GREMLIN Database
YITJ - Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase
UniProt: O06745 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 612 (595)
Sequences: 370 (288)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_N223_S7.0951.00
319_S516_Y6.0721.00
50_V96_A5.4391.00
6_D10_Q4.3441.00
93_A98_V4.3251.00
102_M126_L4.1821.00
99_L136_G4.0980.99
77_D80_K3.9450.99
410_A439_I3.7130.99
43_Q91_A3.6560.99
47_K51_E3.3220.98
149_R191_L3.2210.97
561_E564_A3.1760.97
224_V259_A3.1590.97
126_L155_A3.1590.97
562_G566_A3.1410.96
56_I261_I3.0850.96
547_K568_S3.0510.96
148_A165_L2.9250.95
100_G137_L2.8360.94
350_L371_V2.8190.94
325_D353_A2.7860.93
57_I93_A2.7220.92
83_Q132_E2.6580.91
13_I276_M2.6490.91
480_E510_H2.6200.91
461_V488_D2.6170.91
12_L55_N2.6150.91
86_V134_P2.6000.90
58_Q101_T2.5540.90
329_K454_G2.5120.89
66_Y124_E2.4910.88
483_I513_T2.4660.88
61_T85_A2.4510.87
465_F479_L2.4250.87
86_V132_E2.4020.86
35_N85_A2.4000.86
571_D598_Y2.3860.86
436_I463_A2.3590.85
332_F336_L2.3470.85
529_E549_A2.3440.85
274_R278_E2.3420.85
378_R407_D2.2930.84
490_F513_T2.2480.82
529_E545_R2.2380.82
444_E456_K2.2050.81
42_I45_I2.1900.81
180_P347_I2.1880.80
189_A219_D2.1680.80
127_Y154_I2.1270.78
483_I511_L2.1260.78
582_L592_T2.1260.78
313_I544_I2.1090.78
525_S545_R2.0970.77
363_S559_K2.0940.77
360_P384_T2.0760.77
440_K488_D2.0700.77
368_G381_V2.0680.76
5_E8_Q2.0410.75
50_V57_I2.0360.75
479_L511_L2.0050.74
463_A490_F2.0040.74
86_V129_L1.9790.73
498_E572_T1.9700.73
65_N105_I1.9670.73
505_H576_L1.9600.72
35_N60_N1.9500.72
78_I347_I1.9440.72
169_M210_A1.8960.70
440_K461_V1.8830.69
8_Q164_M1.8640.68
325_D538_I1.8370.67
353_A583_I1.8170.66
166_N495_V1.8120.66
469_V475_A1.8020.66
127_Y158_E1.7910.65
79_K83_Q1.7870.65
462_A489_Y1.7850.65
96_A555_K1.7840.65
570_L599_I1.7780.65
548_M562_G1.7680.64
259_A262_I1.7670.64
563_L591_L1.7550.63
425_T429_D1.7440.63
254_F312_E1.7380.63
351_T527_N1.7350.63
499_Q503_D1.7240.62
177_D363_S1.7160.62
271_N274_R1.7020.61
433_F436_I1.7010.61
436_I461_V1.7010.61
97_Y492_S1.6990.61
88_I237_R1.6970.61
59_T134_P1.6960.61
317_K348_D1.6700.59
499_Q564_A1.6660.59
547_K566_A1.6650.59
5_E97_Y1.6590.59
63_G363_S1.6580.59
317_K320_I1.6380.58
367_C442_F1.6010.56
559_K588_R1.5970.56
436_I487_A1.5960.56
13_I280_V1.5690.55
540_L543_T1.5570.54
87_K132_E1.5290.53
166_N228_S1.5290.53
398_M457_T1.5250.52
525_S550_H1.5190.52
370_L374_Q1.5060.51
55_N277_A1.4980.51
483_I512_K1.4950.51
254_F276_M1.4940.51
178_G540_L1.4940.51
14_G225_Y1.4930.51
531_I535_I1.4910.51
137_L425_T1.4900.51
120_R126_L1.4900.51
478_R573_A1.4880.51
43_Q88_I1.4810.50
57_I571_D1.4770.50
149_R187_S1.4730.50
