GREMLIN Database
OPUE - Osmoregulated proline transporter
UniProt: O06493 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 492 (457)
Sequences: 11563 (7270)
Seq/√Len: 340.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
430_V462_A5.8171.00
361_S364_E4.2711.00
419_M463_G3.9481.00
261_D264_D3.8751.00
357_R364_E3.7081.00
18_L22_Y3.5341.00
430_V458_L3.3601.00
170_V377_A3.3501.00
352_Y360_A3.2521.00
464_I468_M3.1301.00
427_A463_G3.1231.00
97_A262_I3.0481.00
420_N470_T3.0461.00
426_A466_V3.0421.00
201_I205_T3.0151.00
462_A466_V2.9901.00
434_T458_L2.9881.00
203_A289_I2.9581.00
466_V470_T2.8801.00
212_P215_H2.8151.00
363_K367_M2.7731.00
423_G467_S2.7051.00
422_W470_T2.6251.00
412_L463_G2.5931.00
157_D160_L2.5681.00
166_T381_V2.5481.00
367_M371_L2.5221.00
178_F258_A2.4301.00
371_L375_V2.4171.00
40_L182_S2.3661.00
290_G307_I2.3601.00
31_N38_R2.3051.00
113_D124_K2.2931.00
11_I15_A2.2431.00
64_G305_E2.2011.00
426_A462_A2.1651.00
420_N423_G2.1351.00
260_K264_D2.1241.00
416_W419_M2.0591.00
423_G466_V2.0511.00
111_F413_S2.0431.00
163_F167_A2.0371.00
360_A364_E2.0111.00
409_A424_A2.0021.00
378_V382_L1.9971.00
32_D37_G1.9911.00
215_H219_A1.9891.00
197_V201_I1.9481.00
422_W426_A1.9471.00
420_N467_S1.9321.00
116_F419_M1.9301.00
357_R360_A1.9301.00
224_L228_F1.9281.00
56_G145_S1.9241.00
195_A327_A1.8751.00
122_L425_L1.8701.00
423_G427_A1.8691.00
35_L38_R1.8661.00
14_I18_L1.8641.00
349_E353_R1.8611.00
433_A437_I1.8441.00
212_P216_E1.8341.00
263_K267_P1.8211.00
294_A314_I1.8191.00
105_A114_K1.7771.00
263_K266_K1.7761.00
44_V186_F1.7611.00
264_D267_P1.7591.00
416_W464_I1.7551.00
176_G180_A1.7551.00
416_W468_M1.7521.00
461_I465_I1.7471.00
19_I187_V1.7391.00
418_R471_K1.7341.00
169_V336_I1.7101.00
223_H226_D1.7061.00
352_Y368_I1.7011.00
367_M370_R1.6741.00
412_L460_M1.6711.00
322_G326_S1.6681.00
226_D229_K1.6491.00
353_R365_L1.6321.00
352_Y357_R1.6181.00
12_Y16_M1.6101.00
224_L227_I1.5991.00
347_V351_L1.5901.00
42_P264_D1.5761.00
147_G162_L1.5701.00
418_R468_M1.5701.00
47_L186_F1.5601.00
110_D350_D1.5591.00
113_D121_S1.5411.00
215_H218_D1.5281.00
340_L377_A1.5271.00
167_A171_L1.5241.00
148_R303_D1.5101.00
6_I10_G1.5081.00
347_V372_S1.5041.00
430_V434_T1.4941.00
45_T259_I1.4941.00
211_A215_H1.4931.00
310_I314_I1.4781.00
426_A430_V1.4641.00
160_L164_L1.4611.00
185_D255_R1.4601.00
94_R99_T1.4441.00
117_Q421_E1.4291.00
117_Q122_L1.4201.00
