WHIA - BACSU - GREMLIN Contacts

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WHIA - Putative sporulation transcription regulator WhiA

UniProt:	O06975	Sequences: MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVLDVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKILGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDSLCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRNSVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTLKELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (306)
Sequences:	1227 (812)
Seq/√Len:	46.4

BACSU - WHIA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
20_C	123_C	5.956	1.00
19_C	123_C	5.490	1.00
65_Y	99_D	5.458	1.00
20_C	122_C	4.873	1.00
24_E	56_R	4.531	1.00
19_C	122_C	4.519	1.00
194_F	198_I	4.273	1.00
248_I	303_I	4.188	1.00
262_R	266_Q	4.106	1.00
244_N	301_D	4.017	1.00
248_I	253_G	3.164	1.00
266_Q	270_D	2.821	1.00
242_V	269_I	2.767	1.00
280_G	293_I	2.758	1.00
244_N	308_R	2.719	1.00
264_I	293_I	2.710	1.00
25_L	57_I	2.706	1.00
248_I	307_L	2.666	1.00
247_Y	308_R	2.482	1.00
48_T	54_A	2.440	1.00
249_D	254_L	2.424	1.00
24_E	129_R	2.418	1.00
271_Y	282_M	2.256	1.00
302_E	306_Q	2.245	1.00
124_K	167_E	2.205	1.00
246_K	249_D	2.196	1.00
6_E	206_R	2.187	1.00
267_L	282_M	2.154	1.00
150_I	194_F	2.115	1.00
263_E	285_S	2.074	1.00
277_K	281_E	2.058	1.00
305_E	308_R	2.023	0.99
192_T	204_L	2.010	0.99
148_L	194_F	1.994	0.99
196_N	201_H	1.984	0.99
170_L	185_L	1.950	0.99
231_L	235_I	1.944	0.99
256_A	300_L	1.917	0.99
138_V	191_I	1.849	0.99
248_I	252_I	1.837	0.99
9_K	13_N	1.835	0.99
220_V	224_V	1.825	0.99
188_A	211_R	1.825	0.99
17_K	20_C	1.808	0.99
224_V	231_L	1.793	0.99
228_T	231_L	1.782	0.99
112_S	160_S	1.764	0.98
162_C	172_S	1.708	0.98
120_K	123_C	1.696	0.98
150_I	165_L	1.668	0.98
206_R	209_D	1.639	0.97
208_E	211_R	1.622	0.97
205_L	212_I	1.622	0.97
196_N	204_L	1.604	0.97
252_I	303_I	1.583	0.97
162_C	174_T	1.484	0.95
30_R	127_Y	1.468	0.95
135_G	150_I	1.454	0.95
56_R	129_R	1.442	0.95
255_E	266_Q	1.441	0.95
280_G	287_K	1.428	0.94
155_K	159_D	1.423	0.94
94_K	98_E	1.415	0.94
31_M	131_A	1.405	0.94
249_D	269_I	1.394	0.94
147_H	186_K	1.389	0.94
11_L	14_L	1.389	0.94
259_E	262_R	1.385	0.93
201_H	205_L	1.383	0.93
22_N	99_D	1.376	0.93
292_G	295_H	1.370	0.93
51_A	55_R	1.359	0.93
7_T	203_S	1.359	0.93
55_R	58_Y	1.356	0.93
