YITH - BACSU - GREMLIN Contacts

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YITH - Uncharacterized N-acetyltransferase YitH

UniProt:	O06743	Sequences: MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRFFGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIRLCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLAAFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQIITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYALISQALG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	282 (273)
Sequences:	1409 (956)
Seq/√Len:	57.9

BACSU - YITH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
194_G	223_L	4.938	1.00
58_I	91_C	4.036	1.00
56_S	87_M	3.982	1.00
212_S	215_V	3.341	1.00
144_T	150_D	3.219	1.00
67_T	95_T	3.186	1.00
109_G	112_L	3.106	1.00
18_L	57_C	2.990	1.00
34_E	197_V	2.927	1.00
224_A	231_M	2.782	1.00
8_I	14_H	2.659	1.00
213_S	274_Y	2.599	1.00
60_L	69_I	2.543	1.00
10_L	18_L	2.526	1.00
146_F	190_L	2.401	1.00
88_V	116_A	2.358	1.00
120_T	258_P	2.246	1.00
221_T	249_M	2.206	1.00
85_R	89_N	2.193	1.00
144_T	185_N	2.177	1.00
157_A	211_P	2.167	1.00
25_A	79_Q	2.157	1.00
53_D	75_D	2.116	1.00
159_L	165_D	2.089	1.00
210_A	216_A	2.085	1.00
192_G	219_I	2.067	1.00
110_L	114_E	2.059	1.00
8_I	49_N	2.020	1.00
106_T	109_G	2.020	1.00
96_D	99_T	1.994	1.00
217_A	248_E	1.956	1.00
127_Y	243_H	1.908	1.00
104_C	259_I	1.885	1.00
208_I	220_I	1.883	1.00
92_I	101_I	1.871	1.00
129_C	251_F	1.870	1.00
193_Y	209_I	1.845	1.00
157_A	209_I	1.823	0.99
217_A	245_S	1.775	0.99
47_Y	54_I	1.756	0.99
124_V	279_Q	1.707	0.99
55_I	78_Y	1.704	0.99
60_L	95_T	1.688	0.99
239_H	242_L	1.687	0.99
10_L	54_I	1.674	0.99
69_I	103_L	1.665	0.99
123_S	237_S	1.612	0.99
111_P	114_E	1.574	0.98
110_L	258_P	1.565	0.98
72_V	88_V	1.564	0.98
194_G	208_I	1.553	0.98
69_I	91_C	1.547	0.98
170_L	193_Y	1.546	0.98
233_I	279_Q	1.539	0.98
68_S	102_R	1.518	0.98
199_T	202_N	1.518	0.98
56_S	74_V	1.480	0.98
126_K	234_D	1.462	0.97
146_F	181_I	1.419	0.97
30_Y	34_E	1.398	0.97
253_K	256_E	1.396	0.97
46_G	54_I	1.391	0.97
204_K	279_Q	1.380	0.96
69_I	88_V	1.379	0.96
8_I	48_Q	1.373	0.96
63_F	162_F	1.370	0.96
62_L	95_T	1.345	0.96
46_G	90_A	1.345	0.96
72_V	106_T	1.341	0.96
103_L	260_L	1.333	0.96
47_Y	56_S	1.325	0.95
38_L	281_L	1.318	0.95
76_K	79_Q	1.316	0.95
69_I	95_T	1.303	0.95
58_I	88_V	1.294	0.95
25_A	76_K	1.293	0.95
161_A	209_I	1.283	0.95
100_A	263_Q	1.276	0.94
103_L	118_F	1.266	0.94
192_G	215_V	1.256	0.94
66_L	162_F	1.252	0.94
44_F	202_N	1.247	0.94
72_V	109_G	1.235	0.93
114_E	119_H	1.228	0.93
199_T	204_K	1.226	0.93
48_Q	83_L	1.221	0.93
86_R	90_A	1.202	0.92
269_Q	272_H	1.176	0.92
