YISK - BACSU - GREMLIN Contacts

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YISK - Uncharacterized protein YisK

UniProt:	O06724	Sequences: MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLIECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYRDHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGTRISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPERLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTPPKFLRSGDKIDITIDPIGTLSNQIG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (256)
Sequences:	5108 (3492)
Seq/√Len:	218.2

ECOLI - YCGM
BACSU - YISK
HALSA - Q9HQR6
SULSO - Q97V63 Q97VT9 Q97UR1 KDAD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_V	263_A	3.862	1.00
221_K	233_S	3.584	1.00
163_S	166_D	3.512	1.00
227_N	284_D	3.466	1.00
289_T	295_T	3.244	1.00
287_D	297_S	3.123	1.00
159_G	162_I	3.108	1.00
164_K	248_E	3.085	1.00
225_R	230_L	2.922	1.00
152_A	177_V	2.872	1.00
242_S	245_E	2.814	1.00
166_D	169_D	2.610	1.00
168_Y	171_V	2.589	1.00
149_G	224_T	2.556	1.00
164_K	245_E	2.550	1.00
230_L	233_S	2.525	1.00
162_I	170_H	2.490	1.00
223_E	233_S	2.462	1.00
223_E	289_T	2.397	1.00
159_G	170_H	2.263	1.00
225_R	287_D	2.250	1.00
199_D	255_T	2.209	1.00
164_K	242_S	2.179	1.00
234_G	238_D	2.166	1.00
149_G	288_I	2.165	1.00
174_Y	211_K	2.149	1.00
204_M	261_I	2.099	1.00
287_D	295_T	2.058	1.00
147_Y	231_R	2.008	1.00
221_K	291_D	1.986	1.00
158_S	258_A	1.986	1.00
231_R	278_K	1.962	1.00
149_G	222_V	1.909	1.00
226_V	280_L	1.902	1.00
129_T	133_D	1.892	1.00
158_S	257_E	1.876	1.00
285_K	297_S	1.843	1.00
225_R	289_T	1.840	1.00
151_L	290_I	1.837	1.00
152_A	175_T	1.825	1.00
172_F	208_L	1.786	1.00
210_H	213_S	1.784	1.00
42_S	45_E	1.748	1.00
221_K	235_S	1.735	1.00
175_T	204_M	1.723	1.00
168_Y	244_P	1.707	1.00
120_V	250_L	1.705	1.00
155_I	247_I	1.696	1.00
136_K	200_T	1.676	1.00
130_G	133_D	1.653	1.00
274_F	278_K	1.650	1.00
47_I	172_F	1.647	1.00
153_V	243_I	1.639	1.00
82_K	133_D	1.637	1.00
137_S	145_L	1.616	1.00
152_A	261_I	1.608	1.00
97_I	246_L	1.602	1.00
135_V	180_I	1.587	1.00
126_V	257_E	1.586	1.00
223_E	230_L	1.569	1.00
142_T	184_D	1.562	1.00
214_I	220_L	1.561	1.00
77_S	80_E	1.554	1.00
176_I	290_I	1.530	1.00
152_A	263_A	1.505	1.00
226_V	231_R	1.490	1.00
154_V	208_L	1.466	1.00
127_T	255_T	1.455	1.00
102_R	106_I	1.421	1.00
103_D	238_D	1.396	1.00
175_T	293_I	1.370	1.00
219_R	237_S	1.359	1.00
180_I	203_P	1.355	1.00
229_E	278_K	1.348	1.00
99_K	115_P	1.346	1.00
91_S	257_E	1.341	1.00
103_D	268_S	1.340	1.00
158_S	170_H	1.337	1.00
