BMRA - BACSU - GREMLIN Contacts

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BMRA - Multidrug resistance ABC transporter ATP-binding/permease protein BmrA

UniProt:	O06967	Sequences: MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSLLIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLRELLWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILFIMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKASNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSGELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQIENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYSPTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEKAAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSSLDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMASHGLYRDFAEQQLKMNADLENKAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	589 (558)
Sequences:	52614 (37281)
Seq/√Len:	1578.2

ECOLI - MSBA MDLB MDLA CYDD CYDC YOJI YDDA PROV
BACSU - BMRA YHEH YFIC SUNT YKNU YKNV YGAD YHEI YWJA YFIB CYDD CYDC YVRA OPUAA OPUCA OPUBA
HALSA - Q9HSQ7 Q9HMX3 BTUDA Q9HMW0
SULSO - Q97UJ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
458_L	468_F	4.392	1.00
342_Q	363_V	4.347	1.00
365_E	368_K	4.195	1.00
368_K	545_Q	4.190	1.00
345_R	359_E	4.166	1.00
545_Q	557_R	4.003	1.00
429_G	433_E	3.930	1.00
453_E	458_L	3.850	1.00
432_R	445_D	3.840	1.00
344_D	397_T	3.818	1.00
560_H	570_Y	3.716	1.00
344_D	399_R	3.476	1.00
458_L	462_K	3.423	1.00
340_P	363_V	3.415	1.00
397_T	404_P	3.252	1.00
358_K	553_E	3.090	1.00
432_R	469_D	3.014	1.00
432_R	436_C	2.942	1.00
445_D	449_E	2.900	1.00
444_T	447_E	2.899	1.00
343_L	346_V	2.878	1.00
567_H	571_R	2.875	1.00
355_L	358_K	2.847	1.00
571_R	575_E	2.839	1.00
347_S	359_E	2.726	1.00
452_A	468_F	2.707	1.00
384_F	533_I	2.685	1.00
416_H	498_S	2.667	1.00
384_F	501_M	2.614	1.00
556_G	566_S	2.568	1.00
342_Q	399_R	2.557	1.00
450_K	454_M	2.506	1.00
449_E	458_L	2.389	1.00
559_T	562_E	2.377	1.00
547_L	557_R	2.372	1.00
349_G	355_L	2.354	1.00
340_P	365_E	2.349	1.00
157_T	161_I	2.346	1.00
496_N	528_R	2.334	1.00
389_R	392_S	2.321	1.00
409_S	412_S	2.320	1.00
364_I	370_T	2.317	1.00
435_I	452_A	2.305	1.00
432_R	448_I	2.292	1.00
347_S	395_A	2.250	1.00
347_S	355_L	2.243	1.00
556_G	568_G	2.214	1.00
55_D	281_G	2.207	1.00
439_L	447_E	2.205	1.00
556_G	567_H	2.199	1.00
418_G	497_P	2.150	1.00
369_V	543_A	2.119	1.00
466_N	470_T	2.113	1.00
449_E	453_E	2.091	1.00
362_A	547_L	2.085	1.00
550_E	569_L	2.083	1.00
340_P	366_A	2.058	1.00
522_E	542_D	2.024	1.00
55_D	279_T	2.020	1.00
435_I	448_I	2.012	1.00
457_A	460_F	1.993	1.00
439_L	442_D	1.991	1.00
343_L	362_A	1.963	1.00