112_L	116_A	1.172	0.91
30_Y	280_A	1.167	0.91
103_L	113_Y	1.159	0.91
55_I	83_L	1.155	0.91
58_I	72_V	1.154	0.91
15_V	18_L	1.154	0.91
183_A	215_V	1.148	0.91
143_L	222_R	1.145	0.90
138_K	143_L	1.133	0.90
220_I	242_L	1.129	0.90
10_L	46_G	1.126	0.90
11_H	93_T	1.124	0.90
157_A	193_Y	1.123	0.90
220_I	249_M	1.122	0.90
137_K	225_A	1.117	0.89
161_A	272_H	1.109	0.89
181_I	195_L	1.104	0.89
196_S	223_L	1.100	0.89
10_L	47_Y	1.092	0.88
17_G	21_L	1.090	0.88
7_L	90_A	1.089	0.88
234_D	260_L	1.087	0.88
123_S	256_E	1.083	0.88
233_I	246_L	1.083	0.88
19_L	71_L	1.069	0.87
63_F	169_L	1.068	0.87
62_L	67_T	1.067	0.87
12_E	36_K	1.065	0.87
72_V	116_A	1.064	0.87
205_F	220_I	1.057	0.87
244_D	247_I	1.045	0.86
277_I	280_A	1.041	0.86
18_L	47_Y	1.038	0.86
43_R	55_I	1.036	0.85
17_G	54_I	1.030	0.85
103_L	106_T	1.030	0.85
72_V	112_L	1.027	0.85
27_W	73_I	1.025	0.85
49_N	52_G	1.025	0.85
23_G	200_P	1.023	0.85
19_L	23_G	1.020	0.85
102_R	106_T	1.011	0.84
186_Q	189_Q	1.010	0.84
62_L	99_T	1.009	0.84
242_L	246_L	1.005	0.84
62_L	94_Q	1.004	0.84
31_G	34_E	1.003	0.83
100_A	262_Y	0.991	0.83
257_P	279_Q	0.989	0.83
155_T	171_Q	0.985	0.82
22_C	30_Y	0.983	0.82
186_Q	191_I	0.981	0.82
153_D	156_A	0.981	0.82
55_I	74_V	0.978	0.82
34_E	126_K	0.971	0.81
85_R	115_K	0.966	0.81
110_L	120_T	0.961	0.81
30_Y	126_K	0.958	0.81
146_F	154_L	0.957	0.81
125_R	237_S	0.956	0.80
16_S	32_E	0.950	0.80
146_F	195_L	0.948	0.80
73_I	234_D	0.947	0.80
27_W	34_E	0.944	0.80
21_L	27_W	0.936	0.79
89_N	93_T	0.933	0.79
183_A	190_L	0.931	0.79
31_G	199_T	0.930	0.79
22_C	257_P	0.928	0.78
43_R	94_Q	0.927	0.78
107_K	110_L	0.927	0.78
24_Q	76_K	0.923	0.78
197_V	202_N	0.922	0.78
151_F	171_Q	0.918	0.78
27_W	234_D	0.916	0.78
124_V	257_P	0.913	0.77
28_P	280_A	0.913	0.77
178_C	198_Q	0.909	0.77
135_Y	142_E	0.908	0.77
126_K	199_T	0.897	0.76
103_L	109_G	0.893	0.76
44_F	197_V	0.892	0.76
18_L	74_V	0.891	0.76
155_T	165_D	0.888	0.75
28_P	126_K	0.886	0.75
54_I	83_L	0.883	0.75
107_K	256_E	0.881	0.75
25_A	73_I	0.876	0.74
28_P	104_C	0.866	0.73
52_G	269_Q	0.862	0.73
179_E	195_L	0.862	0.73
166_R	207_P	0.860	0.73
114_E	120_T	0.858	0.73
103_L	112_L	0.857	0.73
149_Q	185_N	0.855	0.72
60_L	67_T	0.851	0.72
86_R	89_N	0.850	0.72
126_K	197_V	0.850	0.72
71_L	278_S	0.842	0.71
58_I	109_G	0.839	0.71
128_S	254_D	0.839	0.71
18_L	35_L	0.838	0.71
22_C	35_L	0.835	0.71
140_D	218_Q	0.834	0.71
145_S	156_A	0.831	0.70
43_R	62_L	0.829	0.70
53_D	78_Y	0.829	0.70
244_D	265_K	0.826	0.70
167_S	175_S	0.824	0.70
191_I	211_P	0.822	0.69
126_K	257_P	0.812	0.69
60_L	91_C	0.810	0.68
84_G	113_Y	0.808	0.68
64_G	165_D	0.808	0.68
32_E	36_K	0.807	0.68