144_Q	184_D	1.315	1.00
135_V	286_I	1.311	1.00
83_L	131_H	1.297	1.00
122_T	193_F	1.284	1.00
124_S	197_S	1.282	1.00
160_T	199_D	1.272	1.00
97_I	120_V	1.271	1.00
215_Q	292_P	1.254	1.00
132_G	296_L	1.242	1.00
185_L	198_L	1.219	1.00
25_D	29_A	1.200	1.00
218_E	244_P	1.183	1.00
225_R	295_T	1.178	1.00
76_Y	81_V	1.150	1.00
209_V	293_I	1.150	1.00
44_I	48_A	1.144	1.00
218_E	239_M	1.140	1.00
219_R	235_S	1.138	1.00
40_P	45_E	1.136	1.00
78_L	83_L	1.135	1.00
224_T	288_I	1.131	1.00
222_V	226_V	1.108	1.00
142_T	145_L	1.095	1.00
216_E	219_R	1.087	1.00
271_G	276_P	1.084	1.00
157_K	169_D	1.078	1.00
49_E	52_K	1.077	1.00
58_R	62_E	1.076	1.00
85_A	131_H	1.075	1.00
177_V	204_M	1.072	1.00
153_V	262_I	1.069	1.00
151_L	236_A	1.057	1.00
138_H	198_L	1.057	1.00
141_V	161_R	1.045	1.00
231_R	274_F	1.045	1.00
137_S	282_S	1.044	1.00
158_S	162_I	1.037	1.00
168_Y	218_E	1.030	1.00
220_L	290_I	1.028	1.00
143_S	184_D	1.004	1.00
272_K	279_F	1.002	1.00
132_G	297_S	1.002	1.00
163_S	248_E	0.991	1.00
154_V	175_T	0.991	1.00
46_C	57_A	0.990	1.00
144_Q	279_F	0.988	1.00
164_K	244_P	0.987	1.00
99_K	108_M	0.987	1.00
176_I	288_I	0.980	1.00
118_P	246_L	0.973	1.00
171_V	243_I	0.971	1.00
50_G	54_V	0.966	1.00
153_V	247_I	0.964	1.00
60_L	64_A	0.949	1.00
155_I	256_L	0.947	1.00
157_K	170_H	0.944	1.00
226_V	286_I	0.941	1.00
146_D	183_R	0.940	1.00
85_A	128_V	0.939	1.00
207_V	293_I	0.931	0.99
220_L	226_V	0.926	0.99
131_H	296_L	0.926	0.99
174_Y	217_P	0.922	0.99
55_A	212_S	0.921	0.99
95_I	254_M	0.915	0.99
160_T	255_T	0.908	0.99
228_G	285_K	0.905	0.99
218_E	242_S	0.899	0.99
140_E	161_R	0.892	0.99
256_L	262_I	0.881	0.99
158_S	255_T	0.881	0.99
135_V	199_D	0.881	0.99
97_I	250_L	0.869	0.99
101_Y	104_H	0.861	0.99
129_T	200_T	0.856	0.99
98_G	104_H	0.855	0.99
101_Y	264_T	0.852	0.99
50_G	53_F	0.852	0.99
157_K	258_A	0.846	0.99
122_T	197_S	0.841	0.99
111_E	114_I	0.840	0.99
156_G	172_F	0.839	0.99
248_E	252_K	0.838	0.99
225_R	228_G	0.836	0.99
45_E	49_E	0.836	0.99
182_A	185_L	0.827	0.99
241_F	245_E	0.827	0.99
44_I	89_K	0.825	0.99
217_P	236_A	0.824	0.99
193_F	197_S	0.823	0.99
181_T	186_Q	0.820	0.99
145_L	198_L	0.819	0.99
224_T	286_I	0.814	0.99
119_M	192_F	0.814	0.99
59_Q	63_W	0.806	0.99
151_L	174_Y	0.803	0.99
152_A	204_M	0.803	0.99
103_D	107_E	0.800	0.98
98_G	101_Y	0.796	0.98
228_G	287_D	0.785	0.98
153_V	174_Y	0.778	0.98
189_H	194_I	0.776	0.98
274_F	277_P	0.776	0.98
117_H	188_R	0.770	0.98
55_A	58_R	0.769	0.98
26_L	29_A	0.768	0.98
50_G	55_A	0.768	0.98
245_E	248_E	0.767	0.98
194_I	253_G	0.764	0.98
