GREMLIN Database
YVCP - Uncharacterized transcriptional regulatory protein YvcP
UniProt: O06978 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (208)
Sequences: 74095 (51623)
Seq/√Len: 3579.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A30_I3.7181.00
14_A32_E3.1911.00
18_G30_I3.0411.00
7_V37_I2.7231.00
35_N57_F2.6321.00
29_K46_P2.5851.00
34_L58_F2.5731.00
38_K66_Q2.5491.00
33_Q57_F2.5241.00
42_A70_I2.4021.00
58_F66_Q2.3431.00
3_R29_K2.1861.00
3_R27_E2.1131.00
18_G22_Q2.0511.00
20_H105_L2.0421.00
87_Q107_V1.9801.00
24_Y109_M1.9611.00
31_A40_E1.9311.00
160_K163_Q1.9281.00
195_N198_T1.9241.00
32_E36_D1.9211.00
51_L63_W1.8861.00
54_N81_R1.8411.00
33_Q36_D1.8141.00
84_E104_H1.7821.00
77_F90_A1.7421.00
64_C75_I1.7291.00
5_L31_A1.7071.00
29_K40_E1.6631.00
178_R198_T1.6491.00
59_D62_Y1.6481.00
77_F95_G1.6451.00
68_R96_D1.6341.00
66_Q70_I1.6181.00
166_S170_R1.5771.00
58_F62_Y1.5631.00
138_G151_N1.5371.00
21_L112_I1.5271.00
200_N203_R1.5221.00
34_L63_W1.5181.00
40_E44_M1.4961.00
66_Q69_T1.4911.00
167_I184_A1.4861.00
97_D111_K1.4851.00
135_E140_T1.4521.00
29_K44_M1.4461.00
40_E43_E1.4421.00
64_C77_F1.4391.00
49_V73_A1.4331.00
38_K63_W1.4211.00
81_R86_N1.4171.00
48_L112_I1.4151.00
62_Y65_R1.4081.00
51_L64_C1.3861.00
76_I115_V1.3841.00
41_F67_I1.3771.00
161_E207_K1.3751.00
171_E174_K1.3691.00
176_V184_A1.3491.00
35_N58_F1.3481.00
177_S180_E1.3451.00
65_R93_N1.3391.00
96_D118_R1.3361.00
53_I77_F1.3261.00
8_E14_A1.3051.00
11_E32_E1.2891.00
9_D52_D1.2811.00
7_V55_L1.2761.00
40_E46_P1.2631.00
38_K58_F1.2601.00
39_L43_E1.2581.00
31_A37_I1.2371.00
26_Y113_K1.2361.00
53_I61_F1.2321.00
147_E154_R1.2321.00
92_E113_K1.2281.00
167_I171_E1.2201.00
36_D39_L1.1961.00
96_D115_V1.1951.00
35_N39_L1.1811.00
36_D40_E1.1781.00
3_R44_M1.1721.00
142_Y145_Q1.1711.00
83_D86_N1.1601.00
5_L46_P1.1551.00
162_F166_S1.1381.00
41_F71_S1.1361.00
5_L37_I1.1321.00
24_Y113_K1.1251.00
61_F89_M1.1251.00
48_L116_L1.1221.00
84_E88_V1.1211.00
61_F90_A1.1041.00
65_R89_M1.1001.00
25_G113_K1.0931.00
180_E184_A1.0851.00
210_N219_T1.0781.00
109_M113_K1.0771.00
140_T149_E1.0681.00
4_I26_Y1.0671.00
167_I176_V1.0551.00
141_I169_V1.0471.00
179_D194_D1.0441.00
195_N199_V1.0391.00
107_V110_A1.0371.00
199_V202_N1.0331.00
163_Q166_S1.0331.00
61_F93_N1.0191.00
196_T200_N1.0161.00
89_M93_N1.0141.00
17_L78_I1.0111.00
7_V49_V1.0111.00
37_I41_F1.0001.00
37_I63_W0.9971.00
51_L75_I0.9951.00
85_L89_M0.9901.00
5_L40_E0.9901.00
146_N223_Q0.9891.00
110_A114_S0.9711.00
5_L41_F0.9701.00
201_V205_R0.9681.00
143_P166_S0.9671.00
38_K42_A0.9451.00
15_S30_I0.9451.00
31_A36_D0.9421.00
18_G28_V0.9411.00
49_V67_I0.9381.00
88_V92_E0.9341.00
53_I59_D0.9331.00
45_K71_S0.9281.00
6_L17_L0.9231.00
167_I181_L0.9221.00
6_L28_V0.9201.00
12_R16_L0.9201.00
115_V118_R0.9191.00
11_E15_S0.9151.00
62_Y66_Q0.9101.00
26_Y109_M0.9071.00
64_C95_G0.9061.00
39_L42_A0.9061.00
87_Q100_T0.9051.00
11_E14_A0.9051.00
141_I162_F0.9011.00
7_V31_A0.8971.00
51_L77_F0.8901.00
159_Q163_Q0.8871.00
64_C93_N0.8841.00
176_V180_E0.8821.00
210_N215_D0.8791.00
174_K180_E0.8781.00
50_L108_V0.8741.00
89_M92_E0.8661.00
55_L63_W0.8611.00
149_E154_R0.8561.00
195_N202_N0.8541.00
17_L108_V0.8521.00
88_V106_E0.8461.00
144_D174_K0.8411.00
76_I111_K0.8411.00
3_R46_P0.8371.00
65_R69_T0.8361.00
84_E87_Q0.8351.00
82_T100_T0.8301.00
146_N163_Q0.8281.00
