0.8411.00
209_I213_K0.8391.00
162_T166_E0.8361.00
271_Q274_E0.8361.00
273_H347_S0.8341.00
76_A101_L0.8341.00
300_T310_A0.8341.00
110_G113_Y0.8301.00
161_P165_E0.8301.00
247_Q250_F0.8291.00
108_A112_Q0.8271.00
104_K107_N0.8251.00
252_A264_I0.8201.00
102_W106_I0.8181.00
203_E207_S0.8171.00
146_S150_Q0.8151.00
103_T106_I0.8141.00
73_K76_A0.8061.00
160_F163_F0.8061.00
195_K237_D0.8051.00
130_F134_W0.8041.00
200_D232_V0.8041.00
103_T107_N0.8011.00
245_V249_L0.7901.00
286_I331_A0.7891.00
196_P326_G0.7831.00
144_V147_L0.7831.00
245_V279_V0.7821.00
221_L256_S0.7791.00
158_S161_P0.7791.00
248_I341_M0.7771.00
183_Q243_F0.7761.00
322_C345_F0.7751.00
184_T316_Y0.7731.00
105_M108_A0.7701.00
180_M240_W0.7691.00
209_I223_P0.7681.00
75_L79_A0.7681.00
82_S110_G0.7681.00
171_N175_R0.7671.00
172_E175_R0.7661.00
286_I291_L0.7651.00
255_Y284_I0.7651.00
196_P236_S0.7621.00
248_I329_L0.7611.00
167_L171_N0.7611.00
83_N86_G0.7571.00
288_P333_S0.7561.00
199_F238_Q0.7551.00
242_S246_E0.7511.00
95_R103_T0.7481.00
125_K128_Y0.7441.00
76_A105_M0.7441.00
248_I318_A0.7431.00
169_D207_S0.7381.00
246_E250_F0.7341.00
166_E169_D0.7331.00
271_Q344_V0.7331.00
113_Y116_R0.7311.00
162_T165_E0.7291.00
201_L277_L0.7201.00
180_M243_F0.7191.00
194_V240_W0.7191.00
151_E155_G0.7191.00
239_K242_S0.7191.00
112_Q115_S0.7191.00
206_R210_N0.7171.00
165_E168_E0.7151.00
66_F70_T0.7101.00
140_T144_V0.7051.00
85_I89_L0.7001.00
71_Y75_L0.6991.00
142_V178_L0.6971.00
137_H247_Q0.6941.00
128_Y188_E0.6941.00
212_E250_F0.6921.00
278_S332_E0.6881.00
115_S118_S0.6861.00
81_S89_L0.6821.00
96_T102_W0.6791.00
318_A322_C0.6781.00
139_K175_R0.6761.00
62_Y66_F0.6761.00
216_F223_P0.6741.00
176_H180_M0.6731.00
72_V75_L0.6731.00
80_S84_D0.6731.00
76_A79_A0.6711.00
173_R242_S0.6701.00
143_S147_L0.6691.00
274_E346_S0.6691.00
214_R217_I0.6681.00
319_K328_K0.6671.00
92_R107_N0.6651.00
228_P268_I0.6651.00
82_S85_I0.6651.00
63_V67_S0.6631.00
118_S122_N0.6621.00
249_L266_I0.6611.00
221_L253_L0.6611.00
210_N213_K0.6611.00
294_I341_M0.6591.00
313_M317_L0.6591.00
302_E306_T0.6561.00
148_M170_E0.6531.00
100_A103_T0.6521.00
65_Q68_F0.6521.00
123_Q126_Q0.6521.00
243_F321_V0.6511.00
256_S259_G0.6491.00
248_I343_I0.6481.00
216_F264_I0.6451.00
138_M174_F0.6441.00
182_L185_A0.6441.00
286_I333_S0.6441.00
78_Q81_S0.6431.00
221_L225_L0.6421.00
112_Q116_R0.6421.00
266_I279_V0.6411.00
208_L249_L0.6401.00
90_K111_Q0.6381.00
126_Q129_T0.6371.00
113_Y117_L0.6361.00
194_V324_R0.6341.00
67_S70_T0.6331.00
291_L332_E0.6331.00
270_T273_H0.6311.00
111_Q115_S0.6311.00
222_F225_L0.6251.00
220_R259_G0.6241.00
74_K78_Q0.6241.00
281_D284_I0.6201.00
122_N125_K0.6201.00
205_V245_V0.6191.00
79_A105_M0.6191.00
276_R330_Y0.6181.00