91_L411_L1.4161.00
360_A365_L1.4121.00
457_I461_I1.4111.00
364_E367_M1.4011.00
16_M187_V1.3861.00
162_L381_V1.3811.00
352_Y364_E1.3791.00
5_I319_L1.3711.00
207_V213_T1.3681.00
343_T376_I1.3561.00
10_G14_I1.3531.00
15_A19_I1.3521.00
420_N471_K1.3361.00
169_V333_M1.3231.00
166_T377_A1.3181.00
392_L396_G1.3151.00
130_I432_A1.3121.00
115_R413_S1.3011.00
218_D222_P1.2991.00
216_E219_A1.2891.00
110_D349_E1.2891.00
437_I441_T1.2591.00
418_R472_R1.2531.00
185_D337_S1.2451.00
160_L163_F1.2431.00
458_L462_A1.2351.00
129_L133_I1.2301.00
347_V352_Y1.2211.00
184_T337_S1.2111.00
364_E368_I1.2101.00
143_M166_T1.2091.00
124_K350_D1.2081.00
366_V370_R1.2041.00
146_G165_T1.2031.00
111_F115_R1.2021.00
188_Q337_S1.1981.00
29_D32_D1.1971.00
159_K163_F1.1941.00
34_M369_G1.1931.00
113_D354_S1.1881.00
121_S354_S1.1821.00
94_R97_A1.1811.00
66_M73_T1.1711.00
434_T462_A1.1691.00
180_A185_D1.1681.00
228_F231_A1.1601.00
420_N466_V1.1551.00
107_T345_S1.1551.00
52_A338_S1.1511.00
208_G212_P1.1501.00
391_I395_V1.1501.00
419_M423_G1.1491.00
460_M464_I1.1481.00
310_I313_K1.1421.00
126_V425_L1.1411.00
156_A161_G1.1381.00
210_V214_F1.1371.00
36_G40_L1.1341.00
7_I11_I1.1341.00
123_L425_L1.1341.00
348_T369_G1.1331.00
190_A194_A1.1281.00
36_G178_F1.1281.00
48_S338_S1.1131.00
427_A459_S1.1081.00
127_S428_M1.1071.00
362_D365_L1.1071.00
15_A187_V1.1051.00
15_A18_L1.1051.00
163_F381_V1.1051.00
462_A465_I1.1041.00
139_T380_A1.1041.00
418_R473_P1.1021.00
211_A214_F1.0951.00
94_R98_Y1.0931.00
394_L398_A1.0921.00
372_S375_V1.0891.00
216_E292_A1.0851.00
129_L351_L1.0841.00
457_I460_M1.0791.00
151_E158_Y1.0771.00
93_P97_A1.0741.00
368_I372_S1.0721.00
12_Y333_M1.0711.00
48_S51_A1.0671.00
169_V337_S1.0651.00
194_A198_L1.0621.00
181_V184_T1.0541.00
409_A428_M1.0531.00
46_A271_I1.0491.00
312_S324_L1.0461.00
218_D221_N1.0461.00
206_H293_Y1.0451.00
7_I10_G1.0431.00
122_L126_V1.0431.00
427_A431_G1.0401.00
405_A459_S1.0401.00
172_Y333_M1.0391.00
422_W466_V1.0331.00
143_M162_L1.0281.00
452_I456_F1.0271.00
17_L20_G1.0161.00
356_F360_A1.0151.00
442_G445_K1.0141.00
50_G275_W1.0101.00
42_P46_A1.0091.00
74_L78_L1.0031.00
369_G373_V1.0021.00
172_Y337_S1.0021.00
419_M467_S0.9991.00
301_V304_P0.9991.00
421_E425_L0.9981.00
289_I293_Y0.9971.00
454_P457_I0.9951.00
309_I312_S0.9951.00
250_P254_V0.9941.00
185_D338_S0.9941.00
140_S383_L0.9931.00
180_A184_T0.9931.00
396_G399_W0.9911.00
