GNGF - BACSU - GREMLIN Contacts

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GNGF - Gluconeogenesis factor

UniProt:	O06974	Sequences: MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSGRLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNITGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVFLTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICNVMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFDIEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (309)
Sequences:	1771 (1156)
Seq/√Len:	65.7

ECOLI - GNGF
BACSU - GNGF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
136_E	157_K	5.706	1.00
136_E	158_R	4.557	1.00
206_V	209_A	4.470	1.00
8_A	179_A	4.241	1.00
181_L	214_V	4.105	1.00
182_I	209_A	3.568	1.00
182_I	206_V	3.550	1.00
50_L	97_A	3.358	1.00
33_I	172_T	3.299	1.00
4_K	29_D	3.255	1.00
134_H	160_F	3.079	1.00
174_D	178_E	3.037	1.00
52_I	97_A	2.976	1.00
58_I	110_V	2.848	1.00
91_L	95_I	2.809	1.00
6_K	178_E	2.776	1.00
43_S	54_P	2.664	1.00
233_D	236_K	2.567	1.00
124_L	172_T	2.525	1.00
136_E	160_F	2.412	1.00
177_R	205_E	2.381	1.00
174_D	177_R	2.376	1.00
176_I	202_I	2.360	1.00
8_A	31_T	2.356	1.00
42_S	89_H	2.323	1.00
291_Q	306_K	2.230	1.00
235_V	280_L	2.194	1.00
76_F	113_M	2.191	1.00
177_R	208_K	2.173	1.00
204_E	208_K	2.158	1.00
78_H	101_N	2.155	1.00
173_I	177_R	2.139	1.00
251_L	310_L	2.131	1.00
95_I	113_M	2.071	1.00
279_E	282_A	2.056	1.00
129_A	167_D	2.044	1.00
134_H	162_T	2.024	1.00
176_I	205_E	1.951	1.00
138_E	157_K	1.950	1.00
67_D	120_R	1.930	1.00
62_L	123_V	1.928	1.00
138_E	155_R	1.915	1.00
4_K	27_P	1.899	1.00
252_V	287_V	1.887	1.00
277_I	289_R	1.868	1.00
232_A	276_D	1.835	1.00
229_Y	237_A	1.831	1.00
58_I	106_F	1.770	1.00
280_L	285_L	1.746	1.00
8_A	33_I	1.744	1.00
126_A	202_I	1.739	1.00
5_P	27_P	1.706	0.99
235_V	247_I	1.705	0.99
168_P	172_T	1.674	0.99
168_P	173_I	1.620	0.99
39_D	148_T	1.614	0.99
190_Y	229_Y	1.611	0.99
172_T	202_I	1.594	0.99
201_K	204_E	1.563	0.99
134_H	144_S	1.562	0.99
105_D	108_H	1.545	0.99
142_V	160_F	1.540	0.99
157_K	240_Q	1.524	0.99
173_I	202_I	1.513	0.99
236_K	240_Q	1.512	0.99
255_E	291_Q	1.489	0.99
236_K	279_E	1.472	0.98
231_A	275_F	1.463	0.98
137_M	143_V	1.462	0.98
232_A	279_E	1.432	0.98
135_A	156_I	1.428	0.98
209_A	213_K	1.423	0.98
217_C	231_A	1.420	0.98
31_T	124_L	1.413	0.98
6_K	29_D	1.412	0.98
