GREMLIN Database
GATC - Glutamyl-tRNA(Gln) amidotransferase subunit C
UniProt: O06492 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 96 (93)
Sequences: 2338 (1460)
Seq/√Len: 151.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_K25_A3.7161.00
73_P76_D3.1021.00
6_I26_K2.9031.00
72_L77_V2.8921.00
5_S8_E2.7941.00
83_D90_R2.7031.00
21_T24_E2.6191.00
74_V87_G2.5221.00
7_E10_K2.2211.00
73_P77_V1.9631.00
6_I10_K1.9581.00
6_I25_A1.9171.00
77_V89_I1.8781.00
76_D79_K1.8531.00
28_F31_Q1.8421.00
33_D37_S1.8291.00
20_I25_A1.7641.00
78_M84_H1.7261.00
55_H59_M1.7251.00
84_H87_G1.7101.00
26_K29_T1.5161.00
27_M31_Q1.5101.00
46_N49_N1.4741.00
40_E43_N1.3931.00
31_Q34_S1.3621.00
22_E25_A1.3591.00
20_I28_F1.3541.00
70_K73_P1.3541.00
68_A71_G1.3071.00
53_T56_V1.2931.00
33_D36_I1.2931.00
6_I22_E1.2731.00
80_N89_I1.2161.00
41_E44_E1.2071.00
26_K30_E1.2031.00
37_S40_E1.2001.00
74_V77_V1.1591.00
30_E34_S1.1311.00
9_V29_T1.1050.99
38_F42_L1.1030.99
84_H88_Y1.0890.99
3_R33_D1.0840.99
29_T33_D1.0680.99
78_M89_I1.0640.99
3_R40_E1.0350.99
12_V16_A1.0320.99
42_L47_T1.0290.99
18_L28_F1.0290.99
10_K22_E1.0240.99
9_V32_L1.0200.99
14_H17_R0.9660.98
34_S37_S0.9540.98
31_Q35_I0.9540.98
9_V13_A0.9340.98
34_S38_F0.9310.98
8_E11_H0.8780.97
53_T94_I0.8740.97
74_V78_M0.8650.97
12_V33_D0.8360.96
38_F41_E0.8310.96
57_L92_P0.8300.96
52_P55_H0.8230.96
23_E26_K0.7970.95
24_E27_M0.7700.94
6_I29_T0.7690.94
42_L46_N0.7660.94
62_V90_R0.7560.94
9_V12_V0.7420.93
81_A89_I0.7330.92
21_T25_A0.7250.92
23_E27_M0.7140.91
4_I8_E0.7040.91
13_A91_V0.7030.91
35_I39_A0.6980.91
27_M30_E0.6860.90
12_V31_Q0.6840.90
13_A64_R0.6840.90
80_N84_H0.6790.89
52_P56_V0.6780.89
56_V59_M0.6700.89
56_V71_G0.6670.88
78_M81_A0.6630.88
25_A29_T0.6600.88
85_K90_R0.6520.87
54_T91_V0.6460.87
40_E44_E0.6420.87
9_V25_A0.6410.86
42_L45_V0.6370.86
6_I27_M0.6370.86
4_I54_T0.6340.86
20_I41_E0.6300.85
3_R36_I0.6270.85
15_L35_I0.6220.85
63_M88_Y0.6210.85
11_H14_H0.6120.84
92_P95_L0.6060.83
48_D51_E0.6050.83
9_V94_I0.6050.83
28_F32_L0.6050.83
36_I93_S0.6010.83
21_T26_K0.6010.83
39_A88_Y0.6010.83
36_I63_M0.5900.82
13_A82_P0.5860.81
34_S53_T0.5850.81
34_S40_E0.5840.81
57_L60_K0.5810.81
8_E29_T0.5750.80
39_A53_T0.5690.79
90_R95_L0.5610.78
69_G72_L0.5610.78
5_S40_E0.5570.78
20_I24_E0.5560.78
16_A19_A0.5560.78
61_N90_R0.5550.78
8_E12_V0.5540.77
8_E13_A0.5530.77
11_H15_L0.5510.77
21_T27_M0.5490.77
74_V84_H0.5420.76
26_K51_E0.5360.75
18_L90_R0.5360.75
68_A75_E0.5340.75
14_H28_F0.5320.75
7_E29_T0.5320.75
42_L88_Y0.5310.74
58_K62_V0.5300.74
11_H85_K0.5300.74
5_S76_D0.5300.74
13_A18_L0.5300.74
61_N65_E0.5270.74
61_N72_L0.5270.74
82_P91_V0.5250.74
22_E26_K0.5240.73
44_E56_V0.5170.72
57_L61_N0.5130.72
16_A29_T0.5070.71
74_V90_R0.5030.70
53_T71_G0.5010.70
4_I14_H0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4C 1 0.9583 100 0.088 Contact Map
3al0C 1 0.9583 100 0.098 Contact Map
4wj3C 1 0.9792 100 0.126 Contact Map
3h0lC 1 0.9479 100 0.128 Contact Map
3kfuG 1 0.8958 100 0.18 Contact Map
4n0hF 1 0.8438 100 0.222 Contact Map
1pzgA 4 0.4688 15.9 0.917 Contact Map
4dmvA 1 0.8021 12.9 0.92 Contact Map
2bvlA 1 0.8646 10.1 0.924 Contact Map
4xosA 1 0.5104 8.9 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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