447_E	496_N	1.962	1.00
392_S	406_D	1.942	1.00
514_E	536_R	1.929	1.00
364_I	531_I	1.923	1.00
21_R	102_L	1.917	1.00
349_G	394_T	1.914	1.00
345_R	361_S	1.907	1.00
17_A	322_A	1.890	1.00
449_E	462_K	1.888	1.00
558_G	562_E	1.876	1.00
198_E	235_S	1.871	1.00
64_G	68_G	1.867	1.00
25_S	98_G	1.849	1.00
515_K	519_Q	1.779	1.00
451_A	455_A	1.772	1.00
23_N	26_Y	1.765	1.00
370_T	545_Q	1.757	1.00
436_C	448_I	1.745	1.00
339_L	401_G	1.744	1.00
555_T	569_L	1.743	1.00
163_N	272_Q	1.727	1.00
450_K	453_E	1.715	1.00
370_T	547_L	1.709	1.00
106_K	325_E	1.705	1.00
383_L	549_V	1.700	1.00
445_D	469_D	1.695	1.00
318_I	322_A	1.686	1.00
436_C	445_D	1.685	1.00
547_L	554_I	1.682	1.00
456_Y	516_S	1.682	1.00
550_E	555_T	1.682	1.00
454_M	523_V	1.671	1.00
368_K	544_D	1.664	1.00
371_A	543_A	1.651	1.00
221_A	224_V	1.646	1.00
369_V	532_V	1.634	1.00
509_L	517_V	1.614	1.00
341_I	531_I	1.601	1.00
473_G	478_M	1.596	1.00
68_G	72_L	1.595	1.00
564_M	574_A	1.591	1.00
130_D	316_R	1.578	1.00
447_E	450_K	1.571	1.00
404_P	407_T	1.560	1.00
338_H	401_G	1.545	1.00
472_V	479_L	1.544	1.00
372_I	547_L	1.542	1.00
435_I	494_L	1.539	1.00
443_V	494_L	1.533	1.00
562_E	566_S	1.510	1.00
271_M	275_S	1.507	1.00
452_A	461_I	1.495	1.00
193_R	315_E	1.489	1.00
459_N	462_K	1.476	1.00
340_P	401_G	1.472	1.00
449_E	468_F	1.472	1.00
201_R	235_S	1.471	1.00
65_T	69_L	1.458	1.00
51_K	285_A	1.454	1.00
372_I	383_L	1.452	1.00
446_A	449_E	1.446	1.00
556_G	571_R	1.446	1.00
541_V	561_H	1.445	1.00
466_N	471_E	1.444	1.00
160_F	167_T	1.423	1.00
205_L	232_G	1.423	1.00
365_E	545_Q	1.421	1.00
569_L	572_D	1.419	1.00
357_L	360_V	1.416	1.00
267_G	271_M	1.400	1.00
346_V	393_P	1.395	1.00
534_A	539_T	1.392	1.00
375_P	550_E	1.389	1.00
388_E	419_Y	1.386	1.00
194_E	239_L	1.380	1.00
106_K	110_L	1.378	1.00
523_V	526_E	1.375	1.00
452_A	458_L	1.367	1.00
348_F	382_T	1.358	1.00
343_L	387_L	1.355	1.00
561_H	565_A	1.354	1.00
109_K	325_E	1.354	1.00
386_L	398_I	1.349	1.00
428_S	471_E	1.345	1.00
445_D	448_I	1.337	1.00
460_F	483_Q	1.334	1.00
160_F	164_W	1.334	1.00
348_F	386_L	1.332	1.00
359_E	553_E	1.324	1.00
519_Q	523_V	1.308	1.00
464_L	470_T	1.303	1.00
198_E	201_R	1.302	1.00
198_E	239_L	1.297	1.00
187_K	190_S	1.282	1.00
418_G	492_A	1.270	1.00
337_A	401_G	1.269	1.00
348_F	391_Y	1.267	1.00
47_P	289_Y	1.265	1.00
447_E	494_L	1.261	1.00
371_A	540_V	1.260	1.00
436_C	443_V	1.244	1.00
272_Q	277_E	1.244	1.00
347_S	358_K	1.241	1.00
403_E	407_T	1.235	1.00
35_L	80_L	1.232	1.00
225_E	437_Y	1.230	1.00
454_M	493_L	1.227	1.00
375_P	569_L	1.225	1.00
179_L	183_P	1.214	1.00
525_M	530_T	1.213	1.00
344_D	361_S	1.212	1.00
387_L	531_I	1.212	1.00
446_A	450_K	1.211	1.00
