GREMLIN Database
SAT2 - Probable sulfate adenylyltransferase
UniProt: O06736 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (370)
Sequences: 1077 (579)
Seq/√Len: 30.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_D68_A4.8001.00
55_E59_H4.2351.00
95_V107_I4.1981.00
112_I146_I4.0651.00
111_D147_G3.9571.00
230_E372_K3.9191.00
63_K119_Q3.7321.00
294_D297_N3.4641.00
163_F233_Q3.4231.00
27_Q98_V3.4211.00
122_L128_N3.4061.00
291_G294_D3.3911.00
60_S64_E3.2201.00
136_K140_A2.9921.00
54_G111_D2.9691.00
173_A177_L2.8991.00
110_T149_P2.7611.00
55_E111_D2.7591.00
126_K294_D2.7581.00
89_L109_V2.7241.00
349_E353_Q2.7211.00
7_H270_K2.6461.00
94_H108_T2.5971.00
184_G274_C2.5831.00
21_F94_H2.5570.99
66_R306_E2.5560.99
85_T88_Q2.5480.99
323_C332_C2.5340.99
173_A176_K2.5330.99
108_T151_T2.5290.99
26_C93_D2.5120.99
96_K103_T2.4250.99
83_E143_D2.3110.99
74_S263_I2.2880.99
50_T149_P2.2750.99
22_E96_K2.2500.99
335_S338_D2.2080.98
54_G57_D2.1750.98
53_L61_V2.1750.98
117_K143_D2.1670.98
350_L357_P2.1520.98
320_C323_C2.1090.98
89_L146_I2.1090.98
322_K338_D2.0910.98
155_L166_T2.0770.98
83_E87_R2.0630.98
210_L248_S2.0420.97
114_Q144_Y2.0330.97
199_Q240_Y2.0260.97
34_A80_P2.0150.97
362_S367_A2.0090.97
54_G110_T1.9600.97
170_T174_F1.9330.96
22_E25_A1.8820.96
31_D34_A1.8820.96
165_A248_S1.8780.96
356_K368_A1.8780.96
129_D289_Y1.8750.96
83_E114_Q1.8600.96
250_F264_F1.8400.95
237_N242_K1.8270.95
270_K308_G1.8240.95
190_P228_R1.8240.95
323_C334_H1.7790.94
130_P139_L1.7740.94
196_E363_R1.7290.93
118_T128_N1.7240.93
105_G153_S1.7220.93
172_A176_K1.7090.93
230_E369_V1.7000.93
14_R151_T1.7000.93
357_P371_I1.6660.92
186_Q254_M1.6330.91
320_C332_C1.6090.91
109_V146_I1.6070.91
102_V154_S1.6020.90
300_Q313_F1.5870.90
63_K123_S1.5790.90
368_A372_K1.5740.90
38_L150_I1.5680.89
58_Y120_E1.5660.89
343_S348_R1.5570.89
13_N17_P1.5440.89
13_N168_A1.5100.87
115_P145_Y1.4830.87
21_F25_A1.4730.86
28_A107_I1.4690.86
162_Q233_Q1.4630.86
38_L104_Y1.4600.86
72_P302_F1.4560.85
184_G198_I1.4450.85
119_Q123_S1.4340.85
173_A246_M1.4320.85
234_A369_V1.4320.85
35_L104_Y1.4050.83
205_T312_L1.3880.83
223_I228_R1.3750.82
31_D141_R1.3720.82
213_P232_Y1.3630.81
91_A112_I1.3520.81
189_N281_R1.3430.80
6_P9_G1.3410.80
29_E98_V1.3410.80
126_K301_S1.3370.80
250_F268_V1.3270.80
364_P368_A1.2940.78
47_S171_R1.2930.78
127_T135_V1.2810.77
83_E86_A1.2600.76
316_H341_H1.2480.75
16_D151_T1.2360.75
78_T145_Y1.2330.74
54_G147_G1.2300.74
317_S328_T1.2250.74
186_Q189_N1.2180.73
231_S369_V1.2040.73
9_G47_S1.1990.72
107_I146_I1.1980.72
297_N300_Q1.1920.72
16_D19_C1.1700.70
29_E101_G1.1550.69
188_R216_G1.1490.69
294_D298_I1.1420.68
261_E265_H1.1380.68
170_T210_L1.1360.68
281_R343_S1.1340.68
164_Y229_M1.1310.68
16_D25_A1.1270.67
224_P227_I1.1260.67
181_T275_T1.1220.67
38_L105_G1.1150.67
40_L105_G1.1120.66
33_L137_K1.1020.66
123_S126_K1.1010.66
218_T228_R1.1010.66
345_T348_R1.0980.65
12_I125_F1.0940.65
