GREMLIN Database
YITK - UPF0234 protein yitk
UniProt: O06746 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (157)
Sequences: 1288 (627)
Seq/√Len: 50.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E73_R3.7131.00
83_G98_K3.6081.00
40_S53_S3.5181.00
148_V157_V3.2871.00
115_I144_I2.9811.00
112_N124_S2.7791.00
104_D107_N2.6521.00
118_S147_A2.5761.00
70_L80_I2.5051.00
81_D100_V2.4851.00
55_D58_K2.4681.00
9_I148_V2.4391.00
112_N131_V2.4381.00
13_V99_L2.3261.00
24_I69_K2.3141.00
114_I151_A2.1391.00
19_Q23_Q2.1231.00
114_I153_L1.9590.99
115_I133_V1.8840.99
107_N110_K1.7970.99
42_I62_L1.7780.99
113_T117_N1.7660.99
59_L95_Q1.7650.99
16_P19_Q1.7350.99
70_L75_V1.7150.99
130_Q160_I1.7100.99
22_I66_L1.6540.98
112_N116_K1.6130.98
48_E96_R1.6060.98
88_A94_R1.5830.98
124_S131_V1.5750.97
51_L62_L1.5620.97
12_K129_D1.5440.97
29_I62_L1.5400.97
23_Q27_K1.5310.97
85_V93_V1.5170.97
52_V92_T1.5130.97
103_I108_A1.5070.97
74_N149_R1.4990.97
127_Q130_Q1.4980.97
138_K162_F1.4910.96
64_D68_S1.4690.96
18_V70_L1.4610.96
111_I131_V1.4540.96
80_I97_A1.4270.95
28_E69_K1.4080.95
12_K160_I1.3740.94
51_L59_L1.3380.94
10_V160_I1.3190.93
81_D98_K1.3110.93
63_K67_V1.3110.93
65_V69_K1.3080.93
25_A42_I1.3020.93
107_N155_I1.2990.92
140_D143_Q1.2710.92
56_E72_K1.2700.92
57_F61_Q1.2640.91
115_I124_S1.2330.90
51_L97_A1.2310.90
12_K130_Q1.2210.90
48_E98_K1.2110.90
9_I133_V1.2010.89
50_V96_R1.1950.89
78_K154_P1.1660.88
22_I44_L1.1630.88
136_K140_D1.1360.86
63_K82_Y1.1290.86
67_V77_T1.1200.86
114_I117_N1.1180.85
88_A93_V1.1070.85
29_I36_K1.0930.84
47_E101_Q1.0930.84
112_N123_K1.0850.84
103_I131_V1.0620.82
80_I99_L1.0380.81
90_G93_V1.0300.80
35_F58_K1.0240.80
111_I153_L1.0060.79
28_E73_R1.0050.79
105_K128_D0.9980.78
85_V95_Q0.9940.78
41_D52_V0.9840.77
9_I131_V0.9830.77
53_S92_T0.9690.76
146_S150_G0.9650.76
17_E28_E0.9390.74
71_I77_T0.9380.74
116_K123_K0.9230.73
10_V102_G0.9190.72
25_A62_L0.9160.72
18_V75_V0.9120.72
114_I147_A0.9080.71
107_N154_P0.8860.69
138_K163_R0.8780.69
11_S102_G0.8720.68
39_K92_T0.8710.68
114_I118_S0.8640.67
26_L41_D0.8640.67
44_L99_L0.8600.67
143_Q150_G0.8540.67
56_E85_V0.8510.66
45_D48_E0.8450.66
76_P156_D0.8450.66
61_Q76_P0.8430.66
100_V107_N0.8400.65
75_V79_N0.7860.60
69_K74_N0.7850.60
13_V79_N0.7680.58
77_T80_I0.7640.58
63_K95_Q0.7630.58
49_L80_I0.7600.57
122_V135_G0.7570.57
79_N156_D0.7560.57
57_F65_V0.7480.56
49_L99_L0.7460.56
137_N140_D0.7440.56
122_V140_D0.7420.56
97_A100_V0.7370.55
11_S158_Q0.7360.55
17_E69_K0.7320.55
110_K114_I0.7300.54
27_K128_D0.7210.54
26_L30_S0.7190.53
88_A92_T0.7140.53
149_R159_F0.7140.53
37_G54_D0.7120.53