106_K	321_L	1.209	1.00
339_L	366_A	1.207	1.00
227_G	231_M	1.190	1.00
457_A	461_I	1.185	1.00
376_S	513_S	1.184	1.00
279_T	282_A	1.178	1.00
24_P	98_G	1.178	1.00
101_E	105_K	1.172	1.00
209_I	225_E	1.168	1.00
366_A	498_S	1.165	1.00
362_A	383_L	1.164	1.00
44_L	154_G	1.162	1.00
234_S	238_K	1.158	1.00
431_I	487_I	1.156	1.00
393_P	405_V	1.152	1.00
159_L	286_F	1.152	1.00
370_T	531_I	1.151	1.00
340_P	402_D	1.148	1.00
485_Q	507_S	1.144	1.00
460_F	464_L	1.139	1.00
410_L	414_R	1.139	1.00
473_G	476_G	1.131	1.00
223_D	227_G	1.130	1.00
360_V	383_L	1.127	1.00
546_L	560_H	1.125	1.00
403_E	408_Y	1.121	1.00
456_Y	513_S	1.117	1.00
217_K	222_E	1.116	1.00
201_R	232_G	1.115	1.00
166_L	286_F	1.113	1.00
343_L	398_I	1.112	1.00
338_H	366_A	1.109	1.00
439_L	443_V	1.103	1.00
463_E	483_Q	1.103	1.00
462_K	467_Q	1.100	1.00
355_L	394_T	1.099	1.00
479_L	487_I	1.095	1.00
51_K	55_D	1.095	1.00
449_E	452_A	1.092	1.00
116_D	391_Y	1.092	1.00
118_N	122_E	1.090	1.00
48_L	52_Q	1.087	1.00
455_A	490_A	1.085	1.00
212_E	425_P	1.084	1.00
451_A	493_L	1.083	1.00
105_K	109_K	1.082	1.00
364_I	529_T	1.082	1.00
191_I	242_R	1.078	1.00
369_V	530_T	1.078	1.00
269_G	283_L	1.076	1.00
444_T	494_L	1.072	1.00
98_G	102_L	1.071	1.00
459_N	463_E	1.067	1.00
122_E	200_A	1.066	1.00
173_V	261_A	1.066	1.00
560_H	564_M	1.066	1.00
106_K	109_K	1.065	1.00
345_R	395_A	1.063	1.00
17_A	318_I	1.062	1.00
452_A	457_A	1.059	1.00
103_L	320_I	1.057	1.00
90_Y	94_K	1.055	1.00
567_H	575_E	1.052	1.00
412_S	415_E	1.050	1.00
38_V	80_L	1.047	1.00
28_K	90_Y	1.043	1.00
314_T	318_I	1.042	1.00
341_I	387_L	1.042	1.00
119_A	122_E	1.042	1.00
548_F	569_L	1.040	1.00
343_L	383_L	1.029	1.00
532_V	543_A	1.028	1.00
424_S	488_A	1.023	1.00
231_M	235_S	1.023	1.00
237_F	241_V	1.022	1.00
420_V	492_A	1.021	1.00
225_E	228_R	1.018	1.00
205_L	228_R	1.017	1.00
400_L	413_W	1.016	1.00
456_Y	520_A	1.016	1.00
26_Y	30_A	1.014	1.00
448_I	468_F	1.013	1.00
35_L	83_Y	1.008	1.00
116_D	385_K	1.006	1.00
456_Y	519_Q	0.997	1.00
350_Y	356_I	0.994	1.00
153_I	157_T	0.993	1.00
168_L	172_V	0.992	1.00
242_R	245_K	0.991	1.00
386_L	393_P	0.989	1.00
492_A	500_L	0.989	1.00
27_G	31_F	0.985	1.00
498_S	528_R	0.983	1.00
328_T	331_G	0.981	1.00
229_G	233_I	0.980	1.00
165_K	277_E	0.979	1.00
49_L	66_Q	0.978	1.00
451_A	494_L	0.976	1.00
183_P	187_K	0.976	1.00
20_R	23_N	0.975	1.00
456_Y	523_V	0.975	1.00
52_Q	56_G	0.974	1.00
133_V	313_A	0.973	1.00
224_V	228_R	0.973	1.00
433_E	436_C	0.969	1.00
228_R	232_G	0.968	1.00
534_A	540_V	0.968	1.00
216_V	225_E	0.966	1.00
268_Y	272_Q	0.965	1.00
500_L	528_R	0.963	1.00
30_A	34_A	0.962	1.00
32_A	88_L	0.961	1.00
51_K	282_A	0.961	1.00
355_L	395_A	0.957	1.00
