GREMLIN Database
YISY - AB hydrolase superfamily protein YisY
UniProt: O06734 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (249)
Sequences: 63947 (51488)
Seq/√Len: 3262.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_D50_R4.8951.00
91_I116_K4.3461.00
57_R77_D3.6631.00
40_Q259_N3.0651.00
79_K105_Y2.8981.00
218_R244_A2.8851.00
254_E257_K2.7631.00
91_I115_D2.6831.00
241_V261_L2.6741.00
121_S220_D2.6191.00
89_N115_D2.5631.00
120_L258_I2.4041.00
243_F261_L2.3981.00
12_T63_D2.2441.00
16_E34_H2.1631.00
79_K113_D2.1321.00
105_Y109_H2.1011.00
79_K83_Y2.1001.00
92_L102_A2.0931.00
79_K109_H2.0921.00
218_R242_P2.0791.00
232_K238_S2.0701.00
99_G122_A2.0111.00
83_Y113_D1.9981.00
82_I90_A1.9671.00
14_F61_Q1.9301.00
104_R108_R1.9091.00
48_G263_A1.9011.00
23_P52_I1.8521.00
15_V81_V1.8431.00
76_D108_R1.8371.00
225_F242_P1.8081.00
106_M117_L1.8021.00
43_E259_N1.8011.00
17_D52_I1.7991.00
246_S254_E1.7881.00
23_P50_R1.7521.00
23_P87_L1.7361.00
18_I53_G1.7301.00
91_I118_I1.7081.00
91_I266_S1.7011.00
213_L241_V1.6551.00
212_T235_I1.6291.00
49_F91_I1.6261.00
28_H59_Y1.6201.00
28_H56_L1.6181.00
14_F34_H1.6141.00
72_D108_R1.6111.00
102_A117_L1.6011.00
261_L264_Q1.6001.00
22_R115_D1.5921.00
22_R91_I1.5911.00
230_E234_G1.5421.00
56_L101_I1.5331.00
109_H113_D1.5141.00
75_A104_R1.4981.00
54_V78_V1.4901.00
70_D73_T1.4741.00
78_V105_Y1.4671.00
27_L56_L1.4481.00
32_L36_M1.4381.00
260_S264_Q1.4211.00
105_Y114_V1.4101.00
170_S173_L1.4021.00
27_L78_V1.3921.00
109_H112_A1.3851.00
204_E207_A1.3851.00
14_F55_D1.3641.00
213_L265_F1.3551.00
119_L122_A1.3541.00
34_H55_D1.3541.00
118_I262_I1.3341.00
43_E263_A1.3311.00
83_Y109_H1.3301.00
27_L102_A1.3191.00
257_K261_L1.3031.00
105_Y113_D1.2871.00
216_H228_A1.2761.00
103_I119_L1.2611.00
52_I81_V1.2581.00
104_R107_A1.2561.00
225_F229_K1.2541.00
26_F93_A1.2481.00
43_E46_K1.2451.00
41_M53_G1.2311.00
11_V57_R1.2281.00
229_K233_R1.2181.00
19_G50_R1.2161.00
13_L77_D1.2161.00
118_I213_L1.2161.00
95_F251_F1.2101.00
81_V85_L1.2051.00
31_P59_Y1.2001.00
18_I41_M1.1901.00
26_F51_F1.1891.00
257_K260_S1.1751.00
93_A120_L1.1591.00
87_L90_A1.1571.00
34_H61_Q1.1511.00
25_I82_I1.1291.00
96_S248_H1.1261.00
45_P48_G1.1261.00
29_G96_S1.1101.00
215_L243_F1.1061.00
21_G50_R1.1041.00
235_I238_S1.1021.00
24_I49_F1.0891.00
232_K240_L1.0821.00
206_A234_G1.0791.00
116_K211_P1.0791.00
107_A204_E1.0761.00
43_E256_E1.0721.00
54_V81_V1.0671.00
15_V85_L1.0661.00
216_H240_L1.0661.00
243_F246_S1.0471.00
36_M251_F1.0451.00
216_H242_P1.0441.00
90_A114_V1.0401.00
230_E233_R1.0391.00
34_H53_G1.0191.00
31_P96_S1.0131.00
75_A101_I1.0091.00
72_D104_R1.0081.00
213_L239_E1.0071.00
22_R49_F1.0041.00
239_E261_L0.9991.00
