GREMLIN Database
YITH - Uncharacterized N-acetyltransferase YitH
UniProt: O06743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (273)
Sequences: 1409 (956)
Seq/√Len: 57.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_G223_L4.9381.00
58_I91_C4.0361.00
56_S87_M3.9821.00
212_S215_V3.3411.00
144_T150_D3.2191.00
67_T95_T3.1861.00
109_G112_L3.1061.00
18_L57_C2.9901.00
34_E197_V2.9271.00
224_A231_M2.7821.00
8_I14_H2.6591.00
213_S274_Y2.5991.00
60_L69_I2.5431.00
10_L18_L2.5261.00
146_F190_L2.4011.00
88_V116_A2.3581.00
120_T258_P2.2461.00
221_T249_M2.2061.00
85_R89_N2.1931.00
144_T185_N2.1771.00
157_A211_P2.1671.00
25_A79_Q2.1571.00
53_D75_D2.1161.00
159_L165_D2.0891.00
210_A216_A2.0851.00
192_G219_I2.0671.00
110_L114_E2.0591.00
8_I49_N2.0201.00
106_T109_G2.0201.00
96_D99_T1.9941.00
217_A248_E1.9561.00
127_Y243_H1.9081.00
104_C259_I1.8851.00
208_I220_I1.8831.00
92_I101_I1.8711.00
129_C251_F1.8701.00
193_Y209_I1.8451.00
157_A209_I1.8230.99
217_A245_S1.7750.99
47_Y54_I1.7560.99
124_V279_Q1.7070.99
55_I78_Y1.7040.99
60_L95_T1.6880.99
239_H242_L1.6870.99
10_L54_I1.6740.99
69_I103_L1.6650.99
123_S237_S1.6120.99
111_P114_E1.5740.98
110_L258_P1.5650.98
72_V88_V1.5640.98
194_G208_I1.5530.98
69_I91_C1.5470.98
170_L193_Y1.5460.98
233_I279_Q1.5390.98
68_S102_R1.5180.98
199_T202_N1.5180.98
56_S74_V1.4800.98
126_K234_D1.4620.97
146_F181_I1.4190.97
30_Y34_E1.3980.97
253_K256_E1.3960.97
46_G54_I1.3910.97
204_K279_Q1.3800.96
69_I88_V1.3790.96
8_I48_Q1.3730.96
63_F162_F1.3700.96
62_L95_T1.3450.96
46_G90_A1.3450.96
72_V106_T1.3410.96
103_L260_L1.3330.96
47_Y56_S1.3250.95
38_L281_L1.3180.95
76_K79_Q1.3160.95
69_I95_T1.3030.95
58_I88_V1.2940.95
25_A76_K1.2930.95
161_A209_I1.2830.95
100_A263_Q1.2760.94
103_L118_F1.2660.94
192_G215_V1.2560.94
66_L162_F1.2520.94
44_F202_N1.2470.94
72_V109_G1.2350.93
114_E119_H1.2280.93
199_T204_K1.2260.93
48_Q83_L1.2210.93
86_R90_A1.2020.92
269_Q272_H1.1760.92
112_L116_A1.1720.91
30_Y280_A1.1670.91
103_L113_Y1.1590.91
55_I83_L1.1550.91
58_I72_V1.1540.91
15_V18_L1.1540.91
183_A215_V1.1480.91
143_L222_R1.1450.90
138_K143_L1.1330.90
220_I242_L1.1290.90
10_L46_G1.1260.90
11_H93_T1.1240.90
157_A193_Y1.1230.90
220_I249_M1.1220.90
137_K225_A1.1170.89
161_A272_H1.1090.89
181_I195_L1.1040.89
196_S223_L1.1000.89
10_L47_Y1.0920.88
17_G21_L1.0900.88
7_L90_A1.0890.88
234_D260_L1.0870.88
123_S256_E1.0830.88
233_I246_L1.0830.88
19_L71_L1.0690.87
63_F169_L1.0680.87
62_L67_T1.0670.87
12_E36_K1.0650.87
72_V116_A1.0640.87
205_F220_I1.0570.87
244_D247_I1.0450.86
277_I280_A1.0410.86
18_L47_Y1.0380.86
43_R55_I1.0360.85
17_G54_I1.0300.85
103_L106_T1.0300.85
72_V112_L1.0270.85
27_W73_I1.0250.85
49_N52_G1.0250.85
23_G200_P1.0230.85
19_L23_G1.0200.85
102_R106_T1.0110.84
186_Q189_Q1.0100.84
62_L99_T1.0090.84
242_L246_L1.0050.84
62_L94_Q1.0040.84
31_G34_E1.0030.83
100_A262_Y0.9910.83
257_P279_Q0.9890.83
155_T171_Q0.9850.82
