YISP - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YISP - Putative phytoene/squalene synthase YisP

UniProt:	O06728	Sequences: MKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQASWAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFREFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQLVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEECQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (253)
Sequences:	3850 (2614)
Seq/√Len:	164.3

BACSU - YISP
HALSA - Q9HPV3 Q9HPE1 Q9HRI5
SULSO - Q97UT8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
110_D	113_E	5.058	1.00
206_E	242_R	4.775	1.00
178_F	200_Y	4.470	1.00
59_E	102_K	4.258	1.00
147_S	211_E	4.041	1.00
177_Q	200_Y	3.607	1.00
174_V	201_I	2.778	1.00
92_E	96_E	2.658	1.00
56_P	102_K	2.591	1.00
36_A	87_F	2.575	1.00
109_D	113_E	2.455	1.00
82_H	86_T	2.452	1.00
206_E	239_E	2.362	1.00
181_T	184_D	2.323	1.00
110_D	173_Q	2.321	1.00
247_D	250_Q	2.296	1.00
240_K	259_E	2.262	1.00
63_D	95_R	2.247	1.00
155_V	209_L	2.244	1.00
55_L	59_E	2.170	1.00
100_A	121_T	2.066	1.00
63_D	91_S	2.066	1.00
236_A	259_E	2.064	1.00
109_D	172_R	2.008	1.00
59_E	99_A	1.994	1.00
90_E	131_P	1.951	1.00
147_S	208_Y	1.947	1.00
39_A	83_A	1.896	1.00
37_S	129_L	1.882	1.00
195_T	245_Q	1.857	1.00
119_Y	146_V	1.834	1.00
116_M	120_R	1.807	1.00
36_A	86_T	1.786	1.00
109_D	176_Q	1.767	1.00
178_F	196_M	1.744	1.00
162_G	166_Q	1.742	1.00
100_A	120_R	1.703	1.00
10_Q	13_Q	1.656	1.00
111_L	204_E	1.620	1.00
172_R	176_Q	1.615	1.00
107_P	182_E	1.589	1.00
202_A	238_L	1.582	1.00
91_S	95_R	1.581	1.00
40_V	132_I	1.568	1.00
57_A	61_K	1.549	1.00
184_D	189_T	1.546	1.00
103_E	116_M	1.542	1.00
115_L	150_L	1.520	1.00
127_L	146_V	1.512	1.00
41_L	45_H	1.512	1.00
213_Q	235_R	1.509	1.00
174_V	178_F	1.507	1.00
112_D	115_L	1.504	1.00
174_V	200_Y	1.501	1.00
150_L	208_Y	1.493	1.00
59_E	95_R	1.479	1.00
56_P	60_A	1.472	1.00
202_A	242_R	1.456	1.00
40_V	128_M	1.448	1.00
61_K	64_H	1.445	1.00
121_T	157_F	1.426	1.00
64_H	70_N	1.399	1.00
89_L	128_M	1.385	1.00
57_A	60_A	1.385	1.00
66_Y	91_S	1.349	1.00
201_I	204_E	1.346	1.00
140_Q	218_L	1.334	1.00
194_F	198_W	1.332	1.00
33_Q	132_I	1.325	1.00
153_Q	156_R	1.320	1.00
75_H	79_A	1.307	1.00
199_E	242_R	1.306	1.00
197_T	201_I	1.305	1.00
240_K	243_A	1.301	1.00
180_Y	197_T	1.272	1.00
208_Y	211_E	1.255	1.00
178_F	197_T	1.252	1.00
122_G	126_G	1.233	1.00
43_F	47_A	1.226	1.00
236_A	239_E	1.220	1.00
