GREMLIN Database
YITF - Putative isomerase YitF
UniProt: O06741 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (310)
Sequences: 12632 (7595)
Seq/√Len: 431.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_K81_T3.3841.00
120_E343_M3.2421.00
250_P254_Q3.2311.00
229_R258_D3.0981.00
193_D196_A3.0451.00
74_S77_S2.8481.00
226_A230_S2.8191.00
34_I92_A2.7071.00
221_Q224_D2.6821.00
37_I43_D2.6271.00
249_V253_S2.5961.00
35_R43_D2.5531.00
42_I100_I2.4901.00
38_T100_I2.3611.00
202_R205_S2.2891.00
145_E177_T2.2681.00
227_M230_S2.2521.00
205_S233_S2.2101.00
57_V61_K2.1871.00
245_P272_E2.1861.00
76_L275_D2.1821.00
226_A254_Q2.1331.00
202_R231_R2.1251.00
201_E213_L2.0971.00
172_N207_W2.0931.00
183_T211_G2.0741.00
38_T42_I2.0621.00
94_S271_D2.0611.00
227_M231_R2.0211.00
35_R45_W1.9921.00
223_Q254_Q1.9731.00
267_V276_C1.9631.00
203_Y206_E1.9441.00
252_L285_V1.9141.00
168_V203_Y1.9121.00
259_I286_R1.9001.00
201_E232_L1.8771.00
40_S104_A1.8471.00
102_A109_V1.8301.00
141_V177_T1.8181.00
168_V206_E1.8131.00
42_I104_A1.8101.00
169_R172_N1.8021.00
198_F231_R1.8001.00
145_E149_K1.7801.00
248_Y276_C1.7671.00
200_W204_F1.7491.00
279_L283_F1.7271.00
70_K77_S1.7201.00
340_S345_H1.7031.00
122_P153_E1.6921.00
327_M330_P1.6901.00
173_A176_H1.6831.00
78_L97_L1.6711.00
108_S111_E1.6601.00
146_A150_K1.6521.00
36_I97_L1.6201.00
217_L228_L1.5931.00
141_V145_E1.5791.00
148_L182_I1.5791.00
107_C111_E1.5701.00
253_S283_F1.5621.00
278_Q281_R1.5521.00
48_C92_A1.5501.00
195_A227_M1.5381.00
87_Q246_A1.5251.00
42_I103_K1.5161.00
99_E103_K1.5091.00
252_L279_L1.5081.00
85_W88_R1.4571.00
151_G182_I1.4491.00
94_S98_T1.4321.00
120_E345_H1.4321.00
137_I141_V1.4311.00
143_N146_A1.4251.00
194_A227_M1.4251.00
274_R278_Q1.4211.00
77_S81_T1.4111.00
249_V279_L1.3911.00
56_H60_T1.3871.00
165_K169_R1.3851.00
64_I68_L1.3841.00
251_L257_L1.3791.00
163_S166_E1.3771.00
33_L45_W1.3691.00
166_E169_R1.3671.00
306_A346_I1.3651.00
172_N206_E1.3431.00
172_N176_H1.3371.00
273_F304_A1.3351.00
198_F227_M1.3341.00
237_A259_I1.3261.00
194_A228_L1.3191.00
199_K202_R1.3151.00
174_L178_A1.3151.00
185_I212_W1.3081.00
168_V172_N1.3081.00
155_I182_I1.3051.00
252_L283_F1.3001.00
73_G104_A1.2861.00
247_Q250_P1.2861.00
136_W139_R1.2771.00
194_A224_D1.2771.00
217_L224_D1.2711.00
139_R142_S1.2641.00
71_Q74_S1.2641.00
70_K78_L1.2581.00
272_E275_D1.2581.00
186_L210_I1.2571.00
220_D247_Q1.2541.00
250_P253_S1.2531.00
185_I211_G1.2391.00
61_K65_P1.2341.00
226_A256_C1.2331.00