123_L424_A0.9911.00
347_V376_I0.9901.00
360_A368_I0.9841.00
198_L202_V0.9811.00
198_L320_I0.9801.00
221_N224_L0.9791.00
93_P266_K0.9781.00
222_P226_D0.9731.00
27_T32_D0.9681.00
223_H227_I0.9681.00
348_T368_I0.9621.00
121_S125_I0.9551.00
233_V237_I0.9541.00
17_L21_W0.9531.00
204_F209_G0.9521.00
112_F123_L0.9501.00
174_L374_L0.9491.00
250_P342_V0.9461.00
18_L21_W0.9431.00
213_T289_I0.9391.00
79_G83_G0.9381.00
413_S424_A0.9341.00
22_Y26_K0.9341.00
390_T393_D0.9301.00
115_R416_W0.9271.00
112_F127_S0.9251.00
422_W469_I0.9251.00
56_G332_I0.9241.00
126_V428_M0.9231.00
412_L419_M0.9201.00
34_M345_S0.9181.00
116_F413_S0.9161.00
134_F401_G0.9121.00
52_A185_D0.9111.00
303_D306_M0.9111.00
352_Y356_F0.9051.00
395_V399_W0.9031.00
68_A304_P0.9021.00
391_I396_G0.8971.00
412_L464_I0.8961.00
334_S337_S0.8951.00
352_Y358_R0.8931.00
396_G400_A0.8921.00
213_T217_I0.8911.00
200_P282_G0.8891.00
116_F463_G0.8861.00
92_A96_R0.8851.00
431_G435_V0.8841.00
12_Y330_A0.8841.00
290_G311_F0.8821.00
225_L228_F0.8821.00
48_S182_S0.8811.00
341_L344_A0.8811.00
172_Y334_S0.8791.00
408_P460_M0.8791.00
89_L270_R0.8731.00
416_W467_S0.8731.00
172_Y188_Q0.8711.00
182_S185_D0.8681.00
67_F301_V0.8681.00
429_I433_A0.8671.00
158_Y162_L0.8671.00
392_L395_V0.8641.00
460_M463_G0.8621.00
130_I428_M0.8611.00
188_Q330_A0.8591.00
25_K28_T0.8591.00
196_L283_S0.8581.00
270_R274_S0.8561.00
122_L421_E0.8551.00
214_F218_D0.8551.00
156_A164_L0.8551.00
202_V206_H0.8541.00
132_M347_V0.8521.00
86_S90_L0.8521.00
159_K385_L0.8521.00
216_E220_V0.8511.00
465_I468_M0.8501.00
459_S463_G0.8491.00
378_V381_V0.8481.00
42_P267_P0.8481.00
438_W454_P0.8481.00
409_A459_S0.8461.00
375_V379_I0.8451.00
397_Y439_I0.8441.00
55_S138_Y0.8431.00
66_M288_L0.8411.00
344_A348_T0.8401.00
81_T277_I0.8391.00
437_I440_T0.8381.00
233_V236_I0.8381.00
9_L13_F0.8361.00
286_T311_F0.8351.00
47_L189_G0.8341.00
416_W423_G0.8331.00
48_S255_R0.8321.00
259_I265_L0.8261.00
431_G459_S0.8261.00
206_H315_L0.8251.00
458_L461_I0.8251.00
51_A255_R0.8241.00
125_I355_F0.8231.00
214_F217_I0.8221.00
184_T188_Q0.8221.00
222_P227_I0.8211.00
371_L374_L0.8191.00
36_G258_A0.8181.00
172_Y180_A0.8171.00
416_W420_N0.8161.00
48_S52_A0.8151.00
209_G212_P0.8151.00
41_G264_D0.8151.00
67_F296_K0.8131.00
22_Y25_K0.8121.00
13_F16_M0.8121.00
9_L329_L0.8101.00
224_L229_K0.8091.00
423_G426_A0.8061.00
27_T366_V0.8021.00
65_A69_T0.8011.00
425_L429_I0.8011.00