516_S	519_Q	0.954	1.00
389_R	410_L	0.954	1.00
65_T	68_G	0.950	1.00
504_E	535_H	0.948	1.00
97_S	101_E	0.947	1.00
342_Q	402_D	0.944	1.00
221_A	225_E	0.941	1.00
311_I	315_E	0.941	1.00
164_W	168_L	0.940	1.00
512_Q	516_S	0.940	1.00
450_K	496_N	0.939	1.00
368_K	557_R	0.937	1.00
346_V	386_L	0.936	1.00
193_R	197_D	0.935	1.00
378_G	549_V	0.934	1.00
398_I	405_V	0.933	1.00
454_M	524_L	0.933	1.00
371_A	534_A	0.931	1.00
376_S	486_R	0.928	1.00
194_E	198_E	0.927	1.00
562_E	565_A	0.927	1.00
359_E	395_A	0.927	1.00
35_L	87_A	0.926	1.00
453_E	462_K	0.924	1.00
461_I	468_F	0.921	1.00
465_P	470_T	0.920	1.00
466_N	469_D	0.918	1.00
19_V	23_N	0.916	1.00
230_K	234_S	0.915	1.00
114_Y	118_N	0.914	1.00
412_S	416_H	0.912	1.00
432_R	449_E	0.909	1.00
187_K	246_V	0.909	1.00
349_G	356_I	0.908	1.00
448_I	494_L	0.907	1.00
549_V	554_I	0.907	1.00
235_S	239_L	0.905	1.00
397_T	406_D	0.905	1.00
344_D	363_V	0.904	1.00
180_I	253_L	0.902	1.00
162_M	282_A	0.901	1.00
381_T	385_K	0.896	1.00
234_S	237_F	0.894	1.00
169_L	268_Y	0.893	1.00
457_A	463_E	0.893	1.00
72_L	76_V	0.891	1.00
371_A	546_L	0.891	1.00
342_Q	361_S	0.890	1.00
272_Q	275_S	0.890	1.00
224_V	227_G	0.888	1.00
472_V	478_M	0.887	1.00
408_Y	413_W	0.883	1.00
351_K	354_Q	0.882	1.00
191_I	239_L	0.880	1.00
369_V	522_E	0.879	1.00
327_D	330_T	0.878	1.00
462_K	468_F	0.877	1.00
411_E	415_E	0.876	1.00
349_G	353_D	0.876	1.00
103_L	127_V	0.876	1.00
194_E	242_R	0.876	1.00
473_G	477_I	0.875	1.00
195_T	240_G	0.874	1.00
102_L	106_K	0.874	1.00
432_R	468_F	0.873	1.00
388_E	501_M	0.870	1.00
111_P	326_E	0.869	1.00
366_A	401_G	0.868	1.00
388_E	417_I	0.867	1.00
568_G	571_R	0.865	1.00
572_D	575_E	0.861	1.00
19_V	22_T	0.861	1.00
226_Y	230_K	0.859	1.00
554_I	557_R	0.859	1.00
369_V	525_M	0.858	1.00
126_R	319_E	0.858	1.00
159_L	167_T	0.857	1.00
214_R	385_K	0.856	1.00
327_D	331_G	0.856	1.00
443_V	447_E	0.854	1.00
420_V	489_I	0.852	1.00
481_G	486_R	0.851	1.00
130_D	313_A	0.851	1.00
178_A	182_V	0.845	1.00
336_N	401_G	0.843	1.00
400_L	499_I	0.843	1.00
427_M	434_N	0.842	1.00
113_S	326_E	0.841	1.00
32_A	91_N	0.841	1.00
273_V	278_L	0.838	1.00
227_G	230_K	0.837	1.00
156_L	167_T	0.837	1.00
190_S	194_E	0.834	1.00
393_P	398_I	0.832	1.00
228_R	231_M	0.831	1.00
232_G	235_S	0.829	1.00
550_E	553_E	0.828	1.00
328_T	407_T	0.827	1.00
500_L	525_M	0.826	1.00
48_L	158_I	0.825	1.00
454_M	458_L	0.825	1.00
506_T	517_V	0.824	1.00
393_P	406_D	0.824	1.00
187_K	191_I	0.823	1.00
158_I	162_M	0.823	1.00
25_S	94_K	0.821	1.00
489_I	502_L	0.821	1.00
270_G	274_S	0.820	1.00
332_K	403_E	0.820	1.00
426_L	487_I	0.817	1.00
223_D	226_Y	0.817	1.00
399_R	402_D	0.814	1.00
182_V	186_R	0.813	1.00
