GREMLIN Database
YVCI - Uncharacterized Nudix hydrolase YvcI
UniProt: O06972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 158 (123)
Sequences: 3051 (2257)
Seq/√Len: 203.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_R57_Y5.0421.00
13_Q17_K3.9631.00
22_Q103_K3.5551.00
17_K108_D3.4311.00
36_M45_S3.0891.00
41_S44_D2.6341.00
50_Y58_I2.6021.00
108_D111_D2.4951.00
32_P54_T2.4111.00
47_I51_R2.3541.00
111_D114_N2.3011.00
59_I90_S2.2271.00
63_L84_F2.1051.00
58_I88_A1.9731.00
126_D130_K1.9531.00
20_L107_H1.8901.00
59_I92_T1.8261.00
29_W105_Q1.7871.00
8_T45_S1.7611.00
57_Y92_T1.7251.00
63_L66_V1.6181.00
20_L115_L1.6131.00
10_C13_Q1.5281.00
16_D109_V1.5001.00
107_H115_L1.4991.00
60_N90_S1.4741.00
46_V61_P1.4451.00
9_N46_V1.4321.00
64_K87_V1.4311.00
113_Q129_M1.3591.00
59_I89_D1.3541.00
98_E101_E1.3411.00
28_W116_P1.3141.00
97_S101_E1.3061.00
22_Q102_G1.2751.00
67_F127_F1.2721.00
42_V68_T1.2701.00
50_Y88_A1.2161.00
36_M42_V1.2101.00
65_G127_F1.2061.00
19_L104_L1.1971.00
12_L50_Y1.1881.00
20_L117_M1.1731.00
62_Q87_V1.1701.00
105_Q111_D1.1451.00
13_Q109_V1.1391.00
44_D47_I1.1181.00
47_I58_I1.0901.00
14_T17_K1.0621.00
42_V86_F1.0601.00
60_N89_D1.0411.00
13_Q87_V1.0191.00
42_V84_F1.0071.00
22_Q29_W1.0071.00
32_P50_Y1.0061.00
61_P89_D0.9711.00
13_Q16_D0.9620.99
68_T80_E0.9590.99
66_V82_M0.9500.99
47_I60_N0.9420.99
43_R47_I0.9390.99
90_S93_G0.9390.99
21_L101_E0.9360.99
56_I90_S0.9190.99
10_C46_V0.9160.99
55_G99_S0.9040.99
62_Q89_D0.8910.99
123_H127_F0.8820.99
28_W119_P0.8810.99
96_V101_E0.8790.99
63_L86_F0.8780.99
46_V50_Y0.8710.99
29_W107_H0.8690.99
21_L32_P0.8650.99
123_H126_D0.8640.99
51_R55_G0.8640.99
87_V128_M0.8630.99
13_Q89_D0.8590.99
23_K26_R0.8580.99
88_A91_Y0.8510.99
12_L56_I0.8440.99
27_G102_G0.8310.98
16_D108_D0.8280.98
113_Q126_D0.8160.98
6_R36_M0.8100.98
22_Q27_G0.8020.98
6_R82_M0.8000.98
85_T124_I0.7980.98
67_F83_M0.7830.98
60_N91_Y0.7780.98
47_I57_Y0.7760.98
46_V88_A0.7750.98
10_C50_Y0.7690.97
107_H111_D0.7680.97
47_I59_I0.7660.97
119_P122_G0.7600.97
97_S100_E0.7550.97
66_V84_F0.7500.97
16_D110_N0.7500.97
61_P88_A0.7470.97
56_I96_V0.7460.97
21_L104_L0.7410.97
30_V120_G0.7350.97
21_L30_V0.7310.97
21_L102_G0.7220.96
72_K78_V0.7100.96
109_V129_M0.7100.96
28_W118_A0.7040.96
70_I80_E0.7030.96
42_V82_M0.7030.96
6_R13_Q0.6980.96
6_R84_F0.6970.96
8_T121_D0.6940.95
55_G97_S0.6910.95
121_D124_I0.6860.95
71_I74_G0.6830.95
58_I61_P0.6820.95
40_E44_D0.6810.95
29_W115_L0.6730.95
14_T94_Q0.6670.94
20_L105_Q0.6600.94
11_V31_A0.6590.94
24_P98_E0.6540.94
112_I125_L0.6540.94
47_I50_Y0.6400.93
30_V33_G0.6360.93
7_V81_W0.6360.93
12_L16_D0.6320.93
36_M84_F0.6270.92
8_T31_A0.6170.92
69_F83_M0.6170.92
22_Q105_Q0.6160.92
81_W121_D0.6130.91
127_F130_K0.6070.91
14_T89_D0.6040.91
83_M120_G0.6020.91
85_T118_A0.6010.91
30_V121_D0.6000.91
12_L87_V0.5940.90
62_Q131_G0.5930.90
32_P102_G0.5880.90
127_F131_G0.5840.89
47_I62_Q0.5830.89
98_E102_G0.5830.89
26_R81_W0.5830.89
118_A121_D0.5810.89
120_G124_I0.5790.89
99_S102_G0.5760.89
116_P122_G0.5760.89
92_T110_N0.5740.89
31_A85_T0.5710.88
35_K121_D0.5690.88
13_Q108_D0.5670.88
40_E48_R0.5660.88
71_I79_S0.5630.88
69_F85_T0.5630.88
7_V45_S0.5550.87
9_N85_T0.5530.87
35_K84_F0.5520.87
118_A124_I0.5520.87
47_I61_P0.5520.87
85_T128_M0.5510.87
122_G126_D0.5500.86
23_K101_E0.5500.86
70_I79_S0.5490.86
20_L29_W0.5450.86
12_L109_V0.5350.85
31_A125_L0.5350.85
127_F132_Q0.5320.85
30_V81_W0.5300.84
114_N130_K0.5290.84
6_R11_V0.5280.84
117_M120_G0.5280.84
22_Q28_W0.5260.84
30_V83_M0.5230.84
68_T82_M0.5220.83
113_Q122_G0.5160.83
31_A83_M0.5160.83
29_W116_P0.5050.81
6_R9_N0.5050.81
14_T90_S0.5050.81
41_S68_T0.5020.81
30_V35_K0.5020.81
59_I62_Q0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fk9A 2 0.9684 100 0.306 Contact Map
3q93A 1 0.9557 100 0.353 Contact Map
4c9xA 2 0.9557 99.9 0.385 Contact Map
2azwA 1 0.8228 99.9 0.427 Contact Map
3q1pA 2 0.8797 99.9 0.43 Contact Map
4dywA 2 0.7722 99.9 0.431 Contact Map
3gwyA 2 0.7975 99.9 0.432 Contact Map
1mutA 1 0.7911 99.9 0.432 Contact Map
3i7uA 4 0.8481 99.9 0.432 Contact Map
3exqA 2 0.9557 99.9 0.432 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.