21_W175_F0.7981.00
422_W471_K0.7971.00
77_A84_A0.7911.00
207_V212_P0.7861.00
224_L230_G0.7861.00
16_M20_G0.7841.00
21_W24_F0.7821.00
234_I238_S0.7811.00
90_L93_P0.7781.00
188_Q334_S0.7781.00
162_L384_S0.7771.00
90_L94_R0.7771.00
122_L125_I0.7751.00
5_I321_T0.7721.00
225_L229_K0.7721.00
306_M310_I0.7711.00
188_Q335_S0.7681.00
96_R99_T0.7671.00
249_Q252_I0.7671.00
8_S319_L0.7661.00
151_E155_G0.7651.00
347_V368_I0.7651.00
420_N472_R0.7641.00
312_S321_T0.7631.00
424_A431_G0.7631.00
226_D230_G0.7631.00
199_V203_A0.7611.00
93_P262_I0.7601.00
183_L186_F0.7591.00
109_P127_S0.7581.00
44_V182_S0.7561.00
59_L324_L0.7531.00
198_L201_I0.7521.00
5_I8_S0.7511.00
451_E455_G0.7511.00
442_G446_S0.7491.00
456_F459_S0.7481.00
23_A27_T0.7461.00
83_G87_N0.7451.00
51_A188_Q0.7430.99
199_V308_F0.7420.99
259_I264_D0.7420.99
430_V466_V0.7410.99
76_L80_L0.7400.99
163_F378_V0.7290.99
55_S59_L0.7280.99
232_S235_S0.7280.99
121_S124_K0.7270.99
274_S278_I0.7270.99
465_I469_I0.7260.99
205_T210_V0.7250.99
193_F197_V0.7250.99
432_A436_L0.7230.99
88_Y92_A0.7230.99
353_R358_R0.7230.99
178_F182_S0.7210.99
8_S322_G0.7210.99
223_H228_F0.7190.99
42_P271_I0.7190.99
98_Y105_A0.7170.99
17_L171_L0.7170.99
81_T273_M0.7160.99
412_L416_W0.7120.99
356_F359_K0.7110.99
147_G158_Y0.7090.99
71_L288_L0.7080.99
471_K474_A0.7070.99
24_F175_F0.7070.99
373_V377_A0.7070.99
48_S185_D0.7060.99
150_F161_G0.7060.99
110_D114_K0.7050.99
316_F320_I0.7020.99
126_V429_I0.7020.99
92_A265_L0.7010.99
449_V453_I0.7010.99
22_Y183_L0.7010.99
311_F315_L0.6990.99
58_M280_V0.6980.99
117_Q474_A0.6970.99
40_L45_T0.6920.99
227_I230_G0.6910.99
188_Q333_M0.6900.99
107_T350_D0.6900.99
142_G336_I0.6880.99
117_Q123_L0.6870.99
207_V292_A0.6860.99
335_S339_Q0.6860.99
391_I394_L0.6860.99
461_I464_I0.6850.99
242_W245_G0.6850.99
59_L196_L0.6820.99
418_R421_E0.6810.99
445_K448_G0.6810.99
286_T308_F0.6780.99
142_G335_S0.6780.99
132_M343_T0.6770.99
53_D399_W0.6760.99
33_Y370_R0.6750.99
453_I457_I0.6750.99
11_I18_L0.6740.99
33_Y373_V0.6740.99
109_P131_I0.6730.99
418_R422_W0.6730.99
148_R305_E0.6730.99
202_V205_T0.6720.99
301_V310_I0.6710.99
173_T337_S0.6710.99
464_I467_S0.6700.99
339_Q342_V0.6670.99
161_G165_T0.6670.99
106_I110_D0.6650.99
20_G24_F0.6650.99
12_Y188_Q0.6630.99
146_G332_I0.6630.99
344_A373_V0.6610.99
469_I472_R0.6610.99
344_A372_S0.6590.99
365_L369_G0.6570.99
148_R151_E0.6570.99
434_T437_I0.6560.99
