GREMLIN Database
YITE - UPF0750 membrane protein YitE
UniProt: O06740 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (199)
Sequences: 4525 (3289)
Seq/√Len: 233.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_V83_A6.1551.00
19_V91_S3.1901.00
39_A61_V3.1801.00
204_M207_H3.0551.00
112_S174_I2.6081.00
10_L80_G2.5741.00
46_L50_F2.3981.00
165_A173_V2.2951.00
24_G117_L2.2681.00
46_L57_S2.2611.00
86_T90_V2.2571.00
13_M127_Y2.2371.00
26_S95_F2.1761.00
55_G93_L2.1561.00
10_L127_Y2.1481.00
17_G120_G2.1471.00
22_G91_S2.1191.00
185_R189_F2.0411.00
32_H109_D2.0281.00
70_L75_M2.0271.00
169_D172_I2.0271.00
21_Q88_T1.9761.00
67_F71_K1.9691.00
122_G190_I1.9341.00
159_I163_V1.8831.00
15_V87_V1.8811.00
165_A170_W1.8651.00
150_G188_D1.8291.00
23_L27_L1.7711.00
26_S96_D1.7191.00
110_L114_A1.6621.00
124_L131_N1.6571.00
11_T83_A1.6471.00
14_I84_S1.6301.00
39_A65_M1.5841.00
53_P93_L1.5521.00
154_L184_T1.5391.00
18_G87_V1.5381.00
141_I145_R1.5201.00
24_G116_L1.5141.00
148_N151_T1.4971.00
29_L113_G1.4751.00
76_R80_G1.4721.00
52_I57_S1.4611.00
84_S129_I1.4291.00
58_V92_V1.4291.00
107_W178_I1.4031.00
19_V95_F1.3841.00
55_G89_S1.3811.00
155_I159_I1.3761.00
35_P164_T1.3651.00
14_I129_I1.3641.00
77_T130_S1.3611.00
59_W89_S1.3611.00
105_N175_Q1.3521.00
21_Q120_G1.3461.00
181_V185_R1.3371.00
29_L179_C1.3371.00
73_L77_T1.3331.00
9_K13_M1.3161.00
131_N135_G1.3131.00
115_V186_V1.3081.00
158_C162_M1.2991.00
118_G122_G1.2981.00
106_L172_I1.2871.00
53_P56_F1.2811.00
42_I46_L1.2781.00
7_K10_L1.2631.00
70_L78_F1.2571.00
17_G124_L1.2411.00
55_G59_W1.2081.00
24_G120_G1.2011.00
138_A153_L1.1971.00
69_A78_F1.1931.00
110_L182_I1.1921.00
11_T80_G1.1861.00
18_G88_T1.1841.00
34_I110_L1.1821.00
134_F156_M1.1771.00
33_D172_I1.1741.00
79_T83_A1.1691.00
83_A87_V1.1601.00
66_L85_I1.1551.00
30_F54_H1.1451.00
63_V67_F1.1431.00
8_A12_F1.1381.00
107_W175_Q1.1351.00
56_F93_L1.1331.00
42_I163_V1.1321.00
119_L190_I1.1311.00
87_V91_S1.1271.00
59_W86_T1.1021.00
23_L95_F1.0941.00
180_Q184_T1.0471.00
108_L112_S1.0401.00
56_F60_A1.0351.00
72_W140_M1.0291.00
60_A64_S1.0061.00
130_S139_L0.9971.00
66_L82_L0.9821.00
124_L129_I0.9811.00
161_F180_Q0.9801.00
151_T188_D0.9781.00
72_W144_Y0.9751.00
67_F70_L0.9721.00
57_S61_V0.9711.00
30_F47_H0.9671.00
147_G151_T0.9661.00
150_G187_I0.9641.00
169_D173_V0.9631.00
93_L96_D0.9631.00
66_L81_T0.9611.00
155_I158_C0.9611.00
147_G152_I0.9591.00
68_T72_W0.9581.00
35_P176_A0.9471.00
47_H51_Q0.9471.00
33_D48_Y0.9381.00
139_L149_P0.9361.00
11_T15_V0.9351.00
9_K127_Y0.9191.00
44_V47_H0.9131.00
134_F157_N0.9041.00
68_T140_M0.9021.00
42_I45_L0.9021.00
43_A58_V0.8940.99
12_F16_V0.8940.99
114_A182_I0.8890.99
121_I131_N0.8850.99
106_L110_L0.8810.99
114_A118_G0.8770.99
15_V91_S0.8760.99
13_M123_L0.8760.99
45_L163_V0.8750.99
117_L183_S0.8720.99
40_A92_V0.8650.99
153_L187_I0.8640.99
20_L119_L0.8630.99
111_A182_I0.8610.99
185_R188_D0.8610.99
73_L139_L0.8610.99
45_L168_I0.8600.99
91_S94_I0.8530.99
64_S67_F0.8490.99
65_M137_L0.8470.99
93_L97_A0.8450.99
46_L61_V0.8440.99
73_L130_S0.8420.99
156_M160_I0.8380.99
45_L49_L0.8310.99
125_Y139_L0.8230.99
141_I152_I0.8190.99
18_G91_S0.8160.99
150_G184_T0.8150.99
110_L179_C0.8100.99
34_I106_L0.8000.99
16_V20_L0.7970.99
28_F112_S0.7930.99
