GREMLIN Database
YITI - Uncharacterized N-acetyltransferase YitI
UniProt: O06744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (130)
Sequences: 3777 (2892)
Seq/√Len: 253.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_E123_W2.9951.00
54_A94_A2.6501.00
115_K125_E2.4991.00
109_N130_F2.3021.00
112_H129_P2.2571.00
52_S77_T2.1551.00
15_I78_L2.0451.00
129_P137_N2.0191.00
93_H96_H1.9741.00
88_S121_L1.9511.00
95_E143_K1.9121.00
44_V86_A1.8831.00
15_I76_A1.8621.00
43_G50_L1.8261.00
91_I121_L1.8171.00
51_I81_Y1.8071.00
45_F50_L1.7741.00
18_R78_L1.7411.00
105_A142_Y1.6541.00
115_K139_I1.6471.00
57_S73_R1.6341.00
119_A125_E1.6331.00
116_G119_A1.6001.00
126_L140_V1.5971.00
59_Q71_R1.5831.00
97_K101_S1.5811.00
11_D45_F1.5621.00
18_R22_P1.5491.00
115_K119_A1.5431.00
72_L91_I1.5181.00
9_V13_Y1.5181.00
126_L142_Y1.5011.00
95_E106_V1.4711.00
97_K100_E1.4701.00
130_F140_V1.4581.00
88_S92_K1.4471.00
53_I76_A1.4461.00
44_V52_S1.4361.00
42_L97_K1.4271.00
14_E18_R1.3891.00
109_N140_V1.3761.00
42_L94_A1.3711.00
131_D134_G1.3331.00
30_K133_P1.3271.00
131_D137_N1.3221.00
54_A75_M1.2941.00
127_G140_V1.2901.00
49_T80_G1.2891.00
17_H30_K1.2701.00
12_T43_G1.2501.00
88_S120_K1.2491.00
46_Y81_Y1.2461.00
109_N132_I1.2451.00
107_W140_V1.2411.00
125_E139_I1.2341.00
12_T53_I1.2261.00
46_Y51_I1.2161.00
40_F97_K1.2121.00
69_A107_W1.2031.00
75_M91_I1.1911.00
89_T93_H1.1801.00
26_I133_P1.1301.00
17_H28_Q1.1171.00
58_P103_V1.0791.00
7_I11_D1.0721.00
40_F101_S1.0681.00
72_L75_M1.0591.00
99_A143_K1.0561.00
17_H21_R1.0511.00
26_I135_I1.0391.00
110_A141_M1.0231.00
56_F98_L1.0091.00
112_H137_N1.0071.00
24_Q111_R0.9981.00
70_Y103_V0.9971.00
54_A90_L0.9841.00
27_E30_K0.9841.00
96_H100_E0.9801.00
81_Y84_Q0.9791.00
18_R29_C0.9761.00
69_A105_A0.9731.00
112_H115_K0.9591.00
114_V117_Y0.9451.00
17_H22_P0.9231.00
93_H97_K0.9181.00
92_K96_H0.9081.00
107_W142_Y0.9031.00
71_R107_W0.8931.00
42_L54_A0.8721.00
52_S90_L0.8641.00
72_L94_A0.8620.99
10_E13_Y0.8610.99
52_S86_A0.8550.99
78_L81_Y0.8430.99
21_R28_Q0.8370.99
45_F48_G0.8220.99
46_Y49_T0.8220.99
51_I86_A0.8210.99
98_L106_V0.8050.99
87_G117_Y0.8050.99
89_T92_K0.8020.99
13_Y17_H0.7990.99
98_L103_V0.7950.99
71_R109_N0.7940.99
111_R138_H0.7910.99
85_K88_S0.7900.99
70_Y98_L0.7880.99
46_Y84_Q0.7860.99
60_S68_S0.7790.99
49_T78_L0.7720.99
33_E36_A0.7650.99
44_V89_T0.7590.99
92_K121_L0.7480.99
71_R108_C0.7470.99
125_E129_P0.7450.99
22_P27_E0.7430.98
13_Y32_K0.7410.98
112_H139_I0.7270.98
56_F97_K0.7250.98
11_D14_E0.7230.98
39_S57_S0.7220.98
72_L108_C0.7200.98
77_T86_A0.7190.98
32_K35_H0.7150.98
18_R80_G0.7140.98
42_L93_H0.7100.98
57_S71_R0.7040.98
106_V123_W0.7010.98
129_P139_I0.7010.98
17_H31_Y0.6960.98
72_L106_V0.6960.98
32_K36_A0.6880.98
56_F70_Y0.6840.97
58_P61_Q0.6800.97
20_L111_R0.6730.97
56_F94_A0.6680.97
96_H99_A0.6640.97
8_S11_D0.6630.97
108_C141_M0.6600.97
55_S74_G0.6590.97
86_A89_T0.6590.97
58_P70_Y0.6440.96
108_C118_Y0.6370.96
115_K129_P0.6360.96
23_H82_R0.6340.96
36_A39_S0.6290.96
42_L90_L0.6280.96
17_H27_E0.6260.96
123_W143_K0.6190.95
9_V12_T0.6190.95
95_E121_L0.6180.95
119_A124_K0.6170.95
84_Q87_G0.6130.95
31_Y36_A0.6070.95
33_E37_E0.6030.95
81_Y86_A0.5940.94
8_S43_G0.5880.94
23_H74_G0.5880.94
35_H57_S0.5880.94
21_R74_G0.5830.94
23_H79_E0.5780.93
60_S69_A0.5730.93
52_S87_G0.5730.93
41_H53_I0.5670.93
10_E14_E0.5610.92
135_I138_H0.5580.92
72_L123_W0.5540.92
108_C114_V0.5540.92
90_L93_H0.5520.92
132_I135_I0.5510.92
15_I50_L0.5480.92
42_L56_F0.5430.91
7_I37_E0.5420.91
14_E33_E0.5420.91
24_Q138_H0.5400.91
61_Q68_S0.5400.91
73_R111_R0.5390.91
20_L23_H0.5370.91
57_S70_Y0.5320.90
73_R109_N0.5320.90
26_I132_I0.5270.90
11_D50_L0.5270.90
18_R79_E0.5250.90
17_H29_C0.5230.90
39_S58_P0.5220.89
26_I30_K0.5200.89
11_D43_G0.5170.89
74_G82_R0.5120.89
20_L55_S0.5100.88
100_E103_V0.5060.88
10_E31_Y0.5050.88
110_A118_Y0.5030.88
92_K99_A0.5020.88
15_I53_I0.5020.88
40_F56_F0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jdcA 1 0.9732 99.9 0.4 Contact Map
2g0bA 4 0.9866 99.9 0.437 Contact Map
1kzfA 1 0.8993 99.9 0.444 Contact Map
3p2hA 1 0.9463 99.9 0.45 Contact Map
1ro5A 5 0.9933 99.9 0.451 Contact Map
1xebA 2 0.9262 99.9 0.452 Contact Map
3efaA 2 0.9329 99.9 0.456 Contact Map
1q2yA 1 0.9128 99.9 0.457 Contact Map
1y9wA 2 0.9128 99.8 0.546 Contact Map
3gy9A 3 0.9329 99.7 0.574 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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