158_D	281_L	0.807	0.68
143_L	219_I	0.806	0.68
192_G	216_A	0.801	0.67
50_V	83_L	0.800	0.67
10_L	14_H	0.799	0.67
151_F	170_L	0.796	0.67
173_L	197_V	0.795	0.67
33_Q	178_C	0.793	0.67
277_I	281_L	0.786	0.66
128_S	232_R	0.785	0.66
216_A	274_Y	0.784	0.66
22_C	255_D	0.784	0.66
64_G	99_T	0.783	0.66
68_S	106_T	0.780	0.65
85_R	112_L	0.778	0.65
33_Q	36_K	0.777	0.65
30_Y	199_T	0.773	0.65
104_C	280_A	0.767	0.64
20_R	24_Q	0.763	0.64
48_Q	87_M	0.761	0.64
55_I	139_L	0.759	0.63
5_D	48_Q	0.756	0.63
242_L	245_S	0.754	0.63
212_S	274_Y	0.751	0.62
109_G	260_L	0.751	0.62
37_L	172_Q	0.747	0.62
192_G	220_I	0.747	0.62
28_P	31_G	0.745	0.62
69_I	264_K	0.742	0.62
159_L	167_S	0.740	0.61
81_L	189_Q	0.737	0.61
146_F	183_A	0.737	0.61
30_Y	35_L	0.736	0.61
31_G	197_V	0.734	0.61
12_E	16_S	0.733	0.61
235_I	243_H	0.732	0.60
155_T	167_S	0.730	0.60
105_A	255_D	0.729	0.60
227_K	231_M	0.727	0.60
127_Y	233_I	0.726	0.60
71_L	106_T	0.726	0.60
20_R	51_S	0.726	0.60
30_Y	105_A	0.726	0.60
199_T	255_D	0.724	0.60
72_V	280_A	0.723	0.60
125_R	256_E	0.722	0.59
122_G	276_L	0.719	0.59
82_G	103_L	0.718	0.59
208_I	216_A	0.717	0.59
50_V	78_Y	0.716	0.59
10_L	49_N	0.716	0.59
14_H	19_L	0.715	0.59
152_H	167_S	0.712	0.58
190_L	195_L	0.703	0.57
85_R	116_A	0.703	0.57
196_S	226_G	0.703	0.57
60_L	259_I	0.697	0.57
217_A	221_T	0.697	0.57
74_V	84_G	0.697	0.57
199_T	257_P	0.696	0.57
106_T	112_L	0.696	0.57
112_L	260_L	0.694	0.56
136_T	149_Q	0.694	0.56
124_V	276_L	0.692	0.56
60_L	94_Q	0.692	0.56
6_E	9_K	0.690	0.56
68_S	257_P	0.685	0.55
31_G	126_K	0.684	0.55
160_A	272_H	0.682	0.55
105_A	111_P	0.682	0.55
126_K	255_D	0.682	0.55
104_C	276_L	0.680	0.55
101_I	219_I	0.680	0.55
203_L	227_K	0.680	0.55
158_D	207_P	0.678	0.55
30_Y	68_S	0.678	0.55
82_G	216_A	0.678	0.55
15_V	32_E	0.677	0.55
130_H	141_A	0.677	0.55
232_R	254_D	0.675	0.54
169_L	173_L	0.675	0.54
154_L	190_L	0.674	0.54
96_D	262_Y	0.671	0.54
21_L	73_I	0.671	0.54
199_T	279_Q	0.669	0.54
261_F	266_A	0.666	0.53
12_E	39_V	0.660	0.53
206_G	250_G	0.659	0.53
90_A	93_T	0.658	0.52
105_A	112_L	0.657	0.52
8_I	11_H	0.657	0.52
50_V	55_I	0.656	0.52
65_R	159_L	0.654	0.52
47_Y	83_L	0.653	0.52
142_E	186_Q	0.653	0.52
35_L	73_I	0.652	0.52
20_R	200_P	0.651	0.52
244_D	248_E	0.650	0.52
206_G	260_L	0.649	0.51
67_T	92_I	0.649	0.51
126_K	279_Q	0.647	0.51
268_I	273_L	0.646	0.51
15_V	193_Y	0.645	0.51
147_R	237_S	0.644	0.51
88_V	112_L	0.643	0.51
163_G	268_I	0.642	0.51
175_S	224_A	0.639	0.50
108_E	247_I	0.638	0.50
31_G	44_F	0.637	0.50
93_T	96_D	0.636	0.50
197_V	234_D	0.635	0.50
58_I	69_I	0.631	0.50
212_S	244_D	0.630	0.49
95_T	195_L	0.630	0.49
81_L	186_Q	0.630	0.49
