YITE - BACSU - GREMLIN Contacts

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YITE - UPF0750 membrane protein YitE

UniProt:	O06740	Sequences: MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAVLLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDITSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCIIFMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	209 (199)
Sequences:	4525 (3289)
Seq/√Len:	233.1

BACSU - YITE YXKD YQFU YDEO YPJC YVJA YITT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
15_V	83_A	6.155	1.00
19_V	91_S	3.190	1.00
39_A	61_V	3.180	1.00
204_M	207_H	3.055	1.00
112_S	174_I	2.608	1.00
10_L	80_G	2.574	1.00
46_L	50_F	2.398	1.00
165_A	173_V	2.295	1.00
24_G	117_L	2.268	1.00
46_L	57_S	2.261	1.00
86_T	90_V	2.257	1.00
13_M	127_Y	2.237	1.00
26_S	95_F	2.176	1.00
55_G	93_L	2.156	1.00
10_L	127_Y	2.148	1.00
17_G	120_G	2.147	1.00
22_G	91_S	2.119	1.00
185_R	189_F	2.041	1.00
32_H	109_D	2.028	1.00
70_L	75_M	2.027	1.00
169_D	172_I	2.027	1.00
21_Q	88_T	1.976	1.00
67_F	71_K	1.969	1.00
122_G	190_I	1.934	1.00
159_I	163_V	1.883	1.00
15_V	87_V	1.881	1.00
165_A	170_W	1.865	1.00
150_G	188_D	1.829	1.00
23_L	27_L	1.771	1.00
26_S	96_D	1.719	1.00
110_L	114_A	1.662	1.00
124_L	131_N	1.657	1.00
11_T	83_A	1.647	1.00
14_I	84_S	1.630	1.00
39_A	65_M	1.584	1.00
53_P	93_L	1.552	1.00
154_L	184_T	1.539	1.00
18_G	87_V	1.538	1.00
141_I	145_R	1.520	1.00
24_G	116_L	1.514	1.00
148_N	151_T	1.497	1.00
29_L	113_G	1.475	1.00
76_R	80_G	1.472	1.00
52_I	57_S	1.461	1.00
84_S	129_I	1.429	1.00
58_V	92_V	1.429	1.00
107_W	178_I	1.403	1.00
19_V	95_F	1.384	1.00
55_G	89_S	1.381	1.00
155_I	159_I	1.376	1.00
35_P	164_T	1.365	1.00
14_I	129_I	1.364	1.00
77_T	130_S	1.361	1.00
59_W	89_S	1.361	1.00
105_N	175_Q	1.352	1.00
21_Q	120_G	1.346	1.00
181_V	185_R	1.337	1.00
29_L	179_C	1.337	1.00
73_L	77_T	1.333	1.00
9_K	13_M	1.316	1.00
131_N	135_G	1.313	1.00
115_V	186_V	1.308	1.00
158_C	162_M	1.299	1.00
118_G	122_G	1.298	1.00
106_L	172_I	1.287	1.00
53_P	56_F	1.281	1.00
42_I	46_L	1.278	1.00
7_K	10_L	1.263	1.00
70_L	78_F	1.257	1.00
17_G	124_L	1.241	1.00
55_G	59_W	1.208	1.00
24_G	120_G	1.201	1.00
138_A	153_L	1.197	1.00
69_A	78_F	1.193	1.00
110_L	182_I	1.192	1.00
11_T	80_G	1.186	1.00
18_G	88_T	1.184	1.00
34_I	110_L	1.182	1.00
134_F	156_M	1.177	1.00
33_D	172_I	1.174	1.00
79_T	83_A	1.169	1.00
83_A	87_V	1.160	1.00
66_L	85_I	1.155	1.00
30_F	54_H	1.145	1.00
63_V	67_F	1.143	1.00
8_A	12_F	1.138	1.00
107_W	175_Q	1.135	1.00
56_F	93_L	1.133	1.00
42_I	163_V	1.132	1.00
119_L	190_I	1.131	1.00
87_V	91_S	1.127	1.00
59_W	86_T	1.102	1.00