147_S	150_P	1.400	0.98
214_V	311_L	1.393	0.98
181_L	311_L	1.385	0.98
230_T	233_D	1.378	0.98
194_L	237_A	1.374	0.98
251_L	311_L	1.355	0.97
53_P	106_F	1.354	0.97
139_D	154_Q	1.344	0.97
112_E	115_K	1.343	0.97
206_V	213_K	1.332	0.97
228_H	271_R	1.328	0.97
91_L	113_M	1.328	0.97
25_H	305_H	1.326	0.97
150_P	222_Q	1.317	0.97
173_I	205_E	1.305	0.97
10_F	196_N	1.304	0.97
229_Y	233_D	1.299	0.96
292_I	310_L	1.289	0.96
279_E	283_M	1.280	0.96
161_L	186_P	1.277	0.96
127_A	131_V	1.275	0.96
20_L	32_A	1.270	0.96
136_E	142_V	1.257	0.96
237_A	241_H	1.256	0.96
68_V	73_E	1.246	0.96
231_A	250_I	1.235	0.95
76_F	95_I	1.229	0.95
144_S	162_T	1.220	0.95
188_S	222_Q	1.192	0.94
37_A	147_S	1.188	0.94
168_P	201_K	1.175	0.94
5_P	29_D	1.173	0.94
170_P	174_D	1.168	0.94
91_L	98_A	1.161	0.94
82_K	87_T	1.160	0.93
303_D	306_K	1.156	0.93
304_T	310_L	1.155	0.93
150_P	188_S	1.152	0.93
41_G	145_G	1.139	0.93
203_G	207_I	1.133	0.93
19_L	307_V	1.130	0.93
207_I	245_G	1.128	0.92
215_Y	238_L	1.125	0.92
207_I	246_F	1.123	0.92
132_V	144_S	1.095	0.91
19_L	216_I	1.090	0.91
235_V	285_L	1.060	0.90
226_T	229_Y	1.059	0.90
61_V	91_L	1.057	0.90
183_I	216_I	1.052	0.90
10_F	33_I	1.050	0.90
45_R	82_K	1.048	0.89
39_D	132_V	1.046	0.89
216_I	311_L	1.046	0.89
75_L	116_V	1.044	0.89
219_V	293_V	1.042	0.89
49_E	85_D	1.029	0.89
224_G	227_L	1.026	0.88
232_A	236_K	0.998	0.87
63_A	77_Q	0.994	0.87
75_L	91_L	0.993	0.87
294_T	303_D	0.993	0.87
188_S	225_E	0.992	0.87
190_Y	237_A	0.985	0.86
56_G	145_G	0.985	0.86
26_K	312_V	0.985	0.86
294_T	298_D	0.984	0.86
186_P	219_V	0.974	0.86
184_I	213_K	0.974	0.86
46_L	52_I	0.973	0.86
60_N	77_Q	0.972	0.86
111_T	171_E	0.972	0.86
289_R	292_I	0.971	0.85
271_R	274_D	0.963	0.85
203_G	206_V	0.963	0.85
107_F	171_E	0.962	0.85
64_A	121_G	0.960	0.85
17_S	222_Q	0.960	0.85
31_T	175_V	0.956	0.85
208_K	261_I	0.943	0.84
280_L	283_M	0.939	0.84
96_L	198_L	0.938	0.83
277_I	281_K	0.937	0.83
9_I	16_L	0.936	0.83
11_G	15_G	0.928	0.83
41_G	56_G	0.927	0.83
304_T	307_V	0.923	0.82
263_R	266_E	0.923	0.82
201_K	205_E	0.919	0.82
125_P	191_T	0.916	0.82
223_P	269_S	0.908	0.81
161_L	201_K	0.908	0.81
89_H	145_G	0.903	0.81
37_A	150_P	0.901	0.81
33_I	126_A	0.898	0.81
26_K	308_A	0.897	0.81
44_G	55_P	0.895	0.80
91_L	102_I	0.892	0.80
206_V	246_F	0.892	0.80
221_T	234_H	0.892	0.80
97_A	101_N	0.890	0.80
212_K	249_T	0.889	0.80
182_I	213_K	0.884	0.80
