GREMLIN Database
YISX - Uncharacterized protein YisX
UniProt: O06733 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (178)
Sequences: 2051 (1775)
Seq/√Len: 133.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_F75_F3.6301.00
137_H157_G3.5561.00
75_F95_V2.6571.00
145_C165_F2.5921.00
125_F145_C2.4741.00
158_C178_C2.4681.00
65_F85_F2.4121.00
50_V70_L2.2951.00
135_F155_F2.2691.00
70_L90_I2.2671.00
105_V125_F2.2001.00
141_M159_E2.1821.00
153_T173_M2.1361.00
97_Q117_E2.1231.00
77_K97_Q2.1191.00
36_E56_R2.0251.00
121_H139_A1.9421.00
45_I65_F1.9111.00
78_C98_S1.8931.00
140_L160_L1.8601.00
56_R76_E1.8551.00
61_I79_D1.8311.00
171_Q189_K1.8081.00
149_V169_S1.7831.00
35_F55_F1.7531.00
81_S99_K1.7191.00
59_V79_D1.7081.00
139_A159_E1.7061.00
132_Q152_Q1.6841.00
79_D99_K1.6251.00
117_E137_H1.6171.00
169_S189_K1.5971.00
151_Q169_S1.5911.00
85_F105_V1.5861.00
152_Q172_N1.5791.00
142_Q162_G1.5571.00
143_S163_A1.5561.00
126_S144_E1.5441.00
120_G140_L1.5321.00
40_I60_F1.5171.00
57_N77_K1.5091.00
181_E199_H1.5031.00
37_D57_N1.4831.00
72_D92_R1.4761.00
150_L153_T1.4571.00
155_F175_I1.4391.00
110_L130_M1.4331.00
147_D167_G1.4311.00
129_N149_V1.4301.00
127_Y147_D1.4211.00
66_R84_D1.4161.00
116_E136_D1.3951.00
76_E96_K1.3921.00
35_F53_T1.3891.00
95_V115_F1.3781.00
112_N132_Q1.3641.00
60_F80_L1.3561.00
96_K116_E1.3551.00
157_G177_T1.3541.00
58_V78_C1.3461.00
64_S84_D1.3451.00
115_F118_C1.3421.00
75_F78_C1.3391.00
82_N102_G1.3271.00
100_M120_G1.3251.00
118_C138_C1.3201.00
138_C158_C1.3101.00
32_M52_K1.2741.00
161_E179_R1.2481.00
168_T188_D1.2441.00
159_E179_R1.2141.00
50_V55_F1.2061.00
92_R112_N1.2051.00
80_L100_M1.1840.99
115_F135_F1.1780.99
120_G123_S1.1570.99
85_F90_I1.1540.99
53_T73_V1.1340.99
119_H139_A1.1270.99
30_I50_V1.1220.99
50_V53_T1.1170.99
74_I94_S1.1110.99
40_I58_V1.1110.99
54_V74_I1.0900.99
42_G62_D1.0870.99
44_D64_S1.0790.99
175_I195_I1.0780.99
63_V83_A1.0700.99
175_I193_C1.0680.99
180_F185_V1.0670.99
124_S144_E1.0600.99
150_L170_L1.0550.99
156_D177_T1.0550.99
146_S164_S1.0540.99
108_A128_S1.0260.98
93_T113_V1.0230.98
90_I110_L1.0220.98
165_F175_I1.0140.98
98_S118_C1.0030.98
146_S166_T0.9800.98
148_T168_T0.9790.98
162_G167_G0.9710.98
131_K149_V0.9560.97
130_M133_V0.9510.97
86_S104_N0.9420.97
50_V73_V0.9360.97
82_N122_F0.9240.97
86_S107_E0.9220.97
156_D174_D0.9210.97
75_F80_L0.9140.97
85_F95_V0.9040.96
46_E64_S0.8930.96
159_E180_F0.8920.96
44_D48_L0.8910.96
198_E201_I0.8850.96
73_V93_T0.8820.96
121_H141_M0.8810.96
144_E164_S0.8680.96
85_F103_M0.8630.95
140_L163_A0.8620.95
80_L83_A0.8550.95
136_D154_H0.8510.95
128_S148_T0.8440.95
133_V153_T0.8430.95
134_R154_H0.8430.95
184_H206_A0.8420.95
75_F98_S0.8300.94
195_I204_A0.8270.94
114_S134_R0.8250.94
195_I203_F0.8230.94
106_A124_S0.8230.94
115_F138_C0.8170.94
197_P200_A0.8130.94
165_F170_L0.8050.93
94_S114_S0.7920.93
135_F158_C0.7770.92
131_K151_Q0.7760.92
197_P201_I0.7720.92
30_I33_H0.7680.92
140_L158_C0.7650.92
199_H207_L0.7630.91
