GREMLIN Database
YITL - Uncharacterized protein YitL
UniProt: O06747 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (273)
Sequences: 1622 (1227)
Seq/√Len: 74.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_G211_G4.2891.00
171_T210_T3.7501.00
91_E131_K3.5091.00
251_A293_W3.4991.00
27_I55_I3.4761.00
171_T208_R3.1901.00
18_R21_Q3.1201.00
24_T60_E2.9551.00
254_Y267_F2.9511.00
192_C224_L2.9441.00
169_E210_T2.9181.00
211_G224_L2.7621.00
239_E243_T2.6951.00
290_E295_Y2.6861.00
288_Y295_Y2.6691.00
258_S262_D2.6581.00
26_S60_E2.5971.00
29_H43_T2.5621.00
103_V146_A2.4571.00
30_Q35_Y2.4191.00
103_V113_V2.3741.00
244_Y252_M2.3601.00
82_I136_L2.2691.00
94_D128_K2.2461.00
186_T222_V2.2421.00
174_V184_V2.1481.00
184_V224_L2.1351.00
282_M285_G2.1311.00
24_T62_E2.1011.00
134_C146_A2.0931.00
182_S199_R2.0011.00
113_V146_A1.9981.00
255_S293_W1.9891.00
50_E78_K1.9261.00
91_E104_D1.9141.00
28_D38_T1.8761.00
49_S108_S1.8411.00
246_R286_K1.8301.00
254_Y266_R1.8141.00
89_W131_K1.7691.00
103_V134_C1.7591.00
113_V126_P1.7551.00
170_L211_G1.7491.00
282_M289_Q1.7251.00
127_Q130_D1.7101.00
113_V132_L1.6411.00
93_V110_D1.6241.00
235_S239_E1.6231.00
39_D42_D1.5800.99
83_S86_E1.5750.99
137_K145_F1.5750.99
242_L246_R1.5610.99
211_G226_L1.5610.99
280_H284_N1.5410.99
105_V111_A1.5400.99
252_M294_T1.5190.99
201_E207_S1.5180.99
251_A295_Y1.5020.99
111_A136_L1.4970.99
34_G45_L1.4940.99
133_Y173_T1.4840.99
278_L294_T1.4700.99
22_Q79_I1.4620.99
246_R296_E1.4590.99
237_D269_M1.4560.99
35_Y55_I1.4550.99
21_Q83_S1.4530.99
96_V99_M1.4440.99
126_P132_L1.4430.99
30_Q56_E1.4380.99
101_V118_L1.4200.99
254_Y258_S1.4130.99
84_A144_M1.3940.98
177_L182_S1.3760.98
35_Y51_M1.3620.98
242_L296_E1.3540.98
82_I88_G1.3530.98
78_K108_S1.3510.98
56_E59_D1.3410.98
172_G184_V1.3390.98
184_V194_I1.3270.98
47_H74_A1.3200.98
31_T36_F1.2930.98
164_D187_D1.2910.98
255_S278_L1.2700.97
117_H147_K1.2670.97
240_C243_T1.2590.97
22_Q83_S1.2580.97
92_V103_V1.2490.97
39_D44_I1.2420.97
289_Q294_T1.2360.97
38_T44_I1.2250.97
228_P236_V1.2210.97
90_V103_V1.2160.96
269_M273_A1.2090.96
91_E129_G1.2080.96
17_M65_I1.2050.96
155_S190_I1.1980.96
68_D72_R1.1860.96
199_R203_P1.1830.96
260_P272_A1.1780.96
259_Q262_D1.1750.96
282_M294_T1.1720.96
96_V128_K1.1410.95
33_F36_F1.1410.95
19_P138_V1.1380.95
186_T224_L1.1300.95
37_L46_L1.1200.94
198_E214_I1.1190.94
63_V77_M1.1050.94
225_S229_R1.1010.94
30_Q48_N1.0930.94
244_Y267_F1.0860.93
240_C269_M1.0840.93
292_G295_Y1.0820.93
81_I104_D1.0820.93
167_N212_R1.0610.93
231_Q234_M1.0590.92
243_T247_M1.0570.92
195_H223_N1.0570.92
148_P152_D1.0540.92
228_P232_D1.0540.92
52_T55_I1.0490.92
52_T61_V1.0420.92
34_G47_H1.0420.92
248_R253_P1.0400.92
38_T42_D1.0380.92
45_L72_R1.0340.92
104_D110_D1.0330.92
89_W133_Y1.0320.91
213_V224_L1.0220.91
126_P148_P1.0020.90
135_M147_K1.0010.90
111_A146_A0.9960.90
22_Q62_E0.9940.90
234_M280_H0.9830.89
287_V294_T0.9830.89
71_E107_L0.9810.89
