GREMLIN Database
YISB - Uncharacterized protein YisB
UniProt: O06715 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 100 (85)
Sequences: 341 (248)
Seq/√Len: 26.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_T55_E4.5761.00
51_Y69_D3.0971.00
46_Q50_L2.6510.99
41_I45_K2.2040.98
20_T40_C2.0980.97
29_E54_Q1.8910.94
51_Y60_L1.7840.92
50_L60_L1.7680.92
82_Q86_K1.7150.91
27_K31_G1.6700.90
67_R76_V1.6350.89
25_T71_E1.6250.88
44_H48_H1.5990.87
65_E68_S1.5640.86
67_R74_R1.5320.85
63_M67_R1.5270.85
10_E20_T1.5240.85
60_L69_D1.5170.84
68_S80_R1.4570.82
42_P79_I1.4280.81
10_E24_L1.4240.80
30_G39_L1.3890.79
9_C14_R1.3780.78
53_N86_K1.3400.76
41_I53_N1.3200.75
51_Y72_L1.3130.75
9_C12_C1.2670.72
20_T53_N1.2460.71
20_T41_I1.2170.69
27_K32_T1.2150.69
10_E40_C1.1920.67
72_L76_V1.1850.67
49_A90_T1.1280.63
51_Y56_L1.0910.60
46_Q72_L1.0890.60
40_C88_I1.0860.60
24_L62_G1.0540.57
16_D27_K1.0500.57
25_T32_T1.0390.56
40_C86_K1.0360.56
28_E53_N1.0320.56
20_T30_G1.0290.56
52_T93_S1.0170.55
45_K87_L1.0120.54
42_P88_I1.0060.54
11_L72_L1.0030.54
13_G80_R0.9960.53
21_E38_M0.9940.53
45_K92_K0.9750.52
10_E88_I0.9710.51
57_A74_R0.9490.50
25_T61_N0.9430.49
68_S73_A0.9270.48
70_P73_A0.9230.48
52_T74_R0.9210.48
37_A63_M0.9190.47
30_G83_P0.9140.47
31_G49_A0.9110.47
30_G77_K0.9020.46
55_E59_R0.8950.46
50_L69_D0.8890.45
10_E37_A0.8700.44
17_V81_K0.8680.44
30_G36_T0.8670.44
11_L14_R0.8620.43
71_E74_R0.8570.43
42_P87_L0.8310.41
47_I64_A0.8310.41
44_H47_I0.8240.40
40_C82_Q0.8160.40
41_I87_L0.8140.40
51_Y66_L0.8080.39
20_T88_I0.7940.38
56_L61_N0.7800.37
50_L71_E0.7680.36
24_L60_L0.7670.36
25_T35_P0.7620.36
18_Q73_A0.7560.36
59_R65_E0.7560.36
15_S86_K0.7550.35
75_F78_W0.7530.35
8_I77_K0.7460.35
25_T83_P0.7410.35
73_A77_K0.7380.34
74_R81_K0.7320.34
40_C53_N0.7270.34
21_E82_Q0.7200.33
19_L38_M0.7180.33
45_K91_K0.7070.32
16_D19_L0.7010.32
68_S85_E0.6970.32
56_L63_M0.6960.32
55_E69_D0.6910.31
78_W86_K0.6840.31
65_E70_P0.6800.31
17_V27_K0.6730.30
57_A61_N0.6730.30
10_E42_P0.6460.28
15_S84_P0.6450.28
20_T42_P0.6440.28
28_E37_A0.6310.27
18_Q85_E0.6290.27
20_T24_L0.6240.27
13_G47_I0.6150.27
28_E75_F0.6010.26
10_E53_N0.5970.25
82_Q85_E0.5860.25
11_L66_L0.5790.24
21_E41_I0.5790.24
62_G93_S0.5630.24
71_E91_K0.5600.23
61_N65_E0.5590.23
56_L65_E0.5590.23
7_G25_T0.5470.23
32_T84_P0.5450.23
80_R87_L0.5430.23
76_V89_K0.5390.22
35_P42_P0.5350.22
78_W84_P0.5320.22
21_E45_K0.5280.22
75_F89_K0.5230.21
38_M50_L0.5190.21
70_P75_F0.5170.21
53_N89_K0.5160.21
8_I72_L0.5140.21
42_P86_K0.5090.21
35_P52_T0.5060.21
64_A67_R0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ogeA 1 0.91 97.9 0.797 Contact Map
4h9dA 3 0.64 97 0.828 Contact Map
4un4B 1 0.85 95.9 0.847 Contact Map
3m7kA 2 0.71 94.6 0.858 Contact Map
3plwA 1 0.75 84.5 0.888 Contact Map
4uhqA 1 0.56 75.3 0.898 Contact Map
1e7lA 2 0.93 64.7 0.905 Contact Map
3goxA 2 0.61 56.6 0.91 Contact Map
3g27A 2 0.67 52.5 0.912 Contact Map
1k3xA 1 0.34 42.9 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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