189_T192_S0.9981.00
216_H225_F0.9951.00
256_E260_S0.9941.00
27_L92_L0.9821.00
194_I197_R0.9761.00
229_K240_L0.9711.00
258_I262_I0.9631.00
55_D60_G0.9611.00
171_P175_Q0.9591.00
18_I45_P0.9571.00
79_K82_I0.9561.00
79_K108_R0.9491.00
82_I105_Y0.9461.00
93_A262_I0.9421.00
243_F257_K0.9351.00
229_K242_P0.9351.00
80_A83_Y0.9331.00
143_D147_E0.9311.00
145_M149_F0.9311.00
117_L212_T0.9291.00
215_L261_L0.9261.00
45_P51_F0.9241.00
42_N45_P0.9241.00
229_K232_K0.9211.00
82_I87_L0.9211.00
49_F266_S0.9191.00
218_R245_N0.9181.00
25_I90_A0.9111.00
13_L62_S0.9101.00
247_G253_E0.9081.00
94_G102_A0.9071.00
95_F249_G0.9051.00
246_S253_E0.9031.00
241_V264_Q0.9021.00
90_A113_D0.9021.00
11_V63_D0.9011.00
175_Q179_N0.8841.00
80_A84_T0.8821.00
193_G196_L0.8821.00
24_I51_F0.8801.00
52_I85_L0.8791.00
120_L251_F0.8781.00
38_E53_G0.8761.00
22_R89_N0.8731.00
176_W179_N0.8671.00
192_S195_A0.8641.00
56_L97_M0.8581.00
106_M114_V0.8511.00
246_S250_A0.8491.00
187_Y191_H0.8421.00
27_L54_V0.8391.00
39_Y42_N0.8381.00
152_D155_K0.8371.00
104_R204_E0.8251.00
94_G99_G0.8241.00
175_Q178_L0.8211.00
23_P49_F0.8131.00
214_I238_S0.8091.00
110_E113_D0.8061.00
25_I78_V0.7991.00
23_P90_A0.7991.00
120_L250_A0.7981.00
24_I93_A0.7971.00
241_V257_K0.7971.00
76_D79_K0.7971.00
68_G73_T0.7921.00
75_A108_R0.7921.00
209_K236_K0.7791.00
73_T76_D0.7751.00
217_G250_A0.7641.00
35_K38_E0.7601.00
158_A161_G0.7591.00
92_L105_Y0.7571.00
153_R156_T0.7501.00
143_D146_I0.7491.00
76_D80_A0.7471.00
75_A105_Y0.7461.00
160_L164_F0.7461.00
186_S189_T0.7431.00
228_A240_L0.7411.00
41_M51_F0.7381.00
42_N46_K0.7361.00
22_R116_K0.7341.00
144_D148_L0.7311.00
243_F254_E0.7291.00
259_N263_A0.7291.00
201_L204_E0.7221.00
116_K266_S0.7221.00
178_L182_L0.7211.00
226_D229_K0.7201.00
31_P97_M0.7151.00
194_I198_D0.7131.00
92_L114_V0.7121.00
118_I266_S0.7101.00
154_P157_L0.7081.00
218_R225_F0.7071.00
86_Q89_N0.7061.00
227_F230_E0.7051.00
180_L183_E0.7041.00
157_L160_L0.7031.00
74_M97_M0.7001.00
30_W97_M0.7001.00
55_D61_Q0.6981.00
34_H54_V0.6981.00
121_S250_A0.6961.00
16_E38_E0.6951.00
28_H54_V0.6901.00
245_N254_E0.6861.00
26_F37_F0.6831.00
20_H50_R0.6791.00
146_I150_K0.6761.00
88_E113_D0.6751.00
90_A115_D0.6731.00
107_A207_A0.6661.00
56_L74_M0.6651.00
106_M210_V0.6651.00
173_L176_W0.6631.00
189_T193_G0.6581.00
49_F263_A0.6561.00
195_A198_D0.6551.00
38_E42_N0.6541.00
95_F121_S0.6531.00
215_L258_I0.6531.00
121_S217_G0.6521.00
147_E151_A0.6511.00
156_T159_D0.6491.00
161_G165_F0.6491.00
191_H195_A0.6471.00
188_G192_S0.6471.00
121_S216_H0.6471.00
72_D76_D0.6461.00
174_R177_F0.6451.00
94_G98_G0.6441.00
95_F120_L0.6431.00
116_K265_F0.6371.00
25_I92_L0.6361.00
153_R157_L0.6361.00