168_V207_W1.2211.00
95_M270_I1.2121.00
158_K189_N1.2061.00
54_A57_V1.2001.00
101_A105_A1.1911.00
142_S145_E1.1891.00
80_R84_K1.1821.00
196_A199_K1.1821.00
199_K203_Y1.1801.00
107_C112_L1.1741.00
245_P279_L1.1711.00
38_T104_A1.1701.00
216_P236_V1.1681.00
244_G247_Q1.1631.00
82_I90_A1.1601.00
171_I175_Q1.1581.00
289_A308_L1.1541.00
116_R119_E1.1471.00
58_G62_R1.1381.00
248_Y260_I1.1371.00
278_Q282_Y1.1341.00
145_E148_L1.1331.00
202_R233_S1.1191.00
138_S147_Q1.1071.00
122_P343_M1.1031.00
102_A112_L1.1001.00
275_D278_Q1.0951.00
99_E298_R1.0881.00
178_A184_M1.0751.00
205_S234_V1.0711.00
144_V178_A1.0681.00
188_A213_L1.0611.00
238_G251_L1.0591.00
216_P228_L1.0581.00
198_F228_L1.0531.00
47_E294_G1.0511.00
141_V176_H1.0461.00
274_R306_A1.0421.00
255_R285_V1.0371.00
169_R173_A1.0321.00
260_I280_A1.0231.00
279_L282_Y1.0191.00
264_V273_F1.0181.00
148_L155_I1.0181.00
175_Q184_M1.0091.00
197_A201_E0.9981.00
229_R255_R0.9941.00
98_T271_D0.9921.00
175_Q179_G0.9901.00
263_D290_H0.9901.00
237_A261_Q0.9901.00
215_E261_Q0.9891.00
54_A58_G0.9891.00
144_V155_I0.9881.00
73_G105_A0.9831.00
33_L296_L0.9801.00
70_K74_S0.9791.00
235_P310_P0.9721.00
138_S142_S0.9711.00
75_R101_A0.9691.00
73_G101_A0.9661.00
146_A149_K0.9631.00
62_R65_P0.9571.00
124_Y127_F0.9551.00
192_Y197_A0.9491.00
63_I93_V0.9471.00
277_L308_L0.9471.00
105_A112_L0.9451.00
275_D281_R0.9431.00
173_A177_T0.9381.00
160_G167_D0.9351.00
128_Q174_L0.9301.00
249_V283_F0.9231.00
39_E72_A0.9101.00
192_Y200_W0.9101.00
157_V174_L0.9081.00
267_V273_F0.9071.00
217_L225_Y0.8991.00
98_T270_I0.8991.00
126_S148_L0.8991.00
171_I186_L0.8991.00
60_T64_I0.8941.00
228_L236_V0.8931.00
135_Q139_R0.8871.00
252_L260_I0.8841.00
152_F316_N0.8831.00
239_G263_D0.8821.00
125_A129_S0.8791.00
222_P256_C0.8761.00
171_I207_W0.8761.00
277_L287_A0.8701.00
59_F63_I0.8691.00
113_W274_R0.8681.00
197_A217_L0.8651.00
194_A198_F0.8651.00
37_I41_G0.8631.00
67_L70_K0.8591.00
195_A199_K0.8581.00
61_K64_I0.8571.00
245_P275_D0.8541.00
147_Q150_K0.8501.00
223_Q226_A0.8491.00
109_V270_I0.8481.00
188_A201_E0.8461.00
53_P57_V0.8461.00
76_L274_R0.8431.00
224_D227_M0.8401.00
72_A97_L0.8391.00
175_Q209_N0.8361.00
281_R309_P0.8361.00
142_S146_A0.8351.00
78_L81_T0.8321.00
66_F81_T0.8311.00
95_M300_Y0.8281.00
126_S129_S0.8221.00
286_R312_S0.8191.00
230_S255_R0.8181.00
141_V178_A0.8161.00
210_I234_V0.8131.00
101_A112_L0.8091.00
52_L59_F0.8091.00
277_L281_R0.8031.00
257_L260_I0.8021.00
242_M248_Y0.8011.00
175_Q181_S0.8001.00
