GREMLIN Database
COMB - Probable 2-phosphosulfolactate phosphatase
UniProt: O06738 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (206)
Sequences: 936 (716)
Seq/√Len: 49.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_K206_L4.2061.00
20_I129_V4.0691.00
125_T212_M3.2951.00
186_F190_R3.1601.00
29_T120_S3.0311.00
29_T202_C2.8521.00
80_S198_D2.7171.00
22_I139_I2.7161.00
67_E97_K2.6271.00
186_F189_C2.5451.00
197_E200_V2.5001.00
51_A95_I2.3981.00
113_H213_K2.2401.00
64_T84_M2.2381.00
117_T158_I2.2271.00
43_L93_S2.1721.00
41_E93_S2.0811.00
159_K171_A2.0731.00
26_R79_N2.0391.00
115_F128_H2.0321.00
34_A94_L1.9340.99
114_L214_V1.8890.99
204_K207_T1.8740.99
20_I125_T1.8520.99
182_V189_C1.8480.99
36_I208_G1.7690.99
45_V95_I1.7660.99
120_S208_G1.7540.99
18_I129_V1.6770.98
122_A157_Y1.6730.98
119_F153_A1.6360.98
31_A96_Q1.6300.98
161_I206_L1.6300.98
17_D138_V1.6290.98
125_T211_V1.6140.98
28_F116_V1.5790.97
186_F191_Q1.5650.97
26_R198_D1.5600.97
25_I203_T1.5540.97
78_D83_R1.5300.97
113_H132_L1.5230.97
31_A42_I1.5160.97
33_Y201_Y1.5090.97
48_A97_K1.5030.97
124_T211_V1.5030.97
185_K189_C1.4680.96
182_V191_Q1.4680.96
77_L88_N1.4410.96
117_T125_T1.4290.95
187_F190_R1.3940.95
129_V137_C1.3690.94
160_G179_G1.3680.94
55_K76_D1.3620.94
178_K205_E1.3590.94
20_I139_I1.3440.94
129_V158_I1.3420.94
54_L95_I1.3420.94
26_R80_S1.3300.93
115_F132_L1.3250.93
130_K162_I1.3200.93
52_F55_K1.3150.93
117_T129_V1.3110.93
152_M174_I1.3050.93
63_L72_I1.2950.92
139_I158_I1.2910.92
168_V171_A1.2860.92
123_K127_Q1.2650.91
28_F142_V1.2450.91
98_T102_V1.2420.91
24_V154_C1.2380.91
214_V219_E1.2310.90
128_H132_L1.2280.90
34_A39_A1.2240.90
79_N198_D1.2030.89
125_T158_I1.2010.89
115_F125_T1.1910.89
32_H120_S1.1880.89
154_C158_I1.1750.88
32_H118_G1.1650.88
182_V186_F1.1540.87
116_V219_E1.1530.87
186_F203_T1.1280.86
30_V84_M1.1270.86
32_H116_V1.1160.85
112_K134_A1.1150.85
169_T178_K1.1140.85
216_Q219_E1.1130.85
201_Y208_G1.1100.85
182_V185_K1.1070.85
111_A114_L1.1020.85
123_K161_I1.0900.84
26_R202_C1.0830.83
127_Q131_K1.0800.83
24_V116_V1.0720.83
27_A102_V1.0710.83
21_V108_A1.0670.83
183_A186_F1.0530.82
47_T50_E1.0530.82
79_N202_C1.0490.81
62_V77_L1.0480.81
108_A140_N1.0450.81
100_N121_N1.0430.81
19_N138_V1.0380.81
37_G89_M1.0370.81
127_Q130_K1.0270.80
187_F191_Q1.0170.79
21_V28_F1.0150.79
22_I155_A0.9620.75
149_D173_A0.9620.75
119_F154_C0.9620.75
17_D135_N0.9600.75
27_A98_T0.9550.75
34_A44_L0.9550.75
55_K59_P0.9520.75
42_I114_L0.9510.75
71_G83_R0.9410.74
149_D156_E0.9400.74
156_E174_I0.9400.74
80_S202_C0.9390.74
175_E179_G0.9330.73
76_D79_N0.9320.73
86_G90_T0.9310.73
88_N92_K0.9300.73
30_V150_D0.9270.73
106_L109_L0.9270.73
30_V65_G0.9240.72
53_A165_T0.8990.70
30_V35_F0.8980.70
104_A142_V0.8960.70
129_V132_L0.8930.70
21_V128_H0.8890.70
141_I155_A0.8770.68
45_V51_A0.8740.68
22_I154_C0.8730.68
64_T94_L0.8670.68
174_I178_K0.8670.68
182_V187_F0.8670.68
28_F31_A0.8660.68
144_S148_G0.8610.67
31_A212_M0.8600.67
115_F129_V0.8580.67
19_N111_A0.8550.67
24_V119_F0.8550.67
45_V54_L0.8500.66
173_A177_I0.8450.66
100_N142_V0.8430.65
35_F210_F0.8410.65
60_D64_T0.8400.65
159_K175_E0.8340.65
40_K93_S0.8330.64
53_A57_T0.8300.64
39_A89_M0.8240.64
28_F174_I0.8220.63
16_A19_N0.8160.63
156_E178_K0.8160.63
20_I115_F0.8150.63
41_E218_G0.8130.63
35_F212_M0.8130.63
127_Q165_T0.8090.62
181_S187_F0.8020.62
27_A66_E0.8000.61
