GREMLIN Database
WHIA - Putative sporulation transcription regulator WhiA
UniProt: O06975 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (306)
Sequences: 1227 (812)
Seq/√Len: 46.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_C123_C5.9561.00
19_C123_C5.4901.00
65_Y99_D5.4581.00
20_C122_C4.8731.00
24_E56_R4.5311.00
19_C122_C4.5191.00
194_F198_I4.2731.00
248_I303_I4.1881.00
262_R266_Q4.1061.00
244_N301_D4.0171.00
248_I253_G3.1641.00
266_Q270_D2.8211.00
242_V269_I2.7671.00
280_G293_I2.7581.00
244_N308_R2.7191.00
264_I293_I2.7101.00
25_L57_I2.7061.00
248_I307_L2.6661.00
247_Y308_R2.4821.00
48_T54_A2.4401.00
249_D254_L2.4241.00
24_E129_R2.4181.00
271_Y282_M2.2561.00
302_E306_Q2.2451.00
124_K167_E2.2051.00
246_K249_D2.1961.00
6_E206_R2.1871.00
267_L282_M2.1541.00
150_I194_F2.1151.00
263_E285_S2.0741.00
277_K281_E2.0581.00
305_E308_R2.0230.99
192_T204_L2.0100.99
148_L194_F1.9940.99
196_N201_H1.9840.99
170_L185_L1.9500.99
231_L235_I1.9440.99
256_A300_L1.9170.99
138_V191_I1.8490.99
248_I252_I1.8370.99
9_K13_N1.8350.99
220_V224_V1.8250.99
188_A211_R1.8250.99
17_K20_C1.8080.99
224_V231_L1.7930.99
228_T231_L1.7820.99
112_S160_S1.7640.98
162_C172_S1.7080.98
120_K123_C1.6960.98
150_I165_L1.6680.98
206_R209_D1.6390.97
208_E211_R1.6220.97
205_L212_I1.6220.97
196_N204_L1.6040.97
252_I303_I1.5830.97
162_C174_T1.4840.95
30_R127_Y1.4680.95
135_G150_I1.4540.95
56_R129_R1.4420.95
255_E266_Q1.4410.95
280_G287_K1.4280.94
155_K159_D1.4230.94
94_K98_E1.4150.94
31_M131_A1.4050.94
249_D269_I1.3940.94
147_H186_K1.3890.94
11_L14_L1.3890.94
259_E262_R1.3850.93
201_H205_L1.3830.93
22_N99_D1.3760.93
292_G295_H1.3700.93
51_A55_R1.3590.93
7_T203_S1.3590.93
55_R58_Y1.3560.93
11_L129_R1.3500.93
127_Y157_H1.3440.92
25_L100_L1.3440.92
264_I297_L1.3260.92
67_V96_I1.3250.92
201_H204_L1.3140.91
267_L283_V1.3130.91
59_T63_K1.3100.91
158_N183_T1.3080.91
128_M161_L1.3030.91
44_L127_Y1.3030.91
73_V85_Y1.3030.91
125_R197_V1.2990.91
22_N65_Y1.2870.91
32_N53_I1.2740.90
29_I44_L1.2510.89
248_I251_R1.2330.89
261_L296_R1.2280.88
277_K280_G1.2270.88
215_D219_S1.2270.88
27_A131_A1.2250.88
155_K181_Y1.2230.88
28_L53_I1.2210.88
300_L303_I1.2160.88
205_L209_D1.2130.88
21_I63_K1.2030.87
172_S183_T1.1970.87
165_L194_F1.1950.87
305_E309_T1.1880.87
252_I256_A1.1870.87
14_L129_R1.1770.86
45_D88_R1.1760.86
61_L89_F1.1660.86
220_V227_E1.1620.85
128_M194_F1.1590.85
243_E246_K1.1580.85
280_G283_V1.1570.85
192_T196_N1.1530.85
