GREMLIN Database
GNGF - Gluconeogenesis factor
UniProt: O06974 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (309)
Sequences: 1771 (1156)
Seq/√Len: 65.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_E157_K5.7061.00
136_E158_R4.5571.00
206_V209_A4.4701.00
8_A179_A4.2411.00
181_L214_V4.1051.00
182_I209_A3.5681.00
182_I206_V3.5501.00
50_L97_A3.3581.00
33_I172_T3.2991.00
4_K29_D3.2551.00
134_H160_F3.0791.00
174_D178_E3.0371.00
52_I97_A2.9761.00
58_I110_V2.8481.00
91_L95_I2.8091.00
6_K178_E2.7761.00
43_S54_P2.6641.00
233_D236_K2.5671.00
124_L172_T2.5251.00
136_E160_F2.4121.00
177_R205_E2.3811.00
174_D177_R2.3761.00
176_I202_I2.3601.00
8_A31_T2.3561.00
42_S89_H2.3231.00
291_Q306_K2.2301.00
235_V280_L2.1941.00
76_F113_M2.1911.00
177_R208_K2.1731.00
204_E208_K2.1581.00
78_H101_N2.1551.00
173_I177_R2.1391.00
251_L310_L2.1311.00
95_I113_M2.0711.00
279_E282_A2.0561.00
129_A167_D2.0441.00
134_H162_T2.0241.00
176_I205_E1.9511.00
138_E157_K1.9501.00
67_D120_R1.9301.00
62_L123_V1.9281.00
138_E155_R1.9151.00
4_K27_P1.8991.00
252_V287_V1.8871.00
277_I289_R1.8681.00
232_A276_D1.8351.00
229_Y237_A1.8311.00
58_I106_F1.7701.00
280_L285_L1.7461.00
8_A33_I1.7441.00
126_A202_I1.7391.00
5_P27_P1.7060.99
235_V247_I1.7050.99
168_P172_T1.6740.99
168_P173_I1.6200.99
39_D148_T1.6140.99
190_Y229_Y1.6110.99
172_T202_I1.5940.99
201_K204_E1.5630.99
134_H144_S1.5620.99
105_D108_H1.5450.99
142_V160_F1.5400.99
157_K240_Q1.5240.99
173_I202_I1.5130.99
236_K240_Q1.5120.99
255_E291_Q1.4890.99
236_K279_E1.4720.98
231_A275_F1.4630.98
137_M143_V1.4620.98
232_A279_E1.4320.98
135_A156_I1.4280.98
209_A213_K1.4230.98
217_C231_A1.4200.98
31_T124_L1.4130.98
6_K29_D1.4120.98
147_S150_P1.4000.98
214_V311_L1.3930.98
181_L311_L1.3850.98
230_T233_D1.3780.98
194_L237_A1.3740.98
251_L311_L1.3550.97
53_P106_F1.3540.97
139_D154_Q1.3440.97
112_E115_K1.3430.97
206_V213_K1.3320.97
228_H271_R1.3280.97
91_L113_M1.3280.97
25_H305_H1.3260.97
150_P222_Q1.3170.97
173_I205_E1.3050.97
10_F196_N1.3040.97
229_Y233_D1.2990.96
292_I310_L1.2890.96
279_E283_M1.2800.96
161_L186_P1.2770.96
127_A131_V1.2750.96
20_L32_A1.2700.96
136_E142_V1.2570.96
237_A241_H1.2560.96
68_V73_E1.2460.96
231_A250_I1.2350.95
76_F95_I1.2290.95
144_S162_T1.2200.95
188_S222_Q1.1920.94
37_A147_S1.1880.94
168_P201_K1.1750.94
5_P29_D1.1730.94
170_P174_D1.1680.94
91_L98_A1.1610.94
82_K87_T1.1600.93
303_D306_K1.1560.93
304_T310_L1.1550.93
150_P188_S1.1520.93
41_G145_G1.1390.93