16_G	23_F	1.219	1.00
15_V	38_W	1.218	1.00
60_A	64_H	1.205	1.00
182_E	186_Q	1.200	1.00
48_A	164_D	1.189	1.00
36_A	83_A	1.189	1.00
125_A	156_R	1.188	1.00
151_A	155_V	1.177	1.00
48_A	160_D	1.176	1.00
99_A	116_M	1.165	1.00
213_Q	231_L	1.158	1.00
40_V	94_F	1.152	1.00
174_V	197_T	1.144	1.00
33_Q	222_Y	1.138	1.00
119_Y	124_A	1.136	1.00
141_L	218_L	1.118	1.00
219_F	227_V	1.114	1.00
180_Y	185_L	1.109	1.00
111_L	201_I	1.109	1.00
53_K	57_A	1.106	1.00
43_F	98_I	1.096	1.00
119_Y	127_L	1.096	1.00
174_V	204_E	1.085	1.00
103_E	120_R	1.076	0.99
184_D	193_A	1.075	0.99
202_A	246_H	1.068	0.99
63_D	67_Q	1.067	0.99
21_A	233_L	1.064	0.99
80_F	94_F	1.060	0.99
12_G	38_W	1.059	0.99
54_V	57_A	1.058	0.99
174_V	177_Q	1.051	0.99
47_A	98_I	1.050	0.99
165_Q	186_Q	1.050	0.99
206_E	235_R	1.041	0.99
156_R	159_S	1.040	0.99
259_E	262_Q	1.035	0.99
199_E	246_H	1.025	0.99
172_R	182_E	1.020	0.99
173_Q	177_Q	1.018	0.99
109_D	173_Q	1.009	0.99
47_A	58_F	1.002	0.99
45_H	126_G	1.001	0.99
93_P	131_P	1.000	0.99
123_G	149_G	0.996	0.99
89_L	94_F	0.996	0.99
165_Q	185_L	0.978	0.99
84_Y	94_F	0.976	0.99
93_P	127_L	0.966	0.99
209_L	234_H	0.954	0.99
81_D	85_R	0.954	0.99
45_H	49_S	0.949	0.99
104_D	169_R	0.948	0.99
244_K	251_Y	0.938	0.99
192_K	196_M	0.933	0.99
30_P	33_Q	0.930	0.99
59_E	63_D	0.925	0.98
61_K	74_Q	0.919	0.98
203_F	242_R	0.918	0.98
195_T	247_D	0.915	0.98
10_Q	75_H	0.914	0.98
79_A	82_H	0.911	0.98
33_Q	36_A	0.910	0.98
68_R	72_G	0.910	0.98
18_Y	49_S	0.910	0.98
162_G	249_F	0.909	0.98
62_A	66_Y	0.909	0.98
144_A	215_A	0.907	0.98
122_G	153_Q	0.901	0.98
57_A	74_Q	0.897	0.98
240_K	244_K	0.896	0.98
46_T	74_Q	0.892	0.98
207_A	211_E	0.890	0.98
144_A	218_L	0.890	0.98
210_E	235_R	0.885	0.98
45_H	48_A	0.882	0.98
41_L	122_G	0.882	0.98
22_C	41_L	0.881	0.98
151_A	209_L	0.877	0.98
48_A	52_E	0.874	0.98
111_L	174_V	0.872	0.98
62_A	91_S	0.872	0.98
29_L	37_S	0.872	0.98
22_C	45_H	0.872	0.98
90_E	93_P	0.869	0.98
131_P	142_K	0.864	0.98
180_Y	184_D	0.864	0.98
183_A	186_Q	0.858	0.97
41_L	126_G	0.857	0.97
200_Y	204_E	0.857	0.97
158_L	241_I	0.856	0.97
13_Q	17_E	0.854	0.97
184_D	191_N	0.853	0.97
163_T	167_K	0.853	0.97
180_Y	193_A	0.850	0.97
199_E	203_F	0.848	0.97
47_A	101_Q	0.847	0.97
258_T	262_Q	0.846	0.97
114_L	154_L	0.840	0.97
87_F	132_I	0.831	0.97
122_G	156_R	0.825	0.97
22_C	122_G	0.822	0.97
203_F	207_A	0.813	0.97
111_L	200_Y	0.812	0.97
83_A	87_F	0.808	0.96
45_H	160_D	0.805	0.96
242_R	246_H	0.805	0.96