246_L	264_T	0.760	0.98
176_I	293_I	0.756	0.98
206_P	209_V	0.756	0.98
148_E	196_K	0.755	0.98
135_V	200_T	0.754	0.98
147_Y	280_L	0.753	0.98
104_H	107_E	0.753	0.98
214_I	293_I	0.747	0.98
105_A	114_I	0.746	0.98
41_G	45_E	0.742	0.97
247_I	262_I	0.738	0.97
149_G	176_I	0.738	0.97
53_F	56_H	0.737	0.97
239_M	246_L	0.737	0.97
56_H	59_Q	0.734	0.97
43_L	46_C	0.733	0.97
91_S	126_V	0.729	0.97
29_A	32_K	0.727	0.97
108_M	181_T	0.725	0.97
26_L	57_A	0.724	0.97
94_I	101_Y	0.722	0.97
26_L	31_K	0.721	0.97
91_S	125_P	0.721	0.97
126_V	199_D	0.713	0.97
57_A	60_L	0.711	0.97
180_I	286_I	0.711	0.97
223_E	291_D	0.710	0.97
173_G	208_L	0.708	0.97
142_T	182_A	0.704	0.97
124_S	193_F	0.703	0.97
171_V	174_Y	0.703	0.97
156_G	258_A	0.701	0.96
221_K	226_V	0.695	0.96
92_K	95_I	0.690	0.96
105_A	108_M	0.688	0.96
87_I	154_V	0.688	0.96
194_I	197_S	0.685	0.96
96_C	193_F	0.683	0.96
49_E	53_F	0.683	0.96
166_D	170_H	0.681	0.96
198_L	253_G	0.681	0.96
100_N	270_V	0.680	0.96
104_H	270_V	0.677	0.96
43_L	208_L	0.676	0.96
204_M	263_A	0.675	0.96
26_L	30_E	0.673	0.96
168_Y	243_I	0.673	0.96
128_V	204_M	0.673	0.96
248_E	251_S	0.671	0.96
25_D	28_K	0.669	0.95
105_A	240_I	0.668	0.95
222_V	228_G	0.666	0.95
177_V	200_T	0.666	0.95
183_R	186_Q	0.666	0.95
280_L	286_I	0.665	0.95
92_K	126_V	0.665	0.95
87_I	90_P	0.662	0.95
95_I	122_T	0.661	0.95
154_V	261_I	0.661	0.95
188_R	249_T	0.659	0.95
243_I	264_T	0.659	0.95
56_H	60_L	0.655	0.95
105_A	110_S	0.655	0.95
244_P	248_E	0.655	0.95
51_D	55_A	0.654	0.95
168_Y	211_K	0.654	0.95
175_T	205_G	0.654	0.95
108_M	273_G	0.652	0.95
236_A	291_D	0.651	0.95
167_A	171_V	0.647	0.95
147_Y	288_I	0.647	0.95
123_K	197_S	0.646	0.94
271_G	279_F	0.644	0.94
46_C	54_V	0.643	0.94
114_I	240_I	0.642	0.94
220_L	236_A	0.642	0.94
120_V	194_I	0.641	0.94
162_I	251_S	0.638	0.94
60_L	63_W	0.637	0.94
209_V	214_I	0.633	0.94
162_I	248_E	0.628	0.94
169_D	211_K	0.624	0.93
189_H	253_G	0.624	0.93
59_Q	62_E	0.622	0.93
128_V	131_H	0.621	0.93
27_Q	30_E	0.620	0.93
108_M	187_K	0.620	0.93
141_V	198_L	0.620	0.93
96_C	195_G	0.614	0.93
221_K	237_S	0.614	0.93
99_K	103_D	0.613	0.93
43_L	47_I	0.612	0.93
26_L	32_K	0.611	0.93
45_E	48_A	0.610	0.93
161_R	252_K	0.609	0.93
51_D	54_V	0.609	0.93
53_F	57_A	0.607	0.92
159_G	163_S	0.607	0.92
178_N	286_I	0.606	0.92
213_S	220_L	0.605	0.92
52_K	56_H	0.604	0.92
46_C	50_G	0.603	0.92
186_Q	195_G	0.602	0.92
102_R	114_I	0.600	0.92
54_V	58_R	0.600	0.92
115_P	241_F	0.600	0.92
47_I	87_I	0.599	0.92
95_I	250_L	0.599	0.92
71_L	74_F	0.596	0.92
176_I	296_L	0.595	0.92