171_P174_R0.6351.00
13_L57_R0.6341.00
158_A162_K0.6321.00
52_I87_L0.6321.00
255_K259_N0.6321.00
46_K263_A0.6301.00
18_I42_N0.6291.00
190_I193_G0.6261.00
176_W180_L0.6251.00
40_Q258_I0.6241.00
144_D147_E0.6241.00
154_P158_A0.6191.00
24_I91_I0.6191.00
203_K206_A0.6191.00
100_A123_A0.6181.00
200_D204_E0.6161.00
50_R87_L0.6151.00
260_S263_A0.6141.00
155_K158_A0.6131.00
114_V210_V0.6131.00
172_E175_Q0.6111.00
155_K159_D0.6111.00
40_Q43_E0.6111.00
202_R234_G0.6101.00
177_F180_L0.6091.00
174_R178_L0.6091.00
191_H194_I0.6071.00
172_E176_W0.6071.00
93_A118_I0.6071.00
103_I124_A0.6071.00
142_I146_I0.6041.00
119_L214_I0.5971.00
48_G51_F0.5961.00
159_D163_Q0.5961.00
118_I215_L0.5961.00
156_T160_L0.5951.00
37_F41_M0.5951.00
157_L161_G0.5931.00
57_R74_M0.5921.00
14_F62_S0.5921.00
147_E150_K0.5891.00
219_K245_N0.5891.00
145_M148_L0.5881.00
71_Y104_R0.5871.00
214_I228_A0.5831.00
156_T161_G0.5821.00
169_V173_L0.5811.00
99_G119_L0.5791.00
41_M45_P0.5781.00
37_F40_Q0.5781.00
90_A105_Y0.5771.00
26_F53_G0.5751.00
16_E35_K0.5751.00
188_G191_H0.5731.00
21_G49_F0.5721.00
186_S192_S0.5681.00
161_G164_F0.5621.00
170_S174_R0.5611.00
220_D248_H0.5601.00
56_L59_Y0.5581.00
24_I266_S0.5581.00
17_D85_L0.5561.00
228_A232_K0.5551.00
76_D109_H0.5551.00
96_S249_G0.5551.00
215_L241_V0.5541.00
16_E53_G0.5511.00
173_L177_F0.5511.00
103_I122_A0.5511.00
78_V101_I0.5501.00
24_I44_L0.5481.00
192_S196_L0.5461.00
74_M101_I0.5451.00
108_R204_E0.5451.00
214_I240_L0.5421.00
143_D148_L0.5401.00
179_N182_L0.5391.00
169_V172_E0.5361.00
250_A258_I0.5361.00
56_L78_V0.5331.00
193_G197_R0.5321.00
251_F258_I0.5311.00
21_G48_G0.5271.00
232_K235_I0.5251.00
202_R230_E0.5231.00
25_I54_V0.5211.00
142_I145_M0.5201.00
214_I232_K0.5191.00
186_S193_G0.5181.00
211_P237_Q0.5171.00
109_H114_V0.5171.00
73_T77_D0.5161.00
200_D203_K0.5131.00
142_I149_F0.5111.00
44_L262_I0.5111.00
239_E264_Q0.5111.00
132_G135_Y0.5101.00
82_I113_D0.5101.00
106_M208_I0.5091.00
36_M95_F0.5081.00
75_A79_K0.5071.00
208_I235_I0.5061.00
58_G69_Y0.5051.00
116_K213_L0.5041.00
244_A257_K0.5041.00
81_V84_T0.5021.00
214_I235_I0.5011.00
179_N183_E0.5011.00
144_D149_F0.5011.00
159_D164_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inzA 1 0.9888 100 0.126 Contact Map
1ehyA 1 0.9403 100 0.127 Contact Map
3om8A 4 0.9552 100 0.135 Contact Map
1zoiA 3 0.9925 100 0.14 Contact Map
3oosA 1 0.9813 100 0.145 Contact Map
2xuaA 2 0.9478 100 0.148 Contact Map
1iupA 2 0.9664 100 0.152 Contact Map
3fobA 3 0.9925 100 0.153 Contact Map
1a8qA 3 0.9888 100 0.153 Contact Map
4psuA 1 0.9701 100 0.153 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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