GREMLIN Database
CYSC2 - Probable adenylyl-sulfate kinase
UniProt: O06735 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (176)
Sequences: 2695 (1636)
Seq/√Len: 123.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_E151_R4.1851.00
137_V140_Q3.9351.00
89_G117_V2.8081.00
180_T188_L2.7681.00
132_K174_I2.6351.00
110_F163_S2.6281.00
29_V121_F2.5821.00
23_N57_Q2.4991.00
180_T185_G2.3401.00
59_Y97_D2.2871.00
156_K162_D2.2841.00
134_P178_D2.2691.00
157_H162_D2.2251.00
29_V96_V2.1781.00
132_K176_E2.1721.00
115_D119_A2.1601.00
50_K187_D2.0701.00
111_R169_L2.0481.00
175_I185_G2.0301.00
32_F103_L2.0061.00
77_Q80_D2.0051.00
181_S184_D1.9931.00
88_I106_F1.9881.00
127_F192_A1.9761.00
56_I101_M1.9451.00
66_I88_I1.9311.00
47_V189_I1.9261.00
46_A182_I1.9181.00
70_L91_V1.9141.00
30_L129_I1.8891.00
176_E179_Q1.8841.00
149_K154_E1.8741.00
54_K194_Q1.8631.00
132_K167_A1.8181.00
118_R172_D1.7751.00
182_I186_A1.7121.00
134_P137_V1.7001.00
20_Q27_S1.6981.00
133_C138_C1.6881.00
78_T163_S1.6491.00
130_Y174_I1.6261.00
78_T110_F1.5981.00
50_K54_K1.5901.00
148_K152_N1.5631.00
111_R115_D1.5191.00
95_F100_Q1.4401.00
46_A186_A1.4391.00
75_G80_D1.4311.00
96_V121_F1.4291.00
187_D191_N1.3971.00
50_K186_A1.3931.00
47_V186_A1.3701.00
50_K53_R1.3421.00
25_H56_I1.3311.00
22_L52_Y1.3251.00
82_I113_D1.3031.00
83_E86_R1.2921.00
177_S185_G1.2771.00
173_F192_A1.2661.00
43_L131_V1.2491.00
175_I189_I1.2400.99
43_L186_A1.2120.99
116_M119_A1.1710.99
43_L175_I1.1690.99
135_L139_E1.1470.99
77_Q157_H1.1360.99
45_N60_V1.1260.99
22_L57_Q1.1200.99
130_Y167_A1.1040.99
31_W108_S1.1030.99
46_A49_E1.0930.99
27_S96_V1.0910.99
191_N195_N1.0860.99
117_V126_F1.0820.99
69_G90_E1.0720.98
133_C177_S1.0650.98
151_R161_I1.0630.98
82_I112_E1.0380.98
47_V190_I1.0290.98
36_S107_I1.0230.98
133_C137_V1.0210.98
93_K120_L1.0200.98
46_A50_K1.0120.98
49_E53_R1.0090.98
29_V92_A1.0070.98
137_V178_D0.9930.97
48_D103_L0.9930.97
89_G120_L0.9930.97
66_I106_F0.9910.97
111_R167_A0.9710.97
28_C101_M0.9590.97
115_D169_L0.9580.97
158_F162_D0.9510.97
122_P125_E0.9510.97
85_I106_F0.9400.96
59_Y98_S0.9290.96
128_E171_P0.9260.96
85_I117_V0.9250.96
35_L138_C0.9210.96
28_C193_L0.9180.96
33_T165_Y0.9170.96
136_H140_Q0.8980.95
48_D60_V0.8930.95
20_Q26_K0.8830.95
127_F173_F0.8830.95
54_K190_I0.8760.95
157_H163_S0.8750.95
50_K190_I0.8730.95
188_L191_N0.8700.95
182_I185_G0.8680.95
46_A183_S0.8670.94
135_L161_I0.8670.94
65_N68_H0.8610.94
133_C178_D0.8610.94
37_G143_P0.8570.94
121_F125_E0.8550.94
108_S126_F0.8530.94
47_V103_L0.8480.94
191_N194_Q0.8460.94
95_F98_S0.8400.94
37_G146_L0.8380.93
48_D52_Y0.8310.93
26_K125_E0.8300.93
121_F124_G0.8240.93
139_E161_I0.8220.93
171_P174_I0.8130.92
20_Q23_N0.8060.92
188_L192_A0.8040.92
20_Q125_E0.8030.92
135_L151_R0.7970.92
25_H57_Q0.7910.91
50_K183_S0.7900.91
30_L47_V0.7840.91
180_T184_D0.7790.91
110_F113_D0.7720.90
96_V125_E0.7670.90
69_G83_E0.7660.90
133_C174_I0.7600.90
90_E93_K0.7560.89
