YISX - BACSU - GREMLIN Contacts

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YISX - Uncharacterized protein YisX

UniProt:	O06733	Sequences: MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGEDIERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVGMNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCELEGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	212 (178)
Sequences:	2051 (1775)
Seq/√Len:	133.0

ECOLI - YJCF YJBI
BACSU - YISX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
55_F	75_F	3.630	1.00
137_H	157_G	3.556	1.00
75_F	95_V	2.657	1.00
145_C	165_F	2.592	1.00
125_F	145_C	2.474	1.00
158_C	178_C	2.468	1.00
65_F	85_F	2.412	1.00
50_V	70_L	2.295	1.00
135_F	155_F	2.269	1.00
70_L	90_I	2.267	1.00
105_V	125_F	2.200	1.00
141_M	159_E	2.182	1.00
153_T	173_M	2.136	1.00
97_Q	117_E	2.123	1.00
77_K	97_Q	2.119	1.00
36_E	56_R	2.025	1.00
121_H	139_A	1.942	1.00
45_I	65_F	1.911	1.00
78_C	98_S	1.893	1.00
140_L	160_L	1.860	1.00
56_R	76_E	1.855	1.00
61_I	79_D	1.831	1.00
171_Q	189_K	1.808	1.00
149_V	169_S	1.783	1.00
35_F	55_F	1.753	1.00
81_S	99_K	1.719	1.00
59_V	79_D	1.708	1.00
139_A	159_E	1.706	1.00
132_Q	152_Q	1.684	1.00
79_D	99_K	1.625	1.00
117_E	137_H	1.617	1.00
169_S	189_K	1.597	1.00
151_Q	169_S	1.591	1.00
85_F	105_V	1.586	1.00
152_Q	172_N	1.579	1.00
142_Q	162_G	1.557	1.00
143_S	163_A	1.556	1.00
126_S	144_E	1.544	1.00
120_G	140_L	1.532	1.00
40_I	60_F	1.517	1.00
57_N	77_K	1.509	1.00
181_E	199_H	1.503	1.00
37_D	57_N	1.483	1.00
72_D	92_R	1.476	1.00
150_L	153_T	1.457	1.00
155_F	175_I	1.439	1.00
110_L	130_M	1.433	1.00
147_D	167_G	1.431	1.00
129_N	149_V	1.430	1.00
127_Y	147_D	1.421	1.00
66_R	84_D	1.416	1.00
116_E	136_D	1.395	1.00
76_E	96_K	1.392	1.00
35_F	53_T	1.389	1.00
95_V	115_F	1.378	1.00
112_N	132_Q	1.364	1.00
60_F	80_L	1.356	1.00
96_K	116_E	1.355	1.00
157_G	177_T	1.354	1.00
58_V	78_C	1.346	1.00
64_S	84_D	1.345	1.00
115_F	118_C	1.342	1.00
75_F	78_C	1.339	1.00
82_N	102_G	1.327	1.00
100_M	120_G	1.325	1.00
118_C	138_C	1.320	1.00
138_C	158_C	1.310	1.00
32_M	52_K	1.274	1.00
161_E	179_R	1.248	1.00
168_T	188_D	1.244	1.00
159_E	179_R	1.214	1.00
50_V	55_F	1.206	1.00
92_R	112_N	1.205	1.00
80_L	100_M	1.184	0.99
115_F	135_F	1.178	0.99
120_G	123_S	1.157	0.99
85_F	90_I	1.154	0.99
53_T	73_V	1.134	0.99
119_H	139_A	1.127	0.99
30_I	50_V	1.122	0.99
50_V	53_T	1.117	0.99