162_M166_S0.7920.99
30_F44_V0.7920.99
21_Q117_L0.7870.99
121_I125_Y0.7790.99
50_F57_S0.7720.98
140_M144_Y0.7710.98
110_L178_I0.7600.98
183_S187_I0.7590.98
27_L95_F0.7480.98
168_I172_I0.7450.98
159_I162_M0.7390.98
108_L175_Q0.7340.98
153_L157_N0.7290.98
64_S68_T0.7290.98
121_I187_I0.7280.98
69_A77_T0.7260.98
35_P157_N0.7250.98
148_N188_D0.7220.98
71_K89_S0.7150.97
106_L175_Q0.7120.97
106_L109_D0.7070.97
139_L143_I0.7070.97
75_M78_F0.7040.97
7_K80_G0.7030.97
151_T155_I0.7020.97
42_I160_I0.7000.97
119_L123_L0.6980.97
77_T139_L0.6960.97
125_Y135_G0.6920.97
66_L69_A0.6910.97
52_I56_F0.6900.97
54_H58_V0.6900.97
115_V119_L0.6860.97
115_V181_V0.6850.97
163_V166_S0.6850.97
101_D104_S0.6830.97
43_A61_V0.6820.97
49_L167_I0.6800.97
134_F160_I0.6780.96
21_Q121_I0.6720.96
142_S146_G0.6720.96
47_H57_S0.6710.96
40_A88_T0.6700.96
47_H54_H0.6670.96
122_G126_K0.6650.96
9_K126_K0.6650.96
164_T173_V0.6610.96
45_L160_I0.6580.96
109_D171_G0.6530.96
80_G129_I0.6520.96
57_S60_A0.6520.96
8_A11_T0.6490.96
48_Y168_I0.6440.95
161_F164_T0.6360.95
71_K75_M0.6350.95
125_Y138_A0.6330.95
105_N171_G0.6300.95
44_V54_H0.6290.95
173_V179_C0.6270.95
108_L181_V0.6270.95
121_I183_S0.6270.95
20_L116_L0.6260.95
195_L198_L0.6240.94
66_L137_L0.6200.94
27_L31_P0.6180.94
111_A115_V0.6170.94
34_I113_G0.6100.94
18_G84_S0.6040.93
104_S171_G0.6020.93
154_L181_V0.5990.93
59_W63_V0.5980.93
111_A178_I0.5970.93
119_L186_V0.5940.93
35_P44_V0.5930.93
7_K11_T0.5900.93
157_N161_F0.5870.92
82_L85_I0.5870.92
19_V87_V0.5870.92
23_L116_L0.5850.92
34_I114_A0.5810.92
105_N110_L0.5790.92
151_T154_L0.5780.92
85_I89_S0.5750.92
20_L123_L0.5690.91
103_T171_G0.5690.91
81_T136_A0.5690.91
139_L157_N0.5640.91
29_L164_T0.5580.90
124_L198_L0.5570.90
194_R198_L0.5570.90
137_L141_I0.5550.90
123_L127_Y0.5510.90
43_A54_H0.5500.90
165_A180_Q0.5490.90
17_G84_S0.5470.90
26_S30_F0.5470.90
68_T71_K0.5470.90
44_V48_Y0.5450.89
174_I178_I0.5450.89
18_G22_G0.5450.89
126_K161_F0.5440.89
67_F140_M0.5430.89
100_P103_T0.5420.89
13_M126_K0.5400.89
136_A150_G0.5390.89
106_L171_G0.5380.89
25_M40_A0.5370.89
78_F85_I0.5350.89
36_T134_F0.5350.89
41_G175_Q0.5320.88
143_I178_I0.5320.88
87_V94_I0.5290.88
114_A179_C0.5260.88
154_L177_L0.5220.87
103_T109_D0.5210.87
168_I173_V0.5200.87
22_G88_T0.5200.87
112_S116_L0.5180.87
18_G124_L0.5180.87
84_S131_N0.5170.87
43_A158_C0.5160.87
51_Q57_S0.5150.87
16_V123_L0.5130.86
12_F119_L0.5120.86
79_T82_L0.5120.86
54_H72_W0.5110.86
37_G157_N0.5110.86
62_N133_G0.5090.86
157_N180_Q0.5080.86
34_I179_C0.5070.86
90_V94_I0.5060.86
120_G123_L0.5050.86
58_V125_Y0.5030.85
130_S191_Y0.5020.85
80_G176_A0.5020.85
45_L55_G0.5020.85
142_S145_R0.5020.85
39_A43_A0.5020.85
66_L180_Q0.5010.85
160_I163_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oh3A 2 0.9139 22.4 0.943 Contact Map
4tphA 2 0.9043 21.9 0.943 Contact Map
4q65A 1 0.8852 17.9 0.946 Contact Map
2cfqA 1 0.9091 13.2 0.949 Contact Map
3rlbA 1 0.7368 12.6 0.949 Contact Map
4ikvA 1 0.9378 9.3 0.952 Contact Map
2xq2A 2 0.823 4.2 0.959 Contact Map
4uvmA 1 0.9043 3.7 0.96 Contact Map
4tkrA 2 0.7464 3.5 0.961 Contact Map
4xnjA 1 0.9234 3.5 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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