11_L	129_R	1.350	0.93
127_Y	157_H	1.344	0.92
25_L	100_L	1.344	0.92
264_I	297_L	1.326	0.92
67_V	96_I	1.325	0.92
201_H	204_L	1.314	0.91
267_L	283_V	1.313	0.91
59_T	63_K	1.310	0.91
158_N	183_T	1.308	0.91
128_M	161_L	1.303	0.91
44_L	127_Y	1.303	0.91
73_V	85_Y	1.303	0.91
125_R	197_V	1.299	0.91
22_N	65_Y	1.287	0.91
32_N	53_I	1.274	0.90
29_I	44_L	1.251	0.89
248_I	251_R	1.233	0.89
261_L	296_R	1.228	0.88
277_K	280_G	1.227	0.88
215_D	219_S	1.227	0.88
27_A	131_A	1.225	0.88
155_K	181_Y	1.223	0.88
28_L	53_I	1.221	0.88
300_L	303_I	1.216	0.88
205_L	209_D	1.213	0.88
21_I	63_K	1.203	0.87
172_S	183_T	1.197	0.87
165_L	194_F	1.195	0.87
305_E	309_T	1.188	0.87
252_I	256_A	1.187	0.87
14_L	129_R	1.177	0.86
45_D	88_R	1.176	0.86
61_L	89_F	1.166	0.86
220_V	227_E	1.162	0.85
128_M	194_F	1.159	0.85
243_E	246_K	1.158	0.85
280_G	283_V	1.157	0.85
192_T	196_N	1.153	0.85
67_V	89_F	1.144	0.85
35_L	114_S	1.143	0.84
279_L	297_L	1.141	0.84
224_V	228_T	1.137	0.84
192_T	211_R	1.133	0.84
282_M	303_I	1.129	0.84
224_V	227_E	1.106	0.82
161_L	165_L	1.096	0.82
113_I	160_S	1.093	0.82
52_A	55_R	1.093	0.82
85_Y	89_F	1.090	0.82
207_F	211_R	1.080	0.81
235_I	239_L	1.064	0.80
244_N	304_A	1.063	0.80
240_R	301_D	1.061	0.80
27_A	33_G	1.061	0.80
27_A	298_R	1.051	0.79
166_N	171_N	1.050	0.79
50_N	197_V	1.049	0.79
31_M	152_S	1.045	0.79
246_K	272_Q	1.041	0.78
121_R	168_F	1.040	0.78
135_G	152_S	1.038	0.78
261_L	276_L	1.037	0.78
45_D	173_K	1.033	0.78
251_R	307_L	1.033	0.78
4_A	289_S	1.026	0.77
247_Y	307_L	1.019	0.77
137_S	147_H	1.010	0.76
55_R	79_L	1.003	0.76
66_D	99_D	1.002	0.76
139_N	289_S	1.001	0.76
2_S	238_S	1.000	0.76
5_S	49_E	0.989	0.75
92_N	96_I	0.989	0.75
152_S	161_L	0.981	0.74
33_G	290_K	0.979	0.74
185_L	194_F	0.978	0.74
213_V	227_E	0.971	0.73
128_M	165_L	0.964	0.73
159_D	162_C	0.961	0.73
28_L	46_V	0.959	0.72
168_F	197_V	0.958	0.72
30_R	35_L	0.952	0.72
92_N	95_A	0.944	0.71
31_M	157_H	0.942	0.71
131_A	152_S	0.937	0.71
274_V	282_M	0.916	0.69
229_A	296_R	0.913	0.69
228_T	239_L	0.912	0.69
249_D	266_Q	0.907	0.68
204_L	208_E	0.906	0.68
89_F	96_I	0.904	0.68
217_R	221_N	0.897	0.67
248_I	256_A	0.896	0.67
79_L	83_N	0.894	0.67
220_V	228_T	0.886	0.66
54_A	87_V	0.882	0.66
264_I	283_V	0.880	0.66
15_E	56_R	0.879	0.66
188_A	214_R	0.878	0.66
267_L	279_L	0.875	0.65
31_M	134_A	0.862	0.64
24_E	133_L	0.862	0.64