13_V158_Q0.7080.52
119_G135_G0.7080.52
105_K116_K0.7040.52
18_V49_L0.7040.52
18_V99_L0.7040.52
45_D50_V0.7020.52
125_Q134_T0.7010.51
107_N153_L0.7000.51
103_I124_S0.6860.50
42_I66_L0.6860.50
117_N125_Q0.6730.49
19_Q44_L0.6730.49
16_P23_Q0.6720.49
150_G153_L0.6710.48
39_K54_D0.6670.48
33_Y67_V0.6660.48
72_K138_K0.6630.48
71_I74_N0.6630.48
81_D84_K0.6630.48
118_S144_I0.6590.47
41_D99_L0.6540.47
61_Q65_V0.6530.47
43_S150_G0.6520.46
120_L135_G0.6510.46
129_D160_I0.6440.46
24_I73_R0.6420.45
27_K87_N0.6420.45
54_D92_T0.6390.45
27_K94_R0.6360.45
16_P75_V0.6330.45
79_N101_Q0.6310.44
145_I159_F0.6290.44
136_K153_L0.6290.44
15_L44_L0.6280.44
36_K92_T0.6260.44
112_N126_V0.6240.44
49_L66_L0.6230.44
15_L18_V0.6220.43
60_S64_D0.6170.43
41_D49_L0.6120.42
120_L147_A0.6120.42
104_D126_V0.6110.42
38_S53_S0.6110.42
145_I160_I0.6110.42
59_L85_V0.6100.42
82_Y97_A0.6100.42
69_K73_R0.6070.42
26_L40_S0.6050.42
33_Y137_N0.5990.41
72_K125_Q0.5980.41
9_I115_I0.5980.41
103_I111_I0.5940.41
38_S55_D0.5850.40
51_L67_V0.5830.40
87_N93_V0.5830.40
118_S143_Q0.5800.39
17_E24_I0.5770.39
36_K157_V0.5750.39
18_V79_N0.5750.39
55_D93_V0.5680.38
23_Q58_K0.5680.38
37_G135_G0.5680.38
33_Y61_Q0.5670.38
123_K135_G0.5660.38
104_D110_K0.5640.38
37_G137_N0.5640.38
79_N100_V0.5610.37
13_V75_V0.5600.37
112_N125_Q0.5580.37
43_S52_V0.5560.37
100_V155_I0.5560.37
104_D154_P0.5550.37
17_E20_N0.5550.37
123_K137_N0.5530.37
29_I89_S0.5520.37
44_L47_E0.5510.36
29_I84_K0.5490.36
13_V101_Q0.5490.36
84_K87_N0.5480.36
110_K151_A0.5420.36
98_K104_D0.5410.36
38_S54_D0.5380.35
67_V82_Y0.5290.34
69_K163_R0.5280.34
105_K131_V0.5270.34
148_V155_I0.5250.34
87_N96_R0.5240.34
35_F54_D0.5240.34
123_K131_V0.5230.34
108_A126_V0.5230.34
146_S162_F0.5190.33
83_G96_R0.5190.33
31_T36_K0.5190.33
40_S62_L0.5170.33
69_K72_K0.5170.33
36_K88_A0.5160.33
105_K109_K0.5150.33
119_G144_I0.5130.33
60_S95_Q0.5130.33
24_I77_T0.5120.33
39_K91_G0.5120.33
107_N157_V0.5110.33
24_I36_K0.5110.33
76_P137_N0.5100.33
117_N147_A0.5070.32
106_D109_K0.5070.32
12_K101_Q0.5060.32
60_S85_V0.5060.32
50_V98_K0.5020.32
58_K61_Q0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1in0A 1 0.9755 100 0.049 Contact Map
1gtdA 3 0.4479 17.3 0.958 Contact Map
1yj7A 3 0.3988 14.7 0.96 Contact Map
2yqrA 1 0.4908 14.5 0.96 Contact Map
2dgbA 2 0.4417 13.2 0.96 Contact Map
2yx5A 4 0.4479 12.3 0.961 Contact Map
1tv8A 2 0.8957 11.8 0.961 Contact Map
4djgA 2 0.319 10.3 0.962 Contact Map
1zmaA 1 0.3988 10.2 0.962 Contact Map
4trtA 2 0.7423 9.7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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