GREMLIN Database
GERPC - Probable spore germination protein GerPC
UniProt: O06719 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (189)
Sequences: 121 (99)
Seq/√Len: 7.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_D187_A3.7810.95
73_N191_F3.2170.88
61_I80_V3.1570.87
144_E148_K2.8710.82
27_L58_Q2.6850.77
17_V148_K2.5000.71
73_N196_P2.2500.63
127_E134_L2.2460.63
72_L191_F2.2410.62
61_I180_V2.1410.59
138_N191_F2.0890.57
55_K83_F2.0780.56
148_K183_D2.0740.56
24_I27_L1.9760.52
43_Q81_Q1.9340.51
141_H191_F1.9130.50
7_S73_N1.9010.49
115_L146_I1.8690.48
191_F196_P1.8430.47
10_L13_L1.8340.47
127_E130_Y1.8110.46
127_E183_D1.8010.46
20_Q65_D1.7890.45
69_N158_M1.7860.45
17_V32_K1.6890.41
188_V192_L1.6420.39
127_E139_R1.6210.39
98_E118_E1.6150.38
110_N129_Q1.6080.38
45_P80_V1.6040.38
162_K176_I1.5850.37
22_I176_I1.5790.37
20_Q24_I1.5790.37
52_V58_Q1.5520.36
82_N138_N1.5420.36
80_V83_F1.5370.36
19_Q65_D1.5330.35
27_L49_I1.5200.35
31_L34_I1.5130.35
133_R144_E1.5090.35
37_E42_K1.4960.34
61_I150_M1.4850.34
39_N42_K1.4810.34
154_I176_I1.4600.33
111_V177_A1.4540.33
113_M129_Q1.4330.32
141_H158_M1.4040.31
61_I85_V1.3970.31
111_V154_I1.3800.30
110_N173_A1.3700.30
43_Q85_V1.3450.29
157_Y183_D1.3430.29
10_L76_D1.3310.29
116_T147_R1.3300.29
187_A192_L1.3290.29
134_L139_R1.3260.28
46_A150_M1.3150.28
47_T52_V1.3100.28
159_S192_L1.3040.28
144_E147_R1.2570.26
142_V188_V1.2420.26
17_V75_T1.2410.26
27_L50_E1.2270.25
156_Y159_S1.2020.25
45_P129_Q1.1950.25
23_H28_E1.1920.24
39_N43_Q1.1900.24
118_E181_K1.1810.24
9_Y191_F1.1640.24
107_I111_V1.1600.24
47_T187_A1.1560.23
49_I119_I1.1510.23
131_D183_D1.1310.23
34_I142_V1.1140.22
19_Q49_I1.1020.22
152_S159_S1.1020.22
55_K196_P1.0990.22
11_Q148_K1.0980.22
24_I176_I1.0970.22
61_I111_V1.0930.22
141_H196_P1.0820.21
77_P143_I1.0550.21
69_N73_N1.0450.20
49_I58_Q1.0430.20
50_E58_Q1.0370.20
16_F19_Q1.0300.20
78_N83_F1.0160.20
80_V195_I1.0150.20
151_D180_V1.0120.20
146_I193_E1.0120.20
38_M41_M1.0030.19
14_N129_Q1.0030.19
65_D188_V0.9970.19
58_Q81_Q0.9850.19
50_E187_A0.9790.19
127_E133_R0.9650.19
34_I124_E0.9630.18
69_N191_F0.9620.18
150_M180_V0.9550.18
10_L16_F0.9530.18
111_V183_D0.9500.18
49_I77_P0.9490.18
56_F64_L0.9450.18
56_F59_L0.9450.18
60_K64_L0.9450.18
56_F66_G0.9450.18
56_F60_K0.9450.18
66_G149_Q0.9450.18
59_L149_Q0.9450.18
56_F71_G0.9450.18
56_F145_D0.9450.18
59_L71_G0.9450.18
59_L66_G0.9450.18
59_L64_L0.9450.18
59_L145_D0.9450.18
71_G145_D0.9450.18
56_F149_Q0.9450.18
60_K66_G0.9450.18
66_G71_G0.9450.18
64_L145_D0.9450.18
64_L71_G0.9450.18
54_Y66_G0.9450.18
64_L149_Q0.9450.18
66_G145_D0.9450.18
60_K149_Q0.9450.18
54_Y59_L0.9450.18
54_Y60_K0.9450.18
145_D149_Q0.9450.18
54_Y149_Q0.9450.18
54_Y145_D0.9450.18
54_Y71_G0.9450.18
60_K71_G0.9450.18
60_K145_D0.9450.18
54_Y64_L0.9450.18
71_G149_Q0.9450.18
42_K73_N0.9310.18
28_E52_V0.9260.18
69_N85_V0.9140.17
12_N152_S0.9100.17
146_I189_E0.8980.17
44_R135_D0.8830.17
40_T114_Y0.8820.17
28_E115_L0.8810.17
18_Q109_Q0.8700.16
47_T50_E0.8620.16
158_M172_Y0.8610.16
158_M177_A0.8580.16
49_I126_L0.8540.16
108_R187_A0.8540.16
14_N192_L0.8520.16