141_M162_G0.7590.91
202_A206_A0.7520.91
80_L85_F0.7510.91
70_L155_F0.7500.91
172_N192_G0.7480.91
55_F78_C0.7460.91
101_V119_H0.7450.90
145_C155_F0.7440.90
145_C150_L0.7390.90
151_Q171_Q0.7390.90
70_L73_V0.7380.90
95_V100_M0.7370.90
150_L173_M0.7330.90
186_S207_L0.7310.90
165_F185_V0.7260.89
89_V109_T0.7250.89
60_F78_C0.7240.89
81_S101_V0.7170.89
135_F160_L0.7070.88
43_E52_K0.7050.88
164_S184_H0.7020.88
51_E71_T0.7010.88
125_F160_L0.6990.87
200_A205_R0.6960.87
202_A205_R0.6920.87
39_T42_G0.6890.87
80_L98_S0.6890.87
47_R74_I0.6880.87
132_Q179_R0.6870.87
186_S189_K0.6780.86
68_I88_A0.6750.86
55_F73_V0.6720.85
96_K114_S0.6660.85
204_A207_L0.6640.85
154_H177_T0.6630.85
140_L150_L0.6620.84
154_H174_D0.6610.84
201_I204_A0.6610.84
93_T182_Q0.6590.84
111_R132_Q0.6590.84
39_T45_I0.6580.84
104_N124_S0.6500.83
101_V121_H0.6490.83
175_I178_C0.6480.83
176_S196_A0.6460.83
95_V145_C0.6440.83
35_F38_C0.6420.83
70_L88_A0.6400.82
193_C196_A0.6400.82
146_S193_C0.6370.82
110_L113_V0.6300.81
38_C58_V0.6290.81
198_E204_A0.6250.81
88_A108_A0.6210.81
161_E181_E0.6200.80
123_S143_S0.6200.80
34_L54_V0.6170.80
162_G166_T0.6150.80
154_H178_C0.6120.80
143_S168_T0.6110.79
137_H158_C0.6100.79
39_T59_V0.6090.79
71_T74_I0.6060.79
33_H52_K0.6040.79
74_I96_K0.6030.79
36_E39_T0.5960.78
135_F140_L0.5960.78
201_I205_R0.5960.78
118_C158_C0.5950.78
88_A118_C0.5930.77
67_H102_G0.5920.77
30_I35_F0.5870.77
182_Q205_R0.5870.77
160_L175_I0.5870.77
185_V188_D0.5860.77
34_L56_R0.5840.76
54_V58_V0.5830.76
46_E66_R0.5830.76
45_I60_F0.5810.76
140_L143_S0.5740.75
39_T43_E0.5740.75
37_D62_D0.5690.74
43_E48_L0.5640.74
65_F70_L0.5630.74
193_C203_F0.5610.73
43_E53_T0.5590.73
126_S147_D0.5580.73
79_D82_N0.5580.73
149_V173_M0.5580.73
44_D50_V0.5560.73
99_K119_H0.5550.73
120_G138_C0.5530.72
43_E73_V0.5520.72
180_F183_L0.5520.72
174_D178_C0.5510.72
113_V153_T0.5450.71
83_A103_M0.5440.71
82_N101_V0.5430.71
31_S35_F0.5410.71
75_F115_F0.5400.71
35_F49_C0.5380.70
80_L103_M0.5310.69
63_V68_I0.5290.69
133_V192_G0.5290.69
51_E69_E0.5280.69
69_E73_V0.5250.69
168_T176_S0.5240.68
154_H158_C0.5220.68
166_T184_H0.5210.68
79_D83_A0.5200.68
45_I55_F0.5200.68
47_R67_H0.5190.68
33_H36_E0.5160.67
130_M150_L0.5140.67
39_T63_V0.5120.67
49_C69_E0.5110.66
162_G186_S0.5100.66
55_F60_F0.5080.66
199_H202_A0.5080.66
106_A126_S0.5070.66
183_L188_D0.5070.66
75_F79_D0.5060.66
115_F120_G0.5040.65
34_L74_I0.5040.65
33_H49_C0.5030.65
169_S173_M0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w7zA 2 0.9575 100 0.158 Contact Map
2xt2A 2 0.9009 100 0.228 Contact Map
3pssA 2 0.9528 100 0.274 Contact Map
2bm5A 2 0.8538 100 0.28 Contact Map
2xtyA 2 0.9292 100 0.282 Contact Map
2j8kA 1 0.8491 100 0.33 Contact Map
3du1X 1 0.9387 100 0.343 Contact Map
3nb2A 2 0.8349 99.9 0.432 Contact Map
2qyuA 1 0.8915 99.9 0.454 Contact Map
2f3lA 1 0.6226 99.9 0.459 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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