166_N591_L1.4660.49
231_P454_G1.4590.49
309_G312_E1.4570.49
100_G134_P1.4570.49
204_P562_G1.4510.49
31_F231_P1.4360.48
65_N78_I1.4250.47
79_K131_H1.4210.47
318_R599_I1.4200.47
516_Y544_I1.4170.47
362_I402_T1.4150.47
229_S243_D1.4140.47
527_N585_P1.4110.47
62_Y216_I1.4050.46
84_E87_K1.3990.46
352_L416_S1.3960.46
385_C585_P1.3690.45
522_L566_A1.3680.45
198_I207_M1.3680.45
397_L435_L1.3660.44
198_I244_D1.3630.44
347_I512_K1.3590.44
181_L210_A1.3580.44
160_D560_A1.3580.44
85_A134_P1.3570.44
353_A538_I1.3450.43
64_A81_M1.3440.43
412_T432_S1.3320.43
326_P367_C1.3290.43
479_L490_F1.3210.42
508_T515_I1.3190.42
497_S513_T1.3130.42
13_I255_R1.3100.42
56_I99_L1.3100.42
240_Y244_D1.3010.41
38_K98_V1.2990.41
217_F222_L1.2960.41
338_A589_S1.2940.41
381_V398_M1.2900.41
547_K564_A1.2890.41
166_N504_I1.2850.41
566_A591_L1.2820.40
94_G560_A1.2780.40
56_I401_D1.2750.40
371_V377_M1.2650.40
229_S462_A1.2570.39
62_Y104_G1.2560.39
224_V262_I1.2550.39
66_Y120_R1.2550.39
271_N344_E1.2520.39
498_E568_S1.2470.39
97_Y575_E1.2450.39
313_I319_S1.2440.39
126_L137_L1.2400.38
211_L245_T1.2390.38
324_L339_A1.2280.38
178_G519_I1.2280.38
152_L193_A1.2260.38
15_D59_T1.2210.38
352_L402_T1.2160.37
357_L595_L1.2150.37
72_H77_D1.2140.37
147_E422_P1.2130.37
525_S529_E1.2120.37
120_R127_Y1.2070.37
490_F555_K1.2050.37
403_L408_V1.2040.37
39_P94_G1.2010.37
254_F545_R1.1920.36
56_I225_Y1.1870.36
142_Y462_A1.1860.36
544_I565_I1.1840.36
10_Q55_N1.1810.36
417_K425_T1.1780.36
319_S544_I1.1750.35
156_R163_I1.1700.35
534_E537_G1.1670.35
383_I452_P1.1660.35
391_I585_P1.1600.35
340_A374_Q1.1530.34
155_A496_Y1.1510.34
36_I252_S1.1490.34
519_I566_A1.1380.34
351_T584_T1.1340.34
81_M148_A1.1270.33
102_M139_L1.1240.33
520_M581_Y1.1220.33
505_H515_I1.1210.33
340_A390_I1.1210.33
547_K562_G1.1200.33
359_T454_G1.1190.33
542_D546_E1.1170.33
335_F584_T1.1170.33
387_D412_T1.1170.33
431_T468_N1.1120.33
497_S500_Q1.1110.33
127_Y131_H1.1110.33
560_A564_A1.1090.32
59_T85_A1.1060.32
248_Q276_M1.1040.32
6_D97_Y1.1000.32
321_I516_Y1.1000.32
462_A485_C1.0990.32
184_A453_L1.0980.32
343_K375_L1.0980.32
3_L195_I1.0960.32
35_N439_I1.0940.32
309_G316_K1.0920.32
85_A272_H1.0920.32
200_C266_C1.0880.32
200_C265_C1.0880.32
43_Q92_S1.0860.31
231_P237_R1.0840.31
431_T434_D1.0830.31
104_G516_Y1.0820.31
50_V55_N1.0820.31
120_R157_K1.0810.31
353_A397_L1.0750.31
36_I81_M1.0750.31
58_Q362_I1.0750.31
388_R479_L1.0700.31
363_S434_D1.0690.31
41_E44_R1.0690.31
69_L204_P1.0670.31
384_T533_N1.0660.31
88_I377_M1.0660.31
559_K591_L1.0650.31
167_V198_I1.0650.31
50_V93_A1.0640.31
55_N80_K1.0600.30
477_K513_T1.0590.30
42_I254_F1.0570.30
325_D584_T1.0550.30