154_Q185_I0.7951.00
178_A182_I0.7941.00
223_Q250_P0.7931.00
109_V113_W0.7881.00
45_W296_L0.7851.00
339_P344_V0.7831.00
54_A59_F0.7801.00
52_L55_L0.7781.00
79_V83_Q0.7751.00
330_P333_D0.7721.00
243_K247_Q0.7721.00
242_M247_Q0.7721.00
79_V94_S0.7711.00
262_P273_F0.7701.00
225_Y236_V0.7681.00
175_Q178_A0.7681.00
164_F200_W0.7651.00
105_A108_S0.7601.00
222_P251_L0.7571.00
110_C346_I0.7571.00
159_I188_A0.7541.00
326_V330_P0.7541.00
277_L289_A0.7541.00
331_F334_L0.7521.00
194_A217_L0.7501.00
38_T72_A0.7491.00
225_Y238_G0.7491.00
192_Y213_L0.7471.00
37_I45_W0.7451.00
137_I173_A0.7451.00
79_V271_D0.7391.00
180_S209_N0.7381.00
340_S343_M0.7371.00
197_A228_L0.7341.00
302_L346_I0.7331.00
238_G257_L0.7261.00
242_M251_L0.7251.00
262_P277_L0.7241.00
222_P250_P0.7231.00
65_P68_L0.7231.00
315_K318_H0.7211.00
125_A147_Q0.7201.00
58_G61_K0.7171.00
162_T174_L0.7171.00
90_A269_G0.7151.00
152_F317_D0.7141.00
188_A192_Y0.7131.00
274_R307_C0.7101.00
157_V161_G0.7101.00
152_F315_K0.7081.00
139_R143_N0.7081.00
338_Q345_H0.7071.00
76_L80_R0.7071.00
110_C303_F0.7061.00
111_E116_R0.7041.00
248_Y285_V0.7031.00
157_V160_G0.7011.00
83_Q272_E0.6991.00
328_E334_L0.6981.00
270_I274_R0.6981.00
302_L344_V0.6951.00
205_S232_L0.6941.00
229_R236_V0.6931.00
274_R308_L0.6931.00
123_V126_S0.6931.00
314_M317_D0.6911.00
334_L337_L0.6901.00
198_F217_L0.6891.00
52_L56_H0.6881.00
125_A152_F0.6881.00
124_Y128_Q0.6841.00
246_A249_V0.6841.00
137_I169_R0.6831.00
36_I44_G0.6821.00
75_R78_L0.6801.00
46_G51_W0.6791.00
198_F232_L0.6761.00
222_P254_Q0.6711.00
72_A104_A0.6641.00
228_L232_L0.6621.00
120_E341_K0.6621.00
52_L60_T0.6611.00
281_R310_P0.6601.00
98_T109_V0.6591.00
167_D192_Y0.6580.99
171_I204_F0.6570.99
118_R121_I0.6560.99
260_I285_V0.6560.99
78_L82_I0.6560.99
46_G92_A0.6540.99
66_F70_K0.6520.99
37_I40_S0.6510.99
199_K231_R0.6500.99
157_V171_I0.6470.99
261_Q290_H0.6470.99
76_L271_D0.6460.99
298_R302_L0.6460.99
165_K203_Y0.6420.99
72_A101_A0.6420.99
245_P276_C0.6420.99
162_T166_E0.6410.99
113_W270_I0.6410.99
198_F202_R0.6400.99
44_G96_A0.6370.99
100_I104_A0.6360.99
102_A107_C0.6350.99
227_M255_R0.6340.99
144_V148_L0.6330.99
59_F93_V0.6310.99
168_V171_I0.6310.99
46_G49_V0.6310.99
36_I67_L0.6290.99
74_S111_E0.6280.99
115_G119_E0.6270.99
215_E241_N0.6250.99
155_I178_A0.6240.99
44_G99_E0.6230.99
126_S130_Y0.6220.99
62_R66_F0.6220.99
101_A104_A0.6200.99
98_T113_W0.6150.99
46_G50_D0.6100.99
264_V301_A0.6090.99
80_R83_Q0.6090.99
215_E240_E0.6070.99
127_F130_Y0.6070.99
