GREMLIN Database
PSLS - Phosphosulfolactate synthase
UniProt: O06739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (237)
Sequences: 386 (279)
Seq/√Len: 18.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_A44_I3.7271.00
60_L64_I3.4501.00
51_W240_T3.3251.00
33_F67_L3.2990.99
47_V67_L3.2520.99
22_I206_F3.1830.99
81_F107_I3.0970.99
51_W206_F2.9960.99
134_S164_A2.9400.99
29_P35_D2.8850.99
91_N125_D2.8240.98
22_I228_A2.7380.98
16_R45_D2.6260.97
76_F102_C2.4280.96
195_I221_I2.3880.95
33_F47_V2.3600.95
31_Q34_K2.3480.95
65_S69_E2.3200.94
181_S185_D2.1970.93
64_I74_F2.1420.92
31_Q35_D2.1090.91
119_K159_D2.1020.91
60_L96_Y2.0850.90
34_K62_E2.0740.90
111_T247_S1.9480.87
127_S165_E1.9230.86
43_Y56_L1.9140.86
97_C130_F1.8560.84
166_K203_R1.7940.82
108_S170_E1.7850.82
75_F133_L1.7710.81
31_Q38_A1.7040.79
28_Y232_F1.6760.77
119_K134_S1.6530.76
215_Q240_T1.5980.74
78_G108_S1.5880.73
173_E211_K1.5750.73
208_A225_V1.5500.72
124_A127_S1.5400.71
71_D161_E1.5390.71
218_I225_V1.5220.70
81_F122_Y1.5010.69
11_R16_R1.4980.69
180_C213_L1.4870.68
137_G209_P1.4850.68
49_F74_F1.4730.68
50_G79_T1.4560.67
14_K45_D1.4480.66
78_G170_E1.4460.66
79_T82_E1.4340.65
13_N41_S1.4230.65
37_I70_H1.4010.64
82_E139_K1.3980.63
128_D194_I1.3860.63
20_Q107_I1.3790.62
78_G135_E1.3670.62
139_K209_P1.3590.61
67_L74_F1.3520.61
90_V94_H1.3500.61
110_G172_R1.3440.60
162_A227_L1.3410.60
33_F37_I1.3400.60
130_F204_L1.3360.60
50_G246_R1.3200.59
187_R190_I1.2930.57
11_R239_E1.2770.56
23_L153_L1.2690.56
108_S135_E1.2590.55
166_K205_I1.2570.55
191_V216_G1.2390.54
72_I199_I1.2230.53
175_G246_R1.2220.53
133_L179_I1.2160.52
22_I51_W1.2010.52
94_H129_E1.1940.51
179_I191_V1.1910.51
210_N213_L1.1890.51
78_G245_L1.1720.50
77_G170_E1.1640.49
37_I66_T1.1610.49
27_G132_V1.1610.49
41_S72_I1.1580.49
94_H126_F1.1540.49
217_F227_L1.1530.49
135_E170_E1.1440.48
61_E65_S1.1420.48
61_E127_S1.1360.48
137_G170_E1.1230.47
67_L152_W1.1190.46
227_L230_I1.1140.46
17_E114_M1.1070.46
179_I238_L1.1060.46
110_G245_L1.0990.45
209_P214_Q1.0900.45
110_G170_E1.0860.44
102_C126_F1.0860.44
166_K194_I1.0830.44
128_D201_I1.0810.44
213_L228_A1.0770.44
41_S71_D1.0750.44
52_G241_L1.0690.43
34_K71_D1.0680.43
134_S159_D1.0670.43
63_K123_I1.0650.43
50_G178_G1.0640.43
222_G242_R1.0570.43
70_H98_T1.0520.42
218_I241_L1.0470.42
44_I116_N1.0430.42
18_T224_N1.0380.42
46_F75_F1.0310.41
110_G178_G1.0310.41
231_P234_D1.0310.41
90_V122_Y1.0200.40
88_K171_A1.0110.40
110_G175_G1.0030.39
71_D88_K1.0020.39
79_T110_G1.0020.39
11_R15_P1.0000.39
13_N38_A0.9990.39