74_I	94_S	1.111	0.99
40_I	58_V	1.111	0.99
54_V	74_I	1.090	0.99
42_G	62_D	1.087	0.99
44_D	64_S	1.079	0.99
175_I	195_I	1.078	0.99
63_V	83_A	1.070	0.99
175_I	193_C	1.068	0.99
180_F	185_V	1.067	0.99
124_S	144_E	1.060	0.99
150_L	170_L	1.055	0.99
156_D	177_T	1.055	0.99
146_S	164_S	1.054	0.99
108_A	128_S	1.026	0.98
93_T	113_V	1.023	0.98
90_I	110_L	1.022	0.98
165_F	175_I	1.014	0.98
98_S	118_C	1.003	0.98
146_S	166_T	0.980	0.98
148_T	168_T	0.979	0.98
162_G	167_G	0.971	0.98
131_K	149_V	0.956	0.97
130_M	133_V	0.951	0.97
86_S	104_N	0.942	0.97
50_V	73_V	0.936	0.97
82_N	122_F	0.924	0.97
86_S	107_E	0.922	0.97
156_D	174_D	0.921	0.97
75_F	80_L	0.914	0.97
85_F	95_V	0.904	0.96
46_E	64_S	0.893	0.96
159_E	180_F	0.892	0.96
44_D	48_L	0.891	0.96
198_E	201_I	0.885	0.96
73_V	93_T	0.882	0.96
121_H	141_M	0.881	0.96
144_E	164_S	0.868	0.96
85_F	103_M	0.863	0.95
140_L	163_A	0.862	0.95
80_L	83_A	0.855	0.95
136_D	154_H	0.851	0.95
128_S	148_T	0.844	0.95
133_V	153_T	0.843	0.95
134_R	154_H	0.843	0.95
184_H	206_A	0.842	0.95
75_F	98_S	0.830	0.94
195_I	204_A	0.827	0.94
114_S	134_R	0.825	0.94
195_I	203_F	0.823	0.94
106_A	124_S	0.823	0.94
115_F	138_C	0.817	0.94
197_P	200_A	0.813	0.94
165_F	170_L	0.805	0.93
94_S	114_S	0.792	0.93
135_F	158_C	0.777	0.92
131_K	151_Q	0.776	0.92
197_P	201_I	0.772	0.92
30_I	33_H	0.768	0.92
140_L	158_C	0.765	0.92
199_H	207_L	0.763	0.91
141_M	162_G	0.759	0.91
202_A	206_A	0.752	0.91
80_L	85_F	0.751	0.91
70_L	155_F	0.750	0.91
172_N	192_G	0.748	0.91
55_F	78_C	0.746	0.91
101_V	119_H	0.745	0.90
145_C	155_F	0.744	0.90
145_C	150_L	0.739	0.90
151_Q	171_Q	0.739	0.90
70_L	73_V	0.738	0.90
95_V	100_M	0.737	0.90
150_L	173_M	0.733	0.90
186_S	207_L	0.731	0.90
165_F	185_V	0.726	0.89
89_V	109_T	0.725	0.89
60_F	78_C	0.724	0.89
81_S	101_V	0.717	0.89
135_F	160_L	0.707	0.88
43_E	52_K	0.705	0.88
164_S	184_H	0.702	0.88
51_E	71_T	0.701	0.88
125_F	160_L	0.699	0.87
200_A	205_R	0.696	0.87
202_A	205_R	0.692	0.87
39_T	42_G	0.689	0.87
80_L	98_S	0.689	0.87
47_R	74_I	0.688	0.87
132_Q	179_R	0.687	0.87
186_S	189_K	0.678	0.86
68_I	88_A	0.675	0.86
55_F	73_V	0.672	0.85
96_K	114_S	0.666	0.85
204_A	207_L	0.664	0.85
154_H	177_T	0.663	0.85
140_L	150_L	0.662	0.84
154_H	174_D	0.661	0.84
201_I	204_A	0.661	0.84
93_T	182_Q	0.659	0.84
111_R	132_Q	0.659	0.84
39_T	45_I	0.658	0.84
104_N	124_S	0.650	0.83
101_V	121_H	0.649	0.83
175_I	178_C	0.648	0.83