23_L	95_F	1.094	1.00
180_Q	184_T	1.047	1.00
108_L	112_S	1.040	1.00
56_F	60_A	1.035	1.00
72_W	140_M	1.029	1.00
60_A	64_S	1.006	1.00
130_S	139_L	0.997	1.00
66_L	82_L	0.982	1.00
124_L	129_I	0.981	1.00
161_F	180_Q	0.980	1.00
151_T	188_D	0.978	1.00
72_W	144_Y	0.975	1.00
67_F	70_L	0.972	1.00
57_S	61_V	0.971	1.00
30_F	47_H	0.967	1.00
147_G	151_T	0.966	1.00
150_G	187_I	0.964	1.00
169_D	173_V	0.963	1.00
93_L	96_D	0.963	1.00
66_L	81_T	0.961	1.00
155_I	158_C	0.961	1.00
147_G	152_I	0.959	1.00
68_T	72_W	0.958	1.00
35_P	176_A	0.947	1.00
47_H	51_Q	0.947	1.00
33_D	48_Y	0.938	1.00
139_L	149_P	0.936	1.00
11_T	15_V	0.935	1.00
9_K	127_Y	0.919	1.00
44_V	47_H	0.913	1.00
134_F	157_N	0.904	1.00
68_T	140_M	0.902	1.00
42_I	45_L	0.902	1.00
43_A	58_V	0.894	0.99
12_F	16_V	0.894	0.99
114_A	182_I	0.889	0.99
121_I	131_N	0.885	0.99
106_L	110_L	0.881	0.99
114_A	118_G	0.877	0.99
15_V	91_S	0.876	0.99
13_M	123_L	0.876	0.99
45_L	163_V	0.875	0.99
117_L	183_S	0.872	0.99
40_A	92_V	0.865	0.99
153_L	187_I	0.864	0.99
20_L	119_L	0.863	0.99
111_A	182_I	0.861	0.99
185_R	188_D	0.861	0.99
73_L	139_L	0.861	0.99
45_L	168_I	0.860	0.99
91_S	94_I	0.853	0.99
64_S	67_F	0.849	0.99
65_M	137_L	0.847	0.99
93_L	97_A	0.845	0.99
46_L	61_V	0.844	0.99
73_L	130_S	0.842	0.99
156_M	160_I	0.838	0.99
45_L	49_L	0.831	0.99
125_Y	139_L	0.823	0.99
141_I	152_I	0.819	0.99
18_G	91_S	0.816	0.99
150_G	184_T	0.815	0.99
110_L	179_C	0.810	0.99
34_I	106_L	0.800	0.99
16_V	20_L	0.797	0.99
28_F	112_S	0.793	0.99
162_M	166_S	0.792	0.99
30_F	44_V	0.792	0.99
21_Q	117_L	0.787	0.99
121_I	125_Y	0.779	0.99
50_F	57_S	0.772	0.98
140_M	144_Y	0.771	0.98
110_L	178_I	0.760	0.98
183_S	187_I	0.759	0.98
27_L	95_F	0.748	0.98
168_I	172_I	0.745	0.98
159_I	162_M	0.739	0.98
108_L	175_Q	0.734	0.98
153_L	157_N	0.729	0.98
64_S	68_T	0.729	0.98
121_I	187_I	0.728	0.98
69_A	77_T	0.726	0.98
35_P	157_N	0.725	0.98
148_N	188_D	0.722	0.98
71_K	89_S	0.715	0.97
106_L	175_Q	0.712	0.97
106_L	109_D	0.707	0.97
139_L	143_I	0.707	0.97
75_M	78_F	0.704	0.97
7_K	80_G	0.703	0.97
151_T	155_I	0.702	0.97
42_I	160_I	0.700	0.97
119_L	123_L	0.698	0.97
77_T	139_L	0.696	0.97
125_Y	135_G	0.692	0.97
66_L	69_A	0.691	0.97
52_I	56_F	0.690	0.97
54_H	58_V	0.690	0.97
115_V	119_L	0.686	0.97
115_V	181_V	0.685	0.97
163_V	166_S	0.685	0.97
101_D	104_S	0.683	0.97
43_A	61_V	0.682	0.97
49_L	167_I	0.680	0.97
134_F	160_I	0.678	0.96
21_Q	121_I	0.672	0.96
142_S	146_G	0.672	0.96
47_H	57_S	0.671	0.96
40_A	88_T	0.670	0.96
47_H	54_H	0.667	0.96
122_G	126_K	0.665	0.96
9_K	126_K	0.665	0.96
164_T	173_V	0.661	0.96
45_L	160_I	0.658	0.96