55_L59_F0.6060.99
143_N147_Q0.6050.99
109_V112_L0.6040.99
144_V174_L0.6020.99
176_H180_S0.5970.99
71_Q111_E0.5960.99
166_E170_H0.5940.99
63_I67_L0.5920.99
172_N175_Q0.5920.99
212_W288_S0.5910.99
55_L62_R0.5900.99
167_D175_Q0.5900.99
201_E234_V0.5900.99
225_Y228_L0.5900.99
248_Y280_A0.5870.99
305_Q314_M0.5860.99
245_P249_V0.5850.99
260_I276_C0.5840.99
280_A285_V0.5840.99
153_E341_K0.5820.99
200_W203_Y0.5800.99
262_P287_A0.5790.99
154_Q183_T0.5790.99
59_F64_I0.5780.99
55_L58_G0.5780.99
167_D170_H0.5760.99
215_E239_G0.5760.99
142_S177_T0.5740.99
60_T93_V0.5720.99
72_A100_I0.5720.99
145_E178_A0.5700.99
83_Q90_A0.5690.99
281_R287_A0.5680.99
167_D188_A0.5660.98
32_Y56_H0.5660.98
43_D103_K0.5650.98
175_Q207_W0.5630.98
97_L101_A0.5630.98
333_D337_L0.5630.98
63_I82_I0.5600.98
326_V331_F0.5590.98
72_A75_R0.5580.98
141_V174_L0.5580.98
163_S167_D0.5560.98
257_L285_V0.5550.98
280_A287_A0.5540.98
171_I210_I0.5520.98
47_E50_D0.5510.98
94_S269_G0.5500.98
256_C285_V0.5500.98
141_V173_A0.5500.98
53_P56_H0.5490.98
172_N203_Y0.5450.98
270_I300_Y0.5440.98
53_P59_F0.5440.98
287_A308_L0.5440.98
76_L119_E0.5430.98
48_C51_W0.5420.98
79_V82_I0.5420.98
75_R112_L0.5410.98
327_M333_D0.5380.98
124_Y129_S0.5380.98
59_F62_R0.5370.98
246_A250_P0.5370.98
232_L236_V0.5360.98
158_K173_A0.5360.98
211_G235_P0.5360.98
148_L178_A0.5330.98
289_A303_F0.5310.98
78_L93_V0.5300.98
148_L177_T0.5300.98
248_Y262_P0.5300.98
190_Q219_F0.5290.98
291_A298_R0.5270.98
229_R256_C0.5230.97
120_E340_S0.5220.97
67_L93_V0.5190.97
102_A105_A0.5180.97
144_V177_T0.5180.97
53_P61_K0.5180.97
190_Q241_N0.5180.97
80_R275_D0.5170.97
247_Q256_C0.5170.97
168_V175_Q0.5160.97
125_A128_Q0.5160.97
315_K319_I0.5140.97
75_R271_D0.5100.97
34_I93_V0.5100.97
136_W156_K0.5090.97
264_V270_I0.5060.97
201_E204_F0.5050.97
77_S80_R0.5050.97
127_F147_Q0.5050.97
326_V329_N0.5030.97
328_E332_T0.5020.97
168_V200_W0.5020.97
81_T84_K0.5010.97
158_K161_G0.5010.97
52_L58_G0.5010.97
58_G65_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5sA 2 0.9407 100 0.133 Contact Map
2gdqA 5 0.9946 100 0.137 Contact Map
2p8bA 5 0.9596 100 0.14 Contact Map
3dgbA 5 0.9542 100 0.141 Contact Map
3i4kA 4 0.9542 100 0.141 Contact Map
3fcpA 5 0.9164 100 0.144 Contact Map
3i6eA 4 0.9245 100 0.145 Contact Map
3my9A 5 0.9326 100 0.147 Contact Map
1sjdA 5 0.9542 100 0.148 Contact Map
3u9iA 2 0.8976 100 0.148 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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