239_L	242_R	0.810	1.00
349_G	352_P	0.810	1.00
334_I	337_A	0.808	1.00
341_I	400_L	0.808	1.00
49_L	73_V	0.807	1.00
165_K	272_Q	0.805	1.00
360_V	554_I	0.803	1.00
161_I	164_W	0.802	1.00
334_I	408_Y	0.802	1.00
113_S	117_T	0.802	1.00
457_A	487_I	0.802	1.00
426_L	484_R	0.798	1.00
435_I	468_F	0.798	1.00
405_V	413_W	0.795	1.00
536_R	539_T	0.795	1.00
52_Q	66_Q	0.794	1.00
567_H	572_D	0.791	1.00
215_L	219_S	0.790	1.00
435_I	487_I	0.788	1.00
79_G	83_Y	0.787	1.00
317_M	321_L	0.785	1.00
330_T	334_I	0.784	1.00
158_I	161_I	0.780	1.00
460_F	463_E	0.777	1.00
430_T	433_E	0.777	1.00
347_S	394_T	0.777	1.00
423_E	484_R	0.776	1.00
241_V	245_K	0.775	1.00
42_V	76_V	0.774	1.00
202_F	236_L	0.771	1.00
28_K	94_K	0.771	1.00
417_I	499_I	0.770	1.00
122_E	126_R	0.769	1.00
163_N	167_T	0.769	1.00
103_L	317_M	0.768	1.00
497_P	528_R	0.763	1.00
408_Y	412_S	0.763	1.00
336_N	498_S	0.763	1.00
349_G	354_Q	0.762	1.00
464_L	479_L	0.761	1.00
238_K	242_R	0.760	1.00
415_E	495_R	0.760	1.00
160_F	171_L	0.757	1.00
213_I	217_K	0.756	1.00
235_S	238_K	0.756	1.00
48_L	51_K	0.756	1.00
42_V	80_L	0.754	1.00
514_E	518_Q	0.753	1.00
163_N	278_L	0.752	1.00
436_C	442_D	0.751	1.00
165_K	168_L	0.751	1.00
455_A	486_R	0.750	1.00
28_K	87_A	0.750	1.00
41_L	45_L	0.750	1.00
49_L	69_L	0.750	1.00
564_M	571_R	0.749	1.00
212_E	215_L	0.748	1.00
500_L	530_T	0.747	1.00
198_E	232_G	0.747	1.00
451_A	490_A	0.746	1.00
332_K	407_T	0.746	1.00
272_Q	276_G	0.746	1.00
149_I	153_I	0.745	1.00
82_A	86_Y	0.744	1.00
133_V	309_K	0.743	1.00
486_R	513_S	0.743	1.00
67_I	71_A	0.743	1.00
327_D	409_S	0.740	1.00
123_T	320_I	0.740	1.00
472_V	476_G	0.739	1.00
52_Q	55_D	0.738	1.00
256_L	260_A	0.738	1.00
172_V	175_P	0.737	1.00
456_Y	459_N	0.737	1.00
137_L	310_S	0.735	1.00
273_V	283_L	0.735	1.00
358_K	551_K	0.731	1.00
154_G	157_T	0.729	1.00
334_I	412_S	0.727	1.00
69_L	72_L	0.727	1.00
36_S	147_T	0.727	1.00
55_D	58_S	0.726	1.00
162_M	285_A	0.725	1.00
436_C	441_R	0.723	1.00
194_E	197_D	0.723	1.00
137_L	307_L	0.722	1.00
373_V	548_F	0.722	1.00
68_G	71_A	0.722	1.00
148_G	299_Q	0.721	1.00
560_H	574_A	0.721	1.00
110_L	323_E	0.719	1.00
439_L	496_N	0.719	1.00
518_Q	539_T	0.717	1.00
42_V	73_V	0.716	1.00
281_G	285_A	0.716	1.00
66_Q	69_L	0.715	1.00
341_I	499_I	0.715	1.00
107_L	115_F	0.715	1.00
102_L	105_K	0.713	1.00
467_Q	470_T	0.713	1.00
485_Q	508_S	0.712	1.00
518_Q	534_A	0.712	1.00
54_V	284_V	0.711	1.00
339_L	529_T	0.710	1.00
315_E	319_E	0.710	1.00
155_S	292_Q	0.709	1.00
40_T	150_I	0.709	1.00
106_K	324_E	0.708	1.00
436_C	439_L	0.707	1.00
439_L	495_R	0.707	1.00
367_G	529_T	0.706	1.00
399_R	404_P	0.704	1.00
333_Q	412_S	0.702	1.00
96_I	135_K	0.699	1.00