272_A276_R0.9800.89
256_D279_G0.9770.89
170_L224_L0.9750.89
184_V192_C0.9690.89
87_Y185_I0.9640.88
174_V209_V0.9620.88
165_L168_K0.9620.88
242_L286_K0.9580.88
215_Q223_N0.9440.87
175_Y191_R0.9410.87
276_R280_H0.9400.87
36_F43_T0.9300.87
27_I54_D0.9290.87
241_I245_M0.9260.86
118_L126_P0.9220.86
252_M278_L0.9170.86
51_M55_I0.9170.86
252_M274_F0.9150.86
173_T188_D0.9060.85
169_E228_P0.9060.85
254_Y262_D0.9060.85
242_L245_M0.8990.85
31_T34_G0.8980.85
278_L289_Q0.8970.85
273_A276_R0.8960.84
92_V126_P0.8960.84
167_N229_R0.8860.84
62_E79_I0.8840.84
194_I211_G0.8840.84
244_Y248_R0.8750.83
103_V132_L0.8700.83
262_D265_E0.8680.83
173_T208_R0.8610.82
45_L74_A0.8610.82
253_P274_F0.8610.82
237_D273_A0.8590.82
252_M267_F0.8550.82
176_R183_F0.8540.82
67_V71_E0.8530.81
235_S280_H0.8440.81
129_G261_D0.8440.81
114_A117_H0.8330.80
32_D48_N0.8280.79
25_L44_I0.8260.79
64_F76_T0.8260.79
93_V104_D0.8260.79
203_P209_V0.8250.79
36_F69_Q0.8220.79
49_S78_K0.8210.79
279_G283_K0.8190.79
33_F45_L0.8170.79
243_T246_R0.8050.78
147_K153_I0.8020.77
236_V240_C0.8020.77
186_T213_V0.7980.77
28_D32_D0.7950.77
238_A280_H0.7920.76
71_E74_A0.7860.76
214_I225_S0.7820.75
231_Q236_V0.7810.75
241_I278_L0.7800.75
186_T192_C0.7770.75
164_D190_I0.7770.75
25_L37_L0.7760.75
67_V97_E0.7750.75
251_A290_E0.7710.74
137_K147_K0.7690.74
233_A276_R0.7620.74
50_E108_S0.7590.73
27_I33_F0.7590.73
244_Y247_M0.7580.73
84_A138_V0.7570.73
256_D283_K0.7570.73
255_S289_Q0.7560.73
163_E168_K0.7540.73
259_Q264_R0.7540.73
67_V73_L0.7490.72
96_V101_V0.7460.72
50_E77_M0.7460.72
36_F72_R0.7420.72
84_A136_L0.7380.71
92_V132_L0.7370.71
67_V142_G0.7360.71
26_S58_R0.7280.70
82_I105_V0.7270.70
290_E293_W0.7270.70
27_I30_Q0.7250.70
177_L196_P0.7240.70
105_V144_M0.7230.70
278_L282_M0.7200.69
39_D65_I0.7200.69
172_G212_R0.7180.69
124_V148_P0.7180.69
180_S193_F0.7180.69
161_A164_D0.7160.69
235_S238_A0.7120.68
200_K227_L0.7120.68
249_N295_Y0.7080.68
107_L110_D0.7060.68
103_V111_A0.7040.68
255_S291_N0.6990.67
245_M258_S0.6990.67
112_L116_E0.6960.67
196_P202_E0.6890.66
186_T211_G0.6870.66
194_I226_L0.6870.66
174_V205_L0.6870.66
194_I224_L0.6860.66
37_L44_I0.6860.66
89_W173_T0.6850.65
35_Y61_V0.6840.65
192_C217_K0.6820.65
94_D110_D0.6780.65
23_L65_I0.6760.64
194_I209_V0.6720.64
56_E216_V0.6700.64
155_S189_G0.6690.64
102_F109_K0.6670.63
64_F80_P0.6670.63
47_H51_M0.6670.63
34_G37_L0.6650.63
262_D266_R0.6600.63
240_C244_Y0.6600.63
102_F110_D0.6590.62
29_H33_F0.6580.62
217_K221_S0.6580.62
31_T48_N0.6560.62
87_Y150_P0.6560.62
130_D204_R0.6550.62
27_I35_Y0.6540.62
233_A273_A0.6530.62
68_D75_A0.6530.62
252_M269_M0.6520.62
17_M67_V0.6510.62
239_E286_K0.6490.61
112_L145_F0.6460.61
102_F143_R0.6450.61
289_Q293_W0.6400.60
257_K283_K0.6400.60
164_D213_V0.6380.60
241_I267_F0.6360.60
69_Q74_A0.6350.60
253_P269_M0.6340.60
181_G193_F0.6320.59
212_R225_S0.6320.59
168_K187_D0.6310.59
92_V136_L0.6300.59
113_V134_C0.6300.59
186_T216_V0.6290.59
