GREMLIN Database
YITO - Uncharacterized protein YitO
UniProt: O06750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (270)
Sequences: 982 (761)
Seq/√Len: 46.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_I143_W4.8221.00
30_A90_V4.2391.00
88_L98_T4.0271.00
122_A173_L3.8001.00
34_L90_V3.5631.00
33_S102_H3.5001.00
174_Y257_H3.4351.00
100_V131_L3.1891.00
143_W146_R3.1701.00
88_L91_I3.1131.00
192_A196_F3.1111.00
253_A277_L2.9111.00
85_I101_L2.7391.00
173_L273_M2.6571.00
34_L83_I2.6271.00
87_V91_I2.5331.00
95_P142_H2.4811.00
31_L90_V2.4381.00
164_F167_R2.3541.00
128_F131_L2.2481.00
136_T144_S2.2231.00
95_P136_T2.2121.00
89_V102_H2.2101.00
256_M260_F2.1691.00
288_I292_Y2.1581.00
178_T233_I2.1531.00
95_P144_S2.0921.00
194_Y198_Q2.0911.00
94_R147_P1.9840.99
190_G196_F1.9750.99
182_L229_L1.9690.99
102_H127_T1.9310.99
118_G269_F1.8460.99
256_M270_S1.8420.99
235_I253_A1.8090.99
85_I98_T1.8060.99
34_L87_V1.7880.99
103_W131_L1.7790.99
143_W147_P1.7490.98
241_A245_H1.7430.98
125_V129_L1.7390.98
19_T23_G1.7120.98
99_G131_L1.6980.98
224_P259_I1.6920.98
28_I275_G1.6480.98
27_S142_H1.6230.97
118_G266_L1.6010.97
103_W128_F1.6000.97
193_V224_P1.5670.97
148_I152_R1.5660.97
182_L263_M1.5530.96
88_L101_L1.5500.96
170_V277_L1.5380.96
228_T232_Q1.5240.96
89_V99_G1.5090.96
254_V274_A1.4870.95
87_V90_V1.4860.95
19_T139_R1.4760.95
41_H46_M1.4720.95
68_G78_F1.4520.95
128_F132_P1.4510.95
30_A86_L1.4410.95
190_G200_K1.4280.94
245_H249_I1.4180.94
63_S108_S1.4170.94
15_R160_F1.4160.94
235_I277_L1.4090.94
257_H260_F1.4050.94
33_S127_T1.3890.93
95_P102_H1.3550.93
30_A89_V1.3240.92
126_M276_I1.3150.91
284_I288_I1.3140.91
160_F164_F1.3130.91
22_Y182_L1.3090.91
132_P142_H1.3000.91
112_S115_V1.2910.91
151_K154_L1.2870.91
95_P99_G1.2840.90
251_I255_F1.2650.90
261_A266_L1.2640.90
26_R92_G1.2490.89
192_A198_Q1.2430.89
93_W143_W1.2420.89
12_W164_F1.2310.88
90_V223_I1.2300.88
192_A197_A1.2220.88
289_Q293_I1.2030.87
184_Q196_F1.2030.87
93_W147_P1.2010.87
79_R83_I1.2000.87
132_P262_V1.1990.87
170_V276_I1.1960.87
21_V286_S1.1920.87
243_K247_R1.1890.87
255_F259_I1.1770.86
192_A195_Y1.1620.85
89_V127_T1.1590.85
268_S272_I1.1420.84
175_F233_I1.1420.84
18_W21_V1.1390.84
47_K52_I1.1390.84
32_S268_S1.1380.84
181_K232_Q1.1360.84
195_Y198_Q1.1200.83
107_Y124_A1.1010.82
191_T197_A1.0990.82
70_N80_W1.0860.81
232_Q256_M1.0850.81
139_R145_T1.0850.81
23_G27_S1.0780.81
37_L82_C1.0480.79
118_G264_L1.0450.79
106_S110_Q1.0430.78
29_I33_S1.0410.78
227_G251_I1.0330.78
287_T290_F1.0280.77
98_T101_L1.0230.77
29_I127_T1.0210.77
118_G121_Q1.0200.77
266_L269_F1.0140.76
43_S172_V1.0130.76
54_S254_V1.0070.76
250_L281_L0.9990.75
85_I88_L0.9980.75
34_L42_P0.9870.75
40_N46_M0.9840.74
118_G169_Q0.9820.74
192_A202_I0.9800.74
288_I291_T0.9700.73
99_G132_P0.9690.73
275_G279_L0.9690.73
77_L291_T0.9660.73
234_V238_A0.9660.73
202_I264_L0.9640.73
18_W287_T0.9620.73
27_S90_V0.9570.72