203_G207_I1.1330.93
19_L307_V1.1300.93
207_I245_G1.1280.92
215_Y238_L1.1250.92
207_I246_F1.1230.92
132_V144_S1.0950.91
19_L216_I1.0900.91
235_V285_L1.0600.90
226_T229_Y1.0590.90
61_V91_L1.0570.90
183_I216_I1.0520.90
10_F33_I1.0500.90
45_R82_K1.0480.89
39_D132_V1.0460.89
216_I311_L1.0460.89
75_L116_V1.0440.89
219_V293_V1.0420.89
49_E85_D1.0290.89
224_G227_L1.0260.88
232_A236_K0.9980.87
63_A77_Q0.9940.87
75_L91_L0.9930.87
294_T303_D0.9930.87
188_S225_E0.9920.87
190_Y237_A0.9850.86
56_G145_G0.9850.86
26_K312_V0.9850.86
294_T298_D0.9840.86
186_P219_V0.9740.86
184_I213_K0.9740.86
46_L52_I0.9730.86
60_N77_Q0.9720.86
111_T171_E0.9720.86
289_R292_I0.9710.85
271_R274_D0.9630.85
203_G206_V0.9630.85
107_F171_E0.9620.85
64_A121_G0.9600.85
17_S222_Q0.9600.85
31_T175_V0.9560.85
208_K261_I0.9430.84
280_L283_M0.9390.84
96_L198_L0.9380.83
277_I281_K0.9370.83
9_I16_L0.9360.83
11_G15_G0.9280.83
41_G56_G0.9270.83
304_T307_V0.9230.82
263_R266_E0.9230.82
201_K205_E0.9190.82
125_P191_T0.9160.82
223_P269_S0.9080.81
161_L201_K0.9080.81
89_H145_G0.9030.81
37_A150_P0.9010.81
33_I126_A0.8980.81
26_K308_A0.8970.81
44_G55_P0.8950.80
91_L102_I0.8920.80
206_V246_F0.8920.80
221_T234_H0.8920.80
97_A101_N0.8900.80
212_K249_T0.8890.80
182_I213_K0.8840.80
174_D208_K0.8830.80
53_P128_N0.8810.79
100_T109_A0.8780.79
249_T288_I0.8750.79
59_R92_G0.8660.78
232_A285_L0.8640.78
53_P130_S0.8630.78
278_E282_A0.8610.78
9_I20_L0.8600.78
166_I200_P0.8560.77
11_G20_L0.8520.77
61_V146_E0.8460.77
44_G47_R0.8460.77
167_D201_K0.8410.76
278_E281_K0.8400.76
9_I18_V0.8390.76
41_G225_E0.8350.76
220_M265_Y0.8350.76
122_K175_V0.8340.76
143_V148_T0.8330.75
173_I210_P0.8300.75
276_D279_E0.8300.75
4_K28_V0.8290.75
161_L198_L0.8280.75
145_G225_E0.8270.75
141_R154_Q0.8270.75
42_S76_F0.8210.74
263_R267_M0.8200.74
61_V72_V0.8170.74
83_G87_T0.8160.74
95_I109_A0.8150.74
90_S156_I0.8150.74
7_I28_V0.8110.74
249_T252_V0.8060.73
239_N283_M0.8060.73
292_I307_V0.8020.73
39_D147_S0.7920.72
189_L225_E0.7900.72
131_V161_L0.7890.71
131_V166_I0.7880.71
221_T273_V0.7870.71
17_S60_N0.7870.71
63_A66_S0.7830.71
148_T151_E0.7820.71
254_S291_Q0.7760.70
43_S198_L0.7680.69
290_D313_D0.7680.69
239_N247_I0.7630.69
194_L198_L0.7610.69
107_F124_L0.7560.68
55_P186_P0.7550.68
177_R209_A0.7530.68
221_T233_D0.7490.67
168_P202_I0.7470.67
61_V95_I0.7460.67
79_R93_N0.7440.67
194_L231_A0.7440.67
71_L112_E0.7420.67
259_D263_R0.7410.67
213_K247_I0.7400.67
114_S124_L0.7400.67