109_D	171_G	0.653	0.96
80_G	129_I	0.652	0.96
57_S	60_A	0.652	0.96
8_A	11_T	0.649	0.96
48_Y	168_I	0.644	0.95
161_F	164_T	0.636	0.95
71_K	75_M	0.635	0.95
125_Y	138_A	0.633	0.95
105_N	171_G	0.630	0.95
44_V	54_H	0.629	0.95
173_V	179_C	0.627	0.95
108_L	181_V	0.627	0.95
121_I	183_S	0.627	0.95
20_L	116_L	0.626	0.95
195_L	198_L	0.624	0.94
66_L	137_L	0.620	0.94
27_L	31_P	0.618	0.94
111_A	115_V	0.617	0.94
34_I	113_G	0.610	0.94
18_G	84_S	0.604	0.93
104_S	171_G	0.602	0.93
154_L	181_V	0.599	0.93
59_W	63_V	0.598	0.93
111_A	178_I	0.597	0.93
119_L	186_V	0.594	0.93
35_P	44_V	0.593	0.93
7_K	11_T	0.590	0.93
157_N	161_F	0.587	0.92
82_L	85_I	0.587	0.92
19_V	87_V	0.587	0.92
23_L	116_L	0.585	0.92
34_I	114_A	0.581	0.92
105_N	110_L	0.579	0.92
151_T	154_L	0.578	0.92
85_I	89_S	0.575	0.92
20_L	123_L	0.569	0.91
103_T	171_G	0.569	0.91
81_T	136_A	0.569	0.91
139_L	157_N	0.564	0.91
29_L	164_T	0.558	0.90
124_L	198_L	0.557	0.90
194_R	198_L	0.557	0.90
137_L	141_I	0.555	0.90
123_L	127_Y	0.551	0.90
43_A	54_H	0.550	0.90
165_A	180_Q	0.549	0.90
17_G	84_S	0.547	0.90
26_S	30_F	0.547	0.90
68_T	71_K	0.547	0.90
44_V	48_Y	0.545	0.89
174_I	178_I	0.545	0.89
18_G	22_G	0.545	0.89
126_K	161_F	0.544	0.89
67_F	140_M	0.543	0.89
100_P	103_T	0.542	0.89
13_M	126_K	0.540	0.89
136_A	150_G	0.539	0.89
106_L	171_G	0.538	0.89
25_M	40_A	0.537	0.89
78_F	85_I	0.535	0.89
36_T	134_F	0.535	0.89
41_G	175_Q	0.532	0.88
143_I	178_I	0.532	0.88
87_V	94_I	0.529	0.88
114_A	179_C	0.526	0.88
154_L	177_L	0.522	0.87
103_T	109_D	0.521	0.87
168_I	173_V	0.520	0.87
22_G	88_T	0.520	0.87
112_S	116_L	0.518	0.87
18_G	124_L	0.518	0.87
84_S	131_N	0.517	0.87
43_A	158_C	0.516	0.87
51_Q	57_S	0.515	0.87
16_V	123_L	0.513	0.86
12_F	119_L	0.512	0.86
79_T	82_L	0.512	0.86
54_H	72_W	0.511	0.86
37_G	157_N	0.511	0.86
62_N	133_G	0.509	0.86
157_N	180_Q	0.508	0.86
34_I	179_C	0.507	0.86
90_V	94_I	0.506	0.86
120_G	123_L	0.505	0.86
58_V	125_Y	0.503	0.85
130_S	191_Y	0.502	0.85
80_G	176_A	0.502	0.85
45_L	55_G	0.502	0.85
142_S	145_R	0.502	0.85
39_A	43_A	0.502	0.85
66_L	180_Q	0.501	0.85
160_I	163_V	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4oh3A	2	0.9139	22.4	0.943	Contact Map
4tphA	2	0.9043	21.9	0.943	Contact Map
4q65A	1	0.8852	17.9	0.946	Contact Map
2cfqA	1	0.9091	13.2	0.949	Contact Map
3rlbA	1	0.7368	12.6	0.949	Contact Map
4ikvA	1	0.9378	9.3	0.952	Contact Map
2xq2A	2	0.823	4.2	0.959	Contact Map
4uvmA	1	0.9043	3.7	0.96	Contact Map
4tkrA	2	0.7464	3.5	0.961	Contact Map
4xnjA	1	0.9234	3.5	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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