GREMLIN Database
YISJ - Inner spore coat protein H-like protein
UniProt: O06723 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (287)
Sequences: 1257 (1145)
Seq/√Len: 67.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_N290_L7.8051.00
171_L240_L6.4961.00
167_K236_Q4.4461.00
266_C283_E3.6511.00
74_R78_C3.2841.00
226_R229_S3.1011.00
170_F236_Q3.0941.00
165_D194_R3.0491.00
67_D72_R2.8801.00
21_G32_I2.7761.00
46_E110_N2.7111.00
235_S239_T2.6991.00
245_L301_Q2.6501.00
78_C257_L2.6281.00
23_F32_I2.4481.00
80_F175_G2.4391.00
42_K272_D2.2391.00
174_I241_M2.2381.00
127_R131_S2.1941.00
48_S51_K2.1321.00
159_R162_L2.0911.00
258_I290_L2.0671.00
146_I150_T2.0531.00
257_L260_E1.9991.00
18_T35_T1.9981.00
170_F240_L1.9851.00
125_D128_V1.9701.00
82_Q257_L1.9391.00
58_T112_Q1.9271.00
125_D129_P1.8931.00
152_G155_E1.8851.00
250_T253_R1.8371.00
33_L50_E1.8351.00
37_R60_F1.8341.00
94_F268_S1.8311.00
139_A143_E1.8301.00
181_Q186_T1.8091.00
133_F136_D1.7731.00
71_M92_Y1.7651.00
161_K166_V1.6910.99
34_L45_Y1.6870.99
41_E65_Q1.6820.99
45_Y105_Y1.6780.99
240_L243_N1.6720.99
124_A127_R1.6580.99
291_R295_E1.6560.99
60_F110_N1.6540.99
78_C82_Q1.6310.99
255_S290_L1.6230.99
78_C261_W1.5950.99
145_F149_R1.5920.99
287_T291_R1.5900.99
93_S107_N1.5820.99
49_W59_L1.5680.99
125_D130_L1.5520.99
94_F271_D1.5400.99
21_G34_L1.5130.99
74_R261_W1.5040.99
74_R90_A1.4960.99
285_E288_N1.4920.99
153_D226_R1.4820.99
104_I268_S1.4810.99
227_L233_F1.4750.99
64_E106_L1.4740.99
18_T46_E1.4450.98
243_N247_R1.4260.98
154_D158_E1.4160.98
89_V109_K1.4120.98
142_H146_I1.4020.98
227_L234_R1.4000.98
38_D201_E1.3810.98
76_A206_A1.3750.98
81_D87_A1.3740.98
35_T46_E1.3730.98
24_V29_V1.3690.98
96_T101_P1.3690.98
124_A130_L1.3630.98
44_S62_N1.3500.97
77_Y88_P1.3430.97
133_F137_S1.3280.97
124_A131_S1.3280.97
42_K63_A1.3110.97
259_N263_L1.3020.97
90_A106_L1.2810.96
179_T206_A1.2790.96
42_K95_L1.2680.96
137_S149_R1.2530.96
155_E158_E1.2520.96
83_I244_V1.2360.96
144_F195_L1.2220.95
76_A202_T1.2160.95
297_Q301_Q1.2150.95
161_K233_F1.2150.95
134_N137_S1.2010.95
64_E73_R1.2010.95
127_R130_L1.1920.95
126_P129_P1.1830.95
140_F143_E1.1800.94
82_Q253_R1.1740.94
100_Q275_I1.1670.94
46_E60_F1.1670.94
93_S203_R1.1620.94
189_L197_V1.1560.94
241_M245_L1.1500.94
239_T287_T1.1490.94
177_T237_Y1.1450.94
167_K171_L1.1440.93
164_L169_F1.1370.93
96_T99_G1.1350.93
64_E70_L1.1280.93
20_K31_P1.1160.93
104_I265_I1.1150.93
241_M301_Q1.1110.92
281_Q284_K1.1080.92
128_V132_L1.1040.92
116_K198_S1.1020.92
169_F197_V1.0980.92
61_L93_S1.0890.92
175_G202_T1.0840.92
85_V171_L1.0720.91
157_A230_I1.0590.91
122_K127_R1.0570.90
161_K236_Q1.0570.90
206_A293_I1.0570.90
159_R163_Y1.0490.90
57_R114_A1.0480.90
111_H198_S1.0400.90
192_S275_I1.0310.89
37_R62_N1.0270.89
16_K19_A1.0260.89
265_I269_A1.0260.89
297_Q300_L1.0230.89
186_T190_N1.0230.89
95_L105_Y1.0190.89
42_K49_W1.0160.89
160_I166_V1.0150.89
156_L160_I1.0100.88
37_R200_M1.0080.88
298_D302_A1.0030.88
32_I37_R0.9970.88
42_K105_Y0.9950.88
165_D196_Y0.9910.87
71_M258_I0.9790.87
124_A128_V0.9730.86
62_N200_M0.9730.86