54_P126_A0.7400.67
296_K299_V0.7350.66
183_I214_V0.7320.66
108_H112_E0.7300.65
290_D310_L0.7300.65
52_I100_T0.7290.65
45_R163_P0.7230.65
10_F15_G0.7210.65
126_A196_N0.7190.64
105_D159_V0.7190.64
142_V178_E0.7160.64
98_A119_V0.7130.64
147_S151_E0.7120.64
207_I243_G0.7110.63
36_V222_Q0.7100.63
71_L103_T0.7080.63
51_K95_I0.7060.63
239_N245_G0.7060.63
10_F184_I0.7050.63
304_T308_A0.7030.63
93_N192_S0.7020.62
70_P74_D0.7000.62
36_V131_V0.6990.62
63_A163_P0.6980.62
101_N104_G0.6980.62
91_L94_L0.6970.62
36_V188_S0.6970.62
305_H309_S0.6950.62
27_P61_V0.6950.62
52_I214_V0.6940.62
54_P199_V0.6930.61
35_T43_S0.6910.61
103_T307_V0.6900.61
37_A131_V0.6860.61
189_L237_A0.6830.60
114_S119_V0.6810.60
56_G188_S0.6800.60
265_Y301_R0.6780.60
173_I182_I0.6780.60
67_D190_Y0.6780.60
33_I168_P0.6760.60
299_V311_L0.6760.60
207_I244_C0.6750.59
181_L193_I0.6730.59
35_T60_N0.6710.59
266_E271_R0.6700.59
89_H94_L0.6660.58
217_C252_V0.6660.58
133_L242_M0.6650.58
63_A76_F0.6580.57
46_L50_L0.6580.57
42_S45_R0.6560.57
220_M300_I0.6510.57
72_V116_V0.6500.57
37_A159_V0.6490.56
44_G89_H0.6480.56
106_F161_L0.6480.56
36_V234_H0.6480.56
226_T234_H0.6470.56
38_D42_S0.6470.56
39_D241_H0.6470.56
176_I233_D0.6460.56
138_E158_R0.6460.56
305_H310_L0.6440.56
191_T197_L0.6430.56
145_G188_S0.6430.56
56_G89_H0.6410.56
137_M154_Q0.6380.55
43_S225_E0.6370.55
11_G32_A0.6370.55
232_A283_M0.6360.55
235_V239_N0.6340.55
53_P61_V0.6340.55
31_T179_A0.6330.55
294_T299_V0.6330.55
39_D225_E0.6330.55
65_L197_L0.6330.55
155_R233_D0.6290.54
43_S60_N0.6270.54
150_P160_F0.6270.54
203_G242_M0.6260.54
128_N169_L0.6240.54
297_N301_R0.6220.53
238_L242_M0.6220.53
66_S100_T0.6210.53
10_F182_I0.6180.53
188_S191_T0.6180.53
74_D102_I0.6170.53
215_Y220_M0.6150.52
261_I264_K0.6140.52
165_Q200_P0.6140.52
71_L102_I0.6130.52
79_R192_S0.6120.52
139_D190_Y0.6100.52
184_I247_I0.6090.52
62_L113_M0.6080.52
182_I308_A0.6070.52
16_L34_V0.6060.51
45_R85_D0.6060.51
43_S55_P0.6060.51
107_F202_I0.6050.51
46_L83_G0.6050.51
258_P261_I0.6020.51
188_S234_H0.5970.50
7_I73_E0.5950.50
12_G15_G0.5950.50
56_G192_S0.5940.50
277_I287_V0.5940.50
143_V167_D0.5920.50
46_L84_N0.5880.49
58_I246_F0.5870.49
14_T45_R0.5870.49
184_I194_L0.5860.49
74_D254_S0.5810.48
208_K282_A0.5810.48
16_L188_S0.5790.48
17_S39_D0.5790.48
25_H298_D0.5780.48
174_D206_V0.5770.48
113_M149_I0.5770.48
135_A191_T0.5750.48
21_R69_E0.5740.48
279_E285_L0.5740.48
134_H142_V0.5730.48
197_L206_V0.5720.47
294_T297_N0.5710.47