188_R254_M1.0910.65
190_P223_I1.0900.65
25_A94_H1.0900.65
39_E152_V1.0860.64
28_A95_V1.0810.64
54_G149_P1.0760.64
65_M298_I1.0730.64
281_R345_T1.0710.63
369_V372_K1.0710.63
165_A170_T1.0710.63
223_I374_L1.0700.63
16_D21_F1.0590.62
189_N343_S1.0570.62
357_P367_A1.0570.62
189_N348_R1.0540.62
347_V357_P1.0510.62
344_G348_R1.0510.62
32_Q99_K1.0500.62
30_L34_A1.0360.61
346_K350_L1.0350.61
320_C334_H1.0340.61
40_L45_G1.0330.61
16_D20_H1.0190.59
194_A342_L1.0150.59
356_K359_K1.0100.59
251_P272_Y1.0100.59
112_I129_D1.0080.59
165_A173_A1.0040.58
174_F210_L1.0030.58
82_G142_P0.9890.57
30_L38_L0.9770.56
282_D285_G0.9750.56
216_G269_R0.9680.56
127_T274_C0.9650.55
25_A96_K0.9610.55
62_V123_S0.9550.54
12_I50_T0.9530.54
324_G359_K0.9510.54
147_G357_P0.9500.54
109_V112_I0.9500.54
254_M265_H0.9480.54
185_F261_E0.9480.54
126_K297_N0.9390.53
184_G277_F0.9380.53
55_E114_Q0.9340.53
59_H119_Q0.9300.52
37_D253_A0.9290.52
37_D255_R0.9290.52
189_N280_G0.9250.52
28_A146_I0.9220.52
82_G85_T0.9200.52
190_P218_T0.9200.52
216_G222_D0.9140.51
313_F328_T0.9140.51
172_A175_Q0.9110.51
210_L274_C0.9100.51
281_R344_G0.9080.51
191_V211_L0.9000.50
14_R19_C0.9000.50
114_Q143_D0.9000.50
315_E342_L0.8950.50
222_D254_M0.8930.50
346_K349_E0.8930.50
118_T130_P0.8890.49
189_N345_T0.8880.49
233_Q237_N0.8850.49
281_R348_R0.8820.49
191_V228_R0.8730.48
18_A21_F0.8710.48
342_L347_V0.8670.47
56_K111_D0.8650.47
324_G355_K0.8620.47
24_C106_M0.8590.47
189_N344_G0.8570.47
95_V146_I0.8550.47
189_N195_H0.8460.46
117_K145_Y0.8450.46
56_K68_A0.8430.46
269_R343_S0.8420.46
84_K87_R0.8410.45
40_L43_I0.8400.45
254_M269_R0.8380.45
120_E145_Y0.8380.45
281_R293_Y0.8360.45
142_P146_I0.8350.45
269_R281_R0.8290.44
327_G331_T0.8260.44
149_P233_Q0.8150.43
119_Q122_L0.8150.43
184_G199_Q0.8140.43
28_A311_P0.8140.43
29_E100_D0.8130.43
265_H344_G0.8130.43
188_R348_R0.8120.43
121_A138_L0.8110.43
188_R222_D0.8110.43
33_L141_R0.8090.43
340_I346_K0.8010.42
280_G285_G0.8000.42
43_I267_L0.8000.42
51_G73_W0.7970.42
216_G348_R0.7960.42
188_R265_H0.7930.42
350_L355_K0.7920.42
356_K364_P0.7910.42
212_H269_R0.7910.42
281_R284_A0.7880.41
96_K105_G0.7860.41
125_F138_L0.7840.41
293_Y315_E0.7810.41
164_Y251_P0.7790.41
112_I147_G0.7790.41
197_Y318_F0.7780.41
188_R280_G0.7750.40
317_S326_M0.7750.40
23_G27_Q0.7730.40
105_G147_G0.7720.40
89_L372_K0.7710.40
216_G254_M0.7700.40
81_V146_I0.7690.40
41_I47_S0.7690.40
282_D293_Y0.7680.40
89_L112_I0.7680.40
265_H281_R0.7680.40
16_D96_K0.7660.40
169_E172_A0.7640.39
195_H343_S0.7630.39
186_Q222_D0.7600.39
112_I144_Y0.7580.39
285_G345_T0.7550.39
6_P11_L0.7550.39
186_Q284_A0.7520.39
34_A141_R0.7500.38
158_K164_Y0.7490.38
174_F246_M0.7480.38
261_E284_A0.7450.38
101_G154_S0.7450.38
20_H151_T0.7440.38
44_G171_R0.7400.38
23_G26_C0.7390.38
58_Y145_Y0.7360.37
209_L308_G0.7320.37
94_H151_T0.7300.37
28_A85_T0.7260.37
318_F339_H0.7250.37
125_F157_D0.7240.36
218_T223_I0.7220.36
232_Y247_L0.7200.36
