GREMLIN Database
YISU - Putative amino-acid transporter YisU
UniProt: O06730 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (195)
Sequences: 12519 (9133)
Seq/√Len: 654.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_V127_A5.1771.00
103_G207_W3.5601.00
104_W108_N3.4011.00
197_I200_K2.9551.00
89_T92_M2.8111.00
100_L210_A2.6471.00
124_K128_A2.5631.00
57_P123_P2.3881.00
196_L200_K2.3621.00
68_L131_A2.2261.00
107_W200_K2.2061.00
93_A97_L2.1841.00
101_Y105_V2.1701.00
96_F214_G2.0631.00
46_G55_A2.0441.00
158_L161_W2.0331.00
107_W203_A2.0291.00
27_L147_V2.0181.00
41_F58_A2.0011.00
204_A208_A1.8741.00
105_V108_N1.8651.00
110_R200_K1.8521.00
103_G203_A1.8381.00
159_E162_L1.8311.00
65_C135_L1.7671.00
86_V89_T1.7541.00
25_I170_V1.7191.00
100_L207_W1.7161.00
96_F210_A1.7131.00
38_Q62_A1.6881.00
39_N178_L1.6831.00
21_I166_A1.6651.00
186_Q190_T1.6621.00
45_Q49_Q1.6471.00
54_R126_Q1.6051.00
171_S175_F1.5761.00
88_E92_M1.5671.00
158_L162_L1.5571.00
111_P200_K1.5331.00
128_A132_A1.5111.00
32_I170_V1.4981.00
33_L174_W1.4481.00
46_G179_A1.4391.00
60_I127_A1.4381.00
79_V83_E1.4371.00
100_L104_W1.4301.00
89_T93_A1.4211.00
45_Q58_A1.4161.00
58_A130_A1.3561.00
184_L187_T1.3431.00
197_I201_C1.3401.00
127_A131_A1.3351.00
122_T125_K1.3341.00
59_V179_A1.3291.00
164_M167_C1.3131.00
86_V90_V1.3041.00
56_L180_I1.2971.00
43_F182_G1.2901.00
90_V94_G1.2791.00
55_A179_A1.2491.00
93_A96_F1.2241.00
193_R197_I1.2091.00
131_A135_L1.2081.00
98_F102_M1.2041.00
93_A214_G1.1941.00
191_S194_L1.1821.00
71_V75_A1.1791.00
41_F133_V1.1731.00
194_L197_I1.1721.00
49_Q54_R1.1671.00
161_W165_A1.1611.00
165_A168_I1.1551.00
24_G28_A1.1441.00
125_K128_A1.1401.00
174_W178_L1.1371.00
207_W211_G1.1331.00
160_K163_F1.1321.00
45_Q129_F1.1281.00
38_Q134_S1.1071.00
203_A207_W1.1031.00
23_H26_V1.0971.00
51_H180_I1.0871.00
153_L156_S1.0801.00
103_G210_A1.0781.00
42_I46_G1.0771.00
22_I26_V1.0711.00
41_F45_Q1.0711.00
68_L135_L1.0681.00
20_A23_H1.0671.00
56_L176_I1.0661.00
63_S172_W1.0611.00
38_Q133_V1.0601.00
108_N111_P1.0601.00
66_D140_A1.0571.00
61_S127_A1.0511.00
32_I171_S1.0421.00
23_H27_L1.0331.00
164_M168_I1.0251.00
159_E163_F1.0231.00
109_I199_N1.0201.00
42_I175_F1.0201.00
177_S181_A1.0121.00
200_K204_A1.0001.00
65_C131_A0.9991.00
208_A212_Y0.9951.00
159_E166_A0.9921.00
76_G81_V0.9891.00
98_F101_Y0.9871.00
66_D134_S0.9851.00
125_K129_F0.9771.00
44_Q48_L0.9691.00
55_A59_V0.9691.00
172_W176_I0.9631.00
201_C204_A0.9621.00
25_I29_F0.9571.00
39_N175_F0.9561.00
193_R196_L0.9551.00
161_W164_M0.9411.00
29_F170_V0.9391.00
184_L188_I0.9361.00
40_V202_S0.9281.00
51_H183_R0.9261.00
38_Q66_D0.9201.00
76_G83_E0.9151.00
42_I179_A0.8901.00
69_L135_L0.8891.00
66_D69_L0.8871.00
38_Q171_S0.8861.00
132_A136_L0.8711.00
21_I169_A0.8691.00
175_F178_L0.8631.00
121_F125_K0.8631.00
47_A182_G0.8601.00
162_L166_A0.8591.00
106_T203_A0.8591.00
211_G215_V0.8511.00
69_L141_I0.8471.00
40_V44_Q0.8351.00
81_V84_L0.8321.00
56_L179_A0.8251.00
105_V109_I0.8151.00
120_T124_K0.8111.00
27_L30_G0.8071.00
28_A32_I0.8051.00
61_S131_A0.8031.00
146_G150_T0.7951.00
195_M199_N0.7951.00
97_L100_L0.7951.00
64_V131_A0.7931.00
160_K164_M0.7871.00
190_T194_L0.7871.00
176_I180_I0.7861.00