67_V89_F1.1440.85
35_L114_S1.1430.84
279_L297_L1.1410.84
224_V228_T1.1370.84
192_T211_R1.1330.84
282_M303_I1.1290.84
224_V227_E1.1060.82
161_L165_L1.0960.82
113_I160_S1.0930.82
52_A55_R1.0930.82
85_Y89_F1.0900.82
207_F211_R1.0800.81
235_I239_L1.0640.80
244_N304_A1.0630.80
240_R301_D1.0610.80
27_A33_G1.0610.80
27_A298_R1.0510.79
166_N171_N1.0500.79
50_N197_V1.0490.79
31_M152_S1.0450.79
246_K272_Q1.0410.78
121_R168_F1.0400.78
135_G152_S1.0380.78
261_L276_L1.0370.78
45_D173_K1.0330.78
251_R307_L1.0330.78
4_A289_S1.0260.77
247_Y307_L1.0190.77
137_S147_H1.0100.76
55_R79_L1.0030.76
66_D99_D1.0020.76
139_N289_S1.0010.76
2_S238_S1.0000.76
5_S49_E0.9890.75
92_N96_I0.9890.75
152_S161_L0.9810.74
33_G290_K0.9790.74
185_L194_F0.9780.74
213_V227_E0.9710.73
128_M165_L0.9640.73
159_D162_C0.9610.73
28_L46_V0.9590.72
168_F197_V0.9580.72
30_R35_L0.9520.72
92_N95_A0.9440.71
31_M157_H0.9420.71
131_A152_S0.9370.71
274_V282_M0.9160.69
229_A296_R0.9130.69
228_T239_L0.9120.69
249_D266_Q0.9070.68
204_L208_E0.9060.68
89_F96_I0.9040.68
217_R221_N0.8970.67
248_I256_A0.8960.67
79_L83_N0.8940.67
220_V228_T0.8860.66
54_A87_V0.8820.66
264_I283_V0.8800.66
15_E56_R0.8790.66
188_A214_R0.8780.66
267_L279_L0.8750.65
31_M134_A0.8620.64
24_E133_L0.8620.64
233_K245_I0.8620.64
44_L93_A0.8570.64
147_H241_Q0.8560.64
227_E235_I0.8510.63
165_L183_T0.8440.63
249_D256_A0.8430.62
5_S87_V0.8420.62
204_L209_D0.8310.61
283_V288_I0.8300.61
177_R184_Y0.8290.61
139_N260_K0.8200.60
11_L24_E0.8200.60
177_R295_H0.8190.60
61_L210_V0.8140.60
205_L233_K0.8100.59
9_K12_T0.8090.59
296_R304_A0.8010.59
146_Y218_N0.8010.59
170_L183_T0.8000.58
20_C120_K0.7990.58
13_N55_R0.7960.58
260_K289_S0.7950.58
12_T32_N0.7950.58
226_C297_L0.7890.57
280_G286_G0.7870.57
228_T234_T0.7870.57
11_L198_I0.7860.57
96_I161_L0.7850.57
118_V164_L0.7820.57
274_V278_E0.7800.56
202_N205_L0.7770.56
165_L170_L0.7770.56
242_V272_Q0.7770.56
7_T306_Q0.7720.56
61_L67_V0.7720.56
167_E271_Y0.7600.55
217_R237_A0.7600.55
158_N174_T0.7600.55
84_V273_E0.7580.54
247_Y251_R0.7560.54
261_L265_A0.7550.54
234_T237_A0.7510.54
19_C120_K0.7510.54
159_D183_T0.7500.54
204_L211_R0.7480.53
17_K122_C0.7470.53
291_S295_H0.7470.53
9_K50_N0.7380.52
217_R231_L0.7360.52
64_Q161_L0.7300.52
231_L239_L0.7290.51
11_L44_L0.7260.51
104_G111_R0.7250.51
139_N207_F0.7250.51
151_F180_G0.7180.50
3_F175_L0.7170.50
131_A161_L0.7170.50
101_K116_E0.7160.50
98_E105_E0.7160.50
51_A70_E0.7110.50
