GREMLIN Database
GERPE - Probable spore germination protein GerPE
UniProt: O06717 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (121)
Sequences: 128 (104)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_T102_H3.2320.94
13_F16_L2.7520.87
53_F61_F2.6670.86
8_I103_A2.6150.85
32_M111_G2.6130.84
15_S18_I2.4780.81
30_I100_V2.4770.81
105_S111_G2.2740.75
42_S122_Q2.2330.73
51_G120_Q2.2000.72
95_V99_S2.1700.71
6_S105_S2.1470.70
41_R50_E2.0730.68
35_K57_E2.0660.67
6_S103_A2.0510.67
41_R120_Q1.9830.64
20_S96_S1.9410.62
50_E120_Q1.9250.62
19_A23_Q1.7990.56
5_I68_P1.7920.56
23_Q102_H1.6620.50
24_V111_G1.6330.49
62_Q113_A1.6060.48
41_R51_G1.5980.47
99_S116_K1.5860.47
65_A112_D1.4920.42
34_V123_S1.4670.41
24_V116_K1.4550.41
80_H105_S1.4400.40
4_R40_Q1.4200.39
31_D90_I1.4180.39
17_G36_V1.4150.39
35_K115_L1.3760.38
36_V97_A1.3450.36
35_K81_E1.3430.36
13_F56_K1.3400.36
97_A118_I1.3210.35
24_V78_F1.3030.35
6_S50_E1.2840.34
6_S83_P1.2690.33
69_L117_H1.2600.33
44_S120_Q1.2570.33
52_S62_Q1.2410.32
74_V90_I1.2290.32
94_G99_S1.2070.31
60_I95_V1.2010.31
102_H106_A1.1340.28
27_T46_F1.1080.27
20_S115_L1.1080.27
20_S80_H1.0940.27
11_V22_F1.0900.27
56_K107_S1.0780.26
17_G60_I1.0710.26
27_T106_A1.0710.26
8_I24_V1.0680.26
17_G97_A1.0000.24
101_L105_S0.9970.23
42_S121_I0.9950.23
102_H109_I0.9850.23
8_I65_A0.9780.23
2_L23_Q0.9610.22
53_F58_Y0.9590.22
63_Q112_D0.9560.22
80_H88_R0.9520.22
96_S117_H0.9500.22
74_V91_K0.9480.22
34_V62_Q0.9430.22
5_I90_I0.9340.21
4_R112_D0.9210.21
65_A118_I0.9180.21
35_K69_L0.9130.21
37_F56_K0.9040.21
42_S77_A0.8850.20
5_I49_N0.8820.20
36_V115_L0.8810.20
73_G92_I0.8790.20
48_H51_G0.8780.20
94_G121_I0.8610.19
80_H95_V0.8600.19
88_R107_S0.8560.19
24_V75_Q0.8560.19
46_F113_A0.8460.19
116_K122_Q0.8440.19
39_V49_N0.8440.19
70_P74_V0.8440.19
8_I66_V0.8290.18
111_G117_H0.8230.18
25_G104_G0.8200.18
104_G119_R0.8200.18
25_G119_R0.8200.18
14_N107_S0.8190.18
67_K80_H0.8160.18
48_H107_S0.8130.18
41_R47_Y0.8130.18
74_V77_A0.8120.18
66_V121_I0.8070.18
30_I111_G0.7890.17
17_G99_S0.7800.17
12_K80_H0.7790.17
41_R83_P0.7790.17
23_Q33_S0.7760.17
21_V103_A0.7740.17
43_L120_Q0.7720.17
27_T44_S0.7530.17
92_I98_S0.7470.16
37_F117_H0.7430.16
21_V102_H0.7370.16
52_S109_I0.7360.16
17_G94_G0.7350.16
49_N102_H0.7300.16
81_E111_G0.7290.16
13_F124_P0.7200.16
59_Q110_R0.7170.16
19_A38_A0.7160.16
63_Q100_V0.7090.15
97_A110_R0.7090.15
13_F108_L0.7070.15
8_I46_F0.7040.15
16_L22_F0.7000.15
40_Q95_V0.6990.15
11_V14_N0.6960.15
95_V101_L0.6930.15
15_S42_S0.6900.15
9_R69_L0.6900.15
44_S70_P0.6840.15
59_Q116_K0.6770.15
38_A117_H0.6720.15
92_I96_S0.6670.15
15_S56_K0.6620.14
58_Y121_I0.6550.14
65_A114_R0.6510.14
4_R38_A0.6510.14
77_A101_L0.6480.14
32_M112_D0.6470.14
20_S38_A0.6390.14
87_V92_I0.6310.14
21_V109_I0.6300.14
5_I22_F0.6280.14
81_E105_S0.6270.14
17_G98_S0.6210.14
18_I100_V0.6180.13
23_Q30_I0.6160.13
58_Y65_A0.6140.13
37_F51_G0.6030.13
9_R117_H0.6010.13
42_S45_T0.5970.13
82_V113_A0.5960.13
24_V28_N0.5960.13
52_S56_K0.5940.13
40_Q59_Q0.5890.13
15_S27_T0.5860.13
62_Q89_S0.5840.13
26_D117_H0.5760.13
69_L72_T0.5740.13
21_V89_S0.5730.13
49_N109_I0.5620.12
102_H121_I0.5580.12
66_V118_I0.5560.12
18_I58_Y0.5550.12
53_F57_E0.5550.12
59_Q80_H0.5470.12
65_A115_L0.5450.12
16_L46_F0.5450.12
91_K108_L0.5440.12
76_S100_V0.5430.12
21_V58_Y0.5340.12
10_L110_R0.5330.12
41_R118_I0.5320.12
20_S47_Y0.5310.12
46_F50_E0.5280.12
20_S76_S0.5210.12
49_N73_G0.5200.12
16_L71_E0.5160.11
27_T30_I0.5160.11
6_S85_I0.5090.11
71_E90_I0.5090.11
11_V90_I0.5080.11
19_A37_F0.5080.11
110_R115_L0.5050.11
24_V81_E0.5030.11
39_V93_Q0.5000.11
18_I93_Q0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dynA 3 0.3534 9.7 0.948 Contact Map
4uebB 1 0.3083 4.7 0.955 Contact Map
3tj0A 3 0.3158 4.7 0.955 Contact Map
2nr5A 4 0.2857 2 0.963 Contact Map
4s39A 2 0.4211 1.8 0.964 Contact Map
5a1uG 1 0.1955 1.8 0.964 Contact Map
4i5tA 2 0.4361 1.7 0.964 Contact Map
2heoA 1 0.1654 1.5 0.965 Contact Map
1rkiA 1 0.2782 1.5 0.965 Contact Map
3bp3A 1 0.3684 1.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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