160_D190_I0.6270.59
278_L287_V0.6260.59
71_E75_A0.6250.58
133_Y185_I0.6230.58
237_D276_R0.6230.58
132_L148_P0.6210.58
172_G187_D0.6200.58
109_K112_L0.6170.57
172_G209_V0.6150.57
29_H36_F0.6140.57
175_Y183_F0.6140.57
113_V148_P0.6140.57
105_V109_K0.6130.57
178_I183_F0.6120.57
50_E74_A0.6120.57
25_L46_L0.6110.57
259_Q291_N0.6090.56
107_L143_R0.6070.56
96_V115_T0.6060.56
285_G288_Y0.6040.56
126_P130_D0.6040.56
255_S292_G0.6030.56
282_M286_K0.6020.56
204_R238_A0.5960.55
28_D36_F0.5960.55
37_L63_V0.5940.55
44_I65_I0.5940.55
115_T141_R0.5920.54
245_M287_V0.5900.54
259_Q265_E0.5890.54
172_G183_F0.5850.54
267_F278_L0.5850.54
289_Q292_G0.5850.54
71_E98_D0.5840.53
240_C268_N0.5810.53
123_D148_P0.5810.53
29_H45_L0.5790.53
274_F279_G0.5790.53
244_Y294_T0.5780.53
25_L39_D0.5770.53
47_H71_E0.5750.52
23_L207_S0.5740.52
69_Q107_L0.5730.52
159_T187_D0.5730.52
258_S266_R0.5730.52
162_S220_G0.5720.52
253_P262_D0.5700.52
182_S205_L0.5680.51
199_R202_E0.5660.51
30_Q57_D0.5660.51
109_K143_R0.5650.51
76_T107_L0.5650.51
79_I83_S0.5630.51
204_R207_S0.5620.51
64_F106_G0.5610.51
251_A288_Y0.5600.50
47_H69_Q0.5600.50
142_G264_R0.5590.50
102_F112_L0.5580.50
82_I86_E0.5570.50
248_R251_A0.5540.50
209_V226_L0.5540.50
245_M296_E0.5500.49
265_E296_E0.5490.49
195_H272_A0.5490.49
87_Y135_M0.5480.49
45_L70_Q0.5480.49
196_P199_R0.5470.49
17_M44_I0.5460.49
256_D271_K0.5460.49
31_T43_T0.5450.49
139_T143_R0.5440.48
85_D113_V0.5440.48
100_G109_K0.5410.48
104_D107_L0.5400.48
33_F49_S0.5400.48
181_G223_N0.5390.48
63_V75_A0.5390.48
183_F237_D0.5390.48
244_Y278_L0.5390.48
141_R145_F0.5380.48
109_K144_M0.5370.48
248_R252_M0.5350.47
203_P207_S0.5340.47
171_T187_D0.5330.47
47_H53_E0.5330.47
85_D144_M0.5290.47
30_Q54_D0.5290.47
248_R266_R0.5280.46
200_K264_R0.5260.46
260_P263_I0.5240.46
264_R273_A0.5230.46
65_I75_A0.5230.46
114_A145_F0.5220.46
118_L132_L0.5220.46
237_D277_A0.5220.46
28_D43_T0.5200.45
101_V105_V0.5190.45
97_E115_T0.5170.45
264_R268_N0.5160.45
54_D61_V0.5160.45
34_G75_A0.5130.45
25_L45_L0.5130.45
190_I222_V0.5130.45
199_R223_N0.5130.45
37_L75_A0.5120.44
188_D208_R0.5120.44
253_P266_R0.5120.44
55_I61_V0.5120.44
17_M132_L0.5100.44
99_M112_L0.5090.44
21_Q84_A0.5080.44
100_G112_L0.5070.44
88_G136_L0.5040.43
252_M266_R0.5030.43
253_P265_E0.5030.43
251_A265_E0.5020.43
81_I131_K0.5020.43
35_Y57_D0.5020.43
174_V182_S0.5010.43
65_I73_L0.5010.43
26_S251_A0.5000.43
118_L189_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3go5A 1 0.9396 100 0.243 Contact Map
4q7jD 1 0.5034 100 0.622 Contact Map
1kl9A 2 0.4664 99.9 0.704 Contact Map
3j81j 1 0.4765 99.8 0.727 Contact Map
1q8kA 1 0.4799 99.8 0.729 Contact Map
3aevA 1 0.4497 99.8 0.736 Contact Map
2a19A 1 0.4564 99.8 0.746 Contact Map
4nngA 1 0.4966 99.8 0.751 Contact Map
3cw2C 1 0.4698 99.7 0.77 Contact Map
2ba0A 1 0.5503 99.3 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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