23_G145_T0.9520.72
81_V148_I0.9460.71
30_A103_W0.9360.71
86_L102_H0.9340.70
58_C64_L0.9290.70
220_F259_I0.9200.69
167_R279_L0.9190.69
21_V235_I0.9140.69
190_G195_Y0.9110.68
48_P52_I0.9080.68
174_Y269_F0.9050.68
192_A199_E0.8990.67
231_V239_L0.8980.67
16_N157_I0.8950.67
147_P284_I0.8890.67
194_Y200_K0.8870.66
291_T294_R0.8860.66
181_K257_H0.8860.66
93_W144_S0.8850.66
248_L252_I0.8830.66
260_F270_S0.8820.66
122_A169_Q0.8800.66
148_I153_T0.8780.66
19_T140_K0.8750.65
197_A204_F0.8730.65
238_A245_H0.8700.65
20_N141_W0.8700.65
27_S92_G0.8670.65
32_S275_G0.8670.65
68_G74_M0.8630.64
89_V136_T0.8600.64
174_Y273_M0.8590.64
127_T227_G0.8560.64
81_V152_R0.8540.63
95_P135_L0.8510.63
37_L127_T0.8510.63
12_W100_V0.8510.63
190_G194_Y0.8490.63
101_L105_V0.8490.63
190_G202_I0.8470.63
242_P247_R0.8460.63
171_A275_G0.8440.62
196_F199_E0.8380.62
94_R100_V0.8370.62
128_F227_G0.8350.62
130_L233_I0.8330.61
79_R109_L0.8330.61
89_V98_T0.8230.60
220_F223_I0.8220.60
257_H266_L0.8180.60
12_W167_R0.8180.60
65_F108_S0.8170.60
23_G140_K0.8100.59
82_C105_V0.8090.59
193_V197_A0.8010.58
28_I278_I0.7930.58
108_S112_S0.7930.58
148_I288_I0.7910.57
246_W267_I0.7900.57
166_I213_K0.7860.57
131_L139_R0.7850.57
163_Y166_I0.7820.57
31_L255_F0.7790.56
97_I101_L0.7750.56
147_P151_K0.7740.56
205_N209_Q0.7730.56
13_D240_F0.7700.55
284_I287_T0.7690.55
38_L85_I0.7680.55
246_W269_F0.7670.55
152_R242_P0.7640.55
52_I79_R0.7590.54
177_S228_T0.7550.54
36_T40_N0.7540.54
45_I260_F0.7540.54
173_L276_I0.7520.54
16_N20_N0.7510.54
231_V255_F0.7500.53
111_S119_G0.7430.53
91_I131_L0.7420.53
232_Q235_I0.7420.53
155_G158_T0.7360.52
142_H147_P0.7360.52
256_M259_I0.7340.52
117_D265_G0.7340.52
100_V291_T0.7330.52
103_W124_A0.7330.52
224_P275_G0.7320.52
48_P54_S0.7300.51
170_V292_Y0.7300.51
232_Q270_S0.7290.51
33_S85_I0.7270.51
194_Y197_A0.7260.51
247_R251_I0.7260.51
136_T153_T0.7260.51
30_A92_G0.7240.51
177_S202_I0.7230.51
285_D289_Q0.7230.51
17_P139_R0.7220.51
34_L77_L0.7210.51
37_L102_H0.7200.50
166_I254_V0.7120.50
222_V266_L0.7090.49
267_I270_S0.7090.49
247_R281_L0.7050.49
118_G273_M0.7020.49
129_L165_V0.7020.49
285_D288_I0.7000.49
231_V253_A0.7000.49
269_F273_M0.6970.48
270_S280_Y0.6960.48
52_I179_V0.6960.48
230_L251_I0.6960.48
88_L99_G0.6950.48
77_L160_F0.6930.48
106_S228_T0.6910.48
120_E260_F0.6900.48
20_N287_T0.6820.47
158_T162_S0.6810.47
163_Y167_R0.6770.46
30_A270_S0.6760.46
92_G144_S0.6750.46
94_R248_L0.6700.46
94_R98_T0.6670.45
108_S119_G0.6670.45
119_G232_Q0.6650.45
230_L234_V0.6640.45
22_Y246_W0.6640.45
253_A260_F0.6640.45
78_F85_I0.6640.45
177_S232_Q0.6630.45
18_W22_Y0.6590.44
85_I105_V0.6580.44
178_T193_V0.6560.44
145_T148_I0.6560.44
118_G232_Q0.6560.44
114_I272_I0.6550.44
269_F275_G0.6530.44
246_W270_S0.6510.44
97_I153_T0.6490.44
25_A134_T0.6490.44
37_L141_W0.6480.43
47_K50_S0.6480.43
193_V196_F0.6480.43
95_P143_W0.6440.43
130_L135_L0.6440.43