9_I183_I0.5710.47
43_S56_G0.5700.47
281_K286_E0.5680.47
194_L235_V0.5660.47
10_F172_T0.5660.47
186_P211_A0.5650.47
163_P186_P0.5640.46
260_E263_R0.5640.46
276_D280_L0.5640.46
173_I209_A0.5640.46
26_K305_H0.5640.46
238_L241_H0.5630.46
158_R164_E0.5630.46
6_K138_E0.5630.46
105_D112_E0.5620.46
291_Q294_T0.5620.46
23_L171_E0.5610.46
189_L226_T0.5600.46
184_I238_L0.5600.46
290_D304_T0.5590.46
250_I285_L0.5590.46
205_E208_K0.5580.46
63_A73_E0.5560.46
10_F173_I0.5550.45
57_D192_S0.5550.45
8_A142_V0.5550.45
106_F110_V0.5530.45
267_M274_D0.5500.45
124_L213_K0.5490.45
215_Y234_H0.5480.45
53_P127_A0.5440.44
65_L123_V0.5440.44
203_G243_G0.5430.44
41_G188_S0.5420.44
148_T190_Y0.5410.44
20_L65_L0.5410.44
133_L146_E0.5400.44
46_L58_I0.5400.44
41_G92_G0.5400.44
239_N285_L0.5390.44
309_S313_D0.5390.44
159_V241_H0.5390.44
41_G89_H0.5390.44
181_L212_K0.5380.43
27_P72_V0.5380.43
294_T306_K0.5370.43
156_I190_Y0.5370.43
60_N188_S0.5370.43
44_G146_E0.5360.43
282_A286_E0.5350.43
59_R192_S0.5350.43
103_T118_N0.5350.43
235_V250_I0.5340.43
37_A195_P0.5340.43
39_D145_G0.5330.43
65_L307_V0.5320.43
17_S21_R0.5320.43
208_K259_D0.5320.43
70_P73_E0.5310.43
56_G59_R0.5310.43
203_G245_G0.5300.43
175_V179_A0.5280.42
165_Q182_I0.5280.42
37_A189_L0.5260.42
14_T60_N0.5260.42
81_N87_T0.5250.42
280_L287_V0.5240.42
9_I193_I0.5230.42
149_I156_I0.5230.42
216_I307_V0.5220.42
279_E286_E0.5220.42
159_V237_A0.5210.42
174_D260_E0.5200.41
50_L84_N0.5190.41
275_F280_L0.5180.41
177_R207_I0.5180.41
169_L199_V0.5160.41
176_I264_K0.5150.41
69_E73_E0.5140.41
66_S196_N0.5130.41
109_A194_L0.5110.40
251_L288_I0.5110.40
37_A64_A0.5100.40
161_L185_G0.5100.40
223_P268_E0.5090.40
208_K264_K0.5080.40
24_K65_L0.5080.40
60_N146_E0.5080.40
15_G44_G0.5050.40
33_I279_E0.5050.40
299_V303_D0.5040.40
203_G231_A0.5030.39
53_P100_T0.5030.39
254_S289_R0.5020.39
36_V150_P0.5010.39
222_Q234_H0.5010.39
257_I268_E0.5010.39
239_N246_F0.5000.39
58_I84_N0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o2zA 2 0.9811 100 0.142 Contact Map
2p0yA 1 0.7413 100 0.149 Contact Map
2ppvA 2 0.9905 100 0.154 Contact Map
2q7xA 2 0.9464 100 0.159 Contact Map
3c3dA 2 0.8517 100 0.361 Contact Map
4g6hA 2 0.7161 84.5 0.956 Contact Map
3pvzA 2 0.8927 73.7 0.96 Contact Map
3fbsA 2 0.653 67.7 0.962 Contact Map
5cjjA 2 0.5047 66.4 0.962 Contact Map
2v3aA 1 0.6625 65.4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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