410_A468_N1.0530.30
62_Y248_Q1.0520.30
382_H414_D1.0510.30
102_M155_A1.0510.30
40_E301_V1.0490.30
86_V100_G1.0490.30
445_G450_G1.0480.30
386_R493_Q1.0430.30
340_A344_E1.0400.30
522_L561_E1.0370.29
13_I254_F1.0370.29
472_L476_V1.0370.29
100_G129_L1.0360.29
353_A420_D1.0320.29
367_C384_T1.0290.29
104_G407_D1.0280.29
262_I276_M1.0280.29
242_T541_S1.0260.29
401_D455_K1.0260.29
311_D314_A1.0250.29
31_F122_F1.0250.29
99_L375_L1.0240.29
9_R160_D1.0240.29
525_S549_A1.0160.29
495_V572_T1.0150.28
353_A508_T1.0130.28
347_I596_T1.0110.28
244_D568_S1.0100.28
558_Q562_G1.0070.28
14_G45_I1.0000.28
496_Y536_P1.0000.28
100_G198_I1.0000.28
63_G559_K0.9980.28
349_A380_L0.9980.28
201_R356_S0.9960.28
65_N520_M0.9920.28
339_A481_K0.9920.28
430_L523_T0.9910.28
19_G468_N0.9890.27
387_D432_S0.9860.27
98_V221_F0.9840.27
572_T575_E0.9840.27
492_S516_Y0.9830.27
382_H493_Q0.9800.27
414_D493_Q0.9800.27
386_R414_D0.9800.27
382_H386_R0.9800.27
51_E274_R0.9800.27
102_M333_D0.9780.27
90_R151_V0.9620.26
526_R560_A0.9600.26
357_L496_Y0.9540.26
429_D489_Y0.9490.26
381_V578_N0.9480.26
119_K150_E0.9470.26
390_I430_L0.9430.26
123_R154_I0.9410.26
40_E344_E0.9340.25
386_R518_G0.9330.25
493_Q518_G0.9330.25
430_L496_Y0.9330.25
537_G581_Y0.9320.25
126_L139_L0.9320.25
242_T402_T0.9310.25
206_H230_L0.9290.25
433_F485_C0.9270.25
96_A495_V0.9240.25
584_T592_T0.9230.25
64_A69_L0.9230.25
8_Q95_D0.9230.25
243_D495_V0.9220.25
82_N125_Q0.9210.25
14_G56_I0.9210.25
355_N595_L0.9180.25
79_K128_L0.9150.25
36_I304_E0.9140.25
56_I375_L0.9130.25
45_I503_D0.9110.24
516_Y595_L0.9110.24
462_A487_A0.9090.24
5_E9_R0.9090.24
92_S269_T0.9080.24
34_L271_N0.9070.24
255_R283_L0.9060.24
131_H560_A0.9050.24
99_L489_Y0.9040.24
312_E316_K0.9030.24
414_D518_G0.9030.24
382_H518_G0.9030.24
592_T596_T0.9020.24
77_D249_N0.8990.24
487_A566_A0.8990.24
245_T492_S0.8970.24
326_P339_A0.8970.24
177_D202_L0.8960.24
50_V88_I0.8960.24
26_G69_L0.8960.24
505_H508_T0.8960.24
4_L261_I0.8950.24
320_I596_T0.8950.24
11_V152_L0.8940.24
198_I240_Y0.8930.24
325_D583_I0.8920.24
38_K88_I0.8910.24
8_Q142_Y0.8900.24
149_R542_D0.8880.24
151_V215_P0.8880.24
123_R158_E0.8870.24
337_S405_L0.8860.24
381_V446_L0.8860.24
484_D556_E0.8860.24
284_A294_R0.8850.24
339_A343_K0.8820.23
355_N395_S0.8810.23
385_C391_I0.8790.23
151_V154_I0.8780.23
328_K519_I0.8770.23
165_L435_L0.8770.23
62_Y229_S0.8770.23
372_K484_D0.8750.23
185_L491_V0.8740.23
430_L484_D0.8730.23
19_G35_N0.8720.23
101_T362_I0.8710.23
88_I485_C0.8680.23
353_A592_T0.8660.23
357_L417_K0.8660.23
126_L154_I0.8660.23
167_V175_L0.8660.23
437_R481_K0.8650.23
88_I93_A0.8650.23
400_L584_T0.8610.23
320_I581_Y0.8560.23