259_N262_H0.9690.86
46_E58_T0.9660.86
66_D203_R0.9640.86
166_V236_Q0.9610.86
73_R77_Y0.9600.86
70_L272_D0.9540.85
242_K246_K0.9500.85
81_D89_V0.9490.85
262_H286_Q0.9490.85
97_I102_E0.9470.85
75_L206_A0.9440.85
159_R230_I0.9430.85
186_T189_L0.9400.84
64_E203_R0.9380.84
287_T290_L0.9350.84
148_I151_A0.9330.84
92_Y104_I0.9320.84
47_I59_L0.9280.84
75_L258_I0.9260.84
180_N292_E0.9240.83
72_R207_V0.9240.83
122_K125_D0.9210.83
254_L293_I0.9190.83
62_N73_R0.9160.83
144_F149_R0.9060.82
153_D156_L0.9050.82
122_K129_P0.9020.82
76_A179_T0.9000.82
69_S289_I0.8960.81
102_E275_I0.8950.81
74_R106_L0.8950.81
243_N246_K0.8860.81
80_F87_A0.8800.80
16_K35_T0.8780.80
73_R203_R0.8780.80
212_E287_T0.8760.80
69_S282_I0.8740.80
124_A129_P0.8650.79
62_N88_P0.8630.79
167_K240_L0.8620.79
62_N185_Y0.8590.79
113_P120_G0.8550.78
18_T48_S0.8550.78
181_Q203_R0.8540.78
291_R298_D0.8450.78
141_L149_R0.8450.78
160_I265_I0.8390.77
152_G156_L0.8360.77
137_S150_T0.8350.77
79_F254_L0.8330.77
137_S145_F0.8290.76
32_I269_A0.8250.76
271_D274_F0.8250.76
48_S57_R0.8160.75
174_I240_L0.8150.75
278_S281_Q0.8150.75
79_F83_I0.8150.75
88_P200_M0.8120.75
67_D103_G0.8100.74
80_F199_P0.8100.74
73_R187_F0.8100.74
81_D90_A0.8060.74
287_T294_E0.8030.74
207_V292_E0.8030.74
125_D131_S0.8010.74
101_P268_S0.8000.74
61_L95_L0.7980.73
77_Y108_I0.7980.73
247_R250_T0.7970.73
86_P120_G0.7960.73
66_D204_S0.7880.72
126_P131_S0.7860.72
262_H266_C0.7810.72
248_S253_R0.7810.72
48_S58_T0.7810.72
80_F85_V0.7660.70
129_P132_L0.7640.70
160_I164_L0.7640.70
188_C200_M0.7620.70
53_L89_V0.7600.70
72_R208_Q0.7590.70
126_P130_L0.7570.69
242_K247_R0.7540.69
78_C81_D0.7530.69
173_L205_L0.7510.69
214_D218_T0.7490.69
100_Q192_S0.7490.69
178_C241_M0.7480.68
228_L234_R0.7460.68
143_E163_Y0.7410.68
19_A23_F0.7390.68
151_A156_L0.7380.67
73_R186_T0.7360.67
212_E215_P0.7350.67
74_R92_Y0.7340.67
145_F148_I0.7340.67
35_T44_S0.7340.67
94_F101_P0.7320.67
152_G298_D0.7300.67
173_L237_Y0.7300.67
22_L29_V0.7280.66
23_F47_I0.7250.66
83_I249_F0.7220.66
232_A236_Q0.7160.65
262_H283_E0.7160.65
90_A261_W0.7150.65
65_Q185_Y0.7150.65
32_I47_I0.7140.65
62_N80_F0.7110.65
202_T207_V0.7100.64
256_P260_E0.7070.64
169_F227_L0.7040.64
84_G171_L0.7030.64
91_S108_I0.6990.63
122_K132_L0.6990.63
136_D145_F0.6990.63
140_F195_L0.6990.63
137_S144_F0.6950.63
75_L234_R0.6920.62
20_K33_L0.6880.62
204_S208_Q0.6870.62
44_S108_I0.6870.62
22_L28_S0.6870.62
35_T38_D0.6840.62
185_Y200_M0.6830.61
99_G165_D0.6800.61
235_S238_H0.6790.61
269_A282_I0.6790.61
286_Q289_I0.6780.61
240_L244_V0.6770.61
19_A36_Q0.6760.61
63_A173_L0.6740.60
77_Y200_M0.6710.60
195_L237_Y0.6710.60
299_F303_H0.6690.60
98_N296_R0.6680.60
93_S98_N0.6620.59
75_L261_W0.6610.59
230_I235_S0.6600.59
225_S229_S0.6600.59
199_P202_T0.6600.59
181_Q201_E0.6590.59
46_E89_V0.6590.59
168_L196_Y0.6580.59
282_I286_Q0.6560.58
23_F216_L0.6560.58
107_N233_F0.6540.58
147_L156_L0.6540.58
217_L220_G0.6530.58
27_R191_E0.6520.58
204_S207_V0.6490.58
77_Y106_L0.6440.57
144_F147_L0.6410.57
284_K287_T0.6360.56
147_L152_G0.6320.56
50_E57_R0.6320.56