62_A	94_F	0.801	0.96
48_A	153_Q	0.801	0.96
244_K	247_D	0.798	0.96
76_L	83_A	0.796	0.96
180_Y	191_N	0.796	0.96
137_K	140_Q	0.791	0.96
67_Q	70_N	0.788	0.96
97_F	101_Q	0.788	0.96
61_K	77_W	0.787	0.96
48_A	156_R	0.786	0.96
227_V	230_A	0.784	0.96
175_M	197_T	0.781	0.96
35_Q	79_A	0.779	0.96
22_C	156_R	0.778	0.96
22_C	125_A	0.775	0.95
100_A	157_F	0.774	0.95
159_S	234_H	0.772	0.95
103_E	108_Y	0.769	0.95
239_E	242_R	0.762	0.95
236_A	240_K	0.761	0.95
179_G	187_K	0.759	0.95
36_A	39_A	0.758	0.95
83_A	86_T	0.758	0.95
255_L	260_V	0.756	0.95
96_E	99_A	0.754	0.95
145_A	149_G	0.752	0.95
97_F	124_A	0.751	0.95
74_Q	78_K	0.749	0.95
257_E	260_V	0.747	0.94
79_A	83_A	0.738	0.94
22_C	126_G	0.737	0.94
129_L	133_L	0.737	0.94
255_L	259_E	0.737	0.94
241_I	248_V	0.733	0.94
175_M	180_Y	0.729	0.94
99_A	120_R	0.729	0.94
160_D	164_D	0.728	0.94
123_G	150_L	0.728	0.94
41_L	156_R	0.725	0.94
219_F	224_Q	0.724	0.93
111_L	115_L	0.721	0.93
206_E	238_L	0.720	0.93
158_L	238_L	0.720	0.93
20_P	24_K	0.715	0.93
111_L	208_Y	0.715	0.93
97_F	152_I	0.713	0.93
122_G	125_A	0.701	0.92
191_N	250_Q	0.699	0.92
35_Q	39_A	0.699	0.92
71_N	78_K	0.698	0.92
58_F	62_A	0.698	0.92
99_A	102_K	0.698	0.92
45_H	156_R	0.697	0.92
52_E	160_D	0.695	0.92
228_K	232_H	0.693	0.92
45_H	122_G	0.693	0.92
74_Q	83_A	0.692	0.92
59_E	62_A	0.692	0.92
237_V	252_H	0.690	0.92
189_T	193_A	0.688	0.92
153_Q	160_D	0.684	0.91
13_Q	16_G	0.683	0.91
223_S	226_T	0.681	0.91
77_W	80_F	0.681	0.91
194_F	248_V	0.680	0.91
12_G	16_G	0.680	0.91
44_C	125_A	0.675	0.91
11_C	76_L	0.675	0.91
41_L	48_A	0.672	0.91
104_D	117_Y	0.666	0.90
93_P	119_Y	0.664	0.90
155_V	237_V	0.663	0.90
53_K	56_P	0.659	0.90
196_M	199_E	0.656	0.90
55_L	66_Y	0.655	0.90
126_G	153_Q	0.652	0.89
15_V	25_A	0.648	0.89
211_E	214_D	0.646	0.89
33_Q	220_P	0.646	0.89
154_L	208_Y	0.641	0.89
257_E	261_K	0.641	0.89
153_Q	164_D	0.637	0.88
74_Q	81_D	0.636	0.88
96_E	120_R	0.636	0.88
154_L	204_E	0.636	0.88
236_A	263_I	0.632	0.88
45_H	125_A	0.631	0.88
102_K	105_A	0.630	0.88
32_K	86_T	0.629	0.88
56_P	59_E	0.627	0.87
215_A	219_F	0.625	0.87
225_K	229_A	0.623	0.87
214_D	217_P	0.623	0.87
207_A	210_E	0.621	0.87
68_R	71_N	0.620	0.87
85_R	88_T	0.619	0.87
44_C	121_T	0.619	0.87
135_R	220_P	0.618	0.87
107_P	168_N	0.618	0.87
255_L	263_I	0.617	0.87
122_G	160_D	0.617	0.87
129_L	227_V	0.616	0.87
73_K	76_L	0.614	0.86
186_Q	189_T	0.613	0.86
70_N	85_R	0.608	0.86
126_G	152_I	0.607	0.86
155_V	205_A	0.606	0.86