126_M277_L0.6430.43
172_V293_I0.6420.43
145_T153_T0.6410.43
238_A246_W0.6400.43
42_P170_V0.6380.42
84_A87_V0.6380.42
65_F69_E0.6310.42
140_K289_Q0.6300.42
257_H280_Y0.6290.42
172_V284_I0.6280.41
38_L83_I0.6270.41
47_K51_G0.6260.41
194_Y225_T0.6250.41
248_L251_I0.6250.41
35_L170_V0.6220.41
218_S221_V0.6220.41
98_T132_P0.6210.41
151_K258_E0.6200.41
195_Y199_E0.6200.41
21_V192_A0.6200.41
127_T152_R0.6170.40
119_G270_S0.6170.40
117_D267_I0.6160.40
255_F264_L0.6150.40
116_I119_G0.6130.40
84_A97_I0.6110.40
190_G222_V0.6090.40
70_N77_L0.6090.40
117_D232_Q0.6040.39
139_R142_H0.6010.39
165_V172_V0.6010.39
94_R136_T0.5980.39
16_N155_G0.5950.38
227_G252_I0.5950.38
60_M148_I0.5940.38
91_I288_I0.5890.38
121_Q264_L0.5880.38
28_I81_V0.5870.38
194_Y199_E0.5860.38
78_F108_S0.5850.37
148_I291_T0.5850.37
92_G142_H0.5830.37
106_S123_A0.5810.37
51_G83_I0.5810.37
190_G199_E0.5800.37
199_E202_I0.5780.37
237_A241_A0.5780.37
200_K204_F0.5780.37
142_H145_T0.5770.37
238_A255_F0.5760.37
51_G69_E0.5750.37
209_Q212_T0.5740.36
258_E274_A0.5720.36
238_A242_P0.5710.36
230_L289_Q0.5690.36
31_L35_L0.5680.36
181_K229_L0.5660.36
19_T74_M0.5650.36
234_V284_I0.5630.35
82_C133_I0.5600.35
67_L74_M0.5590.35
39_I273_M0.5590.35
134_T209_Q0.5580.35
15_R20_N0.5570.35
23_G141_W0.5540.35
104_Y142_H0.5530.35
249_I253_A0.5520.34
234_V237_A0.5510.34
48_P51_G0.5510.34
91_I155_G0.5500.34
37_L41_H0.5490.34
136_T142_H0.5480.34
23_G146_R0.5480.34
105_V163_Y0.5480.34
139_R143_W0.5470.34
27_S240_F0.5460.34
139_R148_I0.5440.34
111_S194_Y0.5430.34
174_Y190_G0.5430.34
12_W240_F0.5400.33
239_L245_H0.5400.33
35_L93_W0.5390.33
260_F264_L0.5390.33
35_L90_V0.5380.33
47_K217_T0.5370.33
12_W15_R0.5360.33
166_I176_H0.5340.33
233_I254_V0.5330.33
27_S95_P0.5330.33
46_M258_E0.5320.33
239_L273_M0.5320.33
261_A271_I0.5300.33
31_L64_L0.5280.32
80_W129_L0.5280.32
223_I230_L0.5280.32
14_E161_I0.5280.32
21_V163_Y0.5270.32
257_H269_F0.5270.32
159_A222_V0.5260.32
107_Y111_S0.5220.32
36_T265_G0.5220.32
146_R154_L0.5220.32
30_A169_Q0.5210.32
34_L86_L0.5170.31
145_T179_V0.5160.31
116_I134_T0.5160.31
162_S165_V0.5120.31
172_V256_M0.5120.31
101_L127_T0.5120.31
99_G134_T0.5110.31
195_Y225_T0.5110.31
210_A213_K0.5080.31
169_Q269_F0.5070.31
148_I258_E0.5070.31
114_I199_E0.5060.30
250_L277_L0.5060.30
93_W136_T0.5050.30
217_T254_V0.5050.30
125_V169_Q0.5030.30
129_L169_Q0.5020.30
45_I120_E0.5000.30
184_Q192_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mi2A 1 0.1489 9.1 0.962 Contact Map
2mn6B 2 0.1456 7.3 0.963 Contact Map
2l16A 1 0.1521 5.4 0.966 Contact Map
4ogeA 1 0.165 5.3 0.966 Contact Map
3bu8A 4 0.1068 3.7 0.968 Contact Map
2lzrA 1 0.1489 2.6 0.97 Contact Map
4d6uD 1 0.1942 2.2 0.972 Contact Map
1pp9D 2 0.1942 2 0.972 Contact Map
4jpkA 1 0.1392 1.5 0.974 Contact Map
2qv0A 2 0.1165 1.3 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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