22_C30_Y0.9830.82
186_Q191_I0.9810.82
153_D156_A0.9810.82
55_I74_V0.9780.82
34_E126_K0.9710.81
85_R115_K0.9660.81
110_L120_T0.9610.81
30_Y126_K0.9580.81
146_F154_L0.9570.81
125_R237_S0.9560.80
16_S32_E0.9500.80
146_F195_L0.9480.80
73_I234_D0.9470.80
27_W34_E0.9440.80
21_L27_W0.9360.79
89_N93_T0.9330.79
183_A190_L0.9310.79
31_G199_T0.9300.79
22_C257_P0.9280.78
43_R94_Q0.9270.78
107_K110_L0.9270.78
24_Q76_K0.9230.78
197_V202_N0.9220.78
151_F171_Q0.9180.78
27_W234_D0.9160.78
124_V257_P0.9130.77
28_P280_A0.9130.77
178_C198_Q0.9090.77
135_Y142_E0.9080.77
126_K199_T0.8970.76
103_L109_G0.8930.76
44_F197_V0.8920.76
18_L74_V0.8910.76
155_T165_D0.8880.75
28_P126_K0.8860.75
54_I83_L0.8830.75
107_K256_E0.8810.75
25_A73_I0.8760.74
28_P104_C0.8660.73
52_G269_Q0.8620.73
179_E195_L0.8620.73
166_R207_P0.8600.73
114_E120_T0.8580.73
103_L112_L0.8570.73
149_Q185_N0.8550.72
60_L67_T0.8510.72
86_R89_N0.8500.72
126_K197_V0.8500.72
71_L278_S0.8420.71
58_I109_G0.8390.71
128_S254_D0.8390.71
18_L35_L0.8380.71
22_C35_L0.8350.71
140_D218_Q0.8340.71
145_S156_A0.8310.70
43_R62_L0.8290.70
53_D78_Y0.8290.70
244_D265_K0.8260.70
167_S175_S0.8240.70
191_I211_P0.8220.69
126_K257_P0.8120.69
60_L91_C0.8100.68
84_G113_Y0.8080.68
64_G165_D0.8080.68
32_E36_K0.8070.68
158_D281_L0.8070.68
143_L219_I0.8060.68
192_G216_A0.8010.67
50_V83_L0.8000.67
10_L14_H0.7990.67
151_F170_L0.7960.67
173_L197_V0.7950.67
33_Q178_C0.7930.67
277_I281_L0.7860.66
128_S232_R0.7850.66
216_A274_Y0.7840.66
22_C255_D0.7840.66
64_G99_T0.7830.66
68_S106_T0.7800.65
85_R112_L0.7780.65
33_Q36_K0.7770.65
30_Y199_T0.7730.65
104_C280_A0.7670.64
20_R24_Q0.7630.64
48_Q87_M0.7610.64
55_I139_L0.7590.63
5_D48_Q0.7560.63
242_L245_S0.7540.63
212_S274_Y0.7510.62
109_G260_L0.7510.62
37_L172_Q0.7470.62
192_G220_I0.7470.62
28_P31_G0.7450.62
69_I264_K0.7420.62
159_L167_S0.7400.61
81_L189_Q0.7370.61
146_F183_A0.7370.61
30_Y35_L0.7360.61
31_G197_V0.7340.61
12_E16_S0.7330.61
235_I243_H0.7320.60
155_T167_S0.7300.60
105_A255_D0.7290.60
227_K231_M0.7270.60
127_Y233_I0.7260.60
71_L106_T0.7260.60
20_R51_S0.7260.60
30_Y105_A0.7260.60
199_T255_D0.7240.60
72_V280_A0.7230.60
125_R256_E0.7220.59
122_G276_L0.7190.59
82_G103_L0.7180.59
208_I216_A0.7170.59
50_V78_Y0.7160.59
10_L49_N0.7160.59
14_H19_L0.7150.59
152_H167_S0.7120.58
190_L195_L0.7030.57
85_R116_A0.7030.57
196_S226_G0.7030.57
60_L259_I0.6970.57
217_A221_T0.6970.57
74_V84_G0.6970.57
199_T257_P0.6960.57
106_T112_L0.6960.57
112_L260_L0.6940.56
136_T149_Q0.6940.56
124_V276_L0.6920.56
60_L94_Q0.6920.56
6_E9_K0.6900.56
68_S257_P0.6850.55
31_G126_K0.6840.55
160_A272_H0.6820.55
105_A111_P0.6820.55
126_K255_D0.6820.55
104_C276_L0.6800.55
101_I219_I0.6800.55
203_L227_K0.6800.55
158_D207_P0.6780.55
30_Y68_S0.6780.55
82_G216_A0.6780.55
15_V32_E0.6770.55
130_H141_A0.6770.55
232_R254_D0.6750.54
169_L173_L0.6750.54
154_L190_L0.6740.54
96_D262_Y0.6710.54
21_L73_I0.6710.54