366_A403_L0.8540.22
296_K299_I0.8540.22
7_L40_E0.8530.22
69_L487_A0.8520.22
348_D451_K0.8510.22
243_D492_S0.8510.22
14_G436_I0.8490.22
3_L489_Y0.8490.22
139_L342_L0.8490.22
379_S400_L0.8480.22
36_I42_I0.8460.22
135_D147_E0.8460.22
438_L490_F0.8450.22
352_L364_N0.8440.22
156_R543_T0.8440.22
353_A581_Y0.8400.22
324_L481_K0.8400.22
491_V545_R0.8380.22
287_T594_E0.8380.22
105_I118_I0.8370.22
262_I350_L0.8350.22
98_V259_A0.8330.22
163_I292_K0.8290.22
158_E161_L0.8290.22
325_D357_L0.8270.22
212_S533_N0.8270.22
409_L464_A0.8270.22
332_F367_C0.8250.21
102_M224_V0.8230.21
174_V513_T0.8210.21
128_L245_T0.8180.21
20_T92_S0.8180.21
313_I446_L0.8170.21
8_Q156_R0.8170.21
492_S576_L0.8160.21
45_I79_K0.8150.21
162_P450_G0.8150.21
92_S139_L0.8150.21
243_D248_Q0.8140.21
356_S407_D0.8130.21
170_H177_D0.8120.21
385_C519_I0.8120.21
531_I540_L0.8110.21
6_D88_I0.8110.21
570_L573_A0.8110.21
367_C457_T0.8110.21
112_A492_S0.8050.21
101_T216_I0.8000.21
77_D253_E0.7990.21
403_L461_V0.7970.21
150_E154_I0.7940.20
102_M292_K0.7940.20
231_P545_R0.7920.20
51_E55_N0.7910.20
325_D465_F0.7910.20
318_R574_C0.7900.20
403_L532_H0.7890.20
162_P445_G0.7890.20
62_Y286_I0.7890.20
13_I39_P0.7880.20
380_L584_T0.7860.20
362_I388_R0.7850.20
280_V547_K0.7820.20
431_T465_F0.7820.20
410_A461_V0.7820.20
450_G459_F0.7810.20
383_I527_N0.7810.20
322_V548_M0.7790.20
12_L113_Y0.7790.20
55_N183_D0.7790.20
102_M153_K0.7780.20
64_A459_F0.7780.20
492_S527_N0.7760.20
206_H490_F0.7760.20
95_D543_T0.7760.20
444_E470_R0.7740.20
274_R563_L0.7730.20
161_L350_L0.7720.20
254_F320_I0.7710.20
151_V229_S0.7690.20
500_Q503_D0.7680.20
343_K377_M0.7670.20
100_G161_L0.7670.20
50_V372_K0.7670.20
76_D120_R0.7660.20
278_E456_K0.7650.20
171_E202_L0.7650.20
160_D222_L0.7640.19
135_D445_G0.7640.19
66_Y158_E0.7640.19
358_A410_A0.7630.19
78_I245_T0.7570.19
104_G319_S0.7560.19
119_K123_R0.7550.19
357_L465_F0.7550.19
208_I383_I0.7540.19
589_S593_A0.7520.19
101_T417_K0.7490.19
319_S497_S0.7490.19
402_T457_T0.7480.19
351_T520_M0.7470.19
387_D409_L0.7460.19
350_L397_L0.7460.19
40_E213_E0.7450.19
177_D421_F0.7450.19
248_Q279_A0.7440.19
169_M243_D0.7430.19
402_T456_K0.7430.19
501_L576_L0.7430.19
180_P183_D0.7420.19
223_S408_V0.7390.19
328_K394_Q0.7390.19
352_L357_L0.7360.19
86_V98_V0.7350.19
27_I45_I0.7350.19
355_N400_L0.7320.18
344_E572_T0.7320.18
254_F408_V0.7320.18
152_L374_Q0.7310.18
72_H188_I0.7310.18
32_E432_S0.7280.18
84_E495_V0.7280.18
400_L577_F0.7270.18
211_L214_V0.7250.18
313_I316_K0.7240.18
295_A546_E0.7230.18
164_M183_D0.7230.18
522_L529_E0.7230.18
452_P455_K0.7230.18
64_A85_A0.7220.18
28_D495_V0.7220.18
489_Y562_G0.7210.18