193_E212_I0.7110.50
155_K271_Y0.7100.50
61_L96_I0.7090.49
264_I280_G0.7080.49
72_L84_V0.7060.49
125_R196_N0.7060.49
240_R305_E0.7050.49
294_N298_R0.7020.49
177_R182_I0.7010.49
297_L301_D0.6990.49
26_S35_L0.6970.48
182_I233_K0.6970.48
249_D253_G0.6970.48
119_K150_I0.6940.48
49_E273_E0.6930.48
283_V293_I0.6920.48
55_R208_E0.6920.48
65_Y238_S0.6920.48
26_S196_N0.6910.48
35_L93_A0.6880.47
49_E82_N0.6860.47
237_A296_R0.6830.47
257_L303_I0.6830.47
176_E269_I0.6810.47
265_A297_L0.6810.47
264_I288_I0.6810.47
163_D305_E0.6790.47
150_I157_H0.6760.46
58_Y66_D0.6730.46
293_I297_L0.6720.46
214_R235_I0.6690.46
65_Y96_I0.6660.45
303_I307_L0.6660.45
114_S120_K0.6660.45
74_R79_L0.6650.45
35_L111_R0.6630.45
236_G277_K0.6600.45
302_E305_E0.6600.45
188_A239_L0.6590.45
98_E101_K0.6570.44
275_T282_M0.6560.44
177_R299_K0.6550.44
5_S9_K0.6550.44
304_A308_R0.6540.44
216_M224_V0.6540.44
283_V294_N0.6520.44
247_Y250_E0.6510.44
12_T53_I0.6510.44
30_R157_H0.6510.44
267_L297_L0.6480.44
184_Y218_N0.6470.43
249_D252_I0.6470.43
46_V212_I0.6460.43
62_K72_L0.6460.43
178_K289_S0.6450.43
17_K123_C0.6440.43
75_K83_N0.6430.43
51_A85_Y0.6430.43
177_R186_K0.6420.43
52_A79_L0.6380.43
8_K132_F0.6360.42
287_K293_I0.6350.42
288_I292_G0.6340.42
54_A74_R0.6340.42
29_I242_V0.6340.42
226_C295_H0.6340.42
14_L103_L0.6330.42
113_I161_L0.6320.42
76_K150_I0.6320.42
184_Y233_K0.6280.42
246_K300_L0.6260.41
211_R221_N0.6260.41
128_M166_N0.6250.41
35_L103_L0.6230.41
289_S293_I0.6230.41
264_I267_L0.6220.41
166_N172_S0.6220.41
87_V306_Q0.6210.41
201_H216_M0.6210.41
54_A71_L0.6210.41
24_E29_I0.6210.41
257_L265_A0.6210.41
37_F40_R0.6200.41
187_E224_V0.6200.41
2_S28_L0.6200.41
163_D259_E0.6180.41
199_G267_L0.6150.40
127_Y203_S0.6150.40
187_E296_R0.6140.40
146_Y257_L0.6130.40
119_K124_K0.6110.40
48_T214_R0.6100.40
130_G134_A0.6100.40
249_D300_L0.6100.40
187_E294_N0.6090.40
175_L182_I0.6080.40
254_L300_L0.6070.40
3_F273_E0.6070.40
191_I209_D0.6050.39
16_V21_I0.6040.39
224_V277_K0.6030.39
104_G108_V0.6020.39
192_T208_E0.6000.39
124_K235_I0.5980.39
289_S292_G0.5980.39
16_V56_R0.5980.39
26_S158_N0.5970.39
131_A135_G0.5970.39
5_S220_V0.5940.38
254_L262_R0.5940.38
158_N290_K0.5930.38
114_S119_K0.5900.38
221_N226_C0.5900.38
239_L303_I0.5900.38
75_K79_L0.5900.38
256_A303_I0.5880.38
174_T183_T0.5870.38
4_A260_K0.5860.38
30_R302_E0.5850.38
4_A144_S0.5840.37
10_E33_G0.5840.37
239_L289_S0.5840.37
139_N241_Q0.5830.37
28_L32_N0.5830.37
