PSLS - BACSU - GREMLIN Contacts

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PSLS - Phosphosulfolactate synthase

UniProt:	O06739	Sequences: MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYIDFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGCEYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDMEAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFIQKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	252 (237)
Sequences:	386 (279)
Seq/√Len:	18.1

BACSU - PSLS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_A	44_I	3.727	1.00
60_L	64_I	3.450	1.00
51_W	240_T	3.325	1.00
33_F	67_L	3.299	0.99
47_V	67_L	3.252	0.99
22_I	206_F	3.183	0.99
81_F	107_I	3.097	0.99
51_W	206_F	2.996	0.99
134_S	164_A	2.940	0.99
29_P	35_D	2.885	0.99
91_N	125_D	2.824	0.98
22_I	228_A	2.738	0.98
16_R	45_D	2.626	0.97
76_F	102_C	2.428	0.96
195_I	221_I	2.388	0.95
33_F	47_V	2.360	0.95
31_Q	34_K	2.348	0.95
65_S	69_E	2.320	0.94
181_S	185_D	2.197	0.93
64_I	74_F	2.142	0.92
31_Q	35_D	2.109	0.91
119_K	159_D	2.102	0.91
60_L	96_Y	2.085	0.90
34_K	62_E	2.074	0.90
111_T	247_S	1.948	0.87
127_S	165_E	1.923	0.86
43_Y	56_L	1.914	0.86
97_C	130_F	1.856	0.84
166_K	203_R	1.794	0.82
108_S	170_E	1.785	0.82
75_F	133_L	1.771	0.81
31_Q	38_A	1.704	0.79
28_Y	232_F	1.676	0.77
119_K	134_S	1.653	0.76
215_Q	240_T	1.598	0.74
78_G	108_S	1.588	0.73
173_E	211_K	1.575	0.73
208_A	225_V	1.550	0.72
124_A	127_S	1.540	0.71
71_D	161_E	1.539	0.71
218_I	225_V	1.522	0.70
81_F	122_Y	1.501	0.69
11_R	16_R	1.498	0.69
180_C	213_L	1.487	0.68
137_G	209_P	1.485	0.68
49_F	74_F	1.473	0.68
50_G	79_T	1.456	0.67
14_K	45_D	1.448	0.66
78_G	170_E	1.446	0.66
79_T	82_E	1.434	0.65
13_N	41_S	1.423	0.65
37_I	70_H	1.401	0.64
82_E	139_K	1.398	0.63
128_D	194_I	1.386	0.63
20_Q	107_I	1.379	0.62
78_G	135_E	1.367	0.62
139_K	209_P	1.359	0.61
67_L	74_F	1.352	0.61
90_V	94_H	1.350	0.61
110_G	172_R	1.344	0.60
162_A	227_L	1.341	0.60
33_F	37_I	1.340	0.60
130_F	204_L	1.336	0.60
50_G	246_R	1.320	0.59
187_R	190_I	1.293	0.57
11_R	239_E	1.277	0.56
23_L	153_L	1.269	0.56
108_S	135_E	1.259	0.55
166_K	205_I	1.257	0.55
191_V	216_G	1.239	0.54
72_I	199_I	1.223	0.53
175_G	246_R	1.222	0.53
133_L	179_I	1.216	0.52
22_I	51_W	1.201	0.52
94_H	129_E	1.194	0.51
179_I	191_V	1.191	0.51
210_N	213_L	1.189	0.51
78_G	245_L	1.172	0.50
77_G	170_E	1.164	0.49
37_I	66_T	1.161	0.49
27_G	132_V	1.161	0.49
41_S	72_I	1.158	0.49
94_H	126_F	1.154	0.49
217_F	227_L	1.153	0.49
135_E	170_E	1.144	0.48
61_E	65_S	1.142	0.48
61_E	127_S	1.136	0.48
137_G	170_E	1.123	0.47
67_L	152_W	1.119	0.46
227_L	230_I	1.114	0.46
17_E	114_M	1.107	0.46
179_I	238_L	1.106	0.46
110_G	245_L	1.099	0.45
209_P	214_Q	1.090	0.45
110_G	170_E	1.086	0.44
102_C	126_F	1.086	0.44
166_K	194_I	1.083	0.44
128_D	201_I	1.081	0.44
213_L	228_A	1.077	0.44
41_S	71_D	1.075	0.44
52_G	241_L	1.069	0.43
34_K	71_D	1.068	0.43
134_S	159_D	1.067	0.43
63_K	123_I	1.065	0.43
50_G	178_G	1.064	0.43
222_G	242_R	1.057	0.43
70_H	98_T	1.052	0.42
218_I	241_L	1.047	0.42
44_I	116_N	1.043	0.42
18_T	224_N	1.038	0.42
46_F	75_F	1.031	0.41