5_E91_A0.7200.18
341_E589_S0.7200.18
296_K572_T0.7200.18
167_V191_L0.7200.18
301_V546_E0.7190.18
169_M198_I0.7190.18
223_S504_I0.7180.18
298_F600_Q0.7180.18
560_A594_E0.7180.18
381_V453_L0.7180.18
101_T221_F0.7170.18
555_K559_K0.7160.18
166_N425_T0.7160.18
36_I77_D0.7160.18
156_R214_V0.7150.18
357_L538_I0.7140.18
87_K297_E0.7110.18
50_V454_G0.7090.18
497_S547_K0.7090.18
468_N584_T0.7080.18
19_G393_L0.7080.18
295_A299_I0.7080.18
186_R484_D0.7070.18
501_L572_T0.7070.18
425_T599_I0.7060.18
18_M45_I0.7060.18
251_A370_L0.7060.18
355_N436_I0.7040.18
135_D422_P0.7030.18
409_L466_N0.7020.18
206_H588_R0.7020.18
294_R304_E0.7010.18
285_P480_E0.7010.18
391_I418_I0.7010.18
19_G231_P0.7000.18
464_A468_N0.6980.17
107_T118_I0.6980.17
355_N364_N0.6970.17
389_N518_G0.6970.17
388_R396_H0.6970.17
195_I223_S0.6970.17
493_Q537_G0.6960.17
386_R537_G0.6960.17
182_S274_R0.6960.17
419_G429_D0.6960.17
321_I392_G0.6940.17
127_Y151_V0.6940.17
320_I496_Y0.6940.17
313_I317_K0.6940.17
389_N493_Q0.6910.17
47_K114_S0.6910.17
386_R389_N0.6910.17
320_I411_I0.6890.17
32_E385_C0.6880.17
416_S447_S0.6860.17
109_N231_P0.6830.17
170_H176_Q0.6830.17
454_G501_L0.6830.17
435_L530_F0.6820.17
475_A562_G0.6800.17
492_S501_L0.6800.17
137_L155_A0.6800.17
166_N531_I0.6790.17
237_R552_G0.6790.17
128_L343_K0.6790.17
469_V573_A0.6760.17
469_V540_L0.6760.17
117_E546_E0.6760.17
476_V507_E0.6760.17
277_A582_L0.6760.17
394_Q589_S0.6750.17
219_D563_L0.6750.17
432_S538_I0.6740.17
232_S428_Y0.6740.17
213_E564_A0.6730.17
363_S366_A0.6730.17
442_F448_L0.6720.17
63_G541_S0.6720.17
400_L583_I0.6710.17
56_I352_L0.6680.17
331_S454_G0.6680.17
357_L584_T0.6680.17
371_V545_R0.6680.17
325_D581_Y0.6680.17
133_E492_S0.6680.17
243_D259_A0.6680.17
439_I473_D0.6670.17
81_M132_E0.6670.17
357_L536_P0.6660.17
181_L368_G0.6660.17
208_I257_Q0.6620.16
358_A419_G0.6600.16
238_L336_L0.6600.16
325_D420_D0.6600.16
434_D438_L0.6570.16
202_L431_T0.6570.16
90_R132_E0.6560.16
495_V501_L0.6550.16
325_D569_L0.6550.16
275_A373_Q0.6530.16
69_L135_D0.6530.16
433_F489_Y0.6530.16
14_G355_N0.6510.16
491_V581_Y0.6490.16
383_I563_L0.6490.16
430_L558_Q0.6490.16
487_A562_G0.6480.16
303_H512_K0.6470.16
236_G358_A0.6460.16
596_T599_I0.6460.16
411_I590_D0.6460.16
305_R411_I0.6450.16
382_H389_N0.6430.16
389_N414_D0.6430.16
372_K375_L0.6420.16
387_D399_G0.6410.16
69_L445_G0.6400.16
149_R153_K0.6400.16
35_N61_T0.6400.16
66_Y127_Y0.6400.16
384_T388_R0.6380.16
419_G445_G0.6370.16
45_I108_F0.6360.16
39_P248_Q0.6350.16
459_F535_I0.6350.16
148_A190_D0.6340.16
567_R598_Y0.6320.16
349_A406_N0.6310.16
117_E512_K0.6300.16
382_H537_G0.6300.16
414_D537_G0.6300.16
392_G429_D0.6290.16
