GREMLIN Database
YISK - Uncharacterized protein YisK
UniProt: O06724 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (256)
Sequences: 5108 (3492)
Seq/√Len: 218.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_V263_A3.8621.00
221_K233_S3.5841.00
163_S166_D3.5121.00
227_N284_D3.4661.00
289_T295_T3.2441.00
287_D297_S3.1231.00
159_G162_I3.1081.00
164_K248_E3.0851.00
225_R230_L2.9221.00
152_A177_V2.8721.00
242_S245_E2.8141.00
166_D169_D2.6101.00
168_Y171_V2.5891.00
149_G224_T2.5561.00
164_K245_E2.5501.00
230_L233_S2.5251.00
162_I170_H2.4901.00
223_E233_S2.4621.00
223_E289_T2.3971.00
159_G170_H2.2631.00
225_R287_D2.2501.00
199_D255_T2.2091.00
164_K242_S2.1791.00
234_G238_D2.1661.00
149_G288_I2.1651.00
174_Y211_K2.1491.00
204_M261_I2.0991.00
287_D295_T2.0581.00
147_Y231_R2.0081.00
221_K291_D1.9861.00
158_S258_A1.9861.00
231_R278_K1.9621.00
149_G222_V1.9091.00
226_V280_L1.9021.00
129_T133_D1.8921.00
158_S257_E1.8761.00
285_K297_S1.8431.00
225_R289_T1.8401.00
151_L290_I1.8371.00
152_A175_T1.8251.00
172_F208_L1.7861.00
210_H213_S1.7841.00
42_S45_E1.7481.00
221_K235_S1.7351.00
175_T204_M1.7231.00
168_Y244_P1.7071.00
120_V250_L1.7051.00
155_I247_I1.6961.00
136_K200_T1.6761.00
130_G133_D1.6531.00
274_F278_K1.6501.00
47_I172_F1.6471.00
153_V243_I1.6391.00
82_K133_D1.6371.00
137_S145_L1.6161.00
152_A261_I1.6081.00
97_I246_L1.6021.00
135_V180_I1.5871.00
126_V257_E1.5861.00
223_E230_L1.5691.00
142_T184_D1.5621.00
214_I220_L1.5611.00
77_S80_E1.5541.00
176_I290_I1.5301.00
152_A263_A1.5051.00
226_V231_R1.4901.00
154_V208_L1.4661.00
127_T255_T1.4551.00
102_R106_I1.4211.00
103_D238_D1.3961.00
175_T293_I1.3701.00
219_R237_S1.3591.00
180_I203_P1.3551.00
229_E278_K1.3481.00
99_K115_P1.3461.00
91_S257_E1.3411.00
103_D268_S1.3401.00
158_S170_H1.3371.00
144_Q184_D1.3151.00
135_V286_I1.3111.00
83_L131_H1.2971.00
122_T193_F1.2841.00
124_S197_S1.2821.00
160_T199_D1.2721.00
97_I120_V1.2711.00
215_Q292_P1.2541.00
132_G296_L1.2421.00
185_L198_L1.2191.00
25_D29_A1.2001.00
218_E244_P1.1831.00
225_R295_T1.1781.00
76_Y81_V1.1501.00
209_V293_I1.1501.00
44_I48_A1.1441.00
218_E239_M1.1401.00
219_R235_S1.1381.00
40_P45_E1.1361.00
78_L83_L1.1351.00
224_T288_I1.1311.00
222_V226_V1.1081.00
142_T145_L1.0951.00
216_E219_R1.0871.00
271_G276_P1.0841.00
157_K169_D1.0781.00
49_E52_K1.0771.00
58_R62_E1.0761.00
85_A131_H1.0751.00
177_V204_M1.0721.00
153_V262_I1.0691.00
151_L236_A1.0571.00
138_H198_L1.0571.00
141_V161_R1.0451.00
231_R274_F1.0451.00
137_S282_S1.0441.00
158_S162_I1.0371.00
168_Y218_E1.0301.00
220_L290_I1.0281.00
143_S184_D1.0041.00
272_K279_F1.0021.00
132_G297_S1.0021.00
163_S248_E0.9911.00
154_V175_T0.9911.00
46_C57_A0.9901.00
144_Q279_F0.9881.00
164_K244_P0.9871.00
99_K108_M0.9871.00
176_I288_I0.9801.00
118_P246_L0.9731.00
