GREMLIN Database
CYSH2 - Probable phosphoadenosine phosphosulfate reductase
UniProt: O06737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (203)
Sequences: 4660 (2733)
Seq/√Len: 191.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K139_T4.2871.00
192_Y197_D4.1921.00
55_D59_K3.4121.00
113_E116_K2.8371.00
29_L142_I2.7471.00
76_Q80_E2.7321.00
55_D184_Y2.4081.00
122_C208_C2.4041.00
124_Q129_E2.3801.00
65_H95_Q2.2291.00
84_T88_R2.2171.00
80_E84_T2.0741.00
36_Y140_A2.0481.00
121_L124_Q1.9881.00
148_D178_W1.9801.00
59_K188_H1.9561.00
54_L66_I1.9511.00
59_K184_Y1.9001.00
180_D183_T1.8971.00
122_C205_C1.8771.00
31_W35_T1.8771.00
48_A185_I1.8331.00
106_Q111_G1.8291.00
177_T180_D1.7671.00
205_C208_C1.7671.00
28_V158_Y1.7611.00
129_E133_K1.7511.00
183_T187_L1.7371.00
216_N220_A1.7221.00
176_W184_Y1.7131.00
105_E109_K1.7091.00
68_F74_H1.6971.00
70_D79_Y1.6901.00
76_Q206_E1.6561.00
123_C208_C1.6161.00
55_D58_S1.5681.00
97_L134_H1.5431.00
70_D96_M1.5361.00
143_S171_C1.5141.00
84_T191_P1.4991.00
123_C205_C1.4921.00
32_A40_I1.4851.00
217_D220_A1.4741.00
53_L142_I1.4741.00
140_A170_I1.4541.00
156_I174_I1.4501.00
107_G111_G1.4461.00
78_T193_N1.4381.00
201_P212_S1.4181.00
104_T108_T1.4151.00
30_K60_I1.4031.00
55_D188_H1.3931.00
25_E56_L1.3841.00
27_D30_K1.3671.00
179_D183_T1.3641.00
36_Y168_I1.3591.00
54_L85_V1.3561.00
48_A203_I1.3561.00
42_Y57_I1.3521.00
157_Q160_N1.3491.00
29_L57_I1.3311.00
147_R174_I1.3251.00
88_R189_N1.3191.00
210_L224_A1.3111.00
182_W192_Y1.2971.00
32_A170_I1.2941.00
196_H201_P1.2811.00
56_L60_I1.2731.00
28_V175_H1.2721.00
77_E198_Q1.2711.00
41_V67_I1.2631.00
42_Y53_L1.2611.00
29_L56_L1.2401.00
26_L59_K1.2351.00
53_L173_L1.2321.00
219_R222_R1.2301.00
148_D177_T1.2071.00
145_L156_I1.2061.00
132_K165_F1.2001.00
46_F82_I1.1841.00
184_Y188_H1.1831.00
83_E86_K1.1691.00
83_E87_E1.1601.00
30_K34_R1.1381.00
26_L30_K1.1361.00
100_E104_T1.1281.00
56_L184_Y1.1231.00
178_W182_W1.1211.00
26_L56_L1.1201.00
198_Q211_P1.1161.00
108_T111_G1.1131.00
52_V185_I1.1001.00
40_I140_A1.0861.00
52_V181_V1.0861.00
145_L171_C1.0831.00
161_L168_I1.0731.00
73_L207_M1.0671.00
67_I134_H1.0661.00
178_W218_E1.0611.00
52_V184_Y1.0601.00
195_L203_I1.0541.00
47_G50_G1.0491.00
40_I142_I1.0481.00
147_R175_H1.0371.00
24_D27_D1.0321.00
48_A182_W1.0281.00
213_P216_N1.0241.00
182_W186_R1.0201.00
106_Q110_Y1.0181.00
192_Y196_H1.0171.00
89_Y92_F1.0151.00
51_M85_V1.0081.00
132_K136_S1.0081.00
55_D89_Y1.0031.00
86_K94_I0.9950.99
63_N93_A0.9920.99
119_P226_R0.9800.99
52_V55_D0.9620.99
94_I99_P0.9580.99
145_L174_I0.9570.99
33_Y36_Y0.9410.99
185_I190_L0.9410.99
26_L60_I0.9400.99
182_W196_H0.9390.99
82_I86_K0.9270.99
185_I192_Y0.9080.99
57_I64_A0.9060.99
135_L141_W0.9060.99
65_H93_A0.9040.99
151_P154_K0.8990.99
23_I27_D0.8960.99
45_S50_G0.8940.99
159_V170_I0.8930.99
48_A196_H0.8920.99
65_H138_M0.8870.99
121_L125_L0.8850.99
27_D31_W0.8810.99
156_I160_N0.8780.99
55_D190_L0.8760.99
28_V170_I0.8740.99
86_K93_A0.8730.99
100_E129_E0.8650.99
161_L166_E0.8630.99
210_L220_A0.8610.99
101_L105_E0.8590.99
123_C127_K0.8580.99
103_L106_Q0.8560.98
85_V89_Y0.8520.98
158_Y175_H0.8510.98
163_Q166_E0.8430.98
58_S89_Y0.8420.98
79_Y82_I0.8400.98
52_V173_L0.8330.98
104_T107_G0.8330.98
21_Q24_D0.8320.98
183_T186_R0.8230.98
129_E132_K0.8230.98
122_C127_K0.8200.98
25_E176_W0.8150.98