233_K	245_I	0.862	0.64
44_L	93_A	0.857	0.64
147_H	241_Q	0.856	0.64
227_E	235_I	0.851	0.63
165_L	183_T	0.844	0.63
249_D	256_A	0.843	0.62
5_S	87_V	0.842	0.62
204_L	209_D	0.831	0.61
283_V	288_I	0.830	0.61
177_R	184_Y	0.829	0.61
139_N	260_K	0.820	0.60
11_L	24_E	0.820	0.60
177_R	295_H	0.819	0.60
61_L	210_V	0.814	0.60
205_L	233_K	0.810	0.59
9_K	12_T	0.809	0.59
296_R	304_A	0.801	0.59
146_Y	218_N	0.801	0.59
170_L	183_T	0.800	0.58
20_C	120_K	0.799	0.58
13_N	55_R	0.796	0.58
260_K	289_S	0.795	0.58
12_T	32_N	0.795	0.58
226_C	297_L	0.789	0.57
280_G	286_G	0.787	0.57
228_T	234_T	0.787	0.57
11_L	198_I	0.786	0.57
96_I	161_L	0.785	0.57
118_V	164_L	0.782	0.57
274_V	278_E	0.780	0.56
202_N	205_L	0.777	0.56
165_L	170_L	0.777	0.56
242_V	272_Q	0.777	0.56
7_T	306_Q	0.772	0.56
61_L	67_V	0.772	0.56
167_E	271_Y	0.760	0.55
217_R	237_A	0.760	0.55
158_N	174_T	0.760	0.55
84_V	273_E	0.758	0.54
247_Y	251_R	0.756	0.54
261_L	265_A	0.755	0.54
234_T	237_A	0.751	0.54
19_C	120_K	0.751	0.54
159_D	183_T	0.750	0.54
204_L	211_R	0.748	0.53
17_K	122_C	0.747	0.53
291_S	295_H	0.747	0.53
9_K	50_N	0.738	0.52
217_R	231_L	0.736	0.52
64_Q	161_L	0.730	0.52
231_L	239_L	0.729	0.51
11_L	44_L	0.726	0.51
104_G	111_R	0.725	0.51
139_N	207_F	0.725	0.51
151_F	180_G	0.718	0.50
3_F	175_L	0.717	0.50
131_A	161_L	0.717	0.50
101_K	116_E	0.716	0.50
98_E	105_E	0.716	0.50
51_A	70_E	0.711	0.50
193_E	212_I	0.711	0.50
155_K	271_Y	0.710	0.50
61_L	96_I	0.709	0.49
264_I	280_G	0.708	0.49
72_L	84_V	0.706	0.49
125_R	196_N	0.706	0.49
240_R	305_E	0.705	0.49
294_N	298_R	0.702	0.49
177_R	182_I	0.701	0.49
297_L	301_D	0.699	0.49
26_S	35_L	0.697	0.48
182_I	233_K	0.697	0.48
249_D	253_G	0.697	0.48
119_K	150_I	0.694	0.48
49_E	273_E	0.693	0.48
283_V	293_I	0.692	0.48
55_R	208_E	0.692	0.48
65_Y	238_S	0.692	0.48
26_S	196_N	0.691	0.48
35_L	93_A	0.688	0.47
49_E	82_N	0.686	0.47
237_A	296_R	0.683	0.47
257_L	303_I	0.683	0.47
176_E	269_I	0.681	0.47
265_A	297_L	0.681	0.47
264_I	288_I	0.681	0.47
163_D	305_E	0.679	0.47
150_I	157_H	0.676	0.46
58_Y	66_D	0.673	0.46
293_I	297_L	0.672	0.46
214_R	235_I	0.669	0.46
65_Y	96_I	0.666	0.45
303_I	307_L	0.666	0.45
114_S	120_K	0.666	0.45
74_R	79_L	0.665	0.45
35_L	111_R	0.663	0.45
236_G	277_K	0.660	0.45
302_E	305_E	0.660	0.45
188_A	239_L	0.659	0.45
98_E	101_K	0.657	0.44
275_T	282_M	0.656	0.44