127_F172_D0.7550.89
110_F164_P0.7480.89
118_R126_F0.7470.89
74_L80_D0.7450.89
158_F161_I0.7370.88
63_G144_K0.7330.88
117_V120_L0.7260.87
28_C127_F0.7250.87
181_S185_G0.7240.87
45_N48_D0.7200.87
82_I116_M0.7120.86
83_E90_E0.7050.86
43_L185_G0.7040.86
119_A123_K0.6990.85
23_N27_S0.6970.85
36_S146_L0.6970.85
21_S24_G0.6900.85
111_R166_E0.6860.84
45_N102_I0.6840.84
130_Y176_E0.6840.84
186_A189_I0.6830.84
36_S135_L0.6770.83
112_E116_M0.6640.82
92_A104_T0.6630.82
72_K120_L0.6620.82
22_L58_S0.6610.82
184_D187_D0.6590.82
78_T112_E0.6550.81
48_D58_S0.6550.81
69_G73_D0.6470.81
65_N90_E0.6460.81
78_T82_I0.6430.80
74_L87_R0.6400.80
159_T163_S0.6390.80
104_T117_V0.6370.80
32_F44_A0.6340.79
33_T108_S0.6330.79
192_A195_N0.6310.79
129_I173_F0.6300.79
127_F193_L0.6240.78
59_Y95_F0.6240.78
150_A162_D0.6230.78
34_G39_G0.6160.77
167_A176_E0.6130.77
23_N52_Y0.6090.77
104_T107_I0.6050.76
60_V105_A0.6040.76
173_F188_L0.6030.76
139_E150_A0.6030.76
89_G121_F0.6030.76
78_T157_H0.6000.75
42_V182_I0.6000.75
72_K116_M0.5990.75
73_D87_R0.5980.75
52_Y58_S0.5970.75
111_R128_E0.5960.75
128_E170_S0.5910.74
64_D144_K0.5900.74
47_V193_L0.5880.74
74_L84_N0.5860.74
32_F131_V0.5860.74
109_P159_T0.5820.73
92_A96_V0.5800.73
108_S128_E0.5800.73
155_I158_F0.5780.73
118_R128_E0.5770.73
107_I159_T0.5770.73
147_Y160_G0.5750.72
85_I110_F0.5740.72
107_I163_S0.5670.71
108_S165_Y0.5660.71
185_G188_L0.5660.71
33_T126_F0.5660.71
28_C102_I0.5650.71
30_L193_L0.5630.71
29_V105_A0.5620.71
31_W128_E0.5610.71
173_F189_I0.5610.71
45_N49_E0.5580.70
20_Q25_H0.5570.70
187_D194_Q0.5530.69
27_S125_E0.5520.69
48_D65_N0.5510.69
126_F165_Y0.5510.69
66_I70_L0.5500.69
84_N88_I0.5500.69
146_L158_F0.5480.69
79_G82_I0.5480.69
111_R165_Y0.5470.69
84_N87_R0.5440.68
28_C96_V0.5430.68
32_F43_L0.5420.68
142_D145_G0.5410.68
121_F126_F0.5410.68
45_N58_S0.5380.67
24_G194_Q0.5380.67
86_R113_D0.5370.67
65_N94_L0.5360.67
42_V64_D0.5330.67
44_A105_A0.5300.66
126_F172_D0.5300.66
35_L160_G0.5270.66
143_P148_K0.5240.65
49_E112_E0.5220.65
116_M120_L0.5210.65
144_K159_T0.5200.65
49_E52_Y0.5200.65
76_F107_I0.5200.65
61_L102_I0.5200.65
29_V104_T0.5190.65
179_Q188_L0.5160.64
59_Y96_V0.5160.64
190_I194_Q0.5160.64
86_R90_E0.5140.64
26_K188_L0.5120.64
89_G110_F0.5120.64
96_V122_P0.5100.63
30_L103_L0.5100.63
24_G56_I0.5100.63
172_D192_A0.5090.63
93_K97_D0.5080.63
44_A73_D0.5040.62
117_V121_F0.5020.62
138_C151_R0.5020.62
29_V117_V0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x6vB 2 0.9196 100 0.432 Contact Map
1m8pA 5 1 100 0.493 Contact Map
2gksA 2 1 100 0.503 Contact Map
1m7gA 4 0.9849 100 0.534 Contact Map
3cr8A 4 0.8693 100 0.537 Contact Map
4rfvA 2 0.7085 100 0.58 Contact Map
2pezA 2 0.8794 100 0.6 Contact Map
2yvuA 2 0.8844 100 0.613 Contact Map
4bzpA 2 0.8593 100 0.613 Contact Map
3uieA 2 0.9749 99.9 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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