174_D	208_K	0.883	0.80
53_P	128_N	0.881	0.79
100_T	109_A	0.878	0.79
249_T	288_I	0.875	0.79
59_R	92_G	0.866	0.78
232_A	285_L	0.864	0.78
53_P	130_S	0.863	0.78
278_E	282_A	0.861	0.78
9_I	20_L	0.860	0.78
166_I	200_P	0.856	0.77
11_G	20_L	0.852	0.77
61_V	146_E	0.846	0.77
44_G	47_R	0.846	0.77
167_D	201_K	0.841	0.76
278_E	281_K	0.840	0.76
9_I	18_V	0.839	0.76
41_G	225_E	0.835	0.76
220_M	265_Y	0.835	0.76
122_K	175_V	0.834	0.76
143_V	148_T	0.833	0.75
173_I	210_P	0.830	0.75
276_D	279_E	0.830	0.75
4_K	28_V	0.829	0.75
161_L	198_L	0.828	0.75
145_G	225_E	0.827	0.75
141_R	154_Q	0.827	0.75
42_S	76_F	0.821	0.74
263_R	267_M	0.820	0.74
61_V	72_V	0.817	0.74
83_G	87_T	0.816	0.74
95_I	109_A	0.815	0.74
90_S	156_I	0.815	0.74
7_I	28_V	0.811	0.74
249_T	252_V	0.806	0.73
239_N	283_M	0.806	0.73
292_I	307_V	0.802	0.73
39_D	147_S	0.792	0.72
189_L	225_E	0.790	0.72
131_V	161_L	0.789	0.71
131_V	166_I	0.788	0.71
221_T	273_V	0.787	0.71
17_S	60_N	0.787	0.71
63_A	66_S	0.783	0.71
148_T	151_E	0.782	0.71
254_S	291_Q	0.776	0.70
43_S	198_L	0.768	0.69
290_D	313_D	0.768	0.69
239_N	247_I	0.763	0.69
194_L	198_L	0.761	0.69
107_F	124_L	0.756	0.68
55_P	186_P	0.755	0.68
177_R	209_A	0.753	0.68
221_T	233_D	0.749	0.67
168_P	202_I	0.747	0.67
61_V	95_I	0.746	0.67
79_R	93_N	0.744	0.67
194_L	231_A	0.744	0.67
71_L	112_E	0.742	0.67
259_D	263_R	0.741	0.67
213_K	247_I	0.740	0.67
114_S	124_L	0.740	0.67
54_P	126_A	0.740	0.67
296_K	299_V	0.735	0.66
183_I	214_V	0.732	0.66
108_H	112_E	0.730	0.65
290_D	310_L	0.730	0.65
52_I	100_T	0.729	0.65
45_R	163_P	0.723	0.65
10_F	15_G	0.721	0.65
126_A	196_N	0.719	0.64
105_D	159_V	0.719	0.64
142_V	178_E	0.716	0.64
98_A	119_V	0.713	0.64
147_S	151_E	0.712	0.64
207_I	243_G	0.711	0.63
36_V	222_Q	0.710	0.63
71_L	103_T	0.708	0.63
51_K	95_I	0.706	0.63
239_N	245_G	0.706	0.63
10_F	184_I	0.705	0.63
304_T	308_A	0.703	0.63
93_N	192_S	0.702	0.62
70_P	74_D	0.700	0.62
36_V	131_V	0.699	0.62
63_A	163_P	0.698	0.62
101_N	104_G	0.698	0.62
91_L	94_L	0.697	0.62
36_V	188_S	0.697	0.62
305_H	309_S	0.695	0.62
27_P	61_V	0.695	0.62
52_I	214_V	0.694	0.62
54_P	199_V	0.693	0.61
35_T	43_S	0.691	0.61
103_T	307_V	0.690	0.61
37_A	131_V	0.686	0.61
189_L	237_A	0.683	0.60
114_S	119_V	0.681	0.60
56_G	188_S	0.680	0.60
265_Y	301_R	0.678	0.60
173_I	182_I	0.678	0.60
67_D	190_Y	0.678	0.60
33_I	168_P	0.676	0.60
299_V	311_L	0.676	0.60