171_V243_I0.9711.00
50_G54_V0.9661.00
153_V247_I0.9641.00
60_L64_A0.9491.00
155_I256_L0.9471.00
157_K170_H0.9441.00
226_V286_I0.9411.00
146_D183_R0.9401.00
85_A128_V0.9391.00
207_V293_I0.9310.99
220_L226_V0.9260.99
131_H296_L0.9260.99
174_Y217_P0.9220.99
55_A212_S0.9210.99
95_I254_M0.9150.99
160_T255_T0.9080.99
228_G285_K0.9050.99
218_E242_S0.8990.99
140_E161_R0.8920.99
256_L262_I0.8810.99
158_S255_T0.8810.99
135_V199_D0.8810.99
97_I250_L0.8690.99
101_Y104_H0.8610.99
129_T200_T0.8560.99
98_G104_H0.8550.99
101_Y264_T0.8520.99
50_G53_F0.8520.99
157_K258_A0.8460.99
122_T197_S0.8410.99
111_E114_I0.8400.99
156_G172_F0.8390.99
248_E252_K0.8380.99
225_R228_G0.8360.99
45_E49_E0.8360.99
182_A185_L0.8270.99
241_F245_E0.8270.99
44_I89_K0.8250.99
217_P236_A0.8240.99
193_F197_S0.8230.99
181_T186_Q0.8200.99
145_L198_L0.8190.99
224_T286_I0.8140.99
119_M192_F0.8140.99
59_Q63_W0.8060.99
151_L174_Y0.8030.99
152_A204_M0.8030.99
103_D107_E0.8000.98
98_G101_Y0.7960.98
228_G287_D0.7850.98
153_V174_Y0.7780.98
189_H194_I0.7760.98
274_F277_P0.7760.98
117_H188_R0.7700.98
55_A58_R0.7690.98
26_L29_A0.7680.98
50_G55_A0.7680.98
245_E248_E0.7670.98
194_I253_G0.7640.98
246_L264_T0.7600.98
176_I293_I0.7560.98
206_P209_V0.7560.98
148_E196_K0.7550.98
135_V200_T0.7540.98
147_Y280_L0.7530.98
104_H107_E0.7530.98
214_I293_I0.7470.98
105_A114_I0.7460.98
41_G45_E0.7420.97
247_I262_I0.7380.97
149_G176_I0.7380.97
53_F56_H0.7370.97
239_M246_L0.7370.97
56_H59_Q0.7340.97
43_L46_C0.7330.97
91_S126_V0.7290.97
29_A32_K0.7270.97
108_M181_T0.7250.97
26_L57_A0.7240.97
94_I101_Y0.7220.97
26_L31_K0.7210.97
91_S125_P0.7210.97
126_V199_D0.7130.97
57_A60_L0.7110.97
180_I286_I0.7110.97
223_E291_D0.7100.97
173_G208_L0.7080.97
142_T182_A0.7040.97
124_S193_F0.7030.97
171_V174_Y0.7030.97
156_G258_A0.7010.96
221_K226_V0.6950.96
92_K95_I0.6900.96
105_A108_M0.6880.96
87_I154_V0.6880.96
194_I197_S0.6850.96
96_C193_F0.6830.96
49_E53_F0.6830.96
166_D170_H0.6810.96
198_L253_G0.6810.96
100_N270_V0.6800.96
104_H270_V0.6770.96
43_L208_L0.6760.96
204_M263_A0.6750.96
26_L30_E0.6730.96
168_Y243_I0.6730.96
128_V204_M0.6730.96
248_E251_S0.6710.96
25_D28_K0.6690.95
105_A240_I0.6680.95
222_V228_G0.6660.95
177_V200_T0.6660.95
183_R186_Q0.6660.95
280_L286_I0.6650.95
92_K126_V0.6650.95
87_I90_P0.6620.95
95_I122_T0.6610.95
154_V261_I0.6610.95
188_R249_T0.6590.95
243_I264_T0.6590.95
56_H60_L0.6550.95
105_A110_S0.6550.95
244_P248_E0.6550.95
51_D55_A0.6540.95
168_Y211_K0.6540.95
175_T205_G0.6540.95
108_M273_G0.6520.95
236_A291_D0.6510.95
167_A171_V0.6470.95
147_Y288_I0.6470.95
123_K197_S0.6460.94
271_G279_F0.6440.94
46_C54_V0.6430.94
114_I240_I0.6420.94
220_L236_A0.6420.94
120_V194_I0.6410.94
162_I251_S0.6380.94
60_L63_W0.6370.94
209_V214_I0.6330.94
162_I248_E0.6280.94