393_P	397_T	0.698	1.00
376_S	504_E	0.697	1.00
333_Q	409_S	0.697	1.00
431_I	461_I	0.696	1.00
157_T	160_F	0.696	1.00
354_Q	358_K	0.696	1.00
481_G	508_S	0.695	1.00
186_R	190_S	0.695	1.00
506_T	514_E	0.695	1.00
34_A	38_V	0.692	1.00
370_T	557_R	0.692	1.00
556_G	569_L	0.691	1.00
367_G	527_G	0.690	1.00
350_Y	382_T	0.690	1.00
566_S	569_L	0.688	1.00
155_S	293_I	0.688	1.00
545_Q	559_T	0.686	1.00
56_G	59_M	0.685	1.00
64_G	67_I	0.685	1.00
385_K	391_Y	0.685	1.00
179_L	182_V	0.684	1.00
413_W	417_I	0.683	1.00
556_G	563_L	0.681	1.00
31_F	87_A	0.677	1.00
76_V	80_L	0.676	1.00
369_V	542_D	0.675	1.00
102_L	321_L	0.673	1.00
167_T	286_F	0.672	1.00
561_H	564_M	0.672	1.00
428_S	473_G	0.671	1.00
454_M	520_A	0.669	1.00
445_D	468_F	0.669	1.00
103_L	321_L	0.669	1.00
438_G	441_R	0.667	1.00
105_K	226_Y	0.667	1.00
48_L	162_M	0.666	1.00
94_K	97_S	0.664	1.00
27_G	30_A	0.664	1.00
96_I	100_R	0.663	1.00
447_E	451_A	0.663	1.00
38_V	76_V	0.661	1.00
191_I	194_E	0.660	1.00
20_R	102_L	0.660	1.00
163_N	166_L	0.660	1.00
310_S	313_A	0.659	1.00
126_R	130_D	0.658	1.00
429_G	471_E	0.658	1.00
545_Q	562_E	0.656	1.00
119_A	204_G	0.655	1.00
244_A	248_S	0.654	1.00
480_S	483_Q	0.653	1.00
450_K	524_L	0.652	1.00
384_F	531_I	0.651	1.00
44_L	47_P	0.649	1.00
331_G	334_I	0.647	1.00
39_T	81_S	0.646	1.00
489_I	493_L	0.645	1.00
30_A	33_L	0.644	1.00
517_V	520_A	0.643	1.00
457_A	468_F	0.642	1.00
520_A	523_V	0.642	1.00
514_E	539_T	0.638	1.00
183_P	186_R	0.637	1.00
386_L	391_Y	0.637	1.00
430_T	469_D	0.636	1.00
130_D	196_Q	0.636	1.00
364_I	368_K	0.636	1.00
200_A	316_R	0.635	1.00
17_A	20_R	0.634	1.00
112_V	116_D	0.633	1.00
103_L	131_T	0.633	1.00
99_L	131_T	0.632	1.00
423_E	475_R	0.628	1.00
400_L	405_V	0.626	1.00
428_S	478_M	0.625	1.00
136_E	306_Q	0.625	1.00
55_D	59_M	0.625	1.00
519_Q	522_E	0.625	1.00
295_M	299_Q	0.624	1.00
499_I	529_T	0.624	1.00
489_I	517_V	0.624	1.00
449_E	461_I	0.624	1.00
331_G	412_S	0.623	1.00
36_S	84_A	0.623	1.00
501_M	531_I	0.622	1.00
569_L	573_F	0.621	1.00
242_R	246_V	0.620	1.00
110_L	325_E	0.620	1.00
372_I	531_I	0.617	1.00
556_G	572_D	0.617	1.00
560_H	563_L	0.615	1.00
106_K	323_E	0.615	1.00
134_V	314_T	0.614	1.00
145_F	149_I	0.614	1.00
556_G	564_M	0.614	1.00
196_Q	199_T	0.613	1.00
338_H	529_T	0.613	1.00
540_V	543_A	0.613	1.00
360_V	549_V	0.612	1.00
170_V	290_L	0.612	1.00
166_L	272_Q	0.611	1.00
332_K	335_E	0.610	1.00
357_L	549_V	0.609	1.00
354_Q	551_K	0.609	1.00
125_S	203_T	0.609	1.00
75_F	79_G	0.608	1.00
198_E	236_L	0.607	1.00
509_L	513_S	0.607	1.00
557_R	562_E	0.606	1.00
25_S	28_K	0.606	1.00
362_A	554_I	0.605	1.00
147_T	151_S	0.605	1.00
384_F	419_Y	0.605	1.00
343_L	360_V	0.605	1.00