297_A320_Q0.6161.00
95_R99_Q0.6141.00
81_S85_I0.6131.00
107_N111_Q0.6081.00
136_H247_Q0.6081.00
105_M109_L0.6071.00
257_K284_I0.6051.00
199_F235_S0.6041.00
136_H140_T0.6041.00
290_D303_N0.6031.00
259_G262_D0.6011.00
77_E81_S0.6011.00
43_M47_W0.5991.00
206_R209_I0.5991.00
216_F219_R0.5961.00
183_Q240_W0.5941.00
216_F221_L0.5941.00
78_Q91_A0.5911.00
291_L341_M0.5891.00
205_V266_I0.5881.00
79_A106_I0.5861.00
170_E211_Q0.5861.00
288_P292_P0.5851.00
80_S101_L0.5831.00
217_I220_R0.5831.00
153_K164_L0.5821.00
129_T320_Q0.5801.00
294_I316_Y0.5791.00
203_E238_Q0.5771.00
204_M241_L0.5741.00
240_W325_L0.5741.00
202_A232_V0.5731.00
96_T99_Q0.5731.00
220_R258_Q0.5731.00
88_S114_E0.5721.00
144_V166_E0.5721.00
330_Y343_I0.5711.00
83_N87_Q0.5711.00
72_V76_A0.5691.00
252_A279_V0.5681.00
89_L92_R0.5661.00
163_F166_E0.5661.00
90_K107_N0.5661.00
287_P301_G0.5641.00
182_L186_R0.5621.00
78_Q89_L0.5611.00
244_V325_L0.5611.00
73_K77_E0.5611.00
274_E347_S0.5611.00
286_I341_M0.5601.00
81_S84_D0.5601.00
232_V270_T0.5581.00
228_P231_A0.5571.00
109_L112_Q0.5571.00
288_P334_K0.5531.00
131_T135_V0.5521.00
206_R227_V0.5501.00
150_Q154_N0.5501.00
226_H269_E0.5501.00
300_T309_E0.5501.00
249_L264_I0.5481.00
164_L168_E0.5441.00
254_K310_A0.5431.00
80_S105_M0.5431.00
208_L211_Q0.5431.00
287_P291_L0.5421.00
137_H141_P0.5401.00
212_E253_L0.5391.00
219_R253_L0.5381.00
215_Q219_R0.5371.00
148_M167_L0.5361.00
204_M242_S0.5361.00
101_L104_K0.5361.00
280_A336_G0.5351.00
221_L264_I0.5351.00
143_S146_S0.5341.00
134_W181_M0.5341.00
159_S163_F0.5331.00
214_R218_K0.5321.00
201_L275_T0.5321.00
188_E320_Q0.5311.00
51_G55_A0.5311.00
47_W51_G0.5311.00
228_P232_V0.5301.00
95_R102_W0.5291.00
232_V235_S0.5261.00
192_F240_W0.5261.00
118_S121_I0.5261.00
93_K100_A0.5231.00
44_M47_W0.5231.00
329_L341_M0.5211.00
80_S83_N0.5181.00
248_I322_C0.5181.00
121_I125_K0.5161.00
232_V268_I0.5161.00
282_E337_A0.5151.00
268_I277_L0.5141.00
100_A104_K0.5131.00
172_E176_H0.5111.00
82_S86_G0.5091.00
168_E171_N0.5081.00
133_Q137_H0.5071.00
83_N108_A0.5061.00
316_Y320_Q0.5061.00
327_H346_S0.5051.00
228_P267_R0.5041.00
92_R95_R0.5041.00
216_F220_R0.5021.00
95_R98_E0.5001.00
45_Y48_I0.5001.00
102_W109_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.7837 100 0.269 Contact Map
4bixA 2 0.6433 100 0.338 Contact Map
4ctiA 2 0.6404 100 0.369 Contact Map
4mpcA 2 0.8427 100 0.396 Contact Map
4q20A 2 0.6461 100 0.399 Contact Map
2q8gA 2 0.8764 100 0.411 Contact Map
3jz3A 2 0.4494 100 0.412 Contact Map
4e01A 3 0.8146 100 0.417 Contact Map
2c2aA 2 0.6573 100 0.424 Contact Map
3d36A 2 0.6152 100 0.426 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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