102_R	115_P	0.594	0.92
222_V	234_G	0.593	0.92
179_D	196_K	0.593	0.92
128_V	177_V	0.593	0.92
246_L	250_L	0.589	0.91
138_H	142_T	0.589	0.91
165_E	248_E	0.588	0.91
117_H	189_H	0.586	0.91
145_L	282_S	0.584	0.91
236_A	243_I	0.582	0.91
74_F	77_S	0.581	0.91
180_I	200_T	0.579	0.91
105_A	268_S	0.578	0.91
99_K	105_A	0.575	0.90
85_A	130_G	0.571	0.90
125_P	128_V	0.571	0.90
223_E	226_V	0.570	0.90
217_P	220_L	0.567	0.90
180_I	280_L	0.567	0.90
28_K	74_F	0.567	0.90
92_K	260_D	0.567	0.90
186_Q	191_Q	0.566	0.90
44_I	88_P	0.566	0.90
55_A	59_Q	0.565	0.90
250_L	254_M	0.563	0.89
50_G	57_A	0.563	0.89
27_Q	31_K	0.563	0.89
194_I	252_K	0.562	0.89
47_I	154_V	0.559	0.89
250_L	262_I	0.559	0.89
247_I	256_L	0.557	0.89
145_L	182_A	0.555	0.89
99_K	110_S	0.553	0.89
178_N	288_I	0.552	0.88
86_P	175_T	0.550	0.88
92_K	124_S	0.549	0.88
171_V	247_I	0.546	0.88
220_L	224_T	0.546	0.88
97_I	100_N	0.544	0.88
48_A	91_S	0.544	0.88
96_C	192_F	0.543	0.88
77_S	81_V	0.542	0.88
95_I	120_V	0.542	0.88
155_I	258_A	0.540	0.87
120_V	246_L	0.538	0.87
44_I	47_I	0.537	0.87
145_L	180_I	0.537	0.87
110_S	187_K	0.536	0.87
148_E	179_D	0.536	0.87
25_D	30_E	0.536	0.87
97_I	264_T	0.535	0.87
135_V	145_L	0.535	0.87
150_E	266_T	0.534	0.87
185_L	252_K	0.531	0.86
58_R	212_S	0.530	0.86
97_I	101_Y	0.530	0.86
118_P	249_T	0.527	0.86
181_T	187_K	0.523	0.86
105_A	109_G	0.523	0.86
151_L	176_I	0.522	0.86
52_K	55_A	0.522	0.86
70_E	73_S	0.520	0.85
104_H	183_R	0.520	0.85
181_T	272_K	0.518	0.85
134_I	282_S	0.518	0.85
163_S	170_H	0.517	0.85
28_K	31_K	0.517	0.85
87_I	208_L	0.516	0.85
126_V	254_M	0.515	0.85
88_P	257_E	0.515	0.85
99_K	119_M	0.515	0.85
192_F	199_D	0.514	0.85
130_G	206_P	0.514	0.85
163_S	167_A	0.513	0.85
104_H	146_D	0.512	0.84
46_C	53_F	0.512	0.84
187_K	272_K	0.511	0.84
153_V	171_V	0.511	0.84
226_V	256_L	0.510	0.84
144_Q	187_K	0.509	0.84
129_T	180_I	0.507	0.84
116_E	241_F	0.506	0.84
78_L	207_V	0.506	0.84
96_C	101_Y	0.506	0.84
168_Y	174_Y	0.503	0.83
95_I	124_S	0.502	0.83
102_R	240_I	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3r6oA	2	0.8538	100	0.195	Contact Map
3lzkA	2	0.9369	100	0.262	Contact Map
4qkuA	2	0.9767	100	0.264	Contact Map
4dbfA	2	0.8272	100	0.269	Contact Map
3rr6A	1	0.8306	100	0.274	Contact Map
1wzoA	4	0.7841	100	0.287	Contact Map
1hyoA	2	0.9801	100	0.297	Contact Map
2dfuA	2	0.7807	100	0.301	Contact Map
2q18X	3	0.8638	100	0.322	Contact Map
1gttA	1	0.9169	100	0.351	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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