110_G	178_G	1.031	0.41
231_P	234_D	1.031	0.41
90_V	122_Y	1.020	0.40
88_K	171_A	1.011	0.40
110_G	175_G	1.003	0.39
71_D	88_K	1.002	0.39
79_T	110_G	1.002	0.39
11_R	15_P	1.000	0.39
13_N	38_A	0.999	0.39
97_C	105_I	0.995	0.39
101_G	203_R	0.993	0.39
171_A	241_L	0.993	0.39
131_L	223_P	0.989	0.39
142_E	247_S	0.980	0.38
140_D	224_N	0.979	0.38
27_G	63_K	0.977	0.38
156_I	167_V	0.975	0.38
131_L	203_R	0.975	0.38
206_F	210_N	0.970	0.38
136_V	167_V	0.964	0.37
15_P	45_D	0.961	0.37
230_I	248_D	0.955	0.37
170_E	207_E	0.955	0.37
99_Y	114_M	0.945	0.36
50_G	172_R	0.940	0.36
157_V	198_D	0.937	0.36
227_L	247_S	0.936	0.36
26_N	173_E	0.932	0.35
214_Q	245_L	0.931	0.35
44_I	156_I	0.929	0.35
175_G	209_P	0.924	0.35
170_E	209_P	0.920	0.35
209_P	245_L	0.920	0.35
47_V	200_D	0.918	0.35
73_T	103_E	0.917	0.35
179_I	230_I	0.914	0.34
35_D	38_A	0.912	0.34
50_G	175_G	0.905	0.34
29_P	40_A	0.902	0.34
79_T	214_Q	0.902	0.34
193_D	212_T	0.901	0.34
52_G	110_G	0.901	0.34
110_G	209_P	0.900	0.34
37_I	47_V	0.894	0.33
171_A	213_L	0.891	0.33
110_G	246_R	0.886	0.33
37_I	171_A	0.884	0.33
102_C	129_E	0.878	0.32
52_G	108_S	0.878	0.32
218_I	223_P	0.877	0.32
141_A	145_S	0.876	0.32
173_E	248_D	0.875	0.32
169_T	204_L	0.875	0.32
105_I	130_F	0.873	0.32
136_V	186_V	0.872	0.32
22_I	75_F	0.871	0.32
69_E	201_I	0.867	0.32
44_I	171_A	0.863	0.32
173_E	230_I	0.856	0.31
26_N	213_L	0.850	0.31
94_H	102_C	0.843	0.31
123_I	132_V	0.842	0.30
137_G	178_G	0.841	0.30
46_F	194_I	0.840	0.30
228_A	246_R	0.840	0.30
172_R	246_R	0.828	0.30
154_E	185_D	0.827	0.30
50_G	209_P	0.826	0.30
68_K	103_E	0.824	0.30
96_Y	129_E	0.823	0.29
194_I	211_K	0.820	0.29
32_F	232_F	0.816	0.29
214_Q	246_R	0.813	0.29
9_P	152_W	0.812	0.29
171_A	180_C	0.810	0.29
25_D	63_K	0.810	0.29
230_I	238_L	0.807	0.29
63_K	214_Q	0.806	0.29
136_V	152_W	0.806	0.29
60_L	69_E	0.804	0.29
81_F	210_N	0.802	0.28
53_T	240_T	0.801	0.28
53_T	110_G	0.801	0.28
110_G	228_A	0.795	0.28
95_R	189_Q	0.794	0.28
209_P	213_L	0.794	0.28
172_R	175_G	0.788	0.28
14_K	248_D	0.787	0.28
199_I	218_I	0.786	0.28
172_R	245_L	0.781	0.27
209_P	229_N	0.781	0.27
27_G	214_Q	0.774	0.27
91_N	148_S	0.769	0.27
134_S	211_K	0.761	0.26
168_I	186_V	0.759	0.26
78_G	110_G	0.759	0.26
30_L	60_L	0.755	0.26
80_L	240_T	0.753	0.26
142_E	145_S	0.753	0.26
76_F	84_Y	0.747	0.26
30_L	70_H	0.745	0.26
102_C	169_T	0.743	0.26
229_N	246_R	0.740	0.25
149_S	189_Q	0.740	0.25
32_F	97_C	0.739	0.25
53_T	159_D	0.736	0.25
218_I	238_L	0.731	0.25
160_M	220_K	0.725	0.25
82_E	214_Q	0.725	0.25
11_R	19_G	0.724	0.25
29_P	39_G	0.722	0.25
79_T	172_R	0.716	0.24
58_K	200_D	0.709	0.24
85_V	103_E	0.707	0.24
42_D	188_F	0.706	0.24
68_K	195_I	0.703	0.24
202_N	216_G	0.703	0.24
107_I	183_S	0.701	0.24
169_T	247_S	0.701	0.24
82_E	239_E	0.701	0.24
117_K	218_I	0.701	0.24
28_Y	118_E	0.701	0.24
83_K	87_Q	0.701	0.24
162_A	190_I	0.699	0.24
59_D	193_D	0.698	0.23
128_D	223_P	0.698	0.23
25_D	82_E	0.697	0.23
55_L	134_S	0.693	0.23
28_Y	72_I	0.692	0.23
105_I	241_L	0.692	0.23
221_I	225_V	0.687	0.23
71_D	201_I	0.682	0.23
65_S	99_Y	0.681	0.23
38_A	72_I	0.680	0.23