177_R	299_K	0.655	0.44
5_S	9_K	0.655	0.44
304_A	308_R	0.654	0.44
216_M	224_V	0.654	0.44
283_V	294_N	0.652	0.44
247_Y	250_E	0.651	0.44
12_T	53_I	0.651	0.44
30_R	157_H	0.651	0.44
267_L	297_L	0.648	0.44
184_Y	218_N	0.647	0.43
249_D	252_I	0.647	0.43
46_V	212_I	0.646	0.43
62_K	72_L	0.646	0.43
178_K	289_S	0.645	0.43
17_K	123_C	0.644	0.43
75_K	83_N	0.643	0.43
51_A	85_Y	0.643	0.43
177_R	186_K	0.642	0.43
52_A	79_L	0.638	0.43
8_K	132_F	0.636	0.42
287_K	293_I	0.635	0.42
288_I	292_G	0.634	0.42
54_A	74_R	0.634	0.42
29_I	242_V	0.634	0.42
226_C	295_H	0.634	0.42
14_L	103_L	0.633	0.42
113_I	161_L	0.632	0.42
76_K	150_I	0.632	0.42
184_Y	233_K	0.628	0.42
246_K	300_L	0.626	0.41
211_R	221_N	0.626	0.41
128_M	166_N	0.625	0.41
35_L	103_L	0.623	0.41
289_S	293_I	0.623	0.41
264_I	267_L	0.622	0.41
166_N	172_S	0.622	0.41
87_V	306_Q	0.621	0.41
201_H	216_M	0.621	0.41
54_A	71_L	0.621	0.41
24_E	29_I	0.621	0.41
257_L	265_A	0.621	0.41
37_F	40_R	0.620	0.41
187_E	224_V	0.620	0.41
2_S	28_L	0.620	0.41
163_D	259_E	0.618	0.41
199_G	267_L	0.615	0.40
127_Y	203_S	0.615	0.40
187_E	296_R	0.614	0.40
146_Y	257_L	0.613	0.40
119_K	124_K	0.611	0.40
48_T	214_R	0.610	0.40
130_G	134_A	0.610	0.40
249_D	300_L	0.610	0.40
187_E	294_N	0.609	0.40
175_L	182_I	0.608	0.40
254_L	300_L	0.607	0.40
3_F	273_E	0.607	0.40
191_I	209_D	0.605	0.39
16_V	21_I	0.604	0.39
224_V	277_K	0.603	0.39
104_G	108_V	0.602	0.39
192_T	208_E	0.600	0.39
124_K	235_I	0.598	0.39
289_S	292_G	0.598	0.39
16_V	56_R	0.598	0.39
26_S	158_N	0.597	0.39
131_A	135_G	0.597	0.39
5_S	220_V	0.594	0.38
254_L	262_R	0.594	0.38
158_N	290_K	0.593	0.38
114_S	119_K	0.590	0.38
221_N	226_C	0.590	0.38
239_L	303_I	0.590	0.38
75_K	79_L	0.590	0.38
256_A	303_I	0.588	0.38
174_T	183_T	0.587	0.38
4_A	260_K	0.586	0.38
30_R	302_E	0.585	0.38
4_A	144_S	0.584	0.37
10_E	33_G	0.584	0.37
239_L	289_S	0.584	0.37
139_N	241_Q	0.583	0.37
28_L	32_N	0.583	0.37
204_L	214_R	0.582	0.37
232_N	299_K	0.578	0.37
193_E	196_N	0.576	0.37
195_L	205_L	0.574	0.36
29_I	46_V	0.572	0.36
27_A	295_H	0.572	0.36
66_D	69_V	0.572	0.36
209_D	212_I	0.571	0.36
229_A	261_L	0.571	0.36
247_Y	304_A	0.570	0.36
220_V	231_L	0.567	0.36
50_N	53_I	0.565	0.36
141_P	221_N	0.565	0.36
161_L	173_K	0.564	0.36
78_R	216_M	0.563	0.35
18_D	22_N	0.562	0.35
215_D	221_N	0.561	0.35
159_D	163_D	0.560	0.35
217_R	228_T	0.560	0.35