53_I86_N0.8251.00
49_V75_I0.8211.00
179_D183_E0.8201.00
50_L78_I0.8141.00
19_G23_K0.8111.00
194_D198_T0.8091.00
63_W67_I0.8051.00
209_E215_D0.8051.00
107_V111_K0.8001.00
158_S207_K0.7951.00
58_F63_W0.7951.00
54_N80_A0.7941.00
105_L109_M0.7921.00
15_S18_G0.7871.00
91_I111_K0.7801.00
41_F73_A0.7751.00
114_S117_R0.7731.00
76_I97_D0.7701.00
53_I81_R0.7681.00
85_L106_E0.7681.00
74_P96_D0.7671.00
34_L38_K0.7621.00
202_N206_R0.7561.00
203_R206_R0.7531.00
13_I103_F0.7491.00
6_L18_G0.7471.00
103_F108_V0.7471.00
34_L57_F0.7371.00
135_E138_G0.7351.00
219_T223_Q0.7311.00
86_N89_M0.7201.00
38_K41_F0.7201.00
41_F46_P0.7171.00
6_L30_I0.7141.00
212_G215_D0.7141.00
78_I103_F0.7141.00
84_E106_E0.7081.00
178_R194_D0.7061.00
7_V63_W0.7061.00
170_R184_A0.7041.00
8_E55_L0.6971.00
180_E183_E0.6971.00
104_H107_V0.6951.00
149_E152_S0.6951.00
114_S119_T0.6931.00
92_E110_A0.6891.00
167_I170_R0.6871.00
211_A214_T0.6831.00
42_A71_S0.6801.00
116_L119_T0.6781.00
15_S19_G0.6741.00
164_L168_F0.6631.00
138_G150_W0.6621.00
41_F49_V0.6581.00
3_R47_D0.6561.00
22_Q27_E0.6561.00
50_L112_I0.6541.00
42_A66_Q0.6501.00
90_A95_G0.6501.00
205_R210_N0.6481.00
74_P116_L0.6471.00
214_T217_I0.6421.00
21_L26_Y0.6411.00
199_V203_R0.6391.00
106_E110_A0.6391.00
16_L20_H0.6391.00
14_A18_G0.6381.00
209_E214_T0.6321.00
67_I75_I0.6311.00
20_H109_M0.6311.00
192_V197_L0.6301.00
175_I223_Q0.6241.00
139_L150_W0.6221.00
79_S87_Q0.6211.00
111_K115_V0.6211.00
61_F86_N0.6201.00
4_I21_L0.6191.00
201_V213_L0.6161.00
72_N121_G0.6141.00
134_V143_P0.6061.00
34_L55_L0.6061.00
136_L139_L0.6061.00
87_Q104_H0.6031.00
72_N122_E0.6031.00
22_Q28_V0.6031.00
50_L76_I0.6031.00
146_N162_F0.6001.00
168_F201_V0.5981.00
163_Q167_I0.5981.00
119_T123_Y0.5961.00
142_Y147_E0.5931.00
10_D80_A0.5921.00
53_I90_A0.5921.00
97_D114_S0.5911.00
68_R73_A0.5891.00
68_R74_P0.5861.00
143_P170_R0.5861.00
10_D13_I0.5851.00
51_L55_L0.5851.00
4_I48_L0.5851.00
193_D196_T0.5811.00
41_F63_W0.5791.00
52_D101_K0.5781.00
141_I148_A0.5731.00
198_T201_V0.5721.00
38_K70_I0.5721.00
160_K200_N0.5721.00
215_D218_S0.5671.00
103_F107_V0.5661.00
64_C68_R0.5661.00
68_R71_S0.5651.00
136_L169_V0.5601.00
150_W210_N0.5601.00
170_R176_V0.5591.00
154_R219_T0.5511.00
26_Y116_L0.5501.00
9_D79_S0.5501.00
74_P119_T0.5481.00
88_V91_I0.5481.00
150_W209_E0.5471.00
67_I71_S0.5421.00
150_W153_V0.5411.00
110_A113_K0.5401.00
171_E184_A0.5371.00
67_I73_A0.5351.00
134_V169_V0.5341.00
80_A102_P0.5331.00
90_A98_Y0.5321.00
139_L148_A0.5311.00
209_E212_G0.5311.00
113_K117_R0.5311.00
141_I166_S0.5311.00
165_L216_C0.5301.00
135_E139_L0.5281.00
13_I16_L0.5261.00
7_V51_L0.5251.00
51_L67_I0.5241.00
85_L88_V0.5241.00
4_I112_I0.5201.00
6_L14_A0.5201.00
20_H24_Y0.5191.00
112_I116_L0.5151.00
48_L115_V0.5141.00
74_P118_R0.5121.00
7_V34_L0.5091.00
33_Q55_L0.5081.00
211_A215_D0.5031.00
79_S98_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ys7A 2 0.9494 100 0.212 Contact Map
3r0jA 2 0.9241 100 0.214 Contact Map
2gwrA 1 0.9325 100 0.217 Contact Map
4kfcA 2 0.9409 100 0.223 Contact Map
2oqrA 2 0.9494 100 0.225 Contact Map
1kgsA 1 0.9198 100 0.235 Contact Map
4b09A 2 0.8903 100 0.235 Contact Map
2hqrA 2 0.9325 100 0.26 Contact Map
1p2fA 1 0.903 100 0.264 Contact Map
3q9sA 1 0.8861 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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