199_T279_Q0.6690.54
261_F266_A0.6660.53
12_E39_V0.6600.53
206_G250_G0.6590.53
90_A93_T0.6580.52
105_A112_L0.6570.52
8_I11_H0.6570.52
50_V55_I0.6560.52
65_R159_L0.6540.52
47_Y83_L0.6530.52
142_E186_Q0.6530.52
35_L73_I0.6520.52
20_R200_P0.6510.52
244_D248_E0.6500.52
206_G260_L0.6490.51
67_T92_I0.6490.51
126_K279_Q0.6470.51
268_I273_L0.6460.51
15_V193_Y0.6450.51
147_R237_S0.6440.51
88_V112_L0.6430.51
163_G268_I0.6420.51
175_S224_A0.6390.50
108_E247_I0.6380.50
31_G44_F0.6370.50
93_T96_D0.6360.50
197_V234_D0.6350.50
58_I69_I0.6310.50
212_S244_D0.6300.49
95_T195_L0.6300.49
81_L186_Q0.6300.49
34_E44_F0.6300.49
105_A258_P0.6200.48
71_L204_K0.6190.48
27_W106_T0.6180.48
31_G38_L0.6170.48
115_K174_I0.6170.48
109_G116_A0.6170.48
157_A163_G0.6140.48
128_S251_F0.6140.48
126_K202_N0.6120.47
153_D189_Q0.6090.47
93_T191_I0.6080.47
149_Q154_L0.6030.46
146_F150_D0.6020.46
160_A165_D0.6010.46
14_H39_V0.5990.46
87_M224_A0.5980.46
104_C257_P0.5980.46
120_T123_S0.5950.46
20_R134_P0.5950.46
6_E130_H0.5920.45
79_Q108_E0.5910.45
211_P272_H0.5890.45
104_C126_K0.5880.45
38_L59_G0.5840.44
48_Q56_S0.5830.44
104_C204_K0.5830.44
57_C71_L0.5810.44
28_P34_E0.5800.44
72_V104_C0.5800.44
38_L278_S0.5790.44
34_E234_D0.5790.44
79_Q255_D0.5780.44
30_Y255_D0.5780.44
239_H245_S0.5770.44
84_G88_V0.5760.43
89_N116_A0.5760.43
167_S171_Q0.5750.43
60_L116_A0.5720.43
128_S201_A0.5710.43
16_S198_Q0.5690.43
22_C31_G0.5690.43
30_Y279_Q0.5660.42
57_C60_L0.5650.42
247_I253_K0.5620.42
21_L35_L0.5620.42
10_L42_G0.5600.42
139_L142_E0.5580.42
255_D278_S0.5580.42
40_Q77_E0.5560.41
152_H155_T0.5540.41
197_V207_P0.5530.41
104_C255_D0.5500.41
11_H14_H0.5500.41
20_R23_G0.5480.40
46_G94_Q0.5470.40
275_A279_Q0.5470.40
147_R153_D0.5430.40
248_E267_P0.5400.40
95_T99_T0.5380.39
176_A251_F0.5380.39
18_L87_M0.5380.39
103_L116_A0.5370.39
98_N262_Y0.5350.39
182_I222_R0.5350.39
66_L204_K0.5340.39
88_V109_G0.5340.39
155_T230_P0.5320.39
74_V83_L0.5310.39
46_G91_C0.5310.39
64_G92_I0.5300.39
149_Q174_I0.5300.39
45_F275_A0.5300.39
93_T269_Q0.5290.38
165_D168_N0.5270.38
169_L277_I0.5270.38
33_Q52_G0.5270.38
47_Y222_R0.5260.38
14_H17_G0.5220.38
68_S126_K0.5210.38
74_V242_L0.5180.37
209_I249_M0.5160.37
64_G164_G0.5140.37
205_F208_I0.5140.37
129_C187_D0.5120.37
127_Y253_K0.5120.37
22_C234_D0.5100.37
238_E270_N0.5060.36
80_R115_K0.5060.36
44_F61_F0.5030.36
79_Q173_L0.5020.36
211_P215_V0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dddA 1 0.9433 100 0.397 Contact Map
4my0A 4 0.9681 100 0.551 Contact Map
2ozgA 5 0.9787 100 0.555 Contact Map
2i00A 4 0.9716 100 0.555 Contact Map
3n7zA 4 0.9787 100 0.561 Contact Map
3sxnA 4 0.9681 100 0.568 Contact Map
2hv2A 4 0.9894 100 0.569 Contact Map
3r1kA 4 0.961 100 0.584 Contact Map
1p0hA 1 0.9007 99.9 0.645 Contact Map
3tt2A 1 0.9539 99.9 0.648 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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