45_L	73_V	0.604	1.00
337_A	416_H	0.602	1.00
401_G	498_S	0.601	1.00
192_S	243_E	0.601	1.00
278_L	282_A	0.599	1.00
268_Y	271_M	0.598	1.00
97_S	233_I	0.598	1.00
514_E	538_S	0.598	1.00
486_R	509_L	0.598	1.00
197_D	201_R	0.598	1.00
566_S	571_R	0.597	1.00
510_D	513_S	0.597	1.00
456_Y	517_V	0.597	1.00
418_G	495_R	0.597	1.00
511_S	514_E	0.597	1.00
346_V	398_I	0.596	1.00
422_Q	481_G	0.595	1.00
114_Y	123_T	0.594	1.00
455_A	493_L	0.593	1.00
328_T	409_S	0.592	1.00
111_P	114_Y	0.592	1.00
555_T	567_H	0.592	1.00
255_S	298_G	0.591	1.00
452_A	455_A	0.591	1.00
410_L	413_W	0.588	1.00
175_P	179_L	0.587	1.00
238_K	241_V	0.586	1.00
155_S	289_Y	0.586	1.00
215_L	218_A	0.586	1.00
426_L	472_V	0.586	1.00
329_V	333_Q	0.585	1.00
346_V	396_G	0.582	1.00
165_K	268_Y	0.581	1.00
194_E	235_S	0.580	1.00
331_G	409_S	0.578	1.00
191_I	243_E	0.578	1.00
349_G	395_A	0.578	1.00
136_E	140_T	0.576	1.00
439_L	494_L	0.576	1.00
420_V	502_L	0.576	1.00
436_C	452_A	0.575	1.00
148_G	152_V	0.574	1.00
455_A	489_I	0.574	1.00
348_F	356_I	0.574	1.00
86_Y	90_Y	0.574	1.00
178_A	181_L	0.572	1.00
270_G	273_V	0.571	1.00
541_V	560_H	0.571	1.00
125_S	199_T	0.570	1.00
196_Q	312_G	0.570	1.00
89_N	93_Q	0.570	1.00
421_S	424_S	0.569	1.00
122_E	316_R	0.569	1.00
38_V	42_V	0.568	1.00
327_D	334_I	0.568	1.00
364_I	369_V	0.568	1.00
352_P	394_T	0.568	1.00
58_S	61_N	0.568	1.00
365_E	370_T	0.568	1.00
184_I	250_V	0.567	1.00
346_V	361_S	0.567	1.00
518_Q	532_V	0.566	1.00
352_P	355_L	0.565	1.00
21_R	24_P	0.565	1.00
260_A	264_A	0.565	1.00
452_A	490_A	0.565	1.00
546_L	559_T	0.563	1.00
78_A	82_A	0.562	1.00
458_L	461_I	0.562	1.00
482_G	510_D	0.561	1.00
132_M	135_K	0.560	1.00
205_L	209_I	0.560	1.00
264_A	268_Y	0.560	1.00
195_T	243_E	0.560	1.00
93_Q	96_I	0.558	1.00
519_Q	542_D	0.558	1.00
69_L	73_V	0.557	1.00
104_W	108_I	0.557	1.00
453_E	459_N	0.556	1.00
448_I	452_A	0.556	1.00
570_Y	573_F	0.555	1.00
248_S	252_P	0.555	1.00
372_I	533_I	0.555	1.00
39_T	80_L	0.555	1.00
49_L	52_Q	0.555	1.00
89_N	140_T	0.554	1.00
205_L	225_E	0.554	1.00
51_K	281_G	0.553	1.00
120_S	124_V	0.553	1.00
144_G	299_Q	0.552	1.00
125_S	200_A	0.552	1.00
313_A	316_R	0.552	1.00
24_P	102_L	0.551	1.00
99_L	134_V	0.551	1.00
564_M	575_E	0.550	1.00
48_L	285_A	0.550	1.00
92_G	139_T	0.549	1.00
125_S	129_N	0.547	1.00
152_V	156_L	0.546	1.00
131_T	317_M	0.546	1.00
493_L	520_A	0.546	1.00
347_S	357_L	0.546	1.00
360_V	547_L	0.546	1.00
445_D	452_A	0.546	1.00
400_L	408_Y	0.546	1.00
436_C	494_L	0.544	1.00
385_K	419_Y	0.544	1.00
373_V	540_V	0.544	1.00
40_T	43_S	0.543	1.00
431_I	472_V	0.543	1.00
551_K	555_T	0.542	1.00
148_G	151_S	0.542	1.00
271_M	274_S	0.541	1.00
180_I	257_V	0.541	1.00