207_I	244_C	0.675	0.59
181_L	193_I	0.673	0.59
35_T	60_N	0.671	0.59
266_E	271_R	0.670	0.59
89_H	94_L	0.666	0.58
217_C	252_V	0.666	0.58
133_L	242_M	0.665	0.58
63_A	76_F	0.658	0.57
46_L	50_L	0.658	0.57
42_S	45_R	0.656	0.57
220_M	300_I	0.651	0.57
72_V	116_V	0.650	0.57
37_A	159_V	0.649	0.56
44_G	89_H	0.648	0.56
106_F	161_L	0.648	0.56
36_V	234_H	0.648	0.56
226_T	234_H	0.647	0.56
38_D	42_S	0.647	0.56
39_D	241_H	0.647	0.56
176_I	233_D	0.646	0.56
138_E	158_R	0.646	0.56
305_H	310_L	0.644	0.56
191_T	197_L	0.643	0.56
145_G	188_S	0.643	0.56
56_G	89_H	0.641	0.56
137_M	154_Q	0.638	0.55
43_S	225_E	0.637	0.55
11_G	32_A	0.637	0.55
232_A	283_M	0.636	0.55
235_V	239_N	0.634	0.55
53_P	61_V	0.634	0.55
31_T	179_A	0.633	0.55
294_T	299_V	0.633	0.55
39_D	225_E	0.633	0.55
65_L	197_L	0.633	0.55
155_R	233_D	0.629	0.54
43_S	60_N	0.627	0.54
150_P	160_F	0.627	0.54
203_G	242_M	0.626	0.54
128_N	169_L	0.624	0.54
297_N	301_R	0.622	0.53
238_L	242_M	0.622	0.53
66_S	100_T	0.621	0.53
10_F	182_I	0.618	0.53
188_S	191_T	0.618	0.53
74_D	102_I	0.617	0.53
215_Y	220_M	0.615	0.52
261_I	264_K	0.614	0.52
165_Q	200_P	0.614	0.52
71_L	102_I	0.613	0.52
79_R	192_S	0.612	0.52
139_D	190_Y	0.610	0.52
184_I	247_I	0.609	0.52
62_L	113_M	0.608	0.52
182_I	308_A	0.607	0.52
16_L	34_V	0.606	0.51
45_R	85_D	0.606	0.51
43_S	55_P	0.606	0.51
107_F	202_I	0.605	0.51
46_L	83_G	0.605	0.51
258_P	261_I	0.602	0.51
188_S	234_H	0.597	0.50
7_I	73_E	0.595	0.50
12_G	15_G	0.595	0.50
56_G	192_S	0.594	0.50
277_I	287_V	0.594	0.50
143_V	167_D	0.592	0.50
46_L	84_N	0.588	0.49
58_I	246_F	0.587	0.49
14_T	45_R	0.587	0.49
184_I	194_L	0.586	0.49
74_D	254_S	0.581	0.48
208_K	282_A	0.581	0.48
16_L	188_S	0.579	0.48
17_S	39_D	0.579	0.48
25_H	298_D	0.578	0.48
174_D	206_V	0.577	0.48
113_M	149_I	0.577	0.48
135_A	191_T	0.575	0.48
21_R	69_E	0.574	0.48
279_E	285_L	0.574	0.48
134_H	142_V	0.573	0.48
197_L	206_V	0.572	0.47
294_T	297_N	0.571	0.47
9_I	183_I	0.571	0.47
43_S	56_G	0.570	0.47
281_K	286_E	0.568	0.47
194_L	235_V	0.566	0.47
10_F	172_T	0.566	0.47
186_P	211_A	0.565	0.47
163_P	186_P	0.564	0.46
260_E	263_R	0.564	0.46
276_D	280_L	0.564	0.46
173_I	209_A	0.564	0.46
26_K	305_H	0.564	0.46
238_L	241_H	0.563	0.46
158_R	164_E	0.563	0.46
6_K	138_E	0.563	0.46
105_D	112_E	0.562	0.46
291_Q	294_T	0.562	0.46
23_L	171_E	0.561	0.46
189_L	226_T	0.560	0.46
184_I	238_L	0.560	0.46