176_S	196_A	0.646	0.83
95_V	145_C	0.644	0.83
35_F	38_C	0.642	0.83
70_L	88_A	0.640	0.82
193_C	196_A	0.640	0.82
146_S	193_C	0.637	0.82
110_L	113_V	0.630	0.81
38_C	58_V	0.629	0.81
198_E	204_A	0.625	0.81
88_A	108_A	0.621	0.81
161_E	181_E	0.620	0.80
123_S	143_S	0.620	0.80
34_L	54_V	0.617	0.80
162_G	166_T	0.615	0.80
154_H	178_C	0.612	0.80
143_S	168_T	0.611	0.79
137_H	158_C	0.610	0.79
39_T	59_V	0.609	0.79
71_T	74_I	0.606	0.79
33_H	52_K	0.604	0.79
74_I	96_K	0.603	0.79
36_E	39_T	0.596	0.78
135_F	140_L	0.596	0.78
201_I	205_R	0.596	0.78
118_C	158_C	0.595	0.78
88_A	118_C	0.593	0.77
67_H	102_G	0.592	0.77
30_I	35_F	0.587	0.77
182_Q	205_R	0.587	0.77
160_L	175_I	0.587	0.77
185_V	188_D	0.586	0.77
34_L	56_R	0.584	0.76
54_V	58_V	0.583	0.76
46_E	66_R	0.583	0.76
45_I	60_F	0.581	0.76
140_L	143_S	0.574	0.75
39_T	43_E	0.574	0.75
37_D	62_D	0.569	0.74
43_E	48_L	0.564	0.74
65_F	70_L	0.563	0.74
193_C	203_F	0.561	0.73
43_E	53_T	0.559	0.73
126_S	147_D	0.558	0.73
79_D	82_N	0.558	0.73
149_V	173_M	0.558	0.73
44_D	50_V	0.556	0.73
99_K	119_H	0.555	0.73
120_G	138_C	0.553	0.72
43_E	73_V	0.552	0.72
180_F	183_L	0.552	0.72
174_D	178_C	0.551	0.72
113_V	153_T	0.545	0.71
83_A	103_M	0.544	0.71
82_N	101_V	0.543	0.71
31_S	35_F	0.541	0.71
75_F	115_F	0.540	0.71
35_F	49_C	0.538	0.70
80_L	103_M	0.531	0.69
63_V	68_I	0.529	0.69
133_V	192_G	0.529	0.69
51_E	69_E	0.528	0.69
69_E	73_V	0.525	0.69
168_T	176_S	0.524	0.68
154_H	158_C	0.522	0.68
166_T	184_H	0.521	0.68
79_D	83_A	0.520	0.68
45_I	55_F	0.520	0.68
47_R	67_H	0.519	0.68
33_H	36_E	0.516	0.67
130_M	150_L	0.514	0.67
39_T	63_V	0.512	0.67
49_C	69_E	0.511	0.66
162_G	186_S	0.510	0.66
55_F	60_F	0.508	0.66
199_H	202_A	0.508	0.66
106_A	126_S	0.507	0.66
183_L	188_D	0.507	0.66
75_F	79_D	0.506	0.66
115_F	120_G	0.504	0.65
34_L	74_I	0.504	0.65
33_H	49_C	0.503	0.65
169_S	173_M	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2w7zA	2	0.9575	100	0.158	Contact Map
2xt2A	2	0.9009	100	0.228	Contact Map
3pssA	2	0.9528	100	0.274	Contact Map
2bm5A	2	0.8538	100	0.28	Contact Map
2xtyA	2	0.9292	100	0.282	Contact Map
2j8kA	1	0.8491	100	0.33	Contact Map
3du1X	1	0.9387	100	0.343	Contact Map
3nb2A	2	0.8349	99.9	0.432	Contact Map
2qyuA	1	0.8915	99.9	0.454	Contact Map
2f3lA	1	0.6226	99.9	0.459	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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