34_E	44_F	0.630	0.49
105_A	258_P	0.620	0.48
71_L	204_K	0.619	0.48
27_W	106_T	0.618	0.48
31_G	38_L	0.617	0.48
115_K	174_I	0.617	0.48
109_G	116_A	0.617	0.48
157_A	163_G	0.614	0.48
128_S	251_F	0.614	0.48
126_K	202_N	0.612	0.47
153_D	189_Q	0.609	0.47
93_T	191_I	0.608	0.47
149_Q	154_L	0.603	0.46
146_F	150_D	0.602	0.46
160_A	165_D	0.601	0.46
14_H	39_V	0.599	0.46
87_M	224_A	0.598	0.46
104_C	257_P	0.598	0.46
120_T	123_S	0.595	0.46
20_R	134_P	0.595	0.46
6_E	130_H	0.592	0.45
79_Q	108_E	0.591	0.45
211_P	272_H	0.589	0.45
104_C	126_K	0.588	0.45
38_L	59_G	0.584	0.44
48_Q	56_S	0.583	0.44
104_C	204_K	0.583	0.44
57_C	71_L	0.581	0.44
28_P	34_E	0.580	0.44
72_V	104_C	0.580	0.44
38_L	278_S	0.579	0.44
34_E	234_D	0.579	0.44
79_Q	255_D	0.578	0.44
30_Y	255_D	0.578	0.44
239_H	245_S	0.577	0.44
84_G	88_V	0.576	0.43
89_N	116_A	0.576	0.43
167_S	171_Q	0.575	0.43
60_L	116_A	0.572	0.43
128_S	201_A	0.571	0.43
16_S	198_Q	0.569	0.43
22_C	31_G	0.569	0.43
30_Y	279_Q	0.566	0.42
57_C	60_L	0.565	0.42
247_I	253_K	0.562	0.42
21_L	35_L	0.562	0.42
10_L	42_G	0.560	0.42
139_L	142_E	0.558	0.42
255_D	278_S	0.558	0.42
40_Q	77_E	0.556	0.41
152_H	155_T	0.554	0.41
197_V	207_P	0.553	0.41
104_C	255_D	0.550	0.41
11_H	14_H	0.550	0.41
20_R	23_G	0.548	0.40
46_G	94_Q	0.547	0.40
275_A	279_Q	0.547	0.40
147_R	153_D	0.543	0.40
248_E	267_P	0.540	0.40
95_T	99_T	0.538	0.39
176_A	251_F	0.538	0.39
18_L	87_M	0.538	0.39
103_L	116_A	0.537	0.39
98_N	262_Y	0.535	0.39
182_I	222_R	0.535	0.39
66_L	204_K	0.534	0.39
88_V	109_G	0.534	0.39
155_T	230_P	0.532	0.39
74_V	83_L	0.531	0.39
46_G	91_C	0.531	0.39
64_G	92_I	0.530	0.39
149_Q	174_I	0.530	0.39
45_F	275_A	0.530	0.39
93_T	269_Q	0.529	0.38
165_D	168_N	0.527	0.38
169_L	277_I	0.527	0.38
33_Q	52_G	0.527	0.38
47_Y	222_R	0.526	0.38
14_H	17_G	0.522	0.38
68_S	126_K	0.521	0.38
74_V	242_L	0.518	0.37
209_I	249_M	0.516	0.37
64_G	164_G	0.514	0.37
205_F	208_I	0.514	0.37
129_C	187_D	0.512	0.37
127_Y	253_K	0.512	0.37
22_C	234_D	0.510	0.37
238_E	270_N	0.506	0.36
80_R	115_K	0.506	0.36
44_F	61_F	0.503	0.36
79_Q	173_L	0.502	0.36
211_P	215_V	0.500	0.35

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dddA	1	0.9433	100	0.397	Contact Map
4my0A	4	0.9681	100	0.551	Contact Map
2ozgA	5	0.9787	100	0.555	Contact Map
2i00A	4	0.9716	100	0.555	Contact Map
3n7zA	4	0.9787	100	0.561	Contact Map
3sxnA	4	0.9681	100	0.568	Contact Map
2hv2A	4	0.9894	100	0.569	Contact Map
3r1kA	4	0.961	100	0.584	Contact Map
1p0hA	1	0.9007	99.9	0.645	Contact Map
3tt2A	1	0.9539	99.9	0.648	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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