290_D	304_T	0.559	0.46
250_I	285_L	0.559	0.46
205_E	208_K	0.558	0.46
63_A	73_E	0.556	0.46
10_F	173_I	0.555	0.45
57_D	192_S	0.555	0.45
8_A	142_V	0.555	0.45
106_F	110_V	0.553	0.45
267_M	274_D	0.550	0.45
124_L	213_K	0.549	0.45
215_Y	234_H	0.548	0.45
53_P	127_A	0.544	0.44
65_L	123_V	0.544	0.44
203_G	243_G	0.543	0.44
41_G	188_S	0.542	0.44
148_T	190_Y	0.541	0.44
20_L	65_L	0.541	0.44
133_L	146_E	0.540	0.44
46_L	58_I	0.540	0.44
41_G	92_G	0.540	0.44
239_N	285_L	0.539	0.44
309_S	313_D	0.539	0.44
159_V	241_H	0.539	0.44
41_G	89_H	0.539	0.44
181_L	212_K	0.538	0.43
27_P	72_V	0.538	0.43
294_T	306_K	0.537	0.43
156_I	190_Y	0.537	0.43
60_N	188_S	0.537	0.43
44_G	146_E	0.536	0.43
282_A	286_E	0.535	0.43
59_R	192_S	0.535	0.43
103_T	118_N	0.535	0.43
235_V	250_I	0.534	0.43
37_A	195_P	0.534	0.43
39_D	145_G	0.533	0.43
65_L	307_V	0.532	0.43
17_S	21_R	0.532	0.43
208_K	259_D	0.532	0.43
70_P	73_E	0.531	0.43
56_G	59_R	0.531	0.43
203_G	245_G	0.530	0.43
175_V	179_A	0.528	0.42
165_Q	182_I	0.528	0.42
37_A	189_L	0.526	0.42
14_T	60_N	0.526	0.42
81_N	87_T	0.525	0.42
280_L	287_V	0.524	0.42
9_I	193_I	0.523	0.42
149_I	156_I	0.523	0.42
216_I	307_V	0.522	0.42
279_E	286_E	0.522	0.42
159_V	237_A	0.521	0.42
174_D	260_E	0.520	0.41
50_L	84_N	0.519	0.41
275_F	280_L	0.518	0.41
177_R	207_I	0.518	0.41
169_L	199_V	0.516	0.41
176_I	264_K	0.515	0.41
69_E	73_E	0.514	0.41
66_S	196_N	0.513	0.41
109_A	194_L	0.511	0.40
251_L	288_I	0.511	0.40
37_A	64_A	0.510	0.40
161_L	185_G	0.510	0.40
223_P	268_E	0.509	0.40
208_K	264_K	0.508	0.40
24_K	65_L	0.508	0.40
60_N	146_E	0.508	0.40
15_G	44_G	0.505	0.40
33_I	279_E	0.505	0.40
299_V	303_D	0.504	0.40
203_G	231_A	0.503	0.39
53_P	100_T	0.503	0.39
254_S	289_R	0.502	0.39
36_V	150_P	0.501	0.39
222_Q	234_H	0.501	0.39
257_I	268_E	0.501	0.39
239_N	246_F	0.500	0.39
58_I	84_N	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o2zA	2	0.9811	100	0.142	Contact Map
2p0yA	1	0.7413	100	0.149	Contact Map
2ppvA	2	0.9905	100	0.154	Contact Map
2q7xA	2	0.9464	100	0.159	Contact Map
3c3dA	2	0.8517	100	0.361	Contact Map
4g6hA	2	0.7161	84.5	0.956	Contact Map
3pvzA	2	0.8927	73.7	0.96	Contact Map
3fbsA	2	0.653	67.7	0.962	Contact Map
5cjjA	2	0.5047	66.4	0.962	Contact Map
2v3aA	1	0.6625	65.4	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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