548_F	556_G	0.540	1.00
199_T	203_T	0.540	1.00
337_A	366_A	0.540	1.00
278_L	283_L	0.539	1.00
71_A	75_F	0.539	1.00
365_E	529_T	0.538	1.00
259_M	263_V	0.537	1.00
201_R	204_G	0.536	1.00
358_K	361_S	0.536	1.00
25_S	91_N	0.536	1.00
403_E	412_S	0.535	1.00
83_Y	87_A	0.535	1.00
381_T	384_F	0.535	1.00
25_S	95_I	0.535	1.00
505_A	532_V	0.534	1.00
96_I	131_T	0.534	1.00
112_V	390_F	0.534	1.00
176_L	179_L	0.533	1.00
121_G	204_G	0.533	1.00
231_M	234_S	0.533	1.00
274_S	277_E	0.532	1.00
376_S	534_A	0.532	1.00
363_V	557_R	0.532	1.00
59_M	62_L	0.531	1.00
207_N	211_P	0.531	1.00
499_I	531_I	0.531	1.00
393_P	404_P	0.530	1.00
420_V	505_A	0.529	1.00
170_V	293_I	0.529	1.00
328_T	332_K	0.529	1.00
330_T	407_T	0.528	1.00
520_A	524_L	0.528	1.00
269_G	273_V	0.528	1.00
53_L	66_Q	0.528	1.00
36_S	40_T	0.527	1.00
518_Q	542_D	0.527	1.00
372_I	549_V	0.527	1.00
161_I	165_K	0.526	1.00
506_T	509_L	0.526	1.00
40_T	44_L	0.525	1.00
409_S	413_W	0.525	1.00
564_M	567_H	0.525	1.00
434_N	487_I	0.524	1.00
159_L	170_V	0.524	1.00
382_T	391_Y	0.524	1.00
236_L	240_G	0.524	1.00
550_E	572_D	0.523	1.00
376_S	509_L	0.522	1.00
108_I	111_P	0.520	1.00
493_L	524_L	0.519	1.00
21_R	99_L	0.518	1.00
115_F	118_N	0.518	1.00
127_V	131_T	0.518	1.00
339_L	498_S	0.518	1.00
332_K	336_N	0.517	1.00
74_F	78_A	0.516	1.00
80_L	83_Y	0.516	1.00
525_M	528_R	0.516	1.00
439_L	444_T	0.516	1.00
39_T	43_S	0.515	1.00
502_L	505_A	0.515	1.00
513_S	516_S	0.515	1.00
355_L	359_E	0.514	1.00
201_R	205_L	0.514	1.00
531_I	547_L	0.514	1.00
337_A	340_P	0.513	1.00
524_L	528_R	0.513	1.00
216_V	222_E	0.512	1.00
48_L	289_Y	0.512	1.00
337_A	400_L	0.511	1.00
191_I	246_V	0.511	1.00
33_L	36_S	0.510	1.00
126_R	316_R	0.510	1.00
532_V	540_V	0.510	1.00
195_T	199_T	0.509	1.00
513_S	517_V	0.508	1.00
86_Y	89_N	0.508	1.00
156_L	160_F	0.508	1.00
85_T	89_N	0.508	1.00
516_S	520_A	0.508	1.00
23_N	27_G	0.508	1.00
238_K	245_K	0.507	1.00
202_F	206_L	0.507	1.00
329_V	409_S	0.506	1.00
343_L	386_L	0.506	1.00
282_A	285_A	0.504	1.00
557_R	566_S	0.502	1.00
66_Q	70_I	0.502	1.00
446_A	453_E	0.502	1.00
364_I	547_L	0.502	1.00
382_T	386_L	0.501	1.00
263_V	267_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ry2A	2	0.9643	100	0.073	Contact Map
4a82A	2	0.9593	100	0.114	Contact Map
4q4hB	1	0.9728	100	0.139	Contact Map
4f4cA	1	0.9593	100	0.143	Contact Map
3b60A	2	0.9643	100	0.15	Contact Map
3b5xA	2	0.9643	100	0.154	Contact Map
4q9hA	1	0.9643	100	0.159	Contact Map
4mrsA	2	0.9847	100	0.161	Contact Map
3zdqA	2	0.944	100	0.164	Contact Map
4q4hA	1	0.961	100	0.169	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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