22_L419_G0.6280.16
423_G516_Y0.6280.16
308_P376_D0.6270.16
8_Q307_E0.6260.16
81_M279_A0.6250.15
96_A196_V0.6240.15
21_L25_Y0.6230.15
22_L100_G0.6220.15
357_L520_M0.6210.15
292_K297_E0.6210.15
175_L417_K0.6200.15
91_A411_I0.6200.15
125_Q445_G0.6180.15
44_R600_Q0.6180.15
61_T405_L0.6180.15
167_V230_L0.6180.15
564_A568_S0.6170.15
345_A597_S0.6170.15
292_K304_E0.6160.15
50_V499_Q0.6160.15
170_H202_L0.6130.15
105_I108_F0.6130.15
219_D544_I0.6130.15
355_N464_A0.6110.15
55_N62_Y0.6110.15
432_S534_E0.6110.15
172_Q475_A0.6100.15
50_V280_V0.6090.15
169_M584_T0.6090.15
85_A231_P0.6080.15
216_I588_R0.6080.15
8_Q90_R0.6080.15
246_Y534_E0.6080.15
471_H496_Y0.6070.15
62_Y423_G0.6060.15
111_N339_A0.6060.15
188_I404_G0.6050.15
366_A536_P0.6050.15
39_P135_D0.6040.15
360_P391_I0.6040.15
472_L541_S0.6040.15
394_Q445_G0.6020.15
419_G467_P0.6010.15
175_L198_I0.6000.15
57_I87_K0.6000.15
118_I375_L0.6000.15
593_A597_S0.5980.15
357_L391_I0.5980.15
296_K301_V0.5970.15
285_P423_G0.5970.15
529_E548_M0.5970.15
319_S492_S0.5960.15
419_G532_H0.5950.15
438_L531_I0.5940.15
516_Y582_L0.5940.15
401_D411_I0.5940.15
523_T559_K0.5940.15
280_V339_A0.5930.15
544_I568_S0.5930.15
259_A360_P0.5930.15
356_S587_L0.5920.15
408_V411_I0.5910.15
364_N595_L0.5890.15
228_S531_I0.5890.15
90_R94_G0.5880.15
399_G412_T0.5870.15
543_T547_K0.5870.15
51_E261_I0.5870.15
175_L407_D0.5860.15
385_C409_L0.5850.14
45_I500_Q0.5850.14
224_V337_S0.5850.14
229_S416_S0.5840.14
14_G407_D0.5830.14
385_C584_T0.5830.14
21_L371_V0.5830.14
365_V377_M0.5830.14
548_M561_E0.5820.14
183_D428_Y0.5820.14
317_K496_Y0.5820.14
65_N68_K0.5810.14
13_I426_S0.5810.14
207_M286_I0.5810.14
118_I142_Y0.5810.14
322_V427_V0.5800.14
518_G537_G0.5800.14
13_I126_L0.5800.14
52_A57_I0.5790.14
195_I571_D0.5790.14
58_Q62_Y0.5780.14
204_P467_P0.5780.14
329_K434_D0.5780.14
77_D146_E0.5770.14
102_M173_G0.5760.14
207_M222_L0.5750.14
97_Y591_L0.5750.14
12_L163_I0.5750.14
76_D79_K0.5750.14
22_L532_H0.5730.14
126_L276_M0.5730.14
319_S470_R0.5720.14
30_C552_G0.5720.14
221_F279_A0.5720.14
236_G466_N0.5710.14
249_N277_A0.5710.14
90_R148_A0.5700.14
63_G237_R0.5700.14
331_S371_V0.5690.14
85_A88_I0.5690.14
58_Q394_Q0.5660.14
168_S421_F0.5660.14
357_L423_G0.5650.14
144_D278_E0.5640.14
166_N331_S0.5640.14
37_S85_A0.5640.14
357_L364_N0.5640.14
133_E388_R0.5620.14
136_G567_R0.5620.14
271_N565_I0.5600.14
80_K84_E0.5600.14
362_I570_L0.5600.14
321_I380_L0.5590.14
532_H536_P0.5590.14
426_S437_R0.5580.14
119_K122_F0.5580.14
12_L549_A0.5570.14
318_R447_S0.5570.14
50_V485_C0.5570.14
10_Q442_F0.5560.14
104_G229_S0.5550.14
245_T259_A0.5550.14
431_T580_I0.5540.14
383_I388_R0.5540.14