96_F100_L0.7851.00
126_Q129_F0.7851.00
181_A184_L0.7831.00
87_F90_V0.7731.00
26_V30_G0.7711.00
185_F189_D0.7651.00
46_G182_G0.7641.00
62_A66_D0.7601.00
207_W210_A0.7591.00
21_I25_I0.7581.00
51_H179_A0.7571.00
78_S82_Q0.7531.00
104_W207_W0.7531.00
39_N43_F0.7501.00
54_R57_P0.7491.00
51_H176_I0.7481.00
188_I194_L0.7451.00
30_G34_P0.7391.00
94_G97_L0.7381.00
107_W207_W0.7371.00
188_I191_S0.7341.00
59_V63_S0.7331.00
59_V176_I0.7281.00
57_P126_Q0.7271.00
70_I144_T0.7271.00
38_Q175_F0.7261.00
67_T168_I0.7251.00
75_A79_V0.7241.00
63_S168_I0.7191.00
84_L88_E0.7181.00
101_Y104_W0.7171.00
63_S171_S0.7101.00
108_N112_N0.7101.00
49_Q126_Q0.7101.00
25_I166_A0.7091.00
56_L59_V0.7041.00
39_N174_W0.7031.00
161_W166_A0.7021.00
22_I25_I0.7001.00
69_L140_A0.7001.00
85_P89_T0.7001.00
114_S117_E0.6991.00
70_I175_F0.6981.00
64_V68_L0.6971.00
84_L87_F0.6941.00
198_V202_S0.6831.00
32_I39_N0.6831.00
69_L145_I0.6831.00
42_I58_A0.6831.00
42_I62_A0.6821.00
212_Y215_V0.6801.00
32_I174_W0.6631.00
90_V93_A0.6601.00
97_L101_Y0.6591.00
182_G185_F0.6571.00
69_L73_A0.6541.00
136_L145_I0.6521.00
32_I175_F0.6521.00
62_A134_S0.6451.00
111_P196_L0.6441.00
58_A126_Q0.6441.00
159_E167_C0.6421.00
134_S140_A0.6411.00
27_L31_L0.6401.00
94_G136_L0.6391.00
73_A78_S0.6391.00
201_C205_V0.6371.00
29_F33_L0.6361.00
123_P127_A0.6341.00
66_D144_T0.6331.00
43_F178_L0.6301.00
69_L134_S0.6291.00
39_N133_V0.6291.00
79_V82_Q0.6241.00
162_L165_A0.6241.00
187_T190_T0.6231.00
187_T191_S0.6161.00
65_C134_S0.6151.00
45_Q48_L0.6141.00
68_L71_V0.6111.00
163_F167_C0.6081.00
124_K127_A0.6041.00
181_A185_F0.6011.00
21_I168_I0.6001.00
180_I184_L0.6001.00
48_L51_H0.6001.00
194_L198_V0.5991.00
69_L78_S0.5991.00
19_N23_H0.5991.00
173_I177_S0.5961.00
110_R113_T0.5951.00
169_A173_I0.5941.00
44_Q199_N0.5941.00
34_P39_N0.5931.00
66_D171_S0.5911.00
143_D147_V0.5901.00
35_L139_H0.5871.00
54_R122_T0.5871.00
54_R123_P0.5851.00
144_T171_S0.5811.00
160_K167_C0.5811.00
32_I66_D0.5811.00
38_Q140_A0.5801.00
73_A144_T0.5791.00
34_P199_N0.5781.00
58_A133_V0.5761.00
103_G107_W0.5751.00
186_Q189_D0.5741.00
144_T167_C0.5711.00
107_W204_A0.5701.00
120_T123_P0.5691.00
95_G142_L0.5621.00
175_F179_A0.5621.00
105_V129_F0.5551.00
25_I28_A0.5511.00
141_I145_I0.5501.00
129_F133_V0.5481.00
209_A212_Y0.5471.00
100_L214_G0.5451.00
24_G149_G0.5431.00
37_V137_N0.5431.00
174_W177_S0.5411.00
60_I63_S0.5381.00
202_S206_M0.5361.00
70_I164_M0.5351.00
73_A141_I0.5341.00
163_F166_A0.5300.99
185_F188_I0.5270.99
63_S175_F0.5270.99
107_W111_P0.5270.99
31_L147_V0.5260.99
117_E120_T0.5240.99
42_I59_V0.5190.99
63_S66_D0.5190.99
31_L140_A0.5150.99
110_R196_L0.5090.99
24_G151_S0.5090.99
177_S180_I0.5060.99
59_V172_W0.5030.99
56_L60_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9182 15.6 0.938 Contact Map
4x5mA 2 0.4227 11 0.942 Contact Map
3j1zP 8 0.7909 7.2 0.946 Contact Map
4m64A 1 0.9455 7.1 0.947 Contact Map
2wdqD 2 0.1364 6.3 0.948 Contact Map
2gfpA 2 0.9 5.6 0.949 Contact Map
4xnjA 1 0.4227 4.7 0.951 Contact Map
3wdoA 1 0.4409 4.7 0.951 Contact Map
4w6vA 1 0.4545 4.6 0.951 Contact Map
3o7qA 1 0.9273 4.5 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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