195_H280_G0.7190.36
146_I237_N0.7170.36
203_L244_R0.7160.36
189_N219_K0.7160.36
59_H62_V0.7160.36
221_D352_R0.7130.36
240_Y314_F0.7130.36
319_Y324_G0.7110.36
254_M284_A0.7100.35
86_A144_Y0.7090.35
254_M281_R0.7070.35
134_G261_E0.7060.35
78_T198_I0.7050.35
56_K95_V0.7030.35
356_K371_I0.7020.35
28_A32_Q0.7020.35
89_L95_V0.7010.35
71_L267_L0.7000.35
118_T139_L0.7000.35
22_E103_T0.6990.35
184_G202_A0.6980.35
288_S305_E0.6980.35
185_F265_H0.6930.34
14_R17_P0.6910.34
281_R285_G0.6910.34
316_H342_L0.6890.34
231_S373_G0.6880.34
108_T149_P0.6880.34
320_C327_G0.6870.34
211_L229_M0.6870.34
101_G178_G0.6860.34
280_G344_G0.6830.33
55_E119_Q0.6830.33
33_L46_Y0.6820.33
332_C339_H0.6820.33
216_G259_P0.6810.33
185_F213_P0.6800.33
101_G139_L0.6800.33
34_A147_G0.6790.33
76_P192_H0.6790.33
91_A111_D0.6760.33
271_N290_Y0.6760.33
30_L248_S0.6710.33
266_A279_V0.6700.33
265_H284_A0.6700.33
321_R340_I0.6700.33
166_T169_E0.6660.32
62_V119_Q0.6650.32
10_V23_G0.6650.32
170_T311_P0.6650.32
261_E344_G0.6620.32
142_P311_P0.6620.32
45_G268_V0.6620.32
115_P144_Y0.6610.32
303_T306_E0.6590.32
150_I153_S0.6570.32
9_G12_I0.6570.32
195_H285_G0.6570.32
322_K337_R0.6560.32
215_V249_V0.6540.31
269_R282_D0.6530.31
40_L240_Y0.6530.31
81_V112_I0.6520.31
214_L252_A0.6500.31
26_C88_Q0.6500.31
181_T310_K0.6500.31
350_L358_P0.6500.31
104_Y373_G0.6480.31
65_M260_R0.6480.31
14_R18_A0.6480.31
193_R228_R0.6450.31
198_I374_L0.6430.31
186_Q269_R0.6420.31
326_M330_K0.6420.31
218_T252_A0.6410.31
157_D164_Y0.6400.31
222_D348_R0.6400.31
225_S228_R0.6400.31
42_A150_I0.6390.30
69_N233_Q0.6390.30
189_N222_D0.6380.30
195_H344_G0.6380.30
114_Q294_D0.6340.30
150_I166_T0.6320.30
18_A23_G0.6320.30
232_Y253_A0.6320.30
186_Q281_R0.6310.30
302_F306_E0.6300.30
362_S366_V0.6300.30
195_H348_R0.6290.30
228_R251_P0.6240.29
15_C155_L0.6240.29
98_V103_T0.6240.29
188_R344_G0.6220.29
74_S264_F0.6220.29
265_H283_H0.6200.29
55_E88_Q0.6200.29
261_E269_R0.6190.29
116_D119_Q0.6180.29
15_C18_A0.6170.29
191_V199_Q0.6150.29
188_R269_R0.6150.29
46_Y111_D0.6120.29
195_H282_D0.6120.29
254_M344_G0.6110.29
349_E357_P0.6110.29
219_K281_R0.6100.29
219_K345_T0.6100.29
226_D230_E0.6090.28
280_G348_R0.6080.28
200_K206_V0.6080.28
15_C20_H0.6070.28
189_N254_M0.6040.28
220_S226_D0.6030.28
21_F26_C0.6020.28
317_S341_H0.6020.28
158_K161_E0.6010.28
140_A157_D0.5980.28
261_E283_H0.5980.28
211_L236_L0.5970.28
104_Y230_E0.5950.28
44_G48_P0.5940.28
323_C327_G0.5930.27
125_F129_D0.5930.27
186_Q343_S0.5920.27
261_E343_S0.5910.27
12_I42_A0.5910.27
120_E251_P0.5910.27
142_P182_I0.5900.27
124_V187_T0.5890.27
282_D343_S0.5890.27
188_R281_R0.5890.27
72_P95_V0.5870.27
12_I47_S0.5860.27
189_N261_E0.5860.27
132_H261_E0.5860.27
27_Q176_K0.5850.27
65_M257_A0.5850.27
74_S252_A0.5850.27
69_N98_V0.5850.27
267_L307_L0.5840.27
18_A96_K0.5840.27
187_T309_I0.5820.27
122_L177_L0.5810.27
209_L307_L0.5800.27
41_I293_Y0.5790.27
54_G107_I0.5780.27