319_L323_F0.6540.99
181_V255_R0.6540.99
76_L79_G0.6520.99
95_L253_I0.6520.99
53_D80_L0.6510.99
8_S326_S0.6500.99
213_T292_A0.6500.99
407_G411_L0.6500.99
435_V455_G0.6490.99
381_V384_S0.6480.99
419_M427_A0.6470.99
291_V307_I0.6460.99
185_D334_S0.6460.99
125_I129_L0.6450.99
466_V469_I0.6440.99
30_I34_M0.6430.99
204_F210_V0.6410.99
340_L373_V0.6400.99
61_G138_Y0.6400.99
181_V338_S0.6390.98
455_G459_S0.6390.98
41_G44_V0.6380.98
94_R415_Y0.6370.98
355_F358_R0.6360.98
313_K321_T0.6350.98
221_N225_L0.6330.98
85_Y89_L0.6320.98
223_H229_K0.6300.98
21_W25_K0.6290.98
43_F47_L0.6280.98
23_A183_L0.6270.98
344_A369_G0.6270.98
395_V398_A0.6270.98
204_F285_L0.6270.98
374_L378_V0.6200.98
213_T216_E0.6180.98
96_R262_I0.6170.98
306_M309_I0.6170.98
220_V224_L0.6170.98
439_I451_E0.6170.98
273_M277_I0.6170.98
235_S238_S0.6130.98
116_F412_L0.6130.98
144_V148_R0.6130.98
170_V174_L0.6120.98
138_Y339_Q0.6100.98
43_F186_F0.6100.98
67_F307_I0.6100.98
222_P228_F0.6100.98
221_N227_I0.6090.98
284_V288_L0.6090.98
131_I346_A0.6080.98
442_G447_T0.6070.98
139_T336_I0.6060.98
32_D179_L0.6060.98
221_N228_F0.6060.98
7_I14_I0.6050.98
433_A436_L0.6050.98
199_V324_L0.6050.98
112_F409_A0.6040.98
434_T438_W0.6010.98
143_M180_A0.6000.98
83_G243_G0.6000.98
222_P225_L0.6000.98
52_A255_R0.5980.98
5_I322_G0.5980.98
125_I128_A0.5970.98
348_T352_Y0.5960.98
50_G189_G0.5950.98
170_V374_L0.5930.98
213_T288_L0.5920.98
51_A189_G0.5890.97
255_R338_S0.5890.97
393_D396_G0.5890.97
124_K128_A0.5880.97
227_I231_A0.5860.97
233_V238_S0.5850.97
291_V295_H0.5850.97
44_V183_L0.5840.97
65_A73_T0.5840.97
45_T48_S0.5830.97
304_P307_I0.5800.97
203_A315_L0.5800.97
72_S75_W0.5800.97
212_P292_A0.5790.97
333_M337_S0.5790.97
116_F424_A0.5780.97
470_T473_P0.5780.97
200_P285_L0.5770.97
353_R362_D0.5770.97
267_P271_I0.5750.97
292_A295_H0.5740.97
138_Y249_Q0.5740.97
71_L74_L0.5740.97
353_R359_K0.5730.97
197_V200_P0.5730.97
46_A50_G0.5720.97
31_N362_D0.5710.97
400_A435_V0.5700.97
434_T455_G0.5680.97
19_I23_A0.5680.97
436_L440_T0.5680.97
188_Q331_A0.5670.97
91_L99_T0.5670.97
172_Y176_G0.5670.97
446_S454_P0.5660.97
293_Y311_F0.5660.97
204_F213_T0.5660.97
279_T283_S0.5650.97
426_A429_I0.5640.97
92_A95_L0.5640.97
77_A80_L0.5640.97
331_A334_S0.5630.97
20_G23_A0.5620.97
456_F460_M0.5620.97
255_R334_S0.5610.97
270_R273_M0.5610.97
179_L183_L0.5610.97
296_K302_K0.5610.97
144_V158_Y0.5590.97
422_W425_L0.5590.97