149_G	159_S	0.606	0.86
78_K	82_H	0.605	0.86
124_A	149_G	0.604	0.85
143_Q	147_S	0.599	0.85
147_S	150_L	0.597	0.85
48_A	122_G	0.596	0.85
180_Y	194_F	0.595	0.85
15_V	19_A	0.595	0.85
107_P	170_I	0.594	0.85
249_F	253_F	0.594	0.85
65_V	81_D	0.593	0.84
126_G	156_R	0.592	0.84
80_F	84_Y	0.591	0.84
31_L	35_Q	0.589	0.84
15_V	42_S	0.585	0.84
44_C	49_S	0.584	0.84
123_G	130_L	0.582	0.83
183_A	187_K	0.582	0.83
212_C	231_L	0.581	0.83
216_L	231_L	0.579	0.83
60_A	187_K	0.578	0.83
204_E	207_A	0.576	0.83
21_A	51_D	0.574	0.82
58_F	61_K	0.574	0.82
45_H	164_D	0.574	0.82
238_L	242_R	0.573	0.82
73_K	83_A	0.570	0.82
235_R	239_E	0.569	0.82
170_I	182_E	0.569	0.82
76_L	84_Y	0.567	0.82
142_K	146_V	0.567	0.82
216_L	219_F	0.565	0.82
190_V	195_T	0.565	0.82
47_A	129_L	0.565	0.82
155_V	238_L	0.564	0.81
107_P	172_R	0.563	0.81
171_P	201_I	0.559	0.81
156_R	160_D	0.558	0.81
44_C	230_A	0.556	0.80
194_F	197_T	0.556	0.80
217_P	228_K	0.556	0.80
77_W	81_D	0.556	0.80
158_L	202_A	0.555	0.80
44_C	128_M	0.554	0.80
202_A	206_E	0.553	0.80
73_K	78_K	0.551	0.80
130_L	142_K	0.549	0.80
123_G	157_F	0.548	0.80
96_E	119_Y	0.546	0.79
100_A	103_E	0.542	0.79
12_G	35_Q	0.541	0.79
157_F	164_D	0.538	0.78
55_L	58_F	0.537	0.78
206_E	210_E	0.537	0.78
197_T	200_Y	0.536	0.78
130_L	215_A	0.536	0.78
97_F	128_M	0.535	0.78
92_E	131_P	0.534	0.78
247_D	251_Y	0.534	0.78
143_Q	211_E	0.531	0.77
66_Y	84_Y	0.530	0.77
121_T	156_R	0.530	0.77
11_C	39_A	0.529	0.77
252_H	255_L	0.527	0.77
52_E	156_R	0.527	0.77
61_K	73_K	0.526	0.77
180_Y	183_A	0.526	0.77
65_V	68_R	0.525	0.77
156_R	164_D	0.524	0.76
170_I	175_M	0.523	0.76
166_Q	188_G	0.522	0.76
121_T	125_A	0.521	0.76
237_V	255_L	0.520	0.76
20_P	254_A	0.518	0.76
96_E	127_L	0.517	0.76
21_A	159_S	0.515	0.75
15_V	26_L	0.514	0.75
156_R	234_H	0.512	0.75
32_K	35_Q	0.510	0.75
22_C	152_I	0.509	0.74
200_Y	203_F	0.506	0.74
41_L	117_Y	0.506	0.74
127_L	131_P	0.503	0.74
119_Y	150_L	0.503	0.74
204_E	208_Y	0.502	0.73
49_S	160_D	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3we9A	1	0.8951	100	0.1	Contact Map
3acxA	1	0.9963	100	0.117	Contact Map
4hd1A	1	0.9213	100	0.125	Contact Map
3wcaA	1	0.9775	100	0.214	Contact Map
3vj8A	1	0.9888	100	0.226	Contact Map
1yyqA	2	0.9513	86.6	0.924	Contact Map
4dhdA	2	0.8427	84.7	0.926	Contact Map
4lfgA	2	0.8352	81.8	0.929	Contact Map
4f62A	2	0.7566	80.7	0.93	Contact Map
1wy0A	2	0.8652	76.6	0.932	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.