GREMLIN Database
YISL - UPF0344 protein YisL
UniProt: O06725 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 118 (113)
Sequences: 194 (152)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_I96_G4.3361.00
12_A45_I3.1700.98
24_S84_K2.7870.96
82_I86_K2.6160.94
12_A38_L2.5940.94
96_G100_V2.3120.90
53_F67_M2.3100.89
18_V22_L2.2080.87
4_L48_T2.1620.86
72_I76_L2.1110.85
35_H82_I2.1010.84
8_T44_L2.0110.82
19_S34_T1.9510.79
19_S81_L1.9450.79
92_G96_G1.8030.74
11_V41_F1.7930.73
21_S25_S1.7210.70
23_Y35_H1.6900.69
3_H7_T1.6470.67
61_G64_A1.6030.64
75_G83_R1.6010.64
29_K33_I1.5100.60
20_Y102_L1.4850.58
15_L74_I1.4640.57
48_T68_I1.4560.57
75_G79_M1.4560.57
33_I37_I1.4450.56
22_L34_T1.4230.55
50_A54_V1.4010.54
80_L94_W1.3850.53
20_Y35_H1.3750.52
41_F47_L1.3600.51
62_E110_H1.3090.49
14_I18_V1.3010.48
72_I100_V1.3000.48
69_L100_V1.2730.47
69_L104_T1.2700.47
43_I47_L1.2220.44
25_S95_V1.2110.43
43_I46_I1.1750.41
69_L107_L1.1710.41
11_V69_L1.1490.40
69_L103_L1.1370.39
53_F64_A1.1200.39
30_G84_K1.1180.38
23_Y31_A1.1150.38
48_T88_K1.1070.38
65_G85_K1.0970.37
111_L114_G1.0820.37
82_I88_K1.0730.36
17_F106_L1.0710.36
73_T104_T1.0650.36
15_L38_L1.0590.35
72_I91_G1.0470.35
67_M97_F1.0420.35
61_G65_G1.0310.34
6_I9_W1.0220.34
99_I109_L1.0170.33
80_L93_L1.0140.33
42_Y74_I1.0090.33
45_I70_G0.9910.32
70_G73_T0.9900.32
68_I71_I0.9820.32
6_I70_G0.9650.31
70_G111_L0.9590.31
90_T98_V0.9460.30
65_G89_S0.9270.29
30_G33_I0.9170.29
26_G32_K0.9130.28
91_G95_V0.9130.28
6_I112_P0.8990.28
46_I63_Y0.8950.28
44_L48_T0.8830.27
40_L69_L0.8800.27
42_Y82_I0.8770.27
7_T70_G0.8680.26
57_A64_A0.8670.26
55_R71_I0.8530.26
76_L93_L0.8450.26
23_Y43_I0.8440.25
46_I109_L0.8360.25
64_A68_I0.8200.25
19_S97_F0.8130.24
64_A67_M0.8090.24
72_I79_M0.8020.24
47_L50_A0.8000.24
65_G68_I0.7880.23
2_T109_L0.7820.23
48_T65_G0.7740.23
98_V102_L0.7730.23
8_T11_V0.7710.23
62_E107_L0.7660.22
99_I103_L0.7650.22
3_H32_K0.7640.22
20_Y106_L0.7540.22
84_K98_V0.7530.22
79_M82_I0.7510.22
8_T83_R0.7450.22
55_R58_N0.7450.22
34_T71_I0.7400.21
11_V26_G0.7310.21
32_K40_L0.7300.21
20_Y23_Y0.7260.21
17_F21_S0.7130.20
32_K52_L0.7030.20
11_V75_G0.7020.20
29_K64_A0.7010.20
83_R88_K0.6950.20
89_S93_L0.6880.20
105_V110_H0.6860.19
8_T87_E0.6830.19
44_L97_F0.6800.19
44_L95_V0.6750.19
6_I111_L0.6730.19
80_L106_L0.6690.19
27_S33_I0.6680.19
34_T60_N0.6610.19
48_T112_P0.6540.18
19_S85_K0.6490.18
27_S91_G0.6460.18
22_L30_G0.6460.18
51_E64_A0.6410.18
8_T60_N0.6310.18
37_I42_Y0.6310.18
83_R92_G0.6260.17
10_V85_K0.6170.17
86_K114_G0.6150.17
3_H10_V0.6150.17
58_N98_V0.6110.17
36_M40_L0.6100.17
48_T86_K0.6100.17
94_W97_F0.6070.17
84_K91_G0.6040.17
56_F103_L0.6040.17
62_E69_L0.6020.17
107_L110_H0.5980.17
33_I52_L0.5980.17
40_L74_I0.5960.17
62_E105_V0.5920.16
58_N89_S0.5900.16
35_H61_G0.5870.16
4_L70_G0.5870.16
90_T94_W0.5870.16
81_L95_V0.5820.16
43_I56_F0.5740.16
18_V68_I0.5720.16
23_Y89_S0.5710.16
40_L68_I0.5710.16
76_L90_T0.5700.16
24_S28_A0.5670.16
4_L52_L0.5620.16
50_A57_A0.5620.16
45_I56_F0.5610.16
92_G100_V0.5530.15
25_S103_L0.5520.15
54_V103_L0.5510.15
34_T40_L0.5420.15
2_T52_L0.5400.15
2_T95_V0.5370.15
31_A35_H0.5350.15
75_G93_L0.5330.15
106_L110_H0.5280.15
25_S72_I0.5260.15
16_L19_S0.5240.14
65_G90_T0.5180.14
31_A53_F0.5170.14
69_L72_I0.5070.14
24_S27_S0.5010.14
4_L54_V0.5000.14
16_L77_M0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ogqG 1 0.2627 14.4 0.937 Contact Map
1q90G 1 0.2034 11.4 0.94 Contact Map
3owqA 1 0 6.9 0.945 Contact Map
1skhA 1 0.2288 5.2 0.949 Contact Map
3rlfG 1 0.2542 4.7 0.949 Contact Map
4o6yA 2 1 3.3 0.953 Contact Map
4pd6A 3 0.4068 3.1 0.954 Contact Map
3cx5C 2 0.8136 2.5 0.956 Contact Map
4p02A 1 0.678 2.2 0.957 Contact Map
2akhX 1 0.2458 2.2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0235 seconds.