85_Y270_R0.5590.97
162_L166_T0.5560.96
181_V185_D0.5550.96
316_F324_L0.5550.96
210_V213_T0.5530.96
13_F20_G0.5520.96
26_K39_G0.5510.96
30_I365_L0.5500.96
256_F269_R0.5500.96
387_P390_T0.5490.96
408_P463_G0.5490.96
296_K301_V0.5490.96
55_S142_G0.5490.96
50_G279_T0.5480.96
151_E157_D0.5480.96
424_A427_A0.5460.96
130_I405_A0.5450.96
196_L282_G0.5440.96
142_G145_S0.5430.96
217_I291_V0.5430.96
60_M145_S0.5430.96
41_G45_T0.5430.96
348_T365_L0.5410.96
391_I399_W0.5400.96
379_I382_L0.5400.96
211_A216_E0.5390.96
450_Y454_P0.5390.96
427_A430_V0.5380.96
53_D276_M0.5370.96
220_V291_V0.5370.96
404_S408_P0.5360.96
59_L64_G0.5360.96
12_Y20_G0.5340.95
138_Y142_G0.5330.95
78_L84_A0.5320.95
131_I406_F0.5310.95
339_Q406_F0.5300.95
317_H320_I0.5280.95
166_T384_S0.5280.95
138_Y250_P0.5280.95
242_W246_Y0.5280.95
276_M280_V0.5270.95
431_G434_T0.5270.95
202_V315_L0.5270.95
5_I20_G0.5240.95
57_W399_W0.5240.95
55_S61_G0.5240.95
418_R464_I0.5230.95
123_L127_S0.5230.95
40_L258_A0.5230.95
181_V341_L0.5220.95
294_A310_I0.5220.95
124_K354_S0.5210.95
84_A87_N0.5200.95
260_K263_K0.5200.95
196_L279_T0.5200.95
380_A384_S0.5190.95
26_K179_L0.5180.95
62_V66_M0.5180.95
352_Y355_F0.5170.95
203_A206_H0.5160.95
348_T372_S0.5160.95
54_M272_G0.5140.94
347_V375_V0.5140.94
412_L467_S0.5140.94
468_M471_K0.5130.94
385_L388_N0.5130.94
426_A470_T0.5130.94
148_R152_S0.5130.94
76_L83_G0.5120.94
370_R373_V0.5120.94
244_L248_G0.5120.94
65_A68_A0.5120.94
88_Y95_L0.5110.94
27_T179_L0.5110.94
262_I266_K0.5090.94
52_A173_T0.5090.94
217_I288_L0.5080.94
16_M23_A0.5070.94
359_K364_E0.5070.94
430_V433_A0.5070.94
106_I349_E0.5070.94
115_R417_K0.5070.94
24_F27_T0.5060.94
208_G211_A0.5050.94
318_P321_T0.5050.94
288_L292_A0.5050.94
138_Y251_H0.5040.94
194_A197_V0.5020.94
79_G84_A0.5020.94
463_G466_V0.5020.94
108_I410_I0.5010.94
31_N106_I0.5010.94
114_K417_K0.5010.94
105_A111_F0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9411 100 0.214 Contact Map
3dh4A 3 0.8963 100 0.255 Contact Map
3l1lA 2 0.8252 99.4 0.848 Contact Map
3giaA 1 0.8516 99.4 0.851 Contact Map
4wgvA 2 0.7561 99.1 0.865 Contact Map
4djkA 2 0.813 98.8 0.881 Contact Map
2jlnA 1 0.8313 98.7 0.886 Contact Map
4c7rA 3 0.878 97.6 0.914 Contact Map
2wswA 3 0.8171 97.2 0.921 Contact Map
4us3A 1 0.8008 95.9 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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