495_V515_I0.5540.14
90_R214_V0.5540.14
164_M195_I0.5530.14
408_V490_F0.5510.14
394_Q429_D0.5510.14
66_Y82_N0.5490.14
201_R507_E0.5470.14
375_L502_V0.5470.14
97_Y262_I0.5470.14
394_Q450_G0.5470.14
56_I293_T0.5460.14
255_R280_V0.5460.14
145_L566_A0.5450.14
332_F563_L0.5450.14
34_L48_A0.5450.14
515_I561_E0.5440.13
399_G432_S0.5440.13
122_F126_L0.5430.13
13_I277_A0.5430.13
12_L56_I0.5430.13
239_V566_A0.5420.13
358_A538_I0.5420.13
533_N537_G0.5420.13
105_I461_V0.5410.13
354_D493_Q0.5400.13
354_D386_R0.5400.13
196_V524_S0.5390.13
336_L375_L0.5390.13
40_E92_S0.5380.13
40_E278_E0.5370.13
315_A512_K0.5370.13
325_D520_M0.5370.13
163_I307_E0.5370.13
156_R192_G0.5360.13
354_D518_G0.5360.13
363_S523_T0.5360.13
340_A375_L0.5360.13
398_M453_L0.5350.13
419_G424_A0.5350.13
529_E566_A0.5340.13
404_G580_I0.5340.13
66_Y121_S0.5340.13
4_L198_I0.5340.13
355_N583_I0.5340.13
464_A581_Y0.5340.13
429_D467_P0.5330.13
391_I396_H0.5330.13
179_T491_V0.5320.13
311_D460_S0.5320.13
102_M402_T0.5320.13
364_N577_F0.5310.13
473_D546_E0.5310.13
26_G419_G0.5300.13
33_E75_E0.5300.13
442_F485_C0.5300.13
88_I112_A0.5290.13
26_G422_P0.5290.13
231_P326_P0.5280.13
543_T558_Q0.5270.13
321_I385_C0.5270.13
502_V572_T0.5260.13
456_K509_K0.5260.13
442_F551_A0.5260.13
187_S344_E0.5260.13
151_V158_E0.5250.13
228_S244_D0.5240.13
256_K294_R0.5240.13
243_D568_S0.5230.13
259_A326_P0.5220.13
398_M433_F0.5200.13
5_E373_Q0.5200.13
71_R202_L0.5190.13
22_L459_F0.5180.13
281_G549_A0.5180.13
34_L398_M0.5170.13
417_K438_L0.5170.13
79_K564_A0.5170.13
185_L546_E0.5150.13
296_K337_S0.5140.13
91_A405_L0.5140.13
42_I295_A0.5140.13
44_R48_A0.5140.13
385_C556_E0.5130.13
139_L563_L0.5110.13
34_L485_C0.5110.13
85_A549_A0.5110.13
439_I466_N0.5110.13
354_D414_D0.5110.13
354_D382_H0.5110.13
357_L431_T0.5100.13
51_E317_K0.5090.13
450_G514_P0.5070.13
148_A444_E0.5070.13
11_V244_D0.5050.13
166_N517_I0.5050.13
71_R533_N0.5050.13
191_L563_L0.5050.13
531_I536_P0.5030.13
357_L527_N0.5020.13
230_L356_S0.5020.13
222_L245_T0.5020.13
433_F478_R0.5020.13
23_Y26_G0.5010.13
279_A326_P0.5010.13
527_N584_T0.5000.13
71_R120_R0.5000.13
495_V575_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q7zA 1 0.8464 100 0.666 Contact Map
4m3pA 4 0.5588 100 0.674 Contact Map
4cczA 1 0.8382 100 0.683 Contact Map
3aptA 2 0.4592 100 0.752 Contact Map
3fstA 4 0.4542 100 0.766 Contact Map
3ijdA 2 0.4265 100 0.788 Contact Map
2h9aA 1 0.4199 97.9 0.966 Contact Map
1f76A 1 0.402 97.5 0.969 Contact Map
3noyA 2 0.5327 97.1 0.97 Contact Map
3igsA 1 0.348 97.1 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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