66_I92_F0.8130.98
43_A67_I0.8050.98
77_E80_E0.8040.98
122_C126_R0.8000.98
80_E83_E0.7990.98
71_T127_K0.7960.98
202_S221_G0.7920.97
219_R223_W0.7830.97
22_L26_L0.7800.97
102_S105_E0.7780.97
110_Y121_L0.7740.97
97_L133_K0.7720.97
202_S209_T0.7700.97
44_C85_V0.7620.97
194_K198_Q0.7560.97
75_F195_L0.7550.97
49_E149_Q0.7540.97
210_L216_N0.7520.97
75_F200_Y0.7490.96
103_L107_G0.7470.96
52_V176_W0.7390.96
62_K92_F0.7380.96
106_Q114_L0.7320.96
216_N219_R0.7290.96
51_M81_L0.7260.96
21_Q180_D0.7260.96
41_V138_M0.7250.96
44_C51_M0.7220.96
41_V141_W0.7130.95
58_S92_F0.7120.95
25_E32_A0.7090.95
214_D217_D0.7070.95
82_I96_M0.7020.95
157_Q174_I0.7020.95
115_W118_N0.6970.95
103_L111_G0.6940.95
81_L192_Y0.6930.95
68_F82_I0.6930.95
114_L121_L0.6880.94
186_R197_D0.6870.94
72_G98_E0.6830.94
73_L103_L0.6810.94
107_G115_W0.6790.94
127_K205_C0.6780.94
24_D175_H0.6780.94
54_L89_Y0.6760.94
119_P126_R0.6760.94
84_T194_K0.6740.94
73_L205_C0.6710.94
77_E194_K0.6700.94
104_T115_W0.6580.93
122_C130_P0.6570.93
178_W201_P0.6560.93
57_I62_K0.6550.93
28_V32_A0.6540.93
48_A149_Q0.6540.93
102_S106_Q0.6530.93
119_P122_C0.6490.92
122_C125_L0.6490.92
86_K96_M0.6470.92
89_Y190_L0.6440.92
208_C224_A0.6430.92
158_Y174_I0.6420.92
114_L125_L0.6410.92
86_K92_F0.6410.92
73_L206_E0.6390.92
93_A99_P0.6360.92
58_S62_K0.6340.92
219_R224_A0.6250.91
114_L117_H0.6240.91
54_L92_F0.6230.91
176_W180_D0.6200.91
160_N171_C0.6190.91
84_T87_E0.6130.90
88_R191_P0.6100.90
45_S144_G0.6090.90
150_S153_R0.6060.90
22_L187_L0.5990.89
49_E196_H0.5980.89
57_I142_I0.5970.89
195_L200_Y0.5960.89
69_L202_S0.5930.89
154_K174_I0.5910.89
25_E28_V0.5900.88
74_H202_S0.5890.88
81_L194_K0.5820.88
161_L165_F0.5820.88
93_A96_M0.5810.88
83_E96_M0.5810.88
132_K164_K0.5760.87
61_N64_A0.5760.87
78_T203_I0.5710.87
43_A201_P0.5680.87
32_A140_A0.5680.87
49_E182_W0.5650.86
45_S205_C0.5650.86
70_D98_E0.5650.86
127_K153_R0.5640.86
45_S150_S0.5630.86
216_N224_A0.5600.86
38_E65_H0.5600.86
110_Y114_L0.5600.86
69_L143_S0.5590.86
31_W159_V0.5530.85
93_A97_L0.5520.85
102_S129_E0.5490.85
71_T205_C0.5460.84
114_L118_N0.5450.84
67_I97_L0.5430.84
69_L97_L0.5400.84
141_W169_K0.5400.84
212_S216_N0.5380.83
127_K130_P0.5350.83
115_W121_L0.5340.83
24_D158_Y0.5340.83
43_A141_W0.5330.83
182_W185_I0.5330.83
120_N226_R0.5310.83
97_L137_G0.5310.83
47_G149_Q0.5300.83
200_Y211_P0.5300.83
69_L131_L0.5270.82
131_L135_L0.5260.82
218_E222_R0.5220.82
104_T111_G0.5220.82
146_R182_W0.5200.81
73_L107_G0.5200.81
74_H127_K0.5180.81
59_K179_D0.5170.81
71_T204_G0.5150.81
141_W167_L0.5140.81
162_D165_F0.5140.81
68_F79_Y0.5130.80
161_L167_L0.5120.80
161_L164_K0.5100.80
107_G110_Y0.5090.80
46_F149_Q0.5080.80
30_K33_Y0.5080.80
39_K137_G0.5070.80
77_E195_L0.5050.79
25_E158_Y0.5050.79
95_Q137_G0.5040.79
94_I100_E0.5000.79
24_D28_V0.5000.79
47_G181_V0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwvA 2 0.9025 100 0.279 Contact Map
2oq2A 2 0.9958 100 0.285 Contact Map
2goyA 3 0.8941 100 0.331 Contact Map
2o8vA 2 0.9025 100 0.35 Contact Map
1zunA 1 0.7246 100 0.398 Contact Map
3fwkA 1 0.8941 100 0.429 Contact Map
2wsiA 1 0.8856 100 0.446 Contact Map
1surA 2 0.8517 100 0.521 Contact Map
2ywbA 4 0.9364 99.8 0.694 Contact Map
2dplA 2 0.822 99.8 0.698 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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