GREMLIN Database
CRH - HPr-like protein Crh
UniProt: O06976 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 85 (82)
Sequences: 2796 (1875)
Seq/√Len: 207.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_K60_E2.8211.00
65_A74_L2.6521.00
30_T68_E2.4271.00
4_Q78_A2.3491.00
3_Q62_T2.3141.00
6_V78_A2.2171.00
36_E64_I2.0831.00
25_E28_R2.0741.00
29_F76_K2.0161.00
31_S69_D2.0101.00
34_F41_K2.0071.00
41_K64_I1.9601.00
36_E41_K1.9601.00
36_E62_T1.9311.00
78_A82_Q1.8241.00
5_K62_T1.7751.00
71_Q75_E1.7241.00
3_Q64_I1.6981.00
7_E60_E1.6471.00
37_K59_T1.6441.00
2_V74_L1.5961.00
30_T69_D1.5771.00
25_E76_K1.4661.00
22_F44_A1.4061.00
32_D66_Q1.3621.00
9_R82_Q1.3591.00
2_V71_Q1.3201.00
26_A77_L1.3071.00
75_E79_A1.2541.00
72_E76_K1.2311.00
2_V70_E1.2001.00
22_F77_L1.1631.00
29_F73_A1.1411.00
11_K57_T1.1381.00
4_Q75_E1.1071.00
36_E39_G1.0331.00
22_F81_V1.0261.00
42_V53_L1.0111.00
32_D43_N1.0101.00
1_M70_E0.9941.00
31_S65_A0.9841.00
33_V73_A0.9741.00
72_E75_E0.9711.00
56_S59_T0.9581.00
14_L22_F0.9520.99
21_L25_E0.9510.99
55_V61_V0.9350.99
22_F35_L0.9150.99
8_V55_V0.8910.99
46_S49_G0.8790.99
2_V65_A0.8670.99
69_D72_E0.8640.99
43_N46_S0.8580.99
23_V47_I0.8520.99
6_V63_L0.8370.99
12_T18_P0.8330.99
21_L24_Q0.8290.99
33_V65_A0.8250.99
27_N49_G0.7970.98
10_L80_Y0.7940.98
20_A51_M0.7880.98
26_A33_V0.7770.98
34_F64_I0.7750.98
4_Q82_Q0.7670.98
76_K79_A0.7580.97
29_F69_D0.7570.97
42_V49_G0.7560.97
63_L81_V0.7530.97
21_L80_Y0.7470.97
48_M52_S0.7320.97
25_E80_Y0.7280.97
13_G19_A0.7280.97
20_A24_Q0.7140.96
33_V44_A0.7130.96
16_A20_A0.7130.96
61_V81_V0.7030.96
42_V48_M0.6870.95
26_A73_A0.6860.95
6_V14_L0.6670.95
22_F63_L0.6660.95
34_F43_N0.6630.94
24_Q28_R0.6620.94
69_D73_A0.6460.94
20_A46_S0.6410.93
37_K55_V0.6380.93
18_P21_L0.6380.93
43_N48_M0.6330.93
74_L78_A0.6320.93
26_A45_K0.6290.93
63_L74_L0.6220.92
47_I51_M0.6120.92
13_G17_R0.6080.92
19_A50_L0.5980.91
23_V50_L0.5920.90
47_I54_A0.5880.90
48_M51_M0.5880.90
38_D59_T0.5850.90
6_V81_V0.5840.90
15_Q18_P0.5760.89
27_N47_I0.5760.89
10_L15_Q0.5750.89
63_L77_L0.5750.89
12_T81_V0.5700.89
52_S55_V0.5660.88
16_A47_I0.5600.88
35_L50_L0.5590.88
16_A48_M0.5570.88
15_Q80_Y0.5570.88
11_K37_K0.5570.88
4_Q74_L0.5560.87
6_V74_L0.5540.87
36_E42_V0.5540.87
78_A81_V0.5500.87
10_L81_V0.5490.87
10_L51_M0.5420.86
43_N49_G0.5390.86
19_A47_I0.5210.84
54_A59_T0.5170.83
16_A23_V0.5080.82
18_P52_S0.5060.82
8_V61_V0.5010.82
31_S70_E0.5010.82
8_V81_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kklH 1 0.9765 100 0.128 Contact Map
3ihsA 1 0.9647 100 0.128 Contact Map
3le1A 1 1 100 0.129 Contact Map
1ka5A 1 1 100 0.129 Contact Map
1ptfA 1 1 100 0.133 Contact Map
1y51A 1 0.9882 100 0.133 Contact Map
1sphA 2 0.9882 100 0.133 Contact Map
3ccdA 2 1 100 0.134 Contact Map
1pchA 1 0.9882 99.9 0.158 Contact Map
2jpiA 1 0.8941 68.9 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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