231_L	294_N	0.558	0.35
246_K	250_E	0.558	0.35
55_R	59_T	0.557	0.35
74_R	86_I	0.553	0.35
267_L	300_L	0.553	0.35
210_V	214_R	0.552	0.35
9_K	275_T	0.552	0.35
46_V	182_I	0.551	0.34
251_R	265_A	0.550	0.34
253_G	262_R	0.548	0.34
12_T	189_E	0.548	0.34
30_R	103_L	0.547	0.34
114_S	118_V	0.545	0.34
288_I	302_E	0.545	0.34
162_C	165_L	0.545	0.34
46_V	57_I	0.544	0.34
37_F	79_L	0.541	0.34
129_R	224_V	0.541	0.34
39_N	198_I	0.540	0.33
266_Q	282_M	0.539	0.33
158_N	162_C	0.537	0.33
159_D	300_L	0.537	0.33
125_R	234_T	0.537	0.33
12_T	52_A	0.536	0.33
9_K	52_A	0.535	0.33
35_L	154_Y	0.534	0.33
20_C	126_S	0.534	0.33
26_S	33_G	0.534	0.33
144_S	286_G	0.534	0.33
44_L	206_R	0.534	0.33
129_R	209_D	0.532	0.33
191_I	294_N	0.528	0.32
31_M	135_G	0.528	0.32
18_D	63_K	0.527	0.32
247_Y	302_E	0.527	0.32
172_S	185_L	0.527	0.32
129_R	261_L	0.527	0.32
2_S	86_I	0.526	0.32
73_V	238_S	0.526	0.32
296_R	299_K	0.525	0.32
265_A	269_I	0.524	0.32
208_E	212_I	0.523	0.32
216_M	280_G	0.523	0.32
20_C	124_K	0.523	0.32
61_L	64_Q	0.523	0.32
29_I	201_H	0.521	0.32
258_P	261_L	0.521	0.32
103_L	297_L	0.520	0.32
303_I	306_Q	0.519	0.32
95_A	159_D	0.519	0.32
218_N	249_D	0.518	0.32
139_N	147_H	0.518	0.32
159_D	174_T	0.514	0.31
94_K	250_E	0.514	0.31
194_F	207_F	0.513	0.31
53_I	80_K	0.512	0.31
102_I	194_F	0.512	0.31
48_T	177_R	0.512	0.31
139_N	176_E	0.511	0.31
95_A	264_I	0.511	0.31
36_S	45_D	0.511	0.31
7_T	36_S	0.510	0.31
178_K	235_I	0.510	0.31
226_C	233_K	0.510	0.31
186_K	241_Q	0.509	0.31
23_A	279_L	0.509	0.31
62_K	74_R	0.509	0.31
170_L	194_F	0.508	0.31
4_A	151_F	0.507	0.31
53_I	189_E	0.507	0.31
120_K	194_F	0.506	0.31
12_T	41_H	0.505	0.30
62_K	233_K	0.505	0.30
129_R	227_E	0.505	0.30
279_L	293_I	0.505	0.30
127_Y	160_S	0.502	0.30
13_N	52_A	0.502	0.30
40_R	94_K	0.502	0.30
196_N	280_G	0.500	0.30
59_T	66_D	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hyiA	1	0.8924	100	0.109	Contact Map
2dchX	3	0.6108	100	0.73	Contact Map
2vs7A	1	0.5601	99.9	0.761	Contact Map
1dq3A	1	0.8671	99.9	0.771	Contact Map
1dfaA	1	0.7089	99.9	0.774	Contact Map
2cw8A	1	0.7278	99.9	0.787	Contact Map
3c0wA	1	0.6361	93.3	0.943	Contact Map
1s7oA	3	0.2342	92.7	0.944	Contact Map
1xsvA	2	0.2342	92	0.945	Contact Map
3r4kA	2	0.193	87.8	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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