33_Y84_M0.7920.61
66_E75_F0.7900.60
185_K191_Q0.7870.60
26_R67_E0.7860.60
81_P151_D0.7860.60
36_I94_L0.7820.60
156_E159_K0.7780.59
65_G83_R0.7750.59
65_G72_I0.7730.59
157_Y178_K0.7720.59
20_I117_T0.7660.58
128_H213_K0.7660.58
67_E79_N0.7650.58
42_I96_Q0.7580.57
31_A116_V0.7580.57
184_E190_R0.7560.57
22_I63_L0.7550.57
65_G75_F0.7550.57
66_E102_V0.7510.56
35_F65_G0.7490.56
63_L75_F0.7460.56
184_E189_C0.7370.55
52_F56_D0.7350.55
109_L114_L0.7320.55
184_E187_F0.7300.54
32_H208_G0.7220.54
160_G172_E0.7210.53
160_G175_E0.7070.52
21_V44_L0.7060.52
29_T71_G0.7060.52
200_V204_K0.7020.51
44_L139_I0.7000.51
55_K63_L0.6990.51
117_T206_L0.6960.51
74_G94_L0.6880.50
101_G150_D0.6820.49
14_A112_K0.6800.49
122_A206_L0.6750.49
26_R144_S0.6740.49
105_A108_A0.6710.48
126_A154_C0.6710.48
198_D202_C0.6660.48
34_A64_T0.6590.47
72_I75_F0.6580.47
129_V218_G0.6580.47
31_A105_A0.6570.47
128_H211_V0.6560.47
33_Y37_G0.6520.46
39_A94_L0.6490.46
130_K164_G0.6490.46
25_I202_C0.6460.46
62_V89_M0.6450.46
99_T146_P0.6430.45
71_G199_I0.6430.45
82_K85_A0.6400.45
50_E53_A0.6380.45
52_F75_F0.6360.45
17_D178_K0.6350.45
100_N104_A0.6340.45
157_Y161_I0.6330.44
42_I62_V0.6320.44
108_A114_L0.6290.44
182_V190_R0.6280.44
149_D152_M0.6250.44
184_E188_D0.6230.43
154_C202_C0.6200.43
105_A214_V0.6160.43
83_R194_F0.6150.43
144_S157_Y0.6150.43
163_E175_E0.6150.43
160_G163_E0.6130.42
35_F42_I0.6130.42
115_F202_C0.6120.42
28_F117_T0.6120.42
99_T102_V0.6100.42
141_I169_T0.6090.42
43_L95_I0.6090.42
28_F194_F0.6070.42
154_C157_Y0.6070.42
149_D153_A0.6060.42
196_S199_I0.6060.42
26_R76_D0.6060.42
35_F39_A0.6010.41
53_A56_D0.5980.41
133_V159_K0.5930.40
69_G74_G0.5900.40
141_I149_D0.5890.40
174_I177_I0.5880.40
152_M177_I0.5860.40
84_M89_M0.5860.40
66_E69_G0.5840.40
19_N102_V0.5830.39
157_Y205_E0.5790.39
183_A190_R0.5750.39
41_E197_E0.5750.39
85_A88_N0.5750.39
66_E99_T0.5740.39
74_G83_R0.5740.39
119_F126_A0.5730.38
20_I126_A0.5730.38
82_K197_E0.5720.38
20_I218_G0.5720.38
142_V194_F0.5660.38
173_A200_V0.5660.38
122_A154_C0.5650.38
92_K104_A0.5610.37
104_A141_I0.5590.37
27_A99_T0.5590.37
26_R83_R0.5570.37
145_H197_E0.5570.37
20_I173_A0.5570.37
101_G151_D0.5550.37
103_T137_C0.5520.36
52_F71_G0.5510.36
29_T203_T0.5500.36
139_I187_F0.5470.36
28_F169_T0.5470.36
119_F203_T0.5470.36
99_T138_V0.5460.36
100_N156_E0.5460.36
46_R103_T0.5450.36
28_F100_N0.5440.36
130_K165_T0.5370.35
52_F127_Q0.5370.35
52_F158_I0.5360.35
76_D80_S0.5330.35
47_T97_K0.5310.35
105_A116_V0.5300.34
40_K43_L0.5220.34
133_V209_D0.5200.33
86_G89_M0.5200.33
159_K195_D0.5190.33
81_P101_G0.5180.33
126_A158_I0.5180.33
22_I62_V0.5160.33
114_L193_L0.5140.33
125_T129_V0.5140.33
122_A129_V0.5140.33
149_D211_V0.5110.33
33_Y120_S0.5090.32
45_V105_A0.5090.32
134_A209_D0.5060.32
20_I158_I0.5060.32
171_A211_V0.5050.32
78_D152_M0.5050.32
51_A152_M0.5030.32
77_L94_L0.5020.32
100_N195_D0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vr0A 2 0.9605 100 0.145 Contact Map
2z0jA 3 0.9825 100 0.17 Contact Map
2yyvA 2 0.9298 100 0.176 Contact Map
2z5eA 2 0.5088 18.5 0.959 Contact Map
4au1A 2 0.6272 17.1 0.96 Contact Map
3e7dA 2 0.636 11.7 0.962 Contact Map
1v9cA 2 0.6667 11.6 0.962 Contact Map
2p10A 5 0.7675 11.6 0.962 Contact Map
1f2vA 2 0.6404 10 0.964 Contact Map
2j48A 1 0.5 8.5 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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