36_S46_Y0.5770.26
218_T251_P0.5760.26
219_K314_F0.5760.26
287_G290_Y0.5750.26
219_K344_G0.5750.26
122_L131_A0.5750.26
93_D130_P0.5740.26
19_C24_C0.5710.26
177_L182_I0.5700.26
347_V362_S0.5690.26
185_F232_Y0.5690.26
200_K363_R0.5690.26
32_Q217_E0.5680.26
193_R197_Y0.5680.26
159_S164_Y0.5680.26
26_C96_K0.5670.26
25_A106_M0.5660.26
194_A362_S0.5650.26
105_G166_T0.5640.26
93_D146_I0.5630.26
194_A316_H0.5630.26
216_G281_R0.5630.26
134_G276_H0.5620.26
305_E310_K0.5620.26
196_E200_K0.5620.26
282_D345_T0.5620.26
113_Y231_S0.5620.26
124_V255_R0.5610.25
73_W299_F0.5610.25
98_V125_F0.5610.25
51_G147_G0.5600.25
58_Y247_L0.5590.25
50_T69_N0.5580.25
7_H71_L0.5570.25
221_D224_P0.5560.25
59_H63_K0.5550.25
42_A152_V0.5550.25
126_K259_P0.5550.25
196_E323_C0.5550.25
41_I56_K0.5550.25
105_G164_Y0.5520.25
46_Y252_A0.5520.25
347_V361_F0.5520.25
30_L105_G0.5520.25
259_P343_S0.5510.25
89_L305_E0.5500.25
265_H293_Y0.5500.25
106_M176_K0.5480.25
57_D110_T0.5480.25
201_T205_T0.5470.25
176_K337_R0.5460.25
328_T332_C0.5450.25
202_A277_F0.5440.24
83_E112_I0.5430.24
46_Y72_P0.5420.24
177_L246_M0.5400.24
283_H287_G0.5400.24
64_E104_Y0.5390.24
64_E90_S0.5380.24
21_F108_T0.5380.24
186_Q293_Y0.5380.24
28_A31_D0.5380.24
265_H348_R0.5380.24
190_P224_P0.5380.24
29_E99_K0.5370.24
270_K277_F0.5360.24
26_C163_F0.5350.24
41_I267_L0.5350.24
186_Q216_G0.5350.24
185_F344_G0.5340.24
191_V221_D0.5330.24
234_A238_H0.5330.24
260_R271_N0.5320.24
196_E347_V0.5320.24
280_G343_S0.5320.24
54_G84_K0.5310.24
156_P164_Y0.5310.24
162_Q173_A0.5310.24
197_Y204_E0.5310.24
222_D343_S0.5300.24
27_Q82_G0.5300.24
53_L267_L0.5300.24
93_D210_L0.5300.24
224_P228_R0.5260.23
70_G182_I0.5260.23
321_R338_D0.5260.23
219_K343_S0.5240.23
117_K139_L0.5240.23
106_M151_T0.5200.23
49_L77_I0.5190.23
21_F151_T0.5190.23
320_C325_N0.5190.23
207_D363_R0.5190.23
320_C339_H0.5180.23
329_S357_P0.5180.23
153_S288_S0.5170.23
17_P109_V0.5170.23
26_C89_L0.5160.23
254_M280_G0.5150.23
349_E359_K0.5150.23
48_P258_G0.5150.23
174_F182_I0.5130.23
218_T314_F0.5120.23
94_H146_I0.5120.23
46_Y242_K0.5120.23
323_C335_S0.5110.23
213_P277_F0.5110.23
60_S123_S0.5080.22
14_R242_K0.5080.22
16_D22_E0.5070.22
195_H281_R0.5070.22
195_H345_T0.5070.22
62_V115_P0.5060.22
17_P112_I0.5040.22
211_L285_G0.5030.22
104_Y154_S0.5030.22
30_L96_K0.5030.22
10_V21_F0.5030.22
20_H23_G0.5020.22
52_F285_G0.5010.22
32_Q89_L0.5000.22
186_Q219_K0.5000.22
25_A136_K0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r6xA 1 0.9434 100 0.105 Contact Map
1x6vB 2 0.9769 100 0.115 Contact Map
4mafA 2 0.9666 100 0.121 Contact Map
1g8fA 5 0.9846 100 0.143 Contact Map
1m8pA 5 0.9871 100 0.146 Contact Map
2gksA 2 0.9075 100 0.184 Contact Map
3cr8A 4 0.8946 100 0.234 Contact Map
1v47A 2 0.8869 100 0.302 Contact Map
4dnxA 2 0.964 100 0.33 Contact Map
4natA 5 0.401 99.4 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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