97_C105_I0.9950.39
101_G203_R0.9930.39
171_A241_L0.9930.39
131_L223_P0.9890.39
142_E247_S0.9800.38
140_D224_N0.9790.38
27_G63_K0.9770.38
156_I167_V0.9750.38
131_L203_R0.9750.38
206_F210_N0.9700.38
136_V167_V0.9640.37
15_P45_D0.9610.37
230_I248_D0.9550.37
170_E207_E0.9550.37
99_Y114_M0.9450.36
50_G172_R0.9400.36
157_V198_D0.9370.36
227_L247_S0.9360.36
26_N173_E0.9320.35
214_Q245_L0.9310.35
44_I156_I0.9290.35
175_G209_P0.9240.35
170_E209_P0.9200.35
209_P245_L0.9200.35
47_V200_D0.9180.35
73_T103_E0.9170.35
179_I230_I0.9140.34
35_D38_A0.9120.34
50_G175_G0.9050.34
29_P40_A0.9020.34
79_T214_Q0.9020.34
193_D212_T0.9010.34
52_G110_G0.9010.34
110_G209_P0.9000.34
37_I47_V0.8940.33
171_A213_L0.8910.33
110_G246_R0.8860.33
37_I171_A0.8840.33
102_C129_E0.8780.32
52_G108_S0.8780.32
218_I223_P0.8770.32
141_A145_S0.8760.32
173_E248_D0.8750.32
169_T204_L0.8750.32
105_I130_F0.8730.32
136_V186_V0.8720.32
22_I75_F0.8710.32
69_E201_I0.8670.32
44_I171_A0.8630.32
173_E230_I0.8560.31
26_N213_L0.8500.31
94_H102_C0.8430.31
123_I132_V0.8420.30
137_G178_G0.8410.30
46_F194_I0.8400.30
228_A246_R0.8400.30
172_R246_R0.8280.30
154_E185_D0.8270.30
50_G209_P0.8260.30
68_K103_E0.8240.30
96_Y129_E0.8230.29
194_I211_K0.8200.29
32_F232_F0.8160.29
214_Q246_R0.8130.29
9_P152_W0.8120.29
171_A180_C0.8100.29
25_D63_K0.8100.29
230_I238_L0.8070.29
63_K214_Q0.8060.29
136_V152_W0.8060.29
60_L69_E0.8040.29
81_F210_N0.8020.28
53_T240_T0.8010.28
53_T110_G0.8010.28
110_G228_A0.7950.28
95_R189_Q0.7940.28
209_P213_L0.7940.28
172_R175_G0.7880.28
14_K248_D0.7870.28
199_I218_I0.7860.28
172_R245_L0.7810.27
209_P229_N0.7810.27
27_G214_Q0.7740.27
91_N148_S0.7690.27
134_S211_K0.7610.26
168_I186_V0.7590.26
78_G110_G0.7590.26
30_L60_L0.7550.26
80_L240_T0.7530.26
142_E145_S0.7530.26
76_F84_Y0.7470.26
30_L70_H0.7450.26
102_C169_T0.7430.26
229_N246_R0.7400.25
149_S189_Q0.7400.25
32_F97_C0.7390.25
53_T159_D0.7360.25
218_I238_L0.7310.25
160_M220_K0.7250.25
82_E214_Q0.7250.25
11_R19_G0.7240.25
29_P39_G0.7220.25
79_T172_R0.7160.24
58_K200_D0.7090.24
85_V103_E0.7070.24
42_D188_F0.7060.24
68_K195_I0.7030.24
202_N216_G0.7030.24
107_I183_S0.7010.24
169_T247_S0.7010.24
82_E239_E0.7010.24
117_K218_I0.7010.24
28_Y118_E0.7010.24
83_K87_Q0.7010.24
162_A190_I0.6990.24
59_D193_D0.6980.23
128_D223_P0.6980.23
25_D82_E0.6970.23
55_L134_S0.6930.23
28_Y72_I0.6920.23
105_I241_L0.6920.23
221_I225_V0.6870.23
71_D201_I0.6820.23
65_S99_Y0.6810.23
38_A72_I0.6800.23
135_E229_N0.6790.23
79_T175_G0.6780.23
67_L102_C0.6730.22
35_D39_G0.6720.22
102_C138_S0.6700.22