169_D211_K0.6240.93
189_H253_G0.6240.93
59_Q62_E0.6220.93
128_V131_H0.6210.93
27_Q30_E0.6200.93
108_M187_K0.6200.93
141_V198_L0.6200.93
96_C195_G0.6140.93
221_K237_S0.6140.93
99_K103_D0.6130.93
43_L47_I0.6120.93
26_L32_K0.6110.93
45_E48_A0.6100.93
161_R252_K0.6090.93
51_D54_V0.6090.93
53_F57_A0.6070.92
159_G163_S0.6070.92
178_N286_I0.6060.92
213_S220_L0.6050.92
52_K56_H0.6040.92
46_C50_G0.6030.92
186_Q195_G0.6020.92
102_R114_I0.6000.92
54_V58_R0.6000.92
115_P241_F0.6000.92
47_I87_I0.5990.92
95_I250_L0.5990.92
71_L74_F0.5960.92
176_I296_L0.5950.92
102_R115_P0.5940.92
222_V234_G0.5930.92
179_D196_K0.5930.92
128_V177_V0.5930.92
246_L250_L0.5890.91
138_H142_T0.5890.91
165_E248_E0.5880.91
117_H189_H0.5860.91
145_L282_S0.5840.91
236_A243_I0.5820.91
74_F77_S0.5810.91
180_I200_T0.5790.91
105_A268_S0.5780.91
99_K105_A0.5750.90
85_A130_G0.5710.90
125_P128_V0.5710.90
223_E226_V0.5700.90
217_P220_L0.5670.90
180_I280_L0.5670.90
28_K74_F0.5670.90
92_K260_D0.5670.90
186_Q191_Q0.5660.90
44_I88_P0.5660.90
55_A59_Q0.5650.90
250_L254_M0.5630.89
50_G57_A0.5630.89
27_Q31_K0.5630.89
194_I252_K0.5620.89
47_I154_V0.5590.89
250_L262_I0.5590.89
247_I256_L0.5570.89
145_L182_A0.5550.89
99_K110_S0.5530.89
178_N288_I0.5520.88
86_P175_T0.5500.88
92_K124_S0.5490.88
171_V247_I0.5460.88
220_L224_T0.5460.88
97_I100_N0.5440.88
48_A91_S0.5440.88
96_C192_F0.5430.88
77_S81_V0.5420.88
95_I120_V0.5420.88
155_I258_A0.5400.87
120_V246_L0.5380.87
44_I47_I0.5370.87
145_L180_I0.5370.87
110_S187_K0.5360.87
148_E179_D0.5360.87
25_D30_E0.5360.87
97_I264_T0.5350.87
135_V145_L0.5350.87
150_E266_T0.5340.87
185_L252_K0.5310.86
58_R212_S0.5300.86
97_I101_Y0.5300.86
118_P249_T0.5270.86
181_T187_K0.5230.86
105_A109_G0.5230.86
151_L176_I0.5220.86
52_K55_A0.5220.86
70_E73_S0.5200.85
104_H183_R0.5200.85
181_T272_K0.5180.85
134_I282_S0.5180.85
163_S170_H0.5170.85
28_K31_K0.5170.85
87_I208_L0.5160.85
126_V254_M0.5150.85
88_P257_E0.5150.85
99_K119_M0.5150.85
192_F199_D0.5140.85
130_G206_P0.5140.85
163_S167_A0.5130.85
104_H146_D0.5120.84
46_C53_F0.5120.84
187_K272_K0.5110.84
153_V171_V0.5110.84
226_V256_L0.5100.84
144_Q187_K0.5090.84
129_T180_I0.5070.84
116_E241_F0.5060.84
78_L207_V0.5060.84
96_C101_Y0.5060.84
168_Y174_Y0.5030.83
95_I124_S0.5020.83
102_R240_I0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r6oA 2 0.8538 100 0.195 Contact Map
3lzkA 2 0.9369 100 0.262 Contact Map
4qkuA 2 0.9767 100 0.264 Contact Map
4dbfA 2 0.8272 100 0.269 Contact Map
3rr6A 1 0.8306 100 0.274 Contact Map
1wzoA 4 0.7841 100 0.287 Contact Map
1hyoA 2 0.9801 100 0.297 Contact Map
2dfuA 2 0.7807 100 0.301 Contact Map
2q18X 3 0.8638 100 0.322 Contact Map
1gttA 1 0.9169 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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