135_E	229_N	0.679	0.23
79_T	175_G	0.678	0.23
67_L	102_C	0.673	0.22
35_D	39_G	0.672	0.22
102_C	138_S	0.670	0.22
138_S	169_T	0.668	0.22
211_K	234_D	0.666	0.22
104_Y	205_I	0.666	0.22
76_F	138_S	0.666	0.22
25_D	229_N	0.665	0.22
115_T	199_I	0.664	0.22
14_K	18_T	0.663	0.22
73_T	131_L	0.662	0.22
26_N	211_K	0.661	0.22
24_I	51_W	0.657	0.22
44_I	115_T	0.646	0.21
139_K	229_N	0.641	0.21
29_P	43_Y	0.640	0.21
65_S	192_D	0.639	0.21
79_T	246_R	0.637	0.21
174_S	235_A	0.635	0.21
187_R	219_Q	0.632	0.21
37_I	93_F	0.632	0.21
90_V	153_L	0.631	0.21
45_D	239_E	0.630	0.21
112_L	227_L	0.625	0.20
9_P	119_K	0.624	0.20
40_A	236_I	0.621	0.20
63_K	229_N	0.619	0.20
128_D	162_A	0.619	0.20
114_M	235_A	0.619	0.20
56_L	148_S	0.618	0.20
204_L	223_P	0.617	0.20
51_W	134_S	0.616	0.20
32_F	72_I	0.615	0.20
107_I	126_F	0.615	0.20
209_P	246_R	0.611	0.20
231_P	237_A	0.611	0.20
139_K	214_Q	0.610	0.20
67_L	169_T	0.605	0.20
49_F	80_L	0.601	0.19
115_T	205_I	0.600	0.19
41_S	185_D	0.596	0.19
94_H	98_T	0.593	0.19
53_T	76_F	0.591	0.19
13_N	161_E	0.591	0.19
29_P	36_A	0.590	0.19
90_V	99_Y	0.589	0.19
137_G	244_G	0.588	0.19
24_I	130_F	0.588	0.19
118_E	121_A	0.585	0.19
133_L	171_A	0.585	0.19
150_E	193_D	0.582	0.19
122_Y	126_F	0.581	0.19
38_A	128_D	0.573	0.18
32_F	49_F	0.572	0.18
124_A	146_R	0.571	0.18
59_D	219_Q	0.569	0.18
161_E	191_V	0.566	0.18
127_S	203_R	0.566	0.18
52_G	245_L	0.566	0.18
136_V	156_I	0.564	0.18
36_A	194_I	0.563	0.18
108_S	246_R	0.561	0.18
157_V	164_A	0.559	0.18
211_K	237_A	0.559	0.18
30_L	71_D	0.552	0.18
61_E	219_Q	0.549	0.18
99_Y	223_P	0.547	0.17
154_E	212_T	0.546	0.17
50_G	110_G	0.546	0.17
208_A	244_G	0.545	0.17
229_N	245_L	0.545	0.17
110_G	139_K	0.544	0.17
89_K	125_D	0.541	0.17
184_G	209_P	0.541	0.17
48_K	207_E	0.541	0.17
42_D	236_I	0.539	0.17
93_F	164_A	0.539	0.17
152_W	169_T	0.539	0.17
109_N	206_F	0.532	0.17
78_G	229_N	0.532	0.17
27_G	245_L	0.531	0.17
31_Q	39_G	0.531	0.17
71_D	191_V	0.531	0.17
46_F	191_V	0.531	0.17
152_W	190_I	0.529	0.17
105_I	154_E	0.528	0.17
216_G	247_S	0.528	0.17
79_T	209_P	0.528	0.17
39_G	169_T	0.527	0.17
150_E	230_I	0.524	0.17
51_W	172_R	0.522	0.17
137_G	207_E	0.521	0.17
49_F	217_F	0.519	0.16
82_E	87_Q	0.517	0.16
151_E	185_D	0.516	0.16
37_I	133_L	0.514	0.16
80_L	235_A	0.512	0.16
175_G	228_A	0.512	0.16
61_E	99_Y	0.510	0.16
93_F	97_C	0.509	0.16
63_K	132_V	0.508	0.16
140_D	237_A	0.503	0.16
135_E	207_E	0.503	0.16
154_E	195_I	0.503	0.16
51_W	152_W	0.503	0.16
213_L	246_R	0.502	0.16
85_V	114_M	0.501	0.16
83_K	218_I	0.501	0.16
54_S	102_C	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1u83A	3	0.8889	100	0.044	Contact Map
1qwgA	3	0.9762	100	0.068	Contact Map
3f4wA	2	0.8056	92.9	0.942	Contact Map
1ydnA	1	0.7937	90.9	0.945	Contact Map
2ftpA	3	0.8373	90.8	0.945	Contact Map
1i60A	1	0.6825	90.1	0.946	Contact Map
1qtwA	1	0.6786	88.9	0.947	Contact Map
3ngfA	1	0.6786	88.5	0.947	Contact Map
3ktcA	4	0.7341	87.9	0.948	Contact Map
2cw6A	5	0.8373	87.9	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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