62_E70_I0.8500.16
105_Q117_E0.8480.16
138_N147_R0.8470.16
119_I139_R0.8440.16
28_E85_V0.8420.16
40_T158_M0.8420.16
107_I192_L0.8410.16
20_Q62_E0.8370.16
16_F154_I0.8280.16
69_N155_H0.8250.15
107_I158_M0.8230.15
155_H179_H0.8160.15
85_V196_P0.8150.15
40_T150_M0.8060.15
20_Q148_K0.8030.15
86_S107_I0.8020.15
103_L162_K0.8000.15
139_R183_D0.7900.15
61_I179_H0.7890.15
49_I92_I0.7870.15
114_Y128_N0.7860.15
134_L194_H0.7850.15
127_E154_I0.7780.15
72_L142_V0.7710.14
142_V175_H0.7680.14
81_Q107_I0.7670.14
11_Q192_L0.7660.14
122_I185_I0.7650.14
45_P191_F0.7630.14
126_L130_Y0.7630.14
93_G122_I0.7570.14
50_E184_V0.7510.14
63_R113_M0.7440.14
55_K129_Q0.7430.14
37_E136_D0.7320.14
17_V33_E0.7180.13
160_H192_L0.7130.13
93_G193_E0.7120.13
136_D183_D0.7110.13
39_N162_K0.7110.13
69_N196_P0.7010.13
50_E188_V0.6990.13
45_P142_V0.6990.13
109_Q180_V0.6990.13
26_Q179_H0.6910.13
13_L17_V0.6900.13
31_L121_D0.6890.13
107_I175_H0.6860.13
22_I118_E0.6830.13
9_Y24_I0.6780.13
142_V196_P0.6780.13
11_Q17_V0.6720.13
178_E184_V0.6710.13
80_V86_S0.6700.13
72_L146_I0.6640.12
49_I161_I0.6610.12
62_E181_K0.6610.12
141_H195_I0.6590.12
59_L68_L0.6580.12
64_L68_L0.6580.12
60_K68_L0.6580.12
56_F68_L0.6580.12
54_Y68_L0.6580.12
68_L149_Q0.6580.12
68_L145_D0.6580.12
68_L71_G0.6580.12
58_Q187_A0.6530.12
21_A73_N0.6530.12
48_T176_I0.6520.12
20_Q53_E0.6430.12
32_K170_A0.6410.12
72_L180_V0.6410.12
10_L34_I0.6360.12
17_V115_L0.6350.12
119_I133_R0.6350.12
49_I143_I0.6330.12
36_T176_I0.6320.12
140_H144_E0.6250.12
79_S83_F0.6240.12
37_E84_D0.6240.12
186_R196_P0.6220.12
73_N141_H0.6190.12
31_L103_L0.6170.12
9_Y14_N0.6150.12
29_R33_E0.6140.12
6_V191_F0.6100.12
47_T58_Q0.6080.12
80_V138_N0.6030.11
79_S90_P0.6030.11
47_T146_I0.6020.11
47_T116_T0.6020.11
29_R99_E0.5990.11
33_E120_P0.5970.11
151_D155_H0.5930.11
125_Q129_Q0.5910.11
135_D157_Y0.5860.11
51_R178_E0.5840.11
73_N165_E0.5800.11
154_I183_D0.5770.11
104_M180_V0.5760.11
157_Y180_V0.5640.11
105_Q123_L0.5630.11
125_Q143_I0.5600.11
39_N98_E0.5590.11
85_V191_F0.5560.11
121_D159_S0.5540.11
49_I151_D0.5530.11
72_L122_I0.5530.11
57_D84_D0.5420.11
42_K61_I0.5400.10
79_S154_I0.5380.10
23_H111_V0.5360.10
108_R183_D0.5330.10
158_M173_A0.5330.10
47_T82_N0.5300.10
35_Q188_V0.5280.10
64_L67_T0.5210.10
59_L67_T0.5210.10
54_Y67_T0.5210.10
67_T145_D0.5210.10
60_K67_T0.5210.10
67_T71_G0.5210.10
56_F67_T0.5210.10
67_T149_Q0.5210.10
55_K133_R0.5200.10
53_E143_I0.5150.10
167_T192_L0.5130.10
42_K118_E0.5090.10
93_G157_Y0.5050.10
23_H177_A0.5030.10
70_I149_Q0.5000.10
60_K70_I0.5000.10
56_F70_I0.5000.10
59_L70_I0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nlwA 1 0.1951 43.4 0.951 Contact Map
4y66A 1 0.6439 42.1 0.951 Contact Map
2akfA 3 0.1561 40 0.952 Contact Map
1nkpB 1 0.2146 34 0.954 Contact Map
2pnvA 5 0.1902 27.5 0.956 Contact Map
1nkpA 1 0.2146 25.3 0.957 Contact Map
3e1rA 2 0.1561 22.7 0.958 Contact Map
2rawB 1 0.2488 22.2 0.958 Contact Map
3iynQ 5 0.2293 21.8 0.958 Contact Map
4iffA 2 0.2049 18.2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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