182_G186_T0.6300.55
176_N185_Y0.6300.55
111_H200_M0.6290.55
78_C253_R0.6290.55
109_K118_S0.6280.55
263_L266_C0.6280.55
203_R277_K0.6280.55
144_F163_Y0.6270.55
273_P278_S0.6270.55
62_N106_L0.6270.55
224_S228_L0.6270.55
156_L226_R0.6260.55
39_R45_Y0.6260.55
115_G119_Y0.6260.55
36_Q43_A0.6240.55
138_S145_F0.6240.55
142_H148_I0.6230.54
74_R173_L0.6220.54
295_E298_D0.6150.54
77_Y90_A0.6150.54
280_F284_K0.6130.53
93_S114_A0.6130.53
187_F190_N0.6120.53
212_E216_L0.6120.53
160_I227_L0.6090.53
47_I244_V0.6080.53
168_L197_V0.6080.53
267_Q270_A0.6040.52
62_N199_P0.6040.52
154_D302_A0.6030.52
183_F222_T0.6010.52
284_K298_D0.5970.51
57_R115_G0.5970.51
134_N150_T0.5960.51
175_G179_T0.5950.51
135_N139_A0.5940.51
41_E276_K0.5920.51
97_I220_G0.5920.51
174_I244_V0.5890.50
260_E263_L0.5890.50
229_S232_A0.5880.50
92_Y195_L0.5870.50
83_I175_G0.5870.50
292_E296_R0.5860.50
184_Y221_K0.5840.50
97_I294_E0.5840.50
116_K186_T0.5820.50
29_V302_A0.5800.49
42_K103_G0.5790.49
229_S270_A0.5780.49
183_F224_S0.5750.49
36_Q62_N0.5750.49
140_F144_F0.5730.49
177_T241_M0.5730.49
172_W244_V0.5710.48
93_S105_Y0.5640.47
38_D181_Q0.5620.47
69_S72_R0.5610.47
294_E302_A0.5580.47
71_M265_I0.5570.47
294_E300_L0.5560.47
34_L83_I0.5540.46
239_T243_N0.5540.46
270_A279_P0.5530.46
113_P117_R0.5520.46
194_R231_P0.5520.46
18_T33_L0.5500.46
193_G196_Y0.5480.46
92_Y200_M0.5480.46
84_G175_G0.5470.45
238_H241_M0.5460.45
288_N291_R0.5450.45
23_F30_S0.5450.45
257_L261_W0.5420.45
231_P271_D0.5420.45
75_L269_A0.5410.45
162_L194_R0.5410.45
135_N242_K0.5400.45
109_K119_Y0.5390.44
251_I297_Q0.5370.44
253_R257_L0.5370.44
235_S302_A0.5350.44
77_Y87_A0.5330.44
98_N203_R0.5330.44
21_G24_V0.5320.44
94_F104_I0.5320.44
65_Q200_M0.5300.43
169_F173_L0.5300.43
212_E263_L0.5290.43
91_S107_N0.5280.43
255_S259_N0.5260.43
236_Q239_T0.5260.43
178_C254_L0.5250.43
25_T91_S0.5240.43
231_P250_T0.5240.43
80_F109_K0.5230.43
293_I297_Q0.5220.42
151_A226_R0.5210.42
111_H188_C0.5210.42
287_T298_D0.5210.42
170_F293_I0.5190.42
174_I179_T0.5190.42
136_D149_R0.5190.42
76_A205_L0.5180.42
291_R302_A0.5170.42
138_S141_L0.5170.42
247_R251_I0.5170.42
64_E108_I0.5170.42
62_N108_I0.5160.42
229_S233_F0.5140.42
186_T198_S0.5140.42
76_A254_L0.5140.42
49_W58_T0.5130.41
68_P75_L0.5130.41
72_R188_C0.5130.41
46_E112_Q0.5120.41
97_I284_K0.5120.41
95_L255_S0.5100.41
46_E197_V0.5100.41
155_E159_R0.5090.41
63_A185_Y0.5080.41
22_L31_P0.5070.41
43_A201_E0.5070.41
147_L195_L0.5050.41
82_Q291_R0.5050.41
88_P111_H0.5030.40
179_T205_L0.5010.40
151_A223_L0.5010.40
17_G20_K0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pu5A 1 0.899 97.6 0.886 Contact Map
3akjA 2 0.7785 96.2 0.906 Contact Map
3tpdA 1 0.8404 94.2 0.918 Contact Map
4cg4A 2 0.2443 14.3 0.961 Contact Map
3wg3A 2 0.4267 11.7 0.962 Contact Map
1cjaA 1 0.8176 10.2 0.963 Contact Map
4jehB 1 0.228 9.4 0.964 Contact Map
4n78F 1 0.2248 8.6 0.964 Contact Map
1ez3A 1 0.2313 8.5 0.964 Contact Map
1rkuA 2 0.2671 6.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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