204_L214_R0.5820.37
232_N299_K0.5780.37
193_E196_N0.5760.37
195_L205_L0.5740.36
29_I46_V0.5720.36
27_A295_H0.5720.36
66_D69_V0.5720.36
209_D212_I0.5710.36
229_A261_L0.5710.36
247_Y304_A0.5700.36
220_V231_L0.5670.36
50_N53_I0.5650.36
141_P221_N0.5650.36
161_L173_K0.5640.36
78_R216_M0.5630.35
18_D22_N0.5620.35
215_D221_N0.5610.35
159_D163_D0.5600.35
217_R228_T0.5600.35
231_L294_N0.5580.35
246_K250_E0.5580.35
55_R59_T0.5570.35
74_R86_I0.5530.35
267_L300_L0.5530.35
210_V214_R0.5520.35
9_K275_T0.5520.35
46_V182_I0.5510.34
251_R265_A0.5500.34
253_G262_R0.5480.34
12_T189_E0.5480.34
30_R103_L0.5470.34
114_S118_V0.5450.34
288_I302_E0.5450.34
162_C165_L0.5450.34
46_V57_I0.5440.34
37_F79_L0.5410.34
129_R224_V0.5410.34
39_N198_I0.5400.33
266_Q282_M0.5390.33
158_N162_C0.5370.33
159_D300_L0.5370.33
125_R234_T0.5370.33
12_T52_A0.5360.33
9_K52_A0.5350.33
35_L154_Y0.5340.33
20_C126_S0.5340.33
26_S33_G0.5340.33
144_S286_G0.5340.33
44_L206_R0.5340.33
129_R209_D0.5320.33
191_I294_N0.5280.32
31_M135_G0.5280.32
18_D63_K0.5270.32
247_Y302_E0.5270.32
172_S185_L0.5270.32
129_R261_L0.5270.32
2_S86_I0.5260.32
73_V238_S0.5260.32
296_R299_K0.5250.32
265_A269_I0.5240.32
208_E212_I0.5230.32
216_M280_G0.5230.32
20_C124_K0.5230.32
61_L64_Q0.5230.32
29_I201_H0.5210.32
258_P261_L0.5210.32
103_L297_L0.5200.32
303_I306_Q0.5190.32
95_A159_D0.5190.32
218_N249_D0.5180.32
139_N147_H0.5180.32
159_D174_T0.5140.31
94_K250_E0.5140.31
194_F207_F0.5130.31
53_I80_K0.5120.31
102_I194_F0.5120.31
48_T177_R0.5120.31
139_N176_E0.5110.31
95_A264_I0.5110.31
36_S45_D0.5110.31
7_T36_S0.5100.31
178_K235_I0.5100.31
226_C233_K0.5100.31
186_K241_Q0.5090.31
23_A279_L0.5090.31
62_K74_R0.5090.31
170_L194_F0.5080.31
4_A151_F0.5070.31
53_I189_E0.5070.31
120_K194_F0.5060.31
12_T41_H0.5050.30
62_K233_K0.5050.30
129_R227_E0.5050.30
279_L293_I0.5050.30
127_Y160_S0.5020.30
13_N52_A0.5020.30
40_R94_K0.5020.30
196_N280_G0.5000.30
59_T66_D0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hyiA 1 0.8924 100 0.109 Contact Map
2dchX 3 0.6108 100 0.73 Contact Map
2vs7A 1 0.5601 99.9 0.761 Contact Map
1dq3A 1 0.8671 99.9 0.771 Contact Map
1dfaA 1 0.7089 99.9 0.774 Contact Map
2cw8A 1 0.7278 99.9 0.787 Contact Map
3c0wA 1 0.6361 93.3 0.943 Contact Map
1s7oA 3 0.2342 92.7 0.944 Contact Map
1xsvA 2 0.2342 92 0.945 Contact Map
3r4kA 2 0.193 87.8 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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