138_S169_T0.6680.22
211_K234_D0.6660.22
104_Y205_I0.6660.22
76_F138_S0.6660.22
25_D229_N0.6650.22
115_T199_I0.6640.22
14_K18_T0.6630.22
73_T131_L0.6620.22
26_N211_K0.6610.22
24_I51_W0.6570.22
44_I115_T0.6460.21
139_K229_N0.6410.21
29_P43_Y0.6400.21
65_S192_D0.6390.21
79_T246_R0.6370.21
174_S235_A0.6350.21
187_R219_Q0.6320.21
37_I93_F0.6320.21
90_V153_L0.6310.21
45_D239_E0.6300.21
112_L227_L0.6250.20
9_P119_K0.6240.20
40_A236_I0.6210.20
63_K229_N0.6190.20
128_D162_A0.6190.20
114_M235_A0.6190.20
56_L148_S0.6180.20
204_L223_P0.6170.20
51_W134_S0.6160.20
32_F72_I0.6150.20
107_I126_F0.6150.20
209_P246_R0.6110.20
231_P237_A0.6110.20
139_K214_Q0.6100.20
67_L169_T0.6050.20
49_F80_L0.6010.19
115_T205_I0.6000.19
41_S185_D0.5960.19
94_H98_T0.5930.19
53_T76_F0.5910.19
13_N161_E0.5910.19
29_P36_A0.5900.19
90_V99_Y0.5890.19
137_G244_G0.5880.19
24_I130_F0.5880.19
118_E121_A0.5850.19
133_L171_A0.5850.19
150_E193_D0.5820.19
122_Y126_F0.5810.19
38_A128_D0.5730.18
32_F49_F0.5720.18
124_A146_R0.5710.18
59_D219_Q0.5690.18
161_E191_V0.5660.18
127_S203_R0.5660.18
52_G245_L0.5660.18
136_V156_I0.5640.18
36_A194_I0.5630.18
108_S246_R0.5610.18
157_V164_A0.5590.18
211_K237_A0.5590.18
30_L71_D0.5520.18
61_E219_Q0.5490.18
99_Y223_P0.5470.17
154_E212_T0.5460.17
50_G110_G0.5460.17
208_A244_G0.5450.17
229_N245_L0.5450.17
110_G139_K0.5440.17
89_K125_D0.5410.17
184_G209_P0.5410.17
48_K207_E0.5410.17
42_D236_I0.5390.17
93_F164_A0.5390.17
152_W169_T0.5390.17
109_N206_F0.5320.17
78_G229_N0.5320.17
27_G245_L0.5310.17
31_Q39_G0.5310.17
71_D191_V0.5310.17
46_F191_V0.5310.17
152_W190_I0.5290.17
105_I154_E0.5280.17
216_G247_S0.5280.17
79_T209_P0.5280.17
39_G169_T0.5270.17
150_E230_I0.5240.17
51_W172_R0.5220.17
137_G207_E0.5210.17
49_F217_F0.5190.16
82_E87_Q0.5170.16
151_E185_D0.5160.16
37_I133_L0.5140.16
80_L235_A0.5120.16
175_G228_A0.5120.16
61_E99_Y0.5100.16
93_F97_C0.5090.16
63_K132_V0.5080.16
140_D237_A0.5030.16
135_E207_E0.5030.16
154_E195_I0.5030.16
51_W152_W0.5030.16
213_L246_R0.5020.16
85_V114_M0.5010.16
83_K218_I0.5010.16
54_S102_C0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u83A 3 0.8889 100 0.044 Contact Map
1qwgA 3 0.9762 100 0.068 Contact Map
3f4wA 2 0.8056 92.9 0.942 Contact Map
1ydnA 1 0.7937 90.9 0.945 Contact Map
2ftpA 3 0.8373 90.8 0.945 Contact Map
1i60A 1 0.6825 90.1 0.946 Contact Map
1qtwA 1 0.6786 88.9 0.947 Contact Map
3ngfA 1 0.6786 88.5 0.947 Contact Map
3ktcA 4 0.7341 